The role of acute normovolemic hemodilution in reducing allogeneic blood transfusion in glioblastoma surgery:a case-control study

作     者：Ping Chen Xin‑Huang Zhang Ying Wang Xian‑Zhong Lin De‑Zhi Kang Qing‑Song Lin 

作者机构：Department of AnesthesiologyThe First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina Department of NeurosurgeryThe First Affiliated Hospital of Fujian Medical UniversityNo.20 Chazhong RdTaijiang DistrictFuzhou 350005FujianChina Department of NeurosurgeryBinhai Branch of National Regional Medical CenterThe First Affiliated Hospital of Fujian Medical UniversityFuzhou 350209FujianChina Fujian Provincial Institutes of Brain Disorders and Brain SciencesThe First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina Fujian Provincial Clinical Research Center for Neurological DiseasesThe First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina Fujian Provincial Key Laboratory of Precision Medicine for CancerThe First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina 

出 版 物：《Chinese Neurosurgical Journal》 (中华神经外科杂志（英文）)

年 卷 期：2024年第10卷第1期

页      面：35-41页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Fujian Provincial Health Technology Project(No.2021GGA031 to Qing-Song Lin) Natural Science Foundation of Fujian Province(No.2021J05148 to Qing-Song Lin) Fujian Provincial Finance Project(No.BPB-LQS2021 to Qing-Song Lin) Nature Science Foundation of Fujian province(No.2022J01678 to Ping Chen) Project to improve the diagnosis and treatment of intractable diseases of the cerebrovascular and nervous system(No.PT-YNBZW2018) 

主　　题：Glioblastoma Acute normovolemic hemodilution Surgery Blood transfusion 

摘      要：Background Acute normovolemic hemodilution(ANH)was first introduced in glioblastoma surgery,and its role in reducing allogeneic blood transfusion was investigated in this *** This study enrolled supratentorial glioblastoma patients who received total *** the ANH group,the patients were required to draw blood before the operation,and the blood will be transfused back to the patient during the *** association between ANH and clinical features was *** Sixty supratentorial glioblastoma patients were enrolled in this study,25 patients were allocated in the ANH group,and another 35 patients were included in the control *** dramatically reduced the need for allogeneic blood transfusion(3[12%]vs 12[34.3%],P=0.049),and the blood transfusion per total of patients was dramatically decreased by the application of ANH(0.40±1.15 units vs 1.06±1.59 units,P=0.069).Furthermore,ANH also markedly reduced the requirement of fresh frozen plasma(FFP)transfusion(2[8%]vs 11[31.4%],P=0.030)and the volume of FFP transfusion per total of patients(32.00±114.46 mL vs 115.71±181.00 mL,P=0.033).The complication rate was similar between the two *** ANH was a safe and effective blood conservation technique in glioblastoma surgery.