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Journal of Integrative Plant Biology 2024年第3期66卷 468-483页

作者： Shuanghe Cao Bingyan Liu daowen wang Awais Rasheed Lina Xie Xianchun Xia Zhonghu He State Key Laboratory of Crop Gene Resources and Breeding/National Wheat Improvement Center Institute of Crop SciencesBeijing 100081China College of Agronomy Henan Agricultural UniversityZhengzhou 450002China International Maize and Wheat Improvement Center(CIMMYT)China Office Chinese Academy of Agricultural SciencesBeijing 100081China

Achieving high yield and good quality in crops is essential for human food security and health.However,there is usually disharmony between yield and quality.Seed storage protein(SSP)and starch,the predominant components in cereal grains,determine yield and quality,and their coupled synthesis causes a yield–quality trade-off.Therefore,dissection of the underlying regulatory mechanism facilitates simultaneous improvement of yield and quality.Here,we summarize current findings about the synergistic molecular machinery underpinning SSP and starch synthesis in the leading staple cereal crops,including maize,rice and wheat.We further evaluate the functional conservation and differentiation of key regulators and specify feasible research approaches to identify additional regulators and expand insights.We also present major strategies to leverage resultant information for simultaneous improvement of yield and quality by molecular breeding.Finally,future perspectives on major challenges are proposed.

关键词： cereal crops grain yield and quality seed storage protein starch synergistic regulation

CRISPR/CasΦ2-mediated gene editing in wheat and rye

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Journal of Integrative Plant Biology 2024年第4期66卷 638-641页

作者： Sanzeng Zhao Xueying Han Yachen Zhu Yuwei Han Huiyun Liu Zhen Chen Huifang Li Dan wang Chaofan Tian Yuting Yuan Yajie Guo Xiaomin Si daowen wang Xiang Ji State Key Laboratory of Wheat and Maize Crop Science and Center for Crop Genome EngineeringCollege of AgronomyHenan Agricultural UniversityZhengzhou 450046China Collaborative Innovation Center of Henan Grain Crops College of AgronomyHenan Agricultural UniversityZhengzhou 450046China State Key Laboratory of Crop Stress Adaptation and Improvement College of AgronomyHenan UniversityKaifeng 475004China The Shennong Laboratory Zhengzhou 450002China

The recent advancements in developing the CRISPR/Cas9 system and various derivative tools(e.g.,base editors)have accelerated basic plant science research and crop improvement by creating multiple types of genetic vari... 详细信息

关键词： CRISPR/Cas9 CRISPR/Cas

Gut microbiota-dependent phenylacetylglutamine in cardiovascular disease:current knowledge and new insights

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Frontiers of Medicine 2024年第1期18卷 31-45页

作者： Yaonan Song Haoran Wei Zhitong Zhou Huiqing wang Weijian Hang Junfang Wu Dao Wen wang Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan430030China

Phenylacetylglutamine(PAGln)is an amino acid derivate that comes from the amino acid phenylalanine.There are increasing studies showing that the level of PAGln is associated with the risk of different cardiovascular diseases.In this review,we discussed the metabolic pathway of PAGln production and the quantitative measurement methods of PAGln.We summarized the epidemiological evidence to show the role of PAGln in diagnostic and prognostic value in several cardiovascular diseases,such as heart failure,coronary heart disease/atherosclerosis,and cardiac arrhythmia.The underlying mechanism of PAGln is now considered to be related to the thrombotic potential of platelets via adrenergic receptors.Besides,other possible mechanisms such as inflammatory response and oxidative stress could also be induced by PAGln.Moreover,since PAGln is produced across different organs including the intestine,liver,and kidney,the cross-talk among multiple organs focused on the function of this uremic toxic metabolite.Finally,the prognostic value of PAGln compared to the classical biomarker was discussed and we also highlighted important gaps in knowledge and areas requiring future investigation of PAGln in cardiovascular diseases.

关键词： PAGln cardiovascular disease gut microbiota uremic metabolite biomarker

An epic war between an oomycete pathogen and plants

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Molecular Plant 2022年第12期15卷 1828-1830页

作者： Huan wang Youhuang Xiang daowen wang Zheng Qing Fu State Key Laboratory of Wheat and Maize Crop Science Center for Crop Genome Engineeringand College of AgronomyHenan Agricultural UniversityZhengzhou 450002China National Key Laboratory of Plant Molecular Genetics CAS Centre for Excellence in Molecular Plant Sciences and Collaborative Innovation Center of Genetics&DevelopmentShanghai Institute of Plant Physiology&EcologyChinese Academy of SciencesShanghai 200032China University of the Chinese Academy of Sciences Beijing 100049China Department of Biological Sciences University of South CarolinaColumbiaSC 29208USA The Shennong Laboratory ZhengzhouChina

Oomycetes,commonly known as water molds and phylogenetically belonging to stramenopiles,can infect a wide range of plants and animals,with some members eliciting the most destructive plant diseases and posing severe threats to globalfood security and natural ecosystems(Thines,2018).For example,Phytophthora infestans causes potato late blight and triggered the Irish Famine in the 1840s,and Phytophthora sojae damages soybean production worldwide.Breeding resistant cultivars is the most efficient measure for managing the diseases instigated by oomycetes,but the success of the endeavor requires a sound and deep understanding of the molecular basis underlying pathogen-host interactions.Recently,Sun et al.(2022)elucidated the mechanism underlying the recognition of XEG1,a key virulent effector of P.sojae,by host immune receptor through combining genetic,molecular,and structural approaches,which represents a significant step forward in deeply understanding the infection biology and host immune responses in oomycete diseases.

关键词： blight soybean cultivar

Rising from the dead: the power of genome editing

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Science China(Life Sciences) 2023年第12期66卷 2949-2951页

作者： Hongyuan Zheng Junyao Zhao daowen wang Zheng Qing Fu State Key Laboratory of Wheat and Maize Crop Science College of Agronomyand Center for Crop Genome EngineeringHenan Agricultural UniversityZhengzhou 450002China Department of Biological Sciences University of South CarolinaColumbia SC 29208USA

To protect themselves against diverse pathogens, plants have developed sophisticated defense mechanisms. Hypersensitive response or the rapid localized death of plant cells is a major defense strategy deployed by plan... 详细信息

关键词： dead genome

TIRggering cell death via two enzymatic reactions

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Molecular Plant 2022年第8期15卷 1263-1265页

作者： Na Liu Huan Chen Xu wang daowen wang Zheng Qing Fu College of Life Sciences Henan Agricultural UniversityZhengzhou 450002China Department of Biological Sciences University of South CarolinaColumbiaSC29208USA State Key Laboratory of Wheat and Maize Crop Science College of AgronomyCenter for Crop Genome EngineeringHenan Agricultural UniversityZhengzhou 450002China

Plant pathogens rely on effectors that are delivered into host cells to cause diseases.To fight back,plants acquired nucleotidebinding site-leucine-rich repeat(NB-LRR or NLR)resistance proteins to recognize these pathogen effectors directly or to detect the activities of these effectors indirectly,triggering effectortriggered immunity(ETI)(Cui et al.,2015).These sensorNLRs also carry a variable toll/interleukin-1 receptor(TIR)or coiledcoil domain on their N termini.

关键词： immunity death

Immunopathogenesis and immunomodulatory therapy for myocarditis

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中国科学:生命科学英文版 2023年第9期66卷 2112-2137页

作者： Wu He Ling Zhou Ke Xu Huihui Li James Jiqi wang Chen Chen daowen wang Division of Cardiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyHubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological DisordersWuhan 430030China

Myocarditis is an inflammatory cardiac disease characterized by the destruction of myocardial cells, infiltration of interstitial inflammatory cells, and fibrosis, and is becoming a major public health concern. The aetiology of myocarditis continues to broaden as new pathogens and drugs emerge. The relationship between immune checkpoint inhibitors, severe acute respiratory syndrome coronavirus 2, vaccines against coronavirus disease-2019, and myocarditis has attracted increased attention. Immunopathological processes play an important role in the different phases of myocarditis, affecting disease occurrence, development, and prognosis. Excessive immune activation can induce severe myocardial injury and lead to fulminant myocarditis,whereas chronic inflammation can lead to cardiac remodelling and inflammatory dilated cardiomyopathy. The use of immunosuppressive treatments, particularly cytotoxic agents, for myocarditis, remains controversial. While reasonable and effective immunomodulatory therapy is the general trend. This review focuses on the current understanding of the aetiology and immunopathogenesis of myocarditis and offers new perspectives on immunomodulatory therapies.

关键词： myocarditis etiology pathogen immunopathogenesis immunomodulatory

A recent burst of gene duplications in Triticeae

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Plant Communications 2022年第2期3卷 1-12页

作者： Xiaoliang wang Xueqing Yan Yiheng Hu Liuyu Qin daowen wang Jizeng Jia Yuannian Jiao State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China College of Agronomy Collaborative Innovation Center of Henan Grain CropsHenan Agricultural UniversityZhengzhouHenan 450046China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China

Gene duplication provides raw genetic materials for evolution and potentially novel genes for crop improvement.The two seminal genomic studies of Aegilops tauschii both mentioned the large number of genes independently duplicated in recent years,but the duplication mechanism and the evolutionary significance of these gene duplicates have not yet been investigated.Here,we found that a recent burst of gene duplications(hereafter abbreviated as the RBGD)has probably occurred in all sequenced Triticeae species.Further investigations of the characteristics of the gene duplicates and their flanking sequences suggested that transposable element(TE)activity may have been involved in generating the RBGD.We also characterized the duplication timing,retention pattern,diversification,and expression of the duplicates following the evolution of Triticeae.Multiple subgenome-specific comparisons of the duplicated gene pairs clearly supported extensive differential regulation and related functional diversity among such pairs in the three subgenomes of bread wheat.Moreover,several duplicated genes from the RBGD have evolved into key factors that influence important agronomic traits of wheat.Our results provide insights into a unique source of gene duplicates in Triticeae species,which has increased the gene dosage together with the two polyploidization events in the evolutionary history of wheat.

关键词： gene duplication transposable elements gene dosage hexaploid wheat Triticeae agronomic traits

Launching, perceiving, and diminishing of airborne signals

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Molecular Plant 2023年第12期16卷 1882-1884页

作者： Mikayla Carty Ruize Zhang Ziyue Li daowen wang Zheng Qing Fu Department of Biological Sciences University of South CarolinaColumbiaSC29208USA State Key Laboratory of Wheat and Maize Crop Science College of Agronomyand Center for Crop Genome EngineeringHenan Agricultural UniversityZhengzhou450002China

Aphids are highly destructive pests that greatly hurt the agricultural industry.Transmitting over 40%of plant viruses,they are the most destructive pests that the agricultural industry faces(Gong et al.,2023).Aphids feed on plants,and in doing so,they consume sap from one plant and then move to another and inject their saliva into the new plant(Hooks and Fereres,2006).This cycle causes diseases and viral pathogens to become rampant between plants as the aphids carry viral pathogens from one plant to another and so on.

关键词： plant carry

MicroRNAs in cardiovascular diseases

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Medical Review 2022年第2期2卷 140-168页

作者： Huaping Li Jiabing Zhan Chen Chen daowen wang Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders WuhanChina.

Cardiovascular diseases(CVDs)are the leadingcauses of death and disability worldwide,despite thewide diversity of molecular targets identified and thedevelopment of therapeutic methods.MicroRNAs(miRNAs)are a class of small(about 22 nucleotides)non-codingRNAs(ncRNAs)that negatively regulate gene expressionat the post-transcriptional level in the cytoplasm and playcomplicated roles in different CVDs.While miRNA overexpression in one type of cell protects against heartdisease,it promotes cardiac dysfunction in another typeof cardiac cell.Moreover,recent studies have shown that,apart from cytosolic miRNAs,subcellular miRNAs suchas mitochondria-and nucleus-localized miRNAs aredysregulated in CVDs.However,the functional propertiesof cellular-and subcellular-localized miRNAs have notbeen well characterized.In this review article,by carefullyrevisiting animal-based miRNA studies in CVDs,we willaddress the regulation and functional properties ofmiRNAs in various CVDs.Specifically,the cell–cellcrosstalk and subcellular perspective of miRNAs arehighlighted.We will provide the background for attractivemolecular targets that might be useful in preventing theprogression of CVDs and heart failure(HF)as well asinsights for future studies.

关键词： apoptosis cardiovascular diseases fibrosis heart failure hypertrophy miRNAs subcellular organelle