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Neutrophil to lymphocyte ratio is a prognosis factor for post-operative pneumonia in aneurysmal subarachnoid hemorrhage patients

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Chinese Medical Journal 2021年第6期134卷 682-689页

作者： Yue Chen Bao-Qiang Lian Lei Peng Chen-Yu Ding Yuan-Xiang Lin Liang-Hong Yu deng-Liang Wang de-zhi kang The Graduate School of Fujian Medical University FuzhouFujian 350001China department of Neurosurgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350001China department of Neurosurgery The People’s Hospital of China Three Gorges UniversityThe First People’s Hospital of YichangYichangHubei 443000China

Background:Although a variety of risk factors of pneumonia after clipping or coiling of the aneurysm(post-operative pneumonia[POP])in patients with aneurysmal subarachnoid hemorrhage(aSAH)have been studied,the predictive model of POP after aSAH has still not been well ***,the aim of this study was to assess the feasibility of using admission neutrophil to lymphocyte ratio(NLR)to predict the occurrence of POP in aSAH ***:We evaluated 711 aSAH patients who were enrolled in a prospective observational study and collected admission blood cell counts *** analyzed available demographics and baseline variables for these patients and analyzed the correlation of these factors with POP using Cox *** screening out the prognosis-related factors,the predictive value of these factors for POP was further ***:POP occurred in 219 patients(30.4%)in this *** with POP had significantly higher NLR than those without(14.11±8.90vs.8.80±5.82,Pdependently associated with POP following aSAH after adjusting for possible confounding factors,including the age,World Federation of Neurosurgical Societies(WFNS)grade,endovascular treatment,and ventilator *** the predictive value of NLR was significantly increased after WFNS grade was combined with NLR(*** grade×NLR,P=0.011).Conclusions:Regardless of good or poor WNFS grade,patients having NLR>10 had significantly worse POP survival rate than patients having NLR≤*** at admission might be helpful as a predictor of POP in aSAH patients.

关键词： Aneurysm Subarachnoid hemorrhage Infection Inflammation Pneumonia Neutrophil Lymphocyte

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The role of acute normovolemic hemodilution in reducing allogeneic blood transfusion in glioblastoma surgery:a case-control study

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Chinese Neurosurgical Journal 2024年第1期10卷 35-41页

作者： Ping Chen Xin‑Huang Zhang Ying Wang Xian‑Zhong Lin de‑zhi kang Qing‑Song Lin department of Anesthesiology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina department of Neurosurgery The First Affiliated Hospital of Fujian Medical UniversityNo.20 Chazhong RdTaijiang DistrictFuzhou 350005FujianChina department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated Hospital of Fujian Medical UniversityFuzhou 350209FujianChina Fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina Fujian Provincial Clinical Research Center for Neurological Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina Fujian Provincial Key Laboratory of Precision Medicine for Cancer The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina

Background Acute normovolemic hemodilution(ANH)was first introduced in glioblastoma surgery,and its role in reducing allogeneic blood transfusion was investigated in this *** This study enrolled supratentorial glioblastoma patients who received total *** the ANH group,the patients were required to draw blood before the operation,and the blood will be transfused back to the patient during the *** association between ANH and clinical features was *** Sixty supratentorial glioblastoma patients were enrolled in this study,25 patients were allocated in the ANH group,and another 35 patients were included in the control *** dramatically reduced the need for allogeneic blood transfusion(3[12%]vs 12[34.3%],P=0.049),and the blood transfusion per total of patients was dramatically decreased by the application of ANH(0.40±1.15 units vs 1.06±1.59 units,P=0.069).Furthermore,ANH also markedly reduced the requirement of fresh frozen plasma(FFP)transfusion(2[8%]vs 11[31.4%],P=0.030)and the volume of FFP transfusion per total of patients(32.00±114.46 mL vs 115.71±181.00 mL,P=0.033).The complication rate was similar between the two *** ANH was a safe and effective blood conservation technique in glioblastoma surgery.

关键词： Glioblastoma Acute normovolemic hemodilution Surgery Blood transfusion

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Twist drill craniostomy for traumatic acute subdural hematoma in the elderly: case series and literature review

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Chinese Neurosurgical Journal 2019年第2期5卷 121-128页

作者： Pei-kun Huang Yong-zhong Sun Xue-ling Xie de-zhi kang Shu-fa Zheng Pei-sen Yao Fujian Medical University Fuzhou 350004China department of Neurosurgery Hui'an County HospitalHui'an 362100China department of Neurosurgery The First Affiliated Hospital of Fujian Medical UniversityNO.20 Chazhong RoadTaijiang DistrictFuzhou 350004China The First Clinical Medical College of Fujian Medical University NO.20 Chazhong RoadTaijiang DistrictFuzhou 350004China

Background:A large craniotomy is usually the first choice for removal of traumatic acute subdural hematoma (TASDH).To date,few studies have reported that TASDH could be successfully treated by twist drill craniostomy (TDC) alone or combined with instillation of *** aimed to define the TDC for the elderly with TASDH and performed literature *** presentation:A total of 7 TASDH patients,who were presented and treated by TDC in this retrospective study between January 2009 and May 2017,consisted of 5 men and 2 women,ranging in age from 65 to 89 (average,78.9) *** patients' baseline characteristics,including age,sex,medical history,received ventriculoperitoneal shunt for hydrocephalus or not,reason for avoiding or refusing large craniotomy,preoperative Glasgow Coma Scale (GCS),suffered from cerebral herniation or not,the location of TASDH,imaging characteristics of TASDH in CT scan,injury/surgery time interval,midline shift,preoperative neurologic deficit,operation time,and infusions of urokinase or not,were *** postoperative GCS,postoperative neurologic deficit,rebleeding or not,intracranial infection,and modified Rankin Scale (mRS) at 6 months after surgery were analyzed to access the safety and efficacy of evacuation with *** results showed that the mean time interval from injury to TDC was 68.6 min (30-120 min).The mean distance of midline shift was 14.6 mm (10-20 mm).The preoperative GCS in all patients ranged from 4 to 13(median,9).The mean duration of the operation was 14.4 min (6-19 min).Postoperative CT scan showed that hematoma evacuation rate was more than 70% in all *** were no cases of acute rebleeding and intracranial infection after *** cases presented with chronic SDH at the ipsilateral side within 6 months after being treated by TDC alone or combined with instillation of *** outcomes were shown in all cases (mRS scores 0-2) at 6 months after ***:TASDH in the elderly could be

关键词： Traumatic acute subdural hematoma Cerebral herniation Twist drill craniostomy Pre-injury antiplatelet therapy The elderly

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Patient-specific ventricular puncture trajectory plane and puncture trajectory: a novel method of frontal ventricular puncture

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Chinese Medical Journal 2021年第19期134卷 2359-2361页

作者： Chen-Yu Ding Jun-Yu Lin Yue Chen Yue Pang Xiao-Yong Chen Wen-Hua Fang Fang-Yu Wang Yuang-Xiang Lin de-zhi kang department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350001China Fujian Provincial Key Laboratory of Precision Medicine for Cancer FuzhouFujian 350001China department of Clinical Medicine Fujian Medical UniversityFuzhouFujian 350001China

Ventricular puncture is a common neurosurgical procedure,which is usually performed freehand using body surface anatomic landmarks as targeting references.[1,2]However,it is reported that the failure rate of freehand lateral ventricle puncture could be as high as 43%in traumatic brain injury cases if body surface anatomic landmarks are used as targeting references,[3]and the occurrence of hemorrhages associated with ventricular puncture could reach 16.2%.[4]Classic puncture sites,such as Kocher point,are helpful in improving the success rate of ventricular ***,it is still risky to perform freehand puncture with classic puncture *** causes could lead to this issue,including the following:(1)Individual patients have different conditions;a puncture approach suitable for all patients might not be possible.(2)Selection of puncture approach is largely dependent on the judgment of the surgeon,because the puncture approach does not usually fall on the coronal,sagittal,or axial images of the regular computed tomography(CT)scan;surgeons need to use spatial imagination based on CT images to design the ventricular puncture trajectory(VPT),which could lead to errors.(3)In freehand puncture,directional deviations could occur easily without the guidance of a frame as a fixed space reference to the puncture path.

关键词： puncture ventricular plane

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The classification of intracranial aneurysm neck: a single center research experience

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Chinese Neurosurgical Journal 2019年第3期5卷 129-136页

作者： Cai-Qiang Huang de-zhi kang Liang-Hong Yu Shu-Fa Zheng Pei-Sen Yao Yuan-Xiang Lin Zhang-Ya Lin department of Neurosurgery The First Affiliated HospitalFujian Medical UniversityNo.20 Changzhou RoadTaijiang DistrictFuzhou 350004Fujian ProvinceChina

There is associating with incidence of unfavorable outcomes compared to microsurgical clippings. We are in order to investigate the outcomes of microsurgical clipping for intracranial aneurysms and determine the ideal clipping methods for different aneurysm subtypes. Method: Retrospectively analyzed the clinical characteristics and follow-up data (completely recorded) of 123 patients with 128 aneurysms were treated. 20 cases were treated as control group from October 2013 to december 2013. Since January 2014, aneurysms were classified base on the 20 cases of aneurysm imaging data. 103 patients were treated as experimental group, the classification of aneurysms previously proposed was used to estimate the way of surgery, and the guiding value of the genotype was verified according to the intraoperative findings. The proposed aneurysm classification is based on the virtual surface of the aneurysm and the parent artery, the aneurysm neck was classified as follows: subtype I, the curved surface of the neck is a single curved surface;subtype II, the neck is hyperboloid;subtype III, neck is a three-curved surface. Aneurysms were divided into further subtypes according to the ratio of the width of the aneurysm neck surface and the length of the artery circumference: subtype A, the ratio of the aneurysm neck surface to the parent artery was not more than 0.5;subtype B, more than 0.5. There are some clamping methods include simple, sliding, interlocking and hybrid. Results: In the control group, patients did not undergo a suitable clipping scheme without classification of aneurysm neck (unclassed clipping). While causing the occurrence of occlusion adverse events, including neck residual, Tumor artery stenosis, electrophysiological changes, the lack of blood supply and so on. The experimental[page1image12073600]group was analyzed by using a predetermined clipping scheme (classed clipping), and the use of aneurysms clamps was approximately the same as expected. Compared the p

关键词： Intracranial aneurysms Microsurgery clipping Aneurysm neck classification Aneurysm neck curved surface

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A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： zhi Li Yang Wei kang Zhou Xin Huang Xing Zhou Jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

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Systemic inflammatory response index improves the prediction of postoperative pneumonia following meningioma resection

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Chinese Medical Journal 2021年第6期134卷 728-730页

作者： Yue Chen Yuan-Xiang Lin Yue Pang Jian-He Zhang Jian-Jun Gu Gao-Qi Zhang Liang-Hong Yu Zhang-ya Lin de-zhi kang Chen-Yu Ding Wen-Hua Fang The Graduate School of Fujian Medical University FuzhouFujian 350001China department of Neurosurgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350001China department of Neurosurgery Affiliated Hospital of Putian UniversityPutianFujian 351100China department of Neurosurgery Zhengzhou University People’s HospitalHenan Provincial People's HospitalZhengzhouHenan 450000China

Meningiomas are common tumors of the central nervous system,[1,2]and surgery is an effective treatment for *** pneumonia(POP)is one of the common complications after meningioma *** with the improvement of surgical techniques and postoperative care,the incidence of POP has still not been significantly *** new predictive indicators can help to screen high-risk POP patients,intervene early,and improve patient prognosis.

关键词： pneumonia postoperative meningioma

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The prevalence of freezing of gait in Parkinson’s disease and in patients with different disease durations and severities

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Chinese Neurosurgical Journal 2020年第2期6卷 92-102页

作者： Hong-Liang Ge Xiao-Yong Chen Yuan-Xiang Lin Ting-Juan Ge Liang-Hong Yu Zhang-Ya Lin Xi-Yue Wu de-zhi kang Chen-Yu Ding department of Neurosurgery The First Affiliated Hospital of Fujian Medical UniversityNo.20 Chazhong RoadFuzhou 350004Fujian ProvincePeople’s Republic of China Brain Center Quzhou Second People HospitalQuzhouPeople’s Republic of China

Background:The prevalence rates of freezing of gait(FOG)in Parkinson’s disease(PD)vary widely,ranging from 14.0 to 55.1%.Our aim is to calculate the overall prevalence of FOG in all PD patients with different disease durations and ***:Using Medline/PubMed/Embase,we carried out a systematic literature search for studies reporting the PD and clinically relevant ***:After primary screening,a total of 35 studies were identified and further analyzed for inclusion into the analysis,and 29 studies fulfilled the quality criteria and included in this *** overall prevalence of FOG in PD was 39.9%(95%CI 35.3-44.5%).The FOG identified by the freezing of gait questionnaire item 3 may be more prevalent(43.8%,95%CI 38.5-49.1%)than the FOG identified by the Unified Parkinson’s Disease Rating Scale item 14(36.0%,95%CI 29.0-43.1%).Disease duration and severity are both the clinical features associated with the *** highest FOG prevalence rate in PD patients was seen in patients with disease durations≥10 years,at 70.8%,followed that of PD patients with disease durations≥5 years(53.3%),and PD patients with disease durationsderable,and highlights the need for accurate identification of FOG in PD.

关键词： Prevalence Freezing Gait Parkinson disease

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Can admission lipoprotein-associated phospholipase A2 predict the symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage?

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Chinese Neurosurgical Journal 2020年第4期6卷 196-203页

作者： Chen-Yu Ding Fang-Yu Wang Han-Pei Cai Xiao-Yong Chen Shu-Fa Zheng Liang-Hong Yu Yuan-Xiang Lin Zhang-Ya Lin de-zhi kang department of Neurosurgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujianPeople’s Republic of China

Background:Inflammation has been believed to be related to the development of cerebral vasospasm following aneurysmal subarachnoid hemorrhage(aSAH).A potential biomarker for vascular inflammation that is well recognized is the lipoprotein-associated phospholipase A2(Lp-PLA2).However,whether Lp-PLA2 can predict the occurrence of symptomatic cerebral vasospasm(SCV)in aSAH patients is still ***,this study aimed to assess the value of Lp-PLA2 for predicting SCV in patients with ***:Between March 2017 and April 2018,we evaluated 128 consecutive aSAH patients who were admitted in the First Affiliated Hospital of Fujian Medical *** Lp-PLA2 level was obtained within 24 h of the initial *** might be related to SCV were ***:Compared to patients without SCV,those with SCV(9.4%,12/128)had significantly higher Lp-PLA2 *** logistic analysis revealed that worse modified Fisher grade(OR=10.08,95%CI=2.04–49.86,P=0.005)and higher Lp-PLA2 level(OR=6.66,95%CI=1.33–3.30,P=0.021)were significantly associated with SCV,even after adjustment for *** on the best threshold,Lp-PLA2 had a sensitivity of 83.3%and a specificity of 51.7%for predicting SCV,as shown by the receiver operating characteristic curve *** the poor World Federation of Neurosurgical Societies grade patient sub-group,patients with Lp-PLA2>200μg/L had significantly higher SCV rate than that of patients having Lp-PLA2≤200μg/***:The admission Lp-PLA2 level might be a helpful predictor for SCV in aSAH.

关键词： Aneurysmal subarachnoid hemorrhage Vasospasm Biological markers

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Risk factors of acute coagulation dysfunction after aneurysmal subarachnoid hemorrhage

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Chinese Neurosurgical Journal 2018年第4期4卷 204-209页

作者： Guo-Rong Chen Pei-Sen Yao Chu-Bin Liu Huang-Cheng Shang-Guan Shu-Fa Zheng Liang-Hong Yu Yuan-Xiang Lin Zhang-Ya Lin de-zhi kang department of Neurosurgery The First Affiliated Hospital of Fujian Medical UniversityNO.20 Chazhong RoadTaijiang DistrictFuzhou City 350004FujianChina department of Neurosurgery The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou City 362000FujianChina

Background: Although coagulopathy have been proved to be a contributor to a poor outcome of aneurysmal subarachnoid hemorrhage (aSAH), the risk factors for triggering coagulation abnormalities have not been studied after aneurysm clipping. Methods: We investigated risk factors of coagulopathy and analyzed the relationship between acute coagulopathy and outcome after aneurysm clipping. The clinical data of 137 patients with ruptured CA admitted to our institution was collected and retrospectively reviewed. Patient demographic data (age, sex), smoking, alcohol use, hypertension, diabetes, Hunt-Hess grade, Fisher grade, operation time, intraoperative total infusion volume, intraoperative blood loss, intraoperative transfusion, intraoperative hemostatic drug treatment, calcium reduction (preoperative free calcium concentration–postoperative free calcium concentration) were recorded. Coagulation was assessed within 24 h. Postoperative hemorrhage and infarction, deep venous thrombosis (DVT), and mortality were analyzed. Results: Coagulopathy was detected in a total of 51 cases (group I), while not in 86 cases (group II). Univariable analysis demonstrated that age, smoking, alcohol use, intraoperative total infusion volume, intraoperative blood loss, intraoperative transfusion, and calcium reduction (≥1.2 mg/dl) were related to coagulopathy. Non-conditional logistic regression analysis showed that age [OR, 1.037 (95% CI, 1.001–1.074);p=0.045] and calcium reduction (≥1.2 mg/dl) [OR, 5.509 (95% CI, 1.900–15.971);p=0.002] were considered as the risk factors for coagulopathy. Hunt-Hess grade [OR, 2.641 (95% CI, 1.079–6.331);p=0.033] and operation time [OR, 0.107 (95% CI, 1.012–0.928);p=0.043] were considered as the risk factors for hypocoagulopathy. There were 6 cases (11.7%) with cerebral infarction in group I, while 6 cases (6.98%) in group II (χ2=0.918, p=0.338). There were 4 cases (7.84%) with rebleeding in group I, while 5 cases (5.81%) in group II (χ2=0.215, p=0.643). Th

关键词： Risk factors Coagulation dysfunction Aneurysmal subarachnoid hemorrhage

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