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Traumatic subcutaneous emphysema of the hand/forearm: A case report

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Chinese j.urnal of Traumatology 2022年第6期25卷 395-399页

作者： Stephen Saela Alexander Decilveo Roman Isaac deepak V.Patel Department of Orthopaedic Surgery St Josephs University Medical CenterPatersonNJ 07503USA Department of Orthopaedic Surgery Seton Hall UniversitySouth OrangeNJ 07079US

Subcutaneous emphysema is commonly associated with infection caused by gas-producing *** this case report,we describe a rare instance of traumatic subcutaneous emphysema of the hand and forearm caused by a puncture inj.ry to the first web space of the *** obj.ctive is to increase awareness of the potential for seemingly minor trauma to cause entrapment of significant air in subcutaneous tissues,thereby decreasing the likelihood that a clinically benign-appearing patient will be started down an unnecessarily aggressive treatment pathway.A 16-year-old,otherwise healthy white female,presented to the pediatric emergency room with an impressive amount of subcutaneous emphysema that developed over a 12-h period after sustaining an accidental laceration to the first web space of her right *** appeared nontoxic and had a clinically benign presentation.A comprehensive work-up was *** was splinted by the orthopedic surgery resident on call,and was admitted to the Pediatric Intensive Care Unit for overnight *** received tetanus vaccination and broad-spectrum *** patient was discharged 2 days after admittance,with a splint applied to her right hand and *** undertook home-based physical and occupational *** had a pain-free range-of-motion in the right wrist,elbow and *** swelling in the right hand subsided *** initially alarming,traumatic subcutaneous emphysema in an otherwise healthy patient from minor wounds(as featured in this case)does not necessarily mean one ought to proceed down an aggressive treatment *** evaluation of the patient's history,clinical examination findings,and determination of the Laboratory Risk Indicator for Necrotizing Fasciitis score can help guide physicians in the management of traumatic subcutaneous emphysema and potentially avoid unnecessary and costly interventions.

关键词： Upper extremity Traumatic subcutaneous emphysema Sucking-wounds Penetrating Necrotizing fasciitis Case reports Laboratory Risk Indicator for Necrotizing Fasciitis(LRINEC)

High energy superstable hybrid capacitor with a self-regulated Zn/electrolyte interface and 3D graphene-like carbon cathode

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InfoMat 2022年第10期4卷 62-77页

作者： Nilesh R.Chodankar Swati j.Patil Sangj.n Lee j.eho Lee Seung-Kyu Hwang Pragati A.Shinde Indraj.t V.Bagal Smita V.Karekar Ganj. Seeta Rama Raj. Kugalur Shanmugam Ranj.th deepak P.Dubal Yun-Suk Huh Young-Kyu Han Department of Energy and Material Engineering Dongguk University-SeoulSeoulRepublic of Korea Department of Biological Engineering NanoBio High-Tech Materials Research CenterInha UniversityIncheonRepublic of Korea Department of Biological Sciences and Bioengineering Inha UniversityIncheonRepublic of Korea Research Institute of Sciences and Engineering University of SharjahSharjahUnited Arab Emirates Department of Physics Chonnam National UniversityGwangjuRepublic of Korea School of Chemistry and Physics Centre for Materials ScienceQueensland University of Technology(QUT)BrisbaneQueenslandAustralia

Rechargeable aqueous zinc ion hybrid capacitors(ZIHCs),as an up-and-comer aqueous electrochemical energy storage system,endure in their infancy because of the substandard reversibility of Zn anodes,structural deterioration of cathode materials,and narrow electrochemical stability ***,a scalable approach is described that addresses Zn-anode/electrolyte interface and cathode materials associated deficiencies and boosts the electrochemical properties of *** Zn-anode/electrolyte interface is self-regulated by alteration of the traditional Zn2+electrolyte with Na-based supporting salt without surrendering the cost,safety,and green features of the Zn-based system which further validates the excellent reversibility over 1100 h with suppressed hydrogen *** deficits of cathode materials were overcome by using a high-mass loaded,oxygen-rich,3D,multiscaled graphene-like carbon(3D MGC)*** to the multiscaled texture,high electronic conductivity,and oxygen-rich functional groups of 3D MGC,reversible redox capacitance was obtained with a traditional adsorption/desorption *** ZIHCs containing the modified electrolyte and an oxygen-rich 3D MGC cathode resulted in battery-like specific energy(203 Wh kg1 at 1.6 A g^(-1))and supercapacitor-type power capability(4.9 kW kg1 at 8 A g^(-1))with outstanding cycling durability(96.75%retention over 30000 cycles at 10 A g^(-1)).These findings pave the way toward the utilization of highly efficient ZIHCs for practical applications.

关键词： electrolyte additive graphene-like carbon interface multivalent ion capacitor zinc

Evaluation of results of open distal femur fractures with primary fixation and antibiotic impregnated collagen

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Chinese j.urnal of Traumatology 2019年第6期22卷 328-332页

作者： Maley deepak Kumar Roop Singh Rakesh Khiyani Kiranpreet Kaur Svareen Department of Orthopaedic Surgery Paraplegia&RehabilitationPt.B.D.Sharma PGIMSHaryanaRohtak 124001India Department of Anesthesiology and Critical Care Pt.B.D.Sharma PGIMSHaryanaRohtak 124001India Baba Saheb Ambedkar Medical College RohiniNew DelhiIndia

Purpose:Distal femoral fracture is one of the most common lower limb inj.ries and accounts for less than 1%of all *** fracture takes 5%-10%of the all distal femoral fractures,which is at an increased risk of *** were limited studies which documented the outcomes of such *** present study aims to evaluate the outcome and complications in these fractures using primary definitive fixation with condylar locking plate and antibiotic impregnated collagen sheet secondary to aggressive ***:This is a prospective study conducted in a tertiary care orthopaedic hospital in northern *** patients of open distal femoral fractures were managed by primary definitive fixation with condylar locking plate and antibiotic impregnated collagen sheet secondary to aggressive *** were followed for minimum of six *** were followed up monthly for first four months,at six months and one year after *** and radiological signs of healing,any complications,time to union,and functional outcome were ***:The mean age of patients was 44.33 years(range 20-82 years)with male predominance of 66.7%.According to Gustilo-Anderson classification,there were 5,15 and 10 patients with open grade I,II and IIIA distal femoral fractures *** to orthopaedic trauma association(OTA)classification,maj.rity of patients in our study were of C3 *** mean time to bony union was 5.6 months(range 4-9 months).Average postoperative knee range of motion(ROM)at the latest follow-up was 98°(range 70°-120°).Lysholm knee scoring scale showed excellent score in 11 patients,good in 9 patients,fair and poor in 5 patients each;however,there was no significant correlation with fracture pattern types(pj.r complications encountered in the *** knee ROM was<90°in 5 patients and 90°-120°in rest of the patients,while 1 patient had extensor lag of 10°.One patient had implant fa

关键词： Distal femur fracture Supracondylar Open fractures plating Outcome

Compact pulsed thulium‐doped fiber laser for topographical patterning of hydrogels

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Opto-Electronic Advances 2020年第6期3卷 9-17,I0001页

作者： Elizabeth Lee Biao Sun j.aqi Luo Satnam Singh deepak Choudhury Derrick Yong Xia Yu Qij.e Wang Singapore Institute of Manufacturing Technology 2 Fusionopolis WayInnovis138634 Singapore School of Electrical&Electronic Engineering Nanyang Technological University50 Nanyang Avenue639798 Singapore Currently with School of Instrumentation and Optoelectronic Engineering Beihang University37 Xueyuan RoadBeijing 100083China

We report the generation of high energy 2μm picosecond pulses from a thulium-doped fiber master oscillator power amplifier *** all-fiber configuration was realized by a flexible large-mode area photonic crystal fiber(LMA-PCF).The amplifier output is a linearly-polarized 1.5 ns,100 kHz pulse train with a pulse energy of up to 250μ*** compression was achieved with(2+2)-pass chirped volume Bragg grating(CVBG)to obtain a 2.8 ps pulse width with a total pulse energy of 46μ*** overall system compactness was enabled by the all-fiber amplifier design and the multi-pass CVBG-based *** laser output was then used to demonstrate high-speed direct-writing capability on a temperature-sensitive biomaterial to change its topography(*** microchannels,foams and pores).The topographical modifications of biomaterials are known to influence cell behavior and fate which is potentially useful in many cell and tissue engineering applications.

关键词： Tm-doped fiber lasers chirped pulse amplification photonic crystal fiber

Recent trends and technical advancements in biosensors and their emerging applications in food and bioscience

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Food Bioscience 2022年第3期47卷 1023-1050页

作者： Oluwatosin E.Bankole deepak Kumar Verma Mónica L.Chávez González j.an Guzmán Ceferino j.séSandoval-Cortés Cristóbal N.Aguilar Department of Chemical Sciences Faculty of Science and Science EducationAnchor UniversityLagos StateNigeria Agricultural and Food Engineering Department Indian Institute of Technology KharagpurKharagpur721302West BengalIndia Bioprocesses Research Group Food Research DepartmentSchool of ChemistryUniversidad Autonoma de CoahuilaUnidad Saltillo25280CoahuilaMexico Los Ríos Multidisciplinary Academic Division Universidad Juárez Autónoma de TabascoTabascoMexico Department of Analytical Chemistry School of ChemistryUniversidad Autonoma de CoahuilaUnidad Saltillo25280CoahuilaMexico

Biosensor development has recently advanced as a result of their strong and indisputable uses as analytical methods in a variety of sectors,including medicine,food industry,environmental monitoring,metabolism,agriculture,military,and *** popularity of biosensors as devices for a variety of applications may be ascribed to their distinct advantages of fast or rapid analysis,high sensitivity,minimal sample demand and preparation,and no need for the specific skill of operation that traditional analytical procedures *** attempted to update earlier studies in this study by incorporating other materials that have been in use but have received less attention,such as carbon nano-onions(CNOs),metal-organic frameworks(MOFs),and biopolymers for biosensor manufacturing and design based on their unique *** assessment also took into account applicable applications in many *** considerable progress has been made in the application of biosensors,there is still a need for research development and enhancement,particularly in transforming most of the laboratory experiments that have already been published into portable on-site and implementable in the public domains.

关键词： Biosensors Nanotechnology Nano-materials Food quality and safety Food snd biomedical industry Industrial application

Co-delivery of rhBMP-2 and zoledronic acid using calcium sulfate/hydroxyapatite carrier as a bioactive bone substitute to enhance and accelerate spinal fusion

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Bioactive Materials 2024年第6期36卷 256-271页

作者： Xinggui Tian Corina Vater deepak Bushan Raina Lisa Findeisen Lucas-Maximilian Matuszewski Magnus Tägil Lars Lidgren Anj. Winkler Robert Gottwald Niels Modler Klaus-Dieter Schaser Alexander C.Disch Stefan Zwingenberger University Center of Orthopaedic Trauma and Plastic SurgeryUniversity Hospital Carl Gustav Carus at TUD Dresden University of Technology01307DresdenGermany Center for Translational Bone Joint and Soft Tissue ResearchUniversity Hospital Carl Gustav Carus at TUD Dresden University of Technology01307DresdenGermany Lund University Faculty of MedicineDepartment of Clinical Sciences LundOrthopaedicsLund22185Sweden Institute of Lightweight Engineering and Polymer Technology at TUD Dresden University of Technology 01062DresdenGermany

Recombinant human bone morphogenetic protein-2(rhBMP-2)has been FDA-approved for lumbar fusion,but supraphysiologic initial burst release due to suboptimal carrier and late excess bone resorption caused by osteoclast activation have limited its clinical *** strategy to mitigate the pro-osteoclast side effect of rhBMP-2 is to give systemic bisphosphonates,but it presents challenges with systemic side effects and low local *** aim of this in vivo study was to analyze if posterolateral spinal fusion(PLF)could be improved by utilizing a calcium sulfate/hydroxyapatite(CaS/HA)carrier co-delivering rhBMP-2 and zoledronic acid(ZA).Six groups were allocated(CaS/HA,CaS/HA+BMP-2,CaS/HA+systemic ZA,CaS/HA+local ZA,CaS/HA+BMP-2+systemic ZA,and CaS/HA+BMP-2+local ZA).10-week-old male Wistar rats,were randomly assigned to undergo L4-L5 PLF with implantation of group-dependent *** 3 and 6 weeks,the animals were euthanized for radiography,μCT,histological staining,or biomechanical testing to evaluate spinal *** results demonstrated that the CaS/HA biomaterial alone or in combination with local or systemic ZA didn’t support ***,the delivery of rhBMP-2 significantly promoted *** systemic ZA with rhBMP-2 didn’t enhance spinal ***,the co-delivery of rhBMP-2 and ZA using the CaS/HA carrier significantly enhanced and accelerated PLF,without inhibiting systemic bone turnover,and potentially reduced the dose of ***,the treatment regimen of CaS/HA biomaterial co-delivering rhBMP-2 and ZA could potentially be a safe and cost-effective off-the-shelf bioactive bone substitute to enhance spinal fusion.

关键词： Calcium sulfate/hydroxyapatite Bone morphogenetic protein 2 Bisphosphonate Spinal fusion Bone substitute

间断或持续PTH刺激对骨及间充质干细胞的不同分化作用

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中华医学杂志 2018年第10期98卷 781-787页

作者：张瀶曦 deepak H. Balani Sophia Trinh Henry M. Kronenberg 母义明解放军总医院内分泌科北京100853 Endocrine Unit Massachusetts General Hospital and Harvard Medical School Boston 02114 USA

目的探讨不同甲状旁腺素（PTH）给药情况下及撤药后，骨及间充质干细胞的不同分化作用机制。方法6周龄雄性C57/BL6j.鼠，基因型为SOX9－creERT/Td－Tomato/Osteocalcin－GFP，分为间断PTH刺激及撤药组（PTH 500 μg·kg^－1·d^－1，... 详细信息

目的探讨不同甲状旁腺素（PTH）给药情况下及撤药后，骨及间充质干细胞的不同分化作用机制。方法6周龄雄性C57/BL6j.鼠，基因型为SOX9－creERT/Td－Tomato/Osteocalcin－GFP，分为间断PTH刺激及撤药组（PTH 500 μg·kg^－1·d^－1，皮下注射）、持续PTH刺激及撤药组（PTH泵，80 μg·kg^－1·d^－1，速度0.25 μl/h，皮下埋入）、空白对照组及撤药对照组，共6组，每组8只。分别于给药2周及撤药2周时观察小鼠血清中钙离子浓度及骨密度，并取小鼠胫骨骨骼分别进行病理及免疫荧光染色。结果间断PTH刺激组血清钙离子浓度一过性升高，达（1.36±0.03）mmol/L。持续PTH泵刺激组血清中钙离子浓度逐渐升高，48 h达高峰[（2.33±0.03）mmol/L]，2周后恢复正常（1.12～1.27 mmol/L）。PTH刺激2周后，间断组[（0.047±0.002）g/cm2]和持续组[（0.046±0.001）g/cm2]骨密度均高于对照组[（0.044±0.001）g/cm2]，但间断组和持续组差异无统计学意义。停药2周后，三组间BMD差异无统计学意义。股骨病理可见间断组骨皮质不明显，大量的骨小梁增生，伴少量纤维组织增生；持续PTH刺激大片纤维组织增生，尤以骨皮质内侧显著，撤药后纤维化消失。间断PTH刺激后骨细胞和成骨细胞明显升高，撤药后明显下降；衬里细胞数量骤减，撤药后有所增加；破骨细胞给药及撤药后差异均无统计学意义。持续PTH刺激破骨细胞增多，衬里细胞骤减，撤药后破骨细胞和衬里细胞增加，成骨细胞减少。腓骨干骺端免疫荧光显示，间断PTH刺激组大量未分化的Td－tomato间充质干细胞，撤药后较前明显减少。持续PTH组少量未分化的Td－tomato间充质干细胞增生，撤药后较前减少。结论间断PTH刺激可通过增加未分化的间充质干细胞和成骨细胞数量，将衬里细胞转换为骨细胞和成骨细胞，进而促进骨生成；持续PTH刺激可使少量未分化的间充质干细胞、成骨细胞和骨细胞增生，伴大量纤维化增生和破骨细胞数量骤增，最终可能导致代谢性骨病，撤药后衬里细胞明显增加，或有利于代谢性骨病的缓解。

关键词：甲状旁腺素间充质干细胞骨成骨细胞破骨细胞

盐酸二甲双胍缓释片的溶胀机制与释放规律相关性研究

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中国医药工业杂志 2013年第4期44卷 352-356页

作者：朱芳芳高慧升 KULKARNI Anand HEGDE deepak 涂家生中国药科大学药学院江苏南京210000 上海药明康德新药开发有限公司上海200131

以羟丙甲纤维素(HPMC)为骨架材料,采用正交设计优化盐酸二甲双胍缓释片的处方。所得优化处方为:HPMCK100M-药物重量比为0.25∶1,聚乙烯吡咯烷酮(PVP)K90为黏合剂。测定了优化制品在不同pH介质(pH 1.0盐酸、pH 4.5乙酸盐缓冲液和pH 7.4... 详细信息

以羟丙甲纤维素(HPMC)为骨架材料,采用正交设计优化盐酸二甲双胍缓释片的处方。所得优化处方为:HPMCK100M-药物重量比为0.25∶1,聚乙烯吡咯烷酮(PVP)K90为黏合剂。测定了优化制品在不同pH介质(pH 1.0盐酸、pH 4.5乙酸盐缓冲液和pH 7.4磷酸盐缓冲液)中的溶胀因子和体外释放行为,并用不同模型拟合,继而考察药物释放与缓释片溶胀因子间的相关性。研究表明,所得制品的溶胀与体外释药况均符合Korsmeyer-Peppas模型;药物释放机制为Fick扩散。释药行为不依赖于介质pH的改变,且骨架片的溶胀对药物的释放起主导作用。本品中药物释放与骨架溶胀间具有良好的线性关系。

关键词：盐酸二甲双胍羟丙甲纤维素骨架片体外释放溶胀

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三聚体纳米颗粒自组装过程的分子动力学模拟

农业工程学报 2017年第3期33卷 300-306页

作者：冯涛王珂周进杰 deepak Bhopatkar 陈枫 Osvaldo Campanella Bruce R.Hamaker Marcelo Carignano 庄海宁上海应用技术学院香料香精技术与工程学院上海201418 普度大学食品科学系惠斯特勒碳水化合物研究中心西拉法耶特市479062009 普度大学信息技术中心罗森高级计算中心西拉法耶特市*** 卡塔尔环境与能源研究所上海市农业科学院食用菌研究所国家食用菌工程技术研究中心上海201403

为了更深入理解直链淀粉/β-乳球蛋白/α-亚油酸三元复合物体系自组装行为的机制,该研究借助Gromacs软件,采用分子动力学模拟对玉米直链淀粉、β-乳球蛋白、α-亚油酸三者在373 K温度下的结合过程进行研究。通过三元纳米粒子在500 ns内... 详细信息

为了更深入理解直链淀粉/β-乳球蛋白/α-亚油酸三元复合物体系自组装行为的机制,该研究借助Gromacs软件,采用分子动力学模拟对玉米直链淀粉、β-乳球蛋白、α-亚油酸三者在373 K温度下的结合过程进行研究。通过三元纳米粒子在500 ns内的自组装快照图,可以得出直链淀粉、α-亚油酸、β-乳球蛋白3种组分的结合顺序。通过三元纳米粒子的自由能曲面图,可知该三元纳米粒子的形成是热力学自发的过程。进一步对其水合半径及溶剂可接触表面积的分析表明,该三元复合物纳米颗粒溶解性良好。研究阐释了水溶性自组装纳米颗粒的形成机理,为纳米科学领域寻找合适的壁材提供了一种新的研究途径。

关键词：纳米颗粒分子动力学自组装直链淀粉 β-乳球蛋白 α-亚油酸