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A study on bonding and energetic aspect of the Fe-Si binary system

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Chinese Journal of Chemistry 1997年第6期15卷 492-503页

作者： chacon Garardo Department of Chemistry Northern Illinois UniversityDekalbeIL60115USA

We have studied the electronic, bonding and energetic characteristics of the Fe-Si binary system using the tight-bonding extended Huckel method. Among the Fe-Si binary compounds, FeSi has the most symmetric geometric arrangement in the crystal structure. It also possesses the largest cohesive energy per atom. This correlates to the fact that FeSi is the most stable congruently-melting compound in the bulk phase diagram. An estimate of interaction energies between different atoms is also given.

关键词： Fe-Si binary system bonding extended Huckel method

Decoupling the role of chemistry and microstructure in hMSCs response to an osteoinductive calcium phosphate ceramic

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Bioactive Materials 2023年第1期19卷 127-138页

作者： V.P.Galván-chacon D.de Melo Pereira S.Vermeulen H.Yuan J.Li P.Habibovic MERLN Institute for Technology Inspired Regenerative Medicine Maastricht Universitythe Netherlands Kuros Biosciences BV 3723 MBBilthoventhe Netherlands

Calcium phosphates(CaP)are widely used synthetic bone graft substitutes,having bioactivity that is regulated by a set of intertwined physico-chemical and structural *** some CaPs have shown to be as effective in regenerating large bone defects as autologous bone,there is still the need to understand the role of individual material properties in CaP ***,we aimed to decouple the effects of chemical composition and surface-microstructure of a beta-tricalcium phosphate(TCP)ceramic,with proven osteoinductive potential,on human mesenchymal stromal cells(hMSCs)*** this end,we replicated the surface structure of the TCP ceramic into polylactic acid without inorganic additives,or containing the chemical constituents of the ceramic,i.e.,a calcium salt,a phosphate salt,or TCP *** microstructure of the different materials was characterized by confocal laser *** were cultured on the materials,and the expression of a set of osteogenic genes was *** cell culture medium was collected and the levels of calcium and phosphate ions were quantified by inductively-coupled plasma mass *** results revealed that none of the tested combinations of properties in polymer/composite replicas was as potent in supporting the osteogenic differentiation of hMSCs as the original ***,we observed some effects of the surface structure in the absence of inorganics,as well as combined effects of surface structure and the added salts,in particular calcium,on osteogenic *** approach presented here can be used to study the role of independent properties in other CaP-based biomaterials.

关键词： Calcium phosphate Microstructure Chemical composition Mesenchymal stromal cells Osteogenic differentiation

The regional employment implications of a net-zero economy in Costa Rica under uncertainty

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Advances in Climate Change Research 2023年第6期14卷 988-999页

作者： Maria JoséSAUMA chacon Alejandro MATARRITA VALVERDE Bernardo ZUNIGA ALVARADO Monica RODRiGUEZ-ZUNIGA Jairo QUIROs-TORTOS Luis ViCTOR-GALLARDO Pauline SCHAAL Paula CUBILLOS Thierry DUPLAN Matthieu ROBIN Slim DALI Universidad de Costa Rica San Jose 11501-2060Costa Rica Agence Frangaise de Developpement Paris 75598 France

This study estimates job creation from Costa Rica's transition to net-zero emissions by 2050,contrasting it with a business-as-usual scenario(BAU)using employment multipliers from Costa Rica's input-output *** model is soft-linked with a bottom-up technology-rich regional model of the CLEW sectors in Costa Rica.A robust decision-making-inspired approach is taken to assess the effects of uncertainty on the *** study addresses a literature gap in modeling subnational employment while accounting for long-term uncertainty and allows to identify economic activities affected by the transformation,so that policies regarding a just transition can be properly developed and stakeholders incentivized to take active participation in the *** baseline assumptions,a net-zero economy would have 135 thousand more jobs by 2050 than the BAU,equivalent to 7%of the employed population in ***-related jobs would triple by mid-21st century,and regions capitalizing on renewables would perceive the highest *** considering uncertainty,the net jobs range between 35-750 *** net positive outcomes in terms of jobs are feasible,global governance should focus efforts on policies that enhance these.

关键词： Decarbonization Environmental policy Input-output Employment multipliers Costa Rica

Particle-in-Cell with Monte CarloCollisions Gun Code Simulations of a Surface-Conversion H^(−)Ion Source

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Communications in Computational Physics 2008年第8期4卷 659-674页

作者： E.chacon-Golcher K.J.Bowers Los Alamos National Laboratory Los AlamosNM 87545USA Los Alamos National Laboratory Guest Scientist currently at D.E.Shaw&CompanyNew YorkNY 10036USA.

We present an extended update on the status of a particle-in-cellwithMonte Carlo collisions(PIC-MCC)gun code developed at LosAlamos for the study of surfaceconverter H−ion *** programis fully *** of the program’s features include:solution of arbitrary electrostatic and magnetostatic fields in an axisymmetric(r,z)geometry to describe the self-consistent time evolution of a plasma;simulation of a multi-species(e^(−),H^(+),H^(+)_(2),H^(+)_(3),H^(−))plasma discharge from a neutral hydrogen gas and filament-originated seed electrons;full 2-dimensional(r,z)3-velocity(v_(r),v_(z),vφ)dynamics for all species;detailed collision physics between charged particles and neutrals and the ability to represent multiple smooth(not stair-stepped)electrodes of arbitrary shape and voltage whose surfaces may be secondary-particle emitters(H^(−)and e^(−)).The status of this development is discussed in terms of its physics content and current implementation details.

关键词： Negative hydrogen ion source simulation particle-in-cell with Monte Carlo collisions low temperature plasma simulation

Effect of inductively coupled plasma surface treatment on silica gel and mesoporous MCM-41 particles

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Plasma Science and Technology 2018年第6期20卷 104-113页

作者： J A JUAREZ-MORENO U chacon-ARGAEZ J BARRON-ZAMBRANO C CARRERA-FIGUEIRAS P QUINTANA-OWEN W TALAVERA-PECH Y PEREZ-PADILLA A AVILA-ORTEGA facultad de ingeniería química-uady periférico norte kilómetro 33.5col.chuburna de hidalgo inn C.P. 97203 Mérida Yucatan México centro de investigación y de estudios avanzados del ipn-unidad mérida km.6 antigua carretera a progreso apdo. Postal 73 Cordemex 97310 Méfida Yucatán México

Silica gel and MCM-41 synthesized mesoporous materials were treated with either oxygen（O_2）,hexamethyldisiloxane（HMDSO） and organic vapors like ethanol（Et OH）,and acrylonitrile（AN）inductive *** radiofrequency power for the modification was fixed to 120 W and30 min,assuring a high degree of organic ionization energy in the *** surface properties were studied by infrared spectroscopy（FTIR）,scanning electron microscopy,x-ray photoelectron spectroscopy and dynamic light scattering technique was used for characterizing size *** the silica and MCM-41 particles were modified by AN and HMDSO plasma gases,the surface morphology of the particles was changed,presenting another color,size or *** contrast,the treatments of oxygen and Et OH did not affect the surface morphology of both particles,but increased the oxygen content at the surface bigger than the AN and HMDSO plasma *** this study,we investigated the influence of different plasma treatments on changes in morphology and the chemical composition of the modified particles which render them a possible new adsorbent for utilization in sorptive extraction techniques for polar compounds.

关键词： silica MCM-41 nanoparticles plasma treatment

The dual role of necrostatin-1 in Parkinson’s disease models

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Neural Regeneration Research 2021年第10期16卷 2019-2020页

作者： Eva Alegre-Cortes Guadalupe Martinez-chacon Jose M.Fuentes Sokhna M.S.Yakhine-Diop Universidad de Extremadura Depto.Bioquimica y Biologia Molecular y GeneticaFacultad de Enfermeria y Terapia OcupacionalAvda de la Universidad s/nCaceresSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED)Madrid Spain Instituto Universitario de Investigacion Biosanitaria de Extremadura(INUBE) CaceresSpain

Neuronal cell death is the main hallmark of Parkinson’s disease(PD).It is an irreversible process promoted by neurotoxins and/or genetic *** types of cell death have been associated with *** mechanisms by which neurons decide to specific type of cell death remain ***,it is well known that cell death can be either programmed or *** is a programmed cell death that involves the release of cytochrome c from damaged mitochondria to cytosol and the activation of caspases leading to nuclear *** is a caspase-independent cell death characterized by a gain in cell volume,rupture of plasma membrane and leak of cell contents,inflammation,and affects neighbouring *** was classified as a nonprogrammed cell death,but there are types of necrotic death triggered by a protein activation cascade,including necroptosis.

关键词： inflammation Necrosis rupture

玻利维亚中央银行应对Facebook虚拟加密货币威胁的策略研究

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玻利维亚中央银行应对Facebook虚拟加密货币威胁的策略研究

作者： Laredo chacon Emmanuel Gabriel 北京交通大学

学位级别：硕士

2019年6月,Facebook发布了加密货币Libra计划及白皮书,旨在建立一套简单的、无国界的货币和为全球用户服务的金融基础设施。理论上,这一计划将为发展中国家中的数十亿人提供便捷的金融服务,但也对各国的金融主权提出了挑战。玻利维亚中... 详细信息

2019年6月,Facebook发布了加密货币Libra计划及白皮书,旨在建立一套简单的、无国界的货币和为全球用户服务的金融基础设施。理论上,这一计划将为发展中国家中的数十亿人提供便捷的金融服务,但也对各国的金融主权提出了挑战。玻利维亚中央银行(BCB)负责制定并执行国家的货币政策,实行金融监管。玻利维亚诺是该国唯一使用的货币,国内的支付方式为:现金、借记卡和信用卡、电子转帐和支票。玻利维亚作为世界上影子经济最为繁荣的国家之一,超过80%的人口从事非正规业务,而玻利维亚的金融科技基础薄弱,现金为主要的支付方式。因此,Libra的Techfin生态系统可能会严重威胁玻利维亚现有的经济体系。基于Libra对玻利维亚可能产生的威胁与挑战,本文运用PEST分析,从影响和不确定性两个维度评估了相关影响因素,并提出了三种可能情况:玻利维亚出台法规禁止金融机构参与Libra的生态系统;Libra进入玻利维亚经济,但BCB拥有一个可以垄断在线银行和互联网金融业务的与Libra竞争的虚拟对手;BCB创建一个中央银行数字货币(CBDC)授权给未能获得金融服务的人群,并同时禁止Libra的使用。基于PEST分析以及相关情况预测,为有效应对Libra对玻利维亚的可能影响,论文提出了两项应对策略:一是禁止Libra在国内运行,然而玻利维亚需积极应对金融科技和监管方面的挑战。第二是玻利维亚在十年内需自主开发一个中央银行数字货币以应对挑战。

关键词：虚拟加密货币 Facebook 玻利维亚中央银行应对策略

First-line cisplatin,docetaxel,and cetuximab for patients with recurrent or metastatic head and neck cancer:A multicenter cohort study

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World Journal of Clinical Oncology 2022年第2期13卷 147-158页

作者： Agustin Falco Mariano Leiva Albano Blanco Guido Cefarelli Andres Rodriguez Juan Melo Federico Cayol Manglio Miguel Rizzo Alejandro Sola Hernan Rodriguez Montani Matias chacon Diego Enrico Federico Waisberg Department of Medical Oncology Head and Neck UnitAlexander Fleming Cancer InstituteBuenos Aires 1428Argentina Department of Medical Oncology Alexander Fleming Cancer InstituteBuenos Aires 1426Argentina Department of Medical Oncology Hospital Italiano de Buenos AiresBuenos Aires 1199Argentina Department of Medical Oncology Hospital Universitario AustralPilar 1629Argentina Department of Medical Oncology Fundación Centro Oncológico de Integración RegionalMendoza 5500Argentina Department of Medical Oncology Hospital Italiano RosarioSanatorio de la MujerRosario 2001Argentina

BACKGROUND The targeted therapy cetuximab[directed at the epidermal growth factor receptor(EGFR)]in combination with 5-fluorouracil and platinum-based chemotherapy(the EXTREME regimen)has shown substantial efficacy for patients with recurrent or metastatic squamous cell carcinoma of the head and neck(R/M SCCHN).Thus,this scheme has been established as the preferred first-line option for these ***,more recently,a new strategy combining platinum,taxanes,and cetuximab(the TPEx regimen)has demonstrated similar efficacy with a more favorable toxicity profile in clinical *** To evaluate the safety and efficacy of the TPEx scheme as first-line therapy in advanced SCCHN in a multicenter cohort *** This retrospective multicenter cohort study included patients with histologically confirmed recurrent or metastatic SCCHN treated with first-line TPEx at five medical centers in Argentina between January 1,2017 and April 31,*** consisted of four cycles of docetaxel,cisplatin,and cetuximab followed by cetuximab maintenance *** outcomes and toxicity profiles were collected from medical *** response was assessed by the investigator in accordance with Response Evaluation Criteria in Solid Tumors(version 1.1).Adverse events were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events(version 4.0).RESULTS Twenty-four patients were *** median age at diagnosis was 58 years(range:36-77 years).The majority of patients(83.3%)received at least four chemotherapy cycles in the initial *** the included group,the overall response rate was 62.5%,and 3 patients achieved a complete response(12.5%).The median time to response was 2.4 mo[95% confidence interval(CI):1.3-3.5].With a median follow-up of 12.7 mo(95%CI:8.8-16.6),the median progression-free survival(PFS)was 6.9 mo(95%CI:6.5-7.3),and the overall survival rate at 12 mo was 82.4%.Patients with documented tumor response s

关键词： Recurrent and/or metastatic head and neck cancer TPEx schema Cetuximab Docetaxel Cisplatin First-line

Evaluation of the Permeation and Penetration of Two Formulations of Terbinafine Chlorhydrate Incorporated in Liposomes (Cream 1%) vs. a Conventional Formulation (Cream 1%), in an <i>in Vitro-ex Vivo</i>Model

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Journal of Biosciences and Medicines 2019年第8期7卷 119-133页

作者： Sanabria Kinski Annunziato Maria Antonieta chacon Nicolas Inatti Alfredo Department of Nanotechnology of Laboratories Leti S.A.V. GuarenasVenezuela Department of Research and Development Laboratories Biocontrolled C.A.GuarenasVenezuela

In this trial, a topical formulation of a 1% liposome TH cream was compared to a conventional TH formulation. Permeation was evaluated through a synthetic membrane. The study provided information on the rate of diffusion and percentage of drug release and also compared the penetration dynamics in the layers of the stratum corneum of both formulations. Liposome TH cream was able to deliver the active ingredient to a larger number of SC layers, with a higher amount of drug, which is very promising for the treatment of superficial mycoses.

关键词： Antifungal Franz Diffusion Cell Tape Striping Method Liposome Terbinafine HCl Drug Carrier Systems Stratum Corneum