MicroRNAs in cardiovascular diseases
作者机构：Division of CardiologyDepartment of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological DisordersWuhanChina.
出 版 物：《Medical Review》 (医学评论（英文）)
年 卷 期：2022年第2卷第2期
页 面：140-168页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by grants from the National Natural Science Foundation of China(nos.81822002 91439203 91839302 81630010 31771264 81790624 82170273 and 31800973).
主 题：apoptosis cardiovascular diseases fibrosis heart failure hypertrophy miRNAs subcellular organelle
摘 要：Cardiovascular diseases(CVDs)are the leadingcauses of death and disability worldwide,despite thewide diversity of molecular targets identified and thedevelopment of therapeutic methods.MicroRNAs(miRNAs)are a class of small(about 22 nucleotides)non-codingRNAs(ncRNAs)that negatively regulate gene expressionat the post-transcriptional level in the cytoplasm and playcomplicated roles in different CVDs.While miRNA overexpression in one type of cell protects against heartdisease,it promotes cardiac dysfunction in another typeof cardiac cell.Moreover,recent studies have shown that,apart from cytosolic miRNAs,subcellular miRNAs suchas mitochondria-and nucleus-localized miRNAs aredysregulated in CVDs.However,the functional propertiesof cellular-and subcellular-localized miRNAs have notbeen well characterized.In this review article,by carefullyrevisiting animal-based miRNA studies in CVDs,we willaddress the regulation and functional properties ofmiRNAs in various CVDs.Specifically,the cell–cellcrosstalk and subcellular perspective of miRNAs arehighlighted.We will provide the background for attractivemolecular targets that might be useful in preventing theprogression of CVDs and heart failure(HF)as well asinsights for future studies.
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