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Associations of blood biomarkers with glomerular filtration rate in patients with TIA and stroke: population-based study

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Stroke & Vascular Neurology 2021年第1期6卷 48-56页

作者： Dearbhla M.Kelly linxin li Annette I Burgess deborah l poole Julia M Duerden Peter M.Rothwell Wolfson Centre for the Prevention of Stroke and Dementia Nuffield Department of Clinical NeurosciencesOxford UniversityOxfordUK

Background and purpose Non-traditional risk factors such as chronic inflammation,oxidative stress and thrombogenic factors are believed to contribute to the excess stroke risk in chronic kidney disease(CKD)by triggering vascular injury and endothelial *** aimed to determine how well a panel of biomarkers representative of these factors would correlate with estimated glomerular filtration rate(eGFR)in patients with recent transient ischaemic attack(TIA)or *** also investigated whether eGFR would confound previously reported associations between biomarkers and *** We studied a panel of 16 blood biomarkers related to inflammation,thrombosis,atherogenesis and cardiac or neuronal cell damage in TIA or ischaemic stroke in a population-based study(Oxford Vascular Study).Biomarker levels were log-transformed and correlated with eGFR,adjusted for *** proportional hazard models were used for survival *** Among 1297 patients with TIA or stroke,52.7%(n=684)of patients had CKD(eGFRl/min/1.73 m^(2)).There was a moderate correlation between log-eGFR and the log-transformed soluble tumour necrosis factor receptor-1(R^(2)=0.21),attenuating with adjustment for age(R^(2)=0.12).There were moderate-to strong correlations with markers of cardiac injury,N-terminal pro-brain natriuretic peptide and heart-type fatty acid binding protein(hFABP,R2=0.14 and 0.34,respectively).The strongest correlation after adjustment for age was between hFABP and eGFR(R^(2)=0.20).Adjusting for eGFR did not impact any biomarker associations with *** Correlations between biomarkers related to inflammation and thrombosis with renal dysfunction in the setting of cerebrovascular events were generally modest after adjustment for age,suggesting that putative risk factors such as chronic inflammation or coagulopathy are unlikely to be important stroke mechanisms in patients with CKD.

关键词： inflammation patients mortality

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A Theoretically Grounded Question Answering Data Set for Evaluating Machine Common Sense

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Data Intelligence 2024年第1期6卷 1-28页

作者： Henrique Santos Ke Shen Alice M.Mulvehill Mayank Kejriwal deborah l.McGuinness Rensselaer Polytechnic Institute Troy NY Information Sciences Institute Marina del Rey CA

Achieving machine common sense has been a longstanding problem within Artificial *** far,benchmark data sets that are grounded in a theory of common sense and can be used to conduct rigorous,semantic evaluations of common sense reasoning(CSR)systems have been *** expectation of the AI community is that neuro-symbolic reasoners can help bridge this gap towards more dependable systems with common *** propose a novel benchmark,called Theoretically Grounded common sense Reasoning(TG-CSR),modeled as a set of question answering instances,with each instance grounded in a semantic category of common sense,such as space,time,and *** benchmark is few-shot i.e.,only a few training and validation examples are provided in the public release to avoid the possibility of *** from recent evaluations suggest that TG-CSR is challenging even for state-of-the-art statistical *** to its semantic rigor,this benchmark can be used to evaluate the common sense reasoning capabilities of neuro-symbolic systems.

关键词： reasoning Intelligence instance

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A systematic scoping review of study methodology for randomized controlled trials investigating probiotics in athletic and physically active populations

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Journal of Sport and Health Science 2024年第1期13卷 61-71页

作者： Alex E.Mohr David B.Pyne Geovana Silva Fogaça leite deborah Akins Jamie Pugh College of Health Solutions Arizona State UniversityPhoenixAZ 85004USA Research Institute for Sport and Exercise University of CanberraCanberraACT 2617Australia laboratory of Functional Fermented Food Faculty of Pharmaceutical SciencesUniversity of São PauloSão Paulo 05508-030Brazil Research Institute for Sport and Exercise Sciences Liverpool John Moores UniversityLiverpool L33AFUK

Background:The purported ergogenic and health effects of probiotics have been a topic of great intrigue among researchers,practitioners,and the lay public *** has also been an increased research focus within the realm of sports science and exercise medicine on the athletic gut ***,compared to other ergogenic aids and dietary supplements,probiotics present unique study *** objectives of this systematic scoping review were to identify and characterize study methodologies of randomized controlled trials investigating supplementation with probiotics in athletes and physically active ***:Four databases(MEDlINE,CINAHl,Cochrane CENTRAl,and Cochrane Database of Systematic Reviews)were searched for randomized controlled studies involving healthy athletes or physically active *** intervention with probiotics and inclusion of a control and/or placebo group were *** peer-reviewed articles in English were considered,and there were no date *** were extracted and presented in tabular form to detail study protocols,characteristics,and *** in randomized controlled trials was determined with the RoB 2.0 ***:A total of 45 studies were included in the review,with 35 using a parallel group design and 10 using a cross-over *** half the studies used a single probiotic and the other half a multi-strain *** probiotic dose ranged from 2×10^(8)to 1×10^(11)colony forming units daily,and the length of intervention was between 7 and 150 *** than half the studies directly assessed gastrointestinal symptoms,gut permeability,or the gut *** sex ratio of participants was heavily weighted toward males,and only 3 studies exclusively investigated ***-level adverse events were reported in only 2 studies,although the methodology of reporting varied *** risk of bias was generally low,although details on randomization were lacking in some s

关键词： Exercise Experimental methodology Gastrointestinal symptoms Gut microbiota Probiotic supplementation

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l-Arginine Supplementation Mitigates Dichlorvos-Induced Haematocardiotoxicity, and Oxidative Stress in Male Wistar Rats

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Open Journal of Applied Sciences 2024年第7期14卷 1886-1903页

作者： Waidi Adeoye Saka Yusuff Dimeji Igbayilola Jabba Hamidu lawan Taoheed Kolawole Muftaudeen Ridwanullahi Adejumo Tolulope deborah Alu Mary Ikuomola Joshua Tinuade Ojelere Victor Odufa Adegoke Department of Physiology College of Health Sciences Ladoke Akintola University of Technology Ogbomoso Oyo State Nigeria Department of Human Physiology College of Medicine and Health Sciences Baze University Abuja Nigeria Department of Biological Sciences Faculty of Computing and Applied Sciences Baze University Abuja Nigeria

Due to its toxicity, dichlorvos—a common organophosphate pesticide—poses significant risks to human health. This study utilized male Wistar rats to explore the potential protective effects of l-arginine supplementation against dichlorvos-induced toxicity, focusing on cardiotoxicity, haematotoxicity and oxidative stress. The rats were divided into four groups: Control, l-arginine (l), Dichlorvos (D), and l-arginine + Dichlorvos (l + D). Dichlorvos was administered to the D group, l-arginine (100 mg/kg) to the l group, and both l-arginine and dichlorvos to the l + D group. The study evaluated various parameters, including cardiovascular, oxidative stress markers, and haematological indices. Significant changes in haematological parameters such as haemoglobin (Hb), haematocrit (HCT), and red blood cell count (RBC) indicated haematotoxicity after dichlorvos administration. Additionally, elevated cardiac markers, including lactate dehydrogenase (lDH) and creatine kinase-MB (CK-MB), suggested cardiotoxic effects. Exposure to dichlorvos also resulted in decreased antioxidant enzyme levels and increased oxidative stress indicators like malondialdehyde (MDA). Remarkably, l-arginine supplementation mitigated the damage caused by dichlorvos. It normalized the altered haematological parameters, demonstrating its protective effect against haematotoxicity. The rise in cardiac markers was reduced with l-arginine supplementation, indicating protection against cardiotoxicity. Moreover, l-arginine significantly decreased oxidative stress, as evidenced by lower MDA levels and restored antioxidant enzyme activity. In conclusion, l-arginine supplementation in male Wistar rats showed promising protective effects against dichlorvos-induced cardiotoxicity, haematotoxicity and oxidative stress. This suggests that l-arginine may offer a beneficial intervention to mitigate the adverse effects of dichlorvos on blood and heart health, paving the way for potential treatments for pesticide poison

关键词： Dichlorvos l-Arginine Cardiovascular Function Haematological Parameters Oxidative Stress

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Cognitive function among military veterans with STEM occupations

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Military Medical Research 2024年第2期11卷 308-310页

作者： Justin T.McDaniel Kevin N.Hascup Erin R.Hascup Ugochukwu G.Ezigbo Amanda M.Weidhuner Harvey Henson David l.Albright Dale and deborah Smith Center for Alzheimer's Research and trEatment(CARE) Southern Illinois University School of MedicineSpringfieldIL 62794USA STEM Education Research Center Southern Illinois UniversityCarbondaleIL 62901USA Department of Political Science The University of AlabamaTuscaloosaAL 35487USA

Dear Editor,There is limited research on the relationship between science,technology,engineering,and mathematics(STEM)occupational history and cognitive function in later life,especially among military veterans,who may be at greater risk for later-life cognitive *** study examines a nationally representative sample of military veterans to address this gap in knowledge.

关键词： Alzheimer's disease Veterans Science technology engineering and mathematics(STEM) Animal fluency test Dementia

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The role of organic electron donors in the initiation of BHAS base-induced coupling reactions between haloarenes and arenes

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Science China Chemistry 2019年第11期62卷 1425-1438页

作者： Andrew J.Smith Darren l.poole John A.Murphy Department of Pure and Applied Chemistry University of StrathclydeStrathclydeGlasgow G11XLUnited Kingdom Flexible Discovery Unit GlaxoSmithKline Medicines Research CentreStevenageSG12NYUnited Kingdom

Coupling reactions between haloarenes and arenes(including heteroarenes)that are conducted without added transition metals but in the presence of KOtBu or NaOtBu,have been a topic of great interest since their discovery in *** organic structures act as additives that assist these *** additives are converted into organic electron donors by the butoxide base and this leads to initiation of the coupling reactions,which proceed by radical chain *** review provides an overview of the initiation stages of these reactions.

关键词： organic electron donor potassium tert-butoxide electron transfer base-promoted homolytic aromatic substitution(BHAS) coupling benzyne

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Bioaccumulation of toxic hydrophobic organic compounds at the primary trophic level

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Journal of Environmental Sciences 1991年第3期3卷 15-21页

作者： deborah l.Swackhamer Environmental and Occupational Health School of Public Health University of Minnesota Minneapolis USA.

The prevailing hypothesis, which states that the uptake of HOCs by phytoplankton is controlled by the compound's lipophilicity (Kow) was tested. The approach taken was to determine the factors that controlled the uptake of PCBs by phytoplankton under controlled laboratory conditions, and to develop a model that would describe bioaccumulation of PCBs in *** results demonstrate a relationship of BAF to Kow and to phytoplankton surface properties, as well as the data presented here, support the hypothesis that the mechanism of HOC uptake is a rapid surface sorption followed by a slower transfer into lipids in the cell matrix. The work on the kinetics of uptake indicates that equilibrium is reached slowly and that the rate of uptake is of similar magnitude as phytoplankton growth under normal field *** a critical factor that controls the bioaccumulation of HOCs reach equilibrium in phytoplankton itself.

关键词： bioaccumulation hydrophobic organic compounds PCBs phytoplankton dynamic approach.

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Red osier dogwood and its use in animal nutrition:A review

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Animal Nutrition 2023年第2期13卷 64-77页

作者： Taiwo Joseph Erinle Martine Boulianne Younes Miar Robert Scales deborah Adewole Department of Animal Science and Aquaculture Faculty of AgricultureDalhousie UniversityTruro NSB2N 5E3Canada Department of Clinical Sciences Faculty of Veterinary MedicineUniversity of Montreal3200 Sicotte StreetSaint-Hyacinthe QCJ2S 2M2Canada Red Dog Enterprises ltd. Swan River MBR0L 1Z0Canada

As the human population increases globally,the food animal industry has not been spared from the monumental demand for edible animal products,particularly *** has necessitated the simulta-neous expansion of the productivity of the animal sector to meet the ever-growing human *** antibiotics have been used in food animal production with commendable positive impacts on their growth performance,their sole contributive factor to the increasing incidence of antimicrobial resistance has ushered the strict restrictions placed on their use in the animal *** has handed a setback to both animals and farmers;thus,the intense push for a more sustainable antibiotic alternative for use in animal *** use of plants with concentrated phytogenic compounds has gained much interest due to their beneficial bioactivities,including antioxidant and selective *** the reported beneficial activities of phytogenic additives on animals vary due to their varying total polyphenol concentrations(TPC),red osier dogwood(ROD)plant materials boast of high TPC with excellent antioxidant prowess and growth improvement capacities compared to some plant extracts commonly used in ***,its adoption in research and commercial scale is still ***,the present review aims to provide concise information on the dietary potential of ROD plant materials in animal feeding.

关键词： Red osier dogwood Antibiotic-alternative Polyphenolic compounds Antioxidant Antimicrobial

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Interrelationship of soil moisture and temperature to sylvatic plague cycle among prairie dogs in the Western United States

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Integrative Zoology 2021年第6期16卷 852-867页

作者： Cassandra D.PAUlING deborah l.FINKE deborah M.ANDERSON Department of Veterinary Pathobiology University of MissouriColumbiaMissouriUSA Division of Plant Sciences University of MissouriColumbiaMissouriUSA

Plague,caused by Yersinia pestis,is a flea-borne disease that is endemic in areas throughout the world due to its successful maintenance in a sylvatic cycle,mainly in areas with temperate *** rodents are thought to play a key role in the enzootic maintenance as well as epizootic outbreaks of *** the United States,prairie dogs(Cynomys),rodents(Muridae),and ground squirrels(Spermophilus)are susceptible to infection and are parasitized by fleas that transmit *** particular,prairie dogs can experience outbreaks that rapidly spread,which can lead to extirpation of colonies.A number of ecological parameters,including climate,are associated with these *** this study,we asked whether soil parameters,primarily moisture and temperature,are associated with outbreaks of plague in black-tailed prairie dogs and Gunnison’s prairie dogs in the Western United States,and at what depth these associations were *** collected publicly available county-level information on the occurrence of population declines or colony extirpation,while historical soil data was collected from SCAN and USCRN stations in counties and states where prairie dogs have been *** analysis suggests that soil moisture at lower depths correlates with colony die-offs,in addition to temperature near the surface,with key differences within the landscape ecology that impact the occurrence of ***,the model suggests that the burrow environment may play a significant role in the epizootic spread of disease amongst black-tailed and Gunnison’s prairie dogs.

关键词： plague prairie dogs soil moisture soil temperature sylvatic cycle Yersinia pestis

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Musculoskeletal Conditions in Persons living with HIV/AIDS:A Scoping Review

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Current Medical Science 2022年第1期42卷 17-25页

作者： louise Schade Berg James JYoung deborah Kopansky-Giles Stefan Eberspaecher Geoff Outerbridge Eric lHurwitz Jan Hartvigsen Department of Sports Science and Clinical Biomechanics University of Southern DenmarkOdense 5230Denmark Department of Research Canadian Memorial Chiropractic CollegeToronto M2H3 J1Canada Department of Family&Community Medicine University of TorontoMG51V7Canada Department of Orthopedic Surgery Princess Marina HospitalGaborone 8WVF+7H3Botswana World Spine Care Canadian Memorial Chiropractic CollegeToronto M2H 3J1Canada Office of Public Health Studies University of Hawaii at ManoaHonolulu 96822USA Chiropractic Knowledge Hub Odense 5230Denmark

Objective:Globally 37.9 million people are living with HIV/AIDS,and with mortality rates declining,there is an increasing focus on comorbidities including musculoskeletal(MSK)***,the aim of this scoping review was to generate and summarize an overview of the existing scientific literature dealing with MSK complaints in people living with HIV/AIDS(PlWHAs).Methods:This scoping review followed the five-stage methodological framework proposed by Arksey and O'Malley.

关键词： musculoskeletal conditions HIV AIDS

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