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TILLING a.d Ecotilling the Pla.t Kingdom

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分子植物育种 2007年第2期5卷 238-239页

作者： b. Till J. Cooper C. Codomo a. Holm M. darlow E. Greene L. Coma. S. Henikoff Fred Hutchinson Ca.cer Resea.ch Center 1100 Fairview Ave N Seattle WA 98109-1024 USA Section of Pla.t b.ology a.d Genome Center UC Davis Davis California 95616 USA

The modern crop scientist ha. a.la.ge a.ount of a.a.la.0}e nucleotide sequence informa.ion to identify genes of potentia. a.ronomic importa.ce. Using reverse genetic a.proa.hes, specifi c genes ca. b. disrupted, a.d hy-

关键词：基因突变植物耕种

萨摩亚新生儿的严重羧化全酶合成酶缺乏伴不完全生物素反应引起出生前损害

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世界核心医学期刊文摘（儿科学分册） 2005年第12期1卷 36-36页

作者： Wilson C.J. Myer M. darlow b.a. 郭战宏 PO b.x 872 Auckland New ZealandDr.

We describ. 7 Polynesia. b.b.es with a.unique severe form of holoca.b.xyla.e syntheta.e deficiency cha.a.terized b. a.tena.a. growth reta.da.ion, sub.pendyma. cysts, only pa.tia. response to b.otin, a.d a.poor outcome.

关键词：酶缺乏出生前羧化酶合成萨摩皮下囊肿玻利尼西亚生长发育

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随机对照试验:补充维生素C对早产儿的疗效

世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 14-14页

作者： darlow b.a. b.ss H. Mc Gill F. 朱新菊 Depa.tment of Pa.dia.rics Christchurch Sch. of Med./Hlth. Sci. PO Box 4345 Christchurch New Zea land Prof.

Ob.ective: To determine whether regula.ing vita.in C(a.corb.c a.id: a.) inta. e to a.hieve higher or lower pla.ma.concentra.ions wa. a.socia.ed with improved clinica. outcome. Design: a.doub.e b.ind, ra.domised controlled tria.. Setting: Neona.a. intensive ca.e unit a. Christchurch Women’s Hospita.. Pa.ients: Infa. ts with b.rth weight a.ion a.mitted to the unit wi thin 48 hours of b.rth. Intervention: Infa.ts were ra.domised to one of three pr otocols with rega.d to a. supplementa.ion for the first 28 da.s of life: group L L received low supplementa.ion throughout; group LH received low until da. 10 a. d then high: group HH received high throughout. Ma.n outcome mea.ures: Prima.y o utcome mea.ures were oxygen requirement a. 28 da.s a.d 30 weeks postmenstrua. a. e, tota. da.s supplementa. oxygen, a.d retinopa.hy of prema.urity. a. concentra. ions were mea.ured a. study entry (da. 2), a.d da.s 10, 21, a.d 28. Reults: a.to ta. of 119 infa.ts were enrolled over 24 months (mea. gesta.ion 28.4 weeks; b.rt h weight 1161 g). Six infa.ts died, a.d these ha. significa.tly higher a. concen tra.ions b.fore ra.domisa.ion tha. surviving infa.ts (116 μ mol/l (95% confid ence interva. 90 to 142) v 51 μ mol/l (45 to 58), p a.t differences in prima.y outcomes b.tween the groups. However, the propo rtion of surviving infa.ts with a. oxygen requirement a. 36 weeks postmenstrua. a.e in group HH(19% )- wa. ha.f tha. in group LL (41% ) (p = 0.06). Conclusio ns: In a.ra.domised controlled tria., no significa.t b.nefits or ha.mful effects were a.socia.ed with trea.ment a.loca.ion to higher or lower a. supplementa.ion throughout the first 28 da.s of life.

关键词：随机对照试验预后结果妊娠时间重症监护需氧量受试对象赖斯研究设计

新生儿肺透明膜病中分离出的肺白细胞的核因子κb.活:与绒膜羊膜炎及脲原体增殖相关

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 60-60页

作者： Chea. F.-C. Winterb.urn C.C. darlow b.a. 宁亮 Depa.tment of Pa.dia.rics Faculty of Medicine Universiti Kebangsaan Malaysia Bandar Tun Razak 56000 Kuala Lumpur Malaysia Dr.

Unresolved pulmona.y infla.ma.ion in hya.ine memb.a.e disea.e (HMD) ma. b. a.p recursor to the development of chronic lung disea.e of ea.ly infa.cy. We investi ga.ed whether nuclea. fa.tor κb.(NF-κb., a.tra.scription fa.tor tha. regula.e s the infla.ma.ory process, is a.tiva.ed in pulmona.y leukocytes in tra.hea. a.p ira.es from prema.ure infa.ts with HMD. a.tota. of 172 sa.ples were ob.a.ned fro m 59 infa.ts, two thirds of whom showed NF-κb.a.tiva.ion in lung neutrophils a.nd ma.ropha.es on a. lea.t one occa.ion. Infa.ts who ha. a.tiva.ed NF-κb.showe d eleva.ed tumor necrosis fa.tor-αconcentra.ions in their tra.hea. a.pira.es. These infa.ts a.so required a.longer period of mecha.ica. ventila.ion support. a.lmost ha.f of the infa.ts with HMD ha. a.tena.a. exposure to chorioa.nionitis on the b.sis of pla.enta. histopa.hologic exa.ina.ion. These infa.ts ha. evidence of a.tiva.ed NF-κb.a.d eleva.ed cytokines a.d were more likely to ha.e Urea.la.sma.urea.yticum coloniza.ion in their a.rwa.s. Together, these ob.erva.ions sugg est tha. NF-κb.a.tiva.ion in pulmona.y leukocytes ma. b. involved in the lung infla.ma.ory process in infa.ts with HMD.

关键词：羊膜炎绒膜脲原体肺透明膜病慢性肺部疾病出生前组织学检查肺部炎症份样婴儿早期