Associations of blood biomarkers with glomerular filtration rate in patients with TIA and stroke: population-based study

作     者：Dearbhla M.Kelly Linxin Li Annette I Burgess Deborah L Poole Julia M Duerden Peter M.Rothwell 

作者机构：Wolfson Centre for the Prevention of Stroke and DementiaNuffield Department of Clinical NeurosciencesOxford UniversityOxfordUK 

出 版 物：《Stroke & Vascular Neurology》 (卒中与血管神经病学（英文）)

年 卷 期：2021年第6卷第1期

页      面：48-56页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：PR has received funding from Wellcome Trust(Grant No:104040/Z/14/Z) the NIHR Oxford Biomedical Research Centre(Grant No:IS-BRC-1215-20008) has received payment for membership of a randomised trial Executive Committee(Bayer).DMK has received a scholarship from the Irish Nephrology Society 

主　　题：inflammation patients mortality 

摘      要：Background and purpose Non-traditional risk factors such as chronic inflammation,oxidative stress and thrombogenic factors are believed to contribute to the excess stroke risk in chronic kidney disease(CKD)by triggering vascular injury and endothelial *** aimed to determine how well a panel of biomarkers representative of these factors would correlate with estimated glomerular filtration rate(eGFR)in patients with recent transient ischaemic attack(TIA)or *** also investigated whether eGFR would confound previously reported associations between biomarkers and *** We studied a panel of 16 blood biomarkers related to inflammation,thrombosis,atherogenesis and cardiac or neuronal cell damage in TIA or ischaemic stroke in a population-based study(Oxford Vascular Study).Biomarker levels were log-transformed and correlated with eGFR,adjusted for *** proportional hazard models were used for survival *** Among 1297 patients with TIA or stroke,52.7%(n=684)of patients had CKD(eGFR60 mL/min/1.73 m^(2)).There was a moderate correlation between log-eGFR and the log-transformed soluble tumour necrosis factor receptor-1(R^(2)=0.21),attenuating with adjustment for age(R^(2)=0.12).There were moderate-to strong correlations with markers of cardiac injury,N-terminal pro-brain natriuretic peptide and heart-type fatty acid binding protein(hFABP,R2=0.14 and 0.34,respectively).The strongest correlation after adjustment for age was between hFABP and eGFR(R^(2)=0.20).Adjusting for eGFR did not impact any biomarker associations with *** Correlations between biomarkers related to inflammation and thrombosis with renal dysfunction in the setting of cerebrovascular events were generally modest after adjustment for age,suggesting that putative risk factors such as chronic inflammation or coagulopathy are unlikely to be important stroke mechanisms in patients with CKD.