Effect of image registration on longitudinal analysis of retinal nerve fiber layer thickness of non-human primates using Optical Coherence Tomography(OCT)

作     者：Shuang Liu Anjali Datta Derek Ho Jordan Dwelle Daifeng Wang Thomas E Milner Henry Grady Rylander III Mia K Markey 

作者机构：Department of Biomedical EngineeringThe University of Texas at AustinAustinTX 78712USA Department of Electrical and Computer EngineeringThe University of Texas at AustinAustinTX 78712USA Department of Imaging PhysicsThe University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Present address:Clinical Neuroscience Imaging Center(CNIC)Department of NeurologyYale School of MedicineNew HavenCT 06510USA 

出 版 物：《Eye and Vision》 (眼视光学杂志（英文）)

年 卷 期：2015年第2卷第1期

页      面：16-27页

核心收录：

学科分类：08[工学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：This study is supported by National Eye Institute at the National Institutes of Health(Grant R01EY016462) 

主　　题：Retinal nerve fiber layer thickness Glaucoma Image registration 

摘      要：Background:In this paper we determined the benefits of image registration on estimating longitudinal retinal nerve fiber layer thickness(RNFLT)***:RNFLT maps around the optic nerve head(ONH)of healthy primate eyes were measured using Optical Coherence Tomography(OCT)weekly for 30 *** automatic algorithm based on mutual information(MI)and the other semi-automatic algorithm based on log-polar transform cross-correlation using manually segmented blood vessels(LPCC_MSBV),were used to register retinal maps *** compared the precision and recall between manually segmented image pairs for the two algorithms using a linear mixed effects ***:We found that the precision calculated between manually segmented image pairs following registration by LPCC_MSBV algorithm is significantly better than the one following registration by MI algorithm(p0.0001).Trend of the all-rings and temporal,superior,nasal and inferior(TSNI)quadrants average of RNFLT over time in healthy primate eyes are not affected by *** of clock hours 1,2,and 10 showed significant change over 30 weeks(p=0.0058,0.0054,and 0.0298 for clock hours 1,2 and 10 respectively)without registration,but stayed constant over time with ***:The LPCC_MSBV provides better registration of RNFLT maps recorded on different dates than the automatic MI *** of RNFLT maps can improve clinical analysis of glaucoma progression.