澳大利亚及新西兰新生儿网络中患严重早产儿视网膜病变的出生前危险因素研究

作     者：Darlow B. A. Hutchinson J. L. Henderson - Smart D.J. 桑延智(译) 

作者机构：Department of Paediatrics Christchurch School of Medicine and Health Sciences PO Box 4345 Christchurch New Zealand 不详 

出 版 物：《世界核心医学期刊文摘（眼科学分册）》 (Digest of the World Core Medical Journals:Ophthalmology)

年 卷 期：2006年第2卷第9期

页      面：8-9页

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：早产儿视网膜病变 危险因素研究 澳大利亚 网络计划 新生儿 出生前 新西兰 logistic回归模型 

摘      要：*** identify prenatal and perinatal risk factors for clinically severe(stage 3 or 4)retinopathy of prematurity(ROP).*** were collected prospectively as part of the ongoing Australian and New Zealand Neonatal Network audit of high-risk infants(birth weight of 1500 g or gestational age GA of 32 weeks)admitted to a level III neonatal unit in Australia or New *** and perinatal factors to 1 minute of age were examined for the subset of infants with GA of 29 weeks who survived to 36 weeks’ postmenstrual age and were examined for ROP(n=2105).The factors significantly associated with stage 3 or 4 ROP were entered into amultivariate logistic regression ***-hundred three infants(9.6%)had stage 3 or more *** was the dominant risk factor,with infants with GA of 25 weeks having 20 times greater odds of severe ROP than infants with GA of 28 *** weight for GA also had a “ dose-response effect;the more growthrestricted infants had greater risk,with infants below the 3rd percentile of weight for GA having 4 times greater odds of severe ROP than those between the 25th and 75th *** gender was also a significant risk factor(odds ratio:1.73;95% confidence interval:1.25-2.40).*** data,for a large,essentially population-based cohort,suggest that factors related to the degree of immaturity,intrauterine growth restriction,and male gender contribute to severe ROP.