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Hypolipidaemic and antioxidant effect of Enicostemma littorale Blume

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Asian Pacific Journal of Tropical Biomedicine 2011年第5期1卷 381-385页

作者： Thirumalai T Viviyan Therasa S Elumalai EK david E Post Graduate and Research Department of Zoology Voorhees CollegePhysiology Wing

Objective:To investigate the hypolipidaemic and antioxidant effects of aqueous leaf extract of Enicoslemma littorale(***)Blume(ens)against ethanol induced hepatic injury in albino ***:Male albino rats of six numbers in each group were undertaken for *** and antioxidant effect of *** Blume(ens)aqueous leaf extract at a dosage of 250 mg/kg bw was ***:Levels of serum and tissue cholesterol,triglycerides and free fatty acids were elevated and levels of tissue thiobarbituric acid reactive substances(TBARS)and lipid hydroperoxide were increased in ethanol treated *** activity levels of liver antioxidant enzymes such as superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GPX)and glutathione-s-transferase(GST)were *** adiminstration of extract of E,littorale Blume,levels of cholesterol,triglycerides and free fatty acids were decreased in serum and liver tissue,levels of TBARS and lipid hydroperoxide were decreased,and Ever antioxidant enzymes were increased in liver tissue;Conclusions:It can be concluded that the aqueous leaf extract of E,littorale Blume(ens)has potent restorative effect on hyperlipidaemic and oxidative stress.

关键词： Hepatoprotective Ethanol Antioxidant enzymes Enicostemma littorale Blume Oxidative stress Hypolipidaemic effect

Shigella Strain Has Developed Non-Studied Pathogenicity Mechanisms of Adaptability in the Colonization of Epithelial Cells

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Advances in Microbiology 2022年第4期12卷 270-294页

作者： Duchel Jeanedvi Kinouani Kinavouidi Christian Aimé Kayath Nicole Prisca Makaya Dangui Nieko Saturnin Nicaise Mokemiabeka david Charles Roland Moukala Etienne Nguimbi Laboratoire de Biologie Cellulaire et Moléculaire (BCM) Faculté des Sciences et Techniques Université Marien Ngouabi Brazzaville République du Congo Institut National de Recherche en Sciences Exactes et Naturelles (IRSEN) Brazzaville République du Congo Ecole Normal Supérieur (ens) Université Marien Ngouabi Brazzaville République du Congo

According to the World Health Organization, foodborne diseases are a major public health problem, particularly in developing countries including the Republic of Congo. They are responsible for several episodes of diarrhea, especially in children under five years old. There is no reliable epidemiological data on the pathogenicity of the Shigella spp. strains circulating in the whole Republic of Congo drafting this paper. The purpose of this study was to examine the Shigella spp strain pathogenicity close to an environment contaminated with faeces in the city of Brazzaville. As a result, 54 isolates have been associated with Shigella spp. The gastric acid resistance test performed on Shigella Environmental Strain (SES) and Shigella Clinical Strains (SCS) resulted in 38.8% (21/54) and 100% acid resistant, respectively. Shigella spp. Strains (SES and SCS) were ranged in a survival percentage from 11% to 93%. By monitoring Biosurfactant-Like Molecule (BLM) production, we showed that the BLM production of SES and SCS was highly dependent on bacterial culture density involving the Quorum Sensing (QS). S. flexneri, S. boydii, and S. sonnei and as well as SES and SCS were able to invade and contaminate eggs by colonizing egg yolk. The counting bacteria were ranging from two to 5 × 107 CFU/mL after contamination. Concomitantly, BLM was secreted during the post contamination of poultry eggs with 100% EI24. Further by trying to show the pathogenicity by the hemolysis test, we have shown that SES and SCS were able to show significant areas of lysis on blood agar. Finally, this work has proposed an additional model of cell invasion including biosurfactants during the pre- and post-invasion phases.

关键词： Shigella Biosurfactant Quorum Sensing Invasion Epithelial Cells Pathogenicity

Dynamics and origin of cytokinins involved in plant manipulation by a leaf-mining insect

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Insect Science 2017年第6期24卷 1065-1078页

作者： Hui Zhang Antoine Guiguet Geraldine Dubreuil Anna Kisiala Peter Andreas R. J. Neil Emery Elisabeth Huguet Melanie Body david Giron Institut de Recherche sur la Biologie de I'lnsecte UMR 7261 CNRSIUniversite Francois-Rabelais de Tours Tours France Departement de Biologie Ecole Normale Superieure de Lyon Lyon France Department of Life and Environmental Sciences Kyoto Prefectural University Kyoto Japan Department of Biology Trent University Peterborough Canada Division of Plant Sciences Christopher S. Bond Life Sciences Center University of Missouri Columbia USA

Several herbivorous insects and plant-associated microorganisms control the phytohormonal balance, thus enabling them to successfully exploit the plant by inhibiting plant defenses and withdrawing plant resources for their own benefit. The leaf-mining moth Phyllonorycter blancardella modifies the cytokinin （CK） profile of mined leaf-tissues, and the insect symbiotic bacteria Wolbachia is involved in the plant manipulation to the benefit of the insect host. To gain a deeper understanding into the possible origin and dynamics of CKs, we conducted an extensive characterization of CKs in larvae and in infected apple leaves. Our results show the enhanced CK levels in mines, both on green and yellow leaves, allowing insects to control their nutritional supply under fluctuating environmental conditions. The spatial distribution of CKs within the mined leaves shows that hormone manipulation is strictly limited to the mine suggesting the absence of CK translocation from distant leaf areas toward the insect feeding site. Mass spectrometry analyses reveal that major CK types accumulating in mines and larvae are similar to what is observed for most gall-inducers, suggesting that strategies underlying the plant manipulation may be shared between herbivorous insects with distinct life histories. Results further show that CKs are detected in the highest levels in larvae, reinforcing our hypothesis that CKs accumulating in the mines originate from the insect itself. Presence of bacteria- specific methylthio-CKs is consistent with previous results suggesting that insect bacterial symbionts contribute to the observed phenotype. Our study provides key findings toward the understanding of molecular mechanisms underlying this intricate plant-insect-microbe interaction.

关键词： cytokinins insect bacterial symbionts leaf-miners phytohormones plantinsect-microbe interactions plant manipulation

Polarization shaping of Poincare´ beams by polariton oscillations

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Light(Science & Applications) 2015年第1期4卷 122-128页

作者： david Colas Lorenzo Dominici Stefano Donati Anastasiia A Pervishko Timothy CH Liew Ivan A Shelykh Dario Ballarini Milena de Giorgi Alberto Bramati Giuseppe Gigli Elena del Valle Fabrice P Laussy Alexey V Kavokin Daniele Sanvitto Departamento de Fı´sica Teorica de la Materia Condensada and Condensed Matter Physics Center(IFIMAC) Universidad Autonoma de MadridE-28049Spain NANOTEC Istituto di Nanotecnologia-CNRVia Arnesano73100 LecceItaly Istituto Italiano di Tecnologia IIT-LecceVia Barsanti73010 LecceItaly Universita del Salento Via Arnesano73100 LecceItaly Division of Physics and Applied Physics Nanyang Technological University637371 SingaporeSingapore Science Institute University of IcelandDunhagi 3IS-107ReykjavikIceland Laboratory of Light-Matter Coupling in Nanostructures ITMO University197101 St.PetersburgRussia Laboratoire Kastler Brossel UPMC-Paris 6ENS et CNRS75005 ParisFrance Russian Quantum Center Novaya 100143025 SkolkovoMoscow RegionRussia CNR-SPIN Tor Vergataviale del Politechnico 1I-00133 RomeItaly

We propose theoretically and demonstrate experimentally the generation of light pulses whose polarization varies temporally to cover selected areas of the Poincare´sphere with both tunable swirling speed and total duration(1 ps and 10 ps,respectively,in our implementation).The effect relies on the Rabi oscillations of two polariton polarized fields excited by two counter-polarized and delayed *** superposition of the oscillating fields result in the precession of the Stokes vector of the emitted light while polariton lifetime imbalance results in its drift from a circle of controllable radius on the Poincare´sphere to a single point at long *** positioning of the initial circle and final point allows to engineer the type of polarization spanning,including a full sweeping of the Poincare´*** universality and simplicity of the scheme should allow for the deployment of time-varying full-Poincare´polarization fields in a variety of platforms,timescales,and regimes.

关键词： full Poincare beams polaritons polarization pulse shaping Rabi oscillations

The LEAFY floral regulator displays pioneer transcription factor properties

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Molecular Plant 2021年第5期14卷 829-837页

作者： Xuelei Lai Romain Blanc-Mathieu Loïc GrandVuillemin Ying Huang Arnaud Stigliani Jeremy Lucas Emmanuel Thevenon Jeanne Loue-Manifel Laura Turchi Hussein Daher Eugenia Brun-Hernandez Gilles Vachon david Latrasse Moussa Benhamed Renaud Dumas Chloe Zubieta François Parcy Laboratoire Physiologie Cellulaire et Vegetale Universite Grenoble AlpesCNRSCEAINRAEIRIG-DBSCI-LPCV17 avenue des martyrs38054GrenobleFrance Universite Paris-Saclay CNRSINRAEUniversite d'EvryInstitute of Plant Sciences Paris-Saclay(IPS2)91405OrsayFrance The Bioinformatics Centre Department of Biology and Biotech and Research Innovation CentreUniversity of CopenhagenOle Maalces Vej 5DK2200 Copenhagen NDenmark Laboratoire Reproduction et Developpement des Plantes Universite de LyonENS de LyonUCB Lyon 1CNRSINRA69342 LyonFrance Institut de Biologie Structurale Universite Grenoble AlpesCEACNRSGrenobleFrance Universite de Paris Institute of Plant Sciences Paris-Saclay(IPS2)75006 ParisFrance

Pioneer transcription factors(TFs)are a special category of TFs with the capacity to bind to closed chromatin regions in which DNA is wrapped around histones and may be highly ***,pioneer TFs are able to modify the chromatin state to initiate gene *** plants,LEAFY(LFY)is a master floral regulator and has been suggested to act as a pioneer TF in ***,we demonstrate that LFY is able to bind both methylated and non-methylated DNA using a combination of in vitro genomewide binding experiments and structural *** between regions bound by LFY in vivo and chromatin accessibility data suggest that a subset of LFY bound regions is occupied by *** confirm that LFY is able to bind nucleosomal DNA in vitro using reconstituted ***,we show that constitutive LFY expression in seedling tissues is sufficient to induce chromatin accessibility in the LFY direct target genes APETALA1 and *** together,our study suggests that LFY possesses key pioneer TF features that contribute to launching the floral gene expression program.

关键词： flower development pioneer transcription factor gene regulation chromatin remodeling

Typology of Natural Hazards and Assessment of Associated Risks in the Mount Bambouto Caldera(Cameroon Line,West-Cameroun)

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地学前缘 2009年第S1期16卷 66-66页

作者： Zangmo Tefogoum Ghislain Kagou Dongmo Armand Nkouathio david Guimolaire Wandji Pierre Department of Earth Science University of Dschang Laboratory of Geology ENSUniversity of Yaounde IB.P.47 Yaounde

Mount Bambouto is a polygenic stratovolcano of the Cameroon Volcanic Line,built between 21 Ma and 4.5 Ma(Nkouathio et al.,2008).It is situated at about 200 km NE of mount Cameroon,at 09°55′and 10°15′East and,05°25′and 05°50′*** volcano covers an area of 500 Km^2 and culminates at 2740 m at Meletan hill and bears a collapsed elliptical caldera at the summit(13×8 km).Mount

关键词： Cameroon Line Mount Bambouto caldera hazards risks

Caveolin-1对乳腺癌细胞系MCF-7增殖和存活的影响

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中国细胞生物学学报 2011年第9期33卷 983-987页

作者：陆瑞盛马骥张燕于玲莉 Ambre Spencer david Cluet Brian B.Rudkin 袁崇刚华东师范大学生命科学学院 Differentiation & Cell Cycle Group Cellular Molecular Biology LaboratoryUMR 5239 CNRS/ENS Lyon/University of Lyon 1IFR 128Bioscience Lyon-Gerland.46Allee d'Italie 69364 Lyon Cedex 07 Differentiation & Cell Cycle Group Cellular Molecular Biology Laboratory UMR 5239 CNRS/ENS Lyon/University of Lyon 1IFR 128Bioscience Lyon-Gerland.46Allee d'Italie 69364 Lyon Cedex 07 Differentiation & Cell Cycle Group

该文研究窖蛋白(Caveolin-1)对乳腺癌细胞系MCF-7细胞增殖与存活的影响。运用蛋白质印迹方法(Western blot)检测发现,caveolin-1在5株不同细胞系均只有低表达。运用电穿孔转染方法在乳腺癌细胞系中高表达Caveolin-1,运用Western blot检... 详细信息

该文研究窖蛋白(Caveolin-1)对乳腺癌细胞系MCF-7细胞增殖与存活的影响。运用蛋白质印迹方法(Western blot)检测发现,caveolin-1在5株不同细胞系均只有低表达。运用电穿孔转染方法在乳腺癌细胞系中高表达Caveolin-1,运用Western blot检测转染后Caveolin-1表达情况发现,转染后细胞内Caveolin-1表达上升,并具有生物活性。运用单核细胞直接细胞毒性测定法(MTT)检测发现,转染后乳腺癌细胞系MCF-7增殖速度降低。运用Western blot方法和免疫荧光(immunofluorescence)方法检测转染后细胞凋亡途径的变化,磷酸化的P38蛋白含量上升,Bax表达量明显上升。据此推测Caveolin-1抑制MCF-7细胞的增殖和存活,并诱导基于Bax途径的细胞凋亡。

关键词： Caveolin-1 乳腺癌增殖和存活