Mineralized collagen scaffolds fabricated with amniotic membrane matrix increase osteogenesis under inflammatory conditions

作     者：Marley J.Dewey Eileen M.Johnson Simona T.Slater Derek J.Milner Matthew B.Wheeler Brendan A.C.Harley 

作者机构：Department of Materials Science and EngineeringUniversity of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Department of BioengineeringUniversity of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Department of Chemical and Biomolecular EngineeringUniversity of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Carl R.Woese Institute for Genomic BiologyUniversity of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Department of Animal SciencesUniversity of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2020年第7卷第3期

页      面：247-258页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：Office of the Assistant Secretary of Defense for Health Affairs Broad Agency, (W81XWH-16-1-0566) National Science Foundation, NSF, (DGE-1144245) National Science Foundation, NSF National Institutes of Health, NIH, (R21 DE026582) National Institutes of Health, NIH National Institute of Dental and Craniofacial Research, NIDCR 

主　　题：mineralized collagen scaffolds amniotic membrane inflammation stem cell osteogenesis 

摘      要：Defects in craniofacial bones occur congenitally,after high-energy impacts,and during the course of treatment for stroke and *** injuries are difficult to heal due to the overwhelming size of the injury area and the inflammatory environment surrounding the *** inflammatory response after injury may greatly inhibit regenerative *** have developed mineralized collagen scaffolds that can induce osteogenic differentiation and matrix biosynthesis in the absence of osteogenic media or supplemental *** amniotic membrane is derived from placentas and has been recently investigated as an extracellular matrix to prevent chronic ***,we hypothesized that a mineralized collagen-amnion composite scaffold could increase osteogenic activity in the presence of inflammatory *** report mechanical properties of a mineralized collagen-amnion scaffold and investigated osteogenic differentiation and mineral deposition of porcine adipose-derived stem cells within these scaffolds as a function of inflammatory *** of amniotic membrane matrix promotes osteogenesis similarly to un-modified mineralized collagen scaffolds,and increases in mineralized collagen-amnion scaffolds under inflammatory ***,these findings suggest that a mineralized collagen-amnion scaffold may provide a beneficial environment to aid craniomaxillofacial bone repair,especially in the course of defects presenting significant inflammatory complications.