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格雷夫斯病患者^(131)I治疗后早期甲状腺功能状态对疗效的预测价值

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中华核医学与分子影像杂志 2024年第1期44卷 30-34页

作者：王岩余锋王任飞孟召伟张桂芝张瑞国孙丹阳王萱谭建郑薇天津医科大学总医院核医学科天津300052 空军军医大学第一附属医院核医学科西安710032 同济大学附属第十人民医院核医学科上海200072 天津医科大学总医院空港医院核医学科天津300308

目的研究格雷夫斯病(GD)患者131I治疗后早期甲状腺功能(简称甲功)变化对疗效的预测价值。方法回顾性分析自2017年11月至2019年1月于天津医科大学总医院行单次131I治疗的273例GD患者[男59例、女214例, 年龄(37.4±11.4)岁]的资料, 观察... 详细信息

目的研究格雷夫斯病(GD)患者131I治疗后早期甲状腺功能(简称甲功)变化对疗效的预测价值。方法回顾性分析自2017年11月至2019年1月于天津医科大学总医院行单次131I治疗的273例GD患者[男59例、女214例, 年龄(37.4±11.4)岁]的资料, 观察患者症状、体征及血清学检查[游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))]评价疗效[完全缓解(CR)、部分缓解(PR)、无效(NR)或复发], 采用χ^(2)检验、单因素方差分析及最小显著差异t检验比较各疗效组131I治疗后1个月的甲功变化幅度[ΔFT_(3)=(治疗前FT_(3)-治疗后FT_(3))/治疗前FT_(3)×100%;ΔFT_(4)=(治疗前FT_(4)-治疗后FT_(4))/治疗前FT_(4)×100%]及疗效组间的差异。绘制ROC曲线, 分析早期甲功变化对131I疗效的预测价值;行logistic回归分析找出131I疗效的影响因素。结果单次131I治疗后, 273例患者的CR率和总有效率分别为67.03%(183/273)和92.67%(253/273)。1个月时甲功正常组(95例)CR率明显高于甲状腺功能亢进症(简称甲亢)组[178例;81.05%(77/95)与59.55%(106/178);χ^(2)=4.60, P=0.032]。CR组(183例)、PR组(70例)、NR或复发组(20例)治疗后1个月的ΔFT_(3)及ΔFT_(4)差异均有统计学意义且依次降低(F值:15.40、12.54,均P<0.001)。ROC曲线分析显示, ΔFT_(3)≥73.64%和(或)ΔFT_(4)≥59.03%时, 患者获得CR概率较高, 灵敏度分别为84.3%及86.7%, 特异性均为62.6%。Logistic回归分析示, 24 h摄131I率[比值比(OR)=1.095, 95%CI:1.031~1.139]、每克甲状腺组织给予131I剂量(OR=1.562, 95%CI:1.321~1.694)、ΔFT_(3)(OR=1.354, 95%CI:1.295~1.482)、ΔFT_(4)(OR=1.498, 95%CI:1.384~1.608)是影响131I疗效的因素(均P<0.05)。结论 GD患者单次131I治疗后1个月时甲功变化幅度可预测131I疗效。

关键词：格雷夫斯病放射疗法碘放射性同位素甲状腺功能试验治疗结果

基于超高效液相色谱混合四级杆飞行时间质谱技术的代谢组学探讨不同背景下甲状腺癌的代谢机制

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中华内分泌代谢杂志 2023年第9期39卷 751-758页

作者：孙丹阳张玉洁李雪王丹韩蕊李宁李亭苇赵雪贾强谭建郑薇宋丽丽孟召伟天津医科大学总医院空港医院核医学科天津300308 天津市第一中心医院病理科天津300190 天津医科大学总医院核医学科天津300052 天津医科大学总医院病理科天津300052 天津中医药大学中药学院天津300193 天津医科大学核医学科天津300203

目的分析正常背景及桥本甲状腺炎(Hashimoto′s thyroiditis, HT)背景下甲状腺乳头状癌(papillary thyroid cancer, PTC)代谢机制的异同, 探索HT与PTC的关系。方法本研究纳入样本匹配自天津医科大学总医院2018年1月至2019年1月期间实行... 详细信息

目的分析正常背景及桥本甲状腺炎(Hashimoto′s thyroiditis, HT)背景下甲状腺乳头状癌(papillary thyroid cancer, PTC)代谢机制的异同, 探索HT与PTC的关系。方法本研究纳入样本匹配自天津医科大学总医院2018年1月至2019年1月期间实行甲状腺切除术, 病理结果证实为伴有HT背景下PTC组织及其癌旁组织样本31例(HT组), 正常背景下PTC组织及癌旁组织样本30例(NC组)。应用超高效液相色谱混合四级杆飞行时间质谱(ultra-high performance liquid chromatography combined with mixed four-stage poles time-of-flight mass spectrometry, UPLC-Q-TOF-MS)技术对样本进行数据采集, 比较2组间代谢产物的异同, 筛选不同背景下PTC的代谢机制异同, 通过Metabo-Analyst 5.0进行代谢通路分析, 探索相关代谢通路。结果 HT组和NC组筛选出7种相同的差异代谢物, 包括精氨酸、谷氨酸、半胱氨酸、柠檬酸、苹果酸、尿嘧啶和牛磺酸, 结合这7种生物标志物的受试者工作特征(receiver operating characteristic, ROC)曲线分析对PTC具有良好的鉴别性(HT组及NC组ROC曲线下面积值分别为0.867和0.973);2组共同的代谢通路为牛磺酸和次牛磺酸代谢, 精氨酸生物合成, 丙氨酸、天冬氨酸和谷氨酸代谢, 精氨酸和脯氨酸代谢, 以及谷氨酰胺和谷氨酸代谢。HT组特异的通路为氨酰基tRNA生物合成, 甘氨酸、丝氨酸和苏氨酸代谢。结论正常背景或HT背景在甲状腺癌中的代谢谱中有重要的异同。HT背景下PTC特异的通路为氨酰tRNA的生物合成及甘氨酸、丝氨酸和苏氨酸的代谢。

关键词：代谢组学桥本甲状腺炎甲状腺乳头状癌代谢通路生物标志物

城市轨道交通的土地增值效应研究——以宁波市为例

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黑龙江科学 2023年第2期14卷 15-19,24页

作者：严振瑞姜雨萌孙丹扬吕金涵张洪康宁波大学浙江宁波315000

为探讨城市轨道交通对周边土地开发形成的溢价效应,以宁波市为例,采用特征价格模型,测度城市轨道交通溢价效应,分析轨道交通的空间增值效应。结果表明,城市土地价格随着与轨道交通站点距离呈现“N”型变化趋势;不同利用类型土地受到轨... 详细信息

为探讨城市轨道交通对周边土地开发形成的溢价效应,以宁波市为例,采用特征价格模型,测度城市轨道交通溢价效应,分析轨道交通的空间增值效应。结果表明,城市土地价格随着与轨道交通站点距离呈现“N”型变化趋势;不同利用类型土地受到轨道交通影响程度存在较大差异。此研究有助于深入理解轨道交通的溢价机制,对于地方制定合理的土地开发策略、回收公共投资成本具有一定的参考价值。

关键词：轨道交通溢价效应特征价格模型宁波

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鼻前庭囊肿的三种手术方式疗效分析

安徽医药 2022年第4期26卷 812-814页

作者：李文丽袁洛花孙丹洋蒋锐明刘海兵四川省妇幼保健院耳鼻喉科四川成都610000 成都市第七人民医院耳鼻喉科四川成都610041

目的比较鼻前庭囊肿的三种手术方式的临床治疗效果。方法回顾分析2012年8月至2018年8月成都市第七人民医院83例鼻前庭囊肿病人,根据手术方式分为唇龈沟摘除组(23例)、鼻内镜揭盖组(31例)和等离子消融组(29例),比较三种手术的手术指征... 详细信息

目的比较鼻前庭囊肿的三种手术方式的临床治疗效果。方法回顾分析2012年8月至2018年8月成都市第七人民医院83例鼻前庭囊肿病人,根据手术方式分为唇龈沟摘除组(23例)、鼻内镜揭盖组(31例)和等离子消融组(29例),比较三种手术的手术指征及临床疗效。结果鼻内镜揭盖组和等离子消融组在手术时间[(21.5±2.3)min、(20.5±2.2)min比(45.5±2.6)min]、术中出血量[(13.1±1.3)mL、(12.5±1.4)mL比(39.3±2.5)mL]、伤口愈合时间[(4.0±0.8)d、(3.1±0.7)d比(5.6±0.9)d]、伤口疼痛程度评分[(1.5±0.5)分、(1.4±0.5)分比(2.5±1.0)分]、1个月内麻木肿胀[16.1%(5/31)、6.9%(2/29)比47.8%(11/23)]均优于唇龈沟摘除组(P0.05)。结论内镜下鼻前庭囊肿揭盖术和消融术手术时间短,痛苦小,术后反应轻,不良反应发生率低,鼻内镜揭盖技术成本不高,可为鼻前庭囊肿的首选治疗方案。

关键词：鼻前庭囊肿唇龈沟鼻内镜等离子体消融

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Synergistic effects of 1T MoS_(2)and interface engineering on hollow NiCoP nanorods for enhanced hydrogen evolution activity

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Journal of Materials Science & Technology 2023年第14期145卷 165-173页

作者： Qiaomei Luo Lan sun Yiwei Zhao Chen Wang Hongqiang Xin danyang Li Fei Ma State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049China

Metallic 1T-phase molybdenum disulfide(1T-MoS_(2))shows more excellent electrocatalytic performance for hydrogen evolution reaction(HER)than semiconducting 2H-phase MoS_(2)(2H-MoS_(2)).Therefore,the facile controllable synthesis of hierarchical structure with rich 1T-MoS_(2)is desired for highly efficient electrocatalytic *** this work,a simple solvothermal method is proposed to fabricate hol-low NiCoP/MoS_(2)-V heterostructure with 63.2%1T-MoS_(2),in which the abundant catalytic active sites are exposed,the mass transfer properties are improved,and the electronic states are ***,the low energy difference between 2H and 1T phases and near zero free energy of hydrogen adsorption(△G H∗)result in fast kinetics and excellent catalytic ***,the NiCoP/MoS_(2)-V com-posite exhibits enhanced HER activity with a low overpotential of 74.6 mV at 10 mA cm^(-2)and superior stability in alkaline *** efficient design opens up new vistas for developing high-activity electrocatalysts.

关键词： Hollow hierarchical structure 1T-MoS_(2) Heterointerface Optimized electronic states Synergistic effect Superior HER activity

MacroH2A1.1 cooperates with EZH2 to promote adipogenesis by regulating Wnt signaling

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Journal of Molecular Cell Biology 2017年第4期9卷 325-337页

作者： danyang Wan Chengyu Liu Yu sun Wenjun Wang Kun Huang Ling Zheng Hubei Key Laboratory of Cell Homeostasis College of Life Sciences Wuhan University Wuhan 430072 China Tongji School of Pharmacy Huazhong University of Science and Technology Wuhan 430030 China

White adipocytes play important roles in many physiological processes, including energy storage, endocrine signaling, and inflammatory responses. Understanding the molecular mechanisms of adipocyte formation （adipogenesis） provides insights into therapeutic approaches against obesity and its related diseases. Many transcriptional Factors and epigenetic enzymes are known to regulate adipogenesis; however, whether histone variants play a role in this process is unknown. Here we found that macroH2A1.1 （mH2A1.1）, a variant of histone H2A, was upregulated during adipocyte differentiation in 3T3-L1 ceils and in the white adipose tissue of obese mice. Ablation of mH2A1.1 activated Wnt/β-catenin signaling pathway, while overexpression of mH2A1.1 showed opposite effects. We farther found that mH2A1.1 regulated Wnt/β-catenin signaling pathway by cooperating with EZH2, a histone H3K27 methyltrans- ferase, thus led to accumulation of H3K27me2 and H3K27me3 on the promoters of Wnt genes. Mutations in the macro-domain, mH2A1.1G224E, and mH2A1.1G314E, not only impaired adipogenesis, but also impaired the binding ability of mH2A1.1 to EZH2 and the enrichments of H3K27me2 and H3K27me3 on the promoters of Wnt genes. Together, our study reveals a novel regulatory role of mH2A1.1 in adipogenesis and obesity, which provides new insights in white fat development.

关键词： adipogenesis EZH2 H3K27me2/me3 macroH2A1.1 Wnt/β-catenin signaling

Tu-Xian Decoction ameliorates diabetic cognitive impairment by inhibiting DAPK-1

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Chinese Journal of Natural Medicines 2023年第12期21卷 950-960页

作者： WANG danyang YAN Bin WANG An sun Qing PANG Junyi CUI Yangming TIAN Guoqing Department of Traditional Chinese Medicine Peking Union Medical College HospitalBeijing 100730China Chinese Academy of Mediucal Sciences&Peking Union Medical College Beijing 100730China Department of Pathology Peking Union Medical College HospitalState Key Laboratory of Complex Severe and Rare DiseaseMolecular Pathology Research CenterBeijing 100730China Animal Research Laboratory Platform Peking Union Medical College Hospitalthe National Science and Technology Key Infrastructure on Translational MedicineBeijing 100730China

Tu-Xian decoction(TXD),a traditional Chinese medicine(TCM)formula,has been frequently administered to manage diabetic cognitive impairment(DCI).Despite its widespread use,the mechanisms underlying TXD’s protective effects on DCI have yet to be fully *** a significant regulator in neurodegenerative conditions,death-associated protein kinase-1(DAPK-1)serves as a focus for understanding the action of *** study was designed to whether TXD mediates its beneficial outcomes by inhibiting *** this end,a diabetic model was established using Sprague-Dawley(SD)rats through a high-fat,high-sugar(HFHS)diet regimen,followed by streptozotocin(STZ)*** experimental cohort was stratified into six groups:Control,Diabetic,TC-DAPK6,high-dose TXD,medium-dose TXD,and low-dose TXD *** a 12-week treatment period,various assessments—including blood glucose levels,body weight measurements,Morris water maze(MWM)testing for cognitive function,brain magnetic resonance imaging(MRI),and histological analyses using hematoxylin-eosin(H&E),and Nissl staining—were *** expression in the hippocampus was quantified through Western blotting *** results revealed that TXD significantly improved spatial learning and memory abilities,and preserved hippocampal structure in diabetic ***,TXD administration led to a down-regulation of proteins indicative of neurological damage and suppressed DAPK-1 activity within the hippocampal *** results underscore TXD's potential in mitigating DCI via DAPK-1 inhibition,positioning it as a viable therapeutic candidate for addressing this *** investigation into TXD's molecular mechanisms may elucidate new pathways for the treatment of DCI.

关键词： Tu-Xian decoction Traditional Chinese medicine Diabetes complications Diabetic cognitive impairment Death associated protein kinase-1

Melatonin biosynthesis pathways in nature and its production in engineered microorganisms

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Synthetic and Systems Biotechnology 2022年第1期7卷 544-553页

作者： Xiaotong Xie Dongqin Ding danyang Bai Yaru Zhu Wei sun Yumei sun Dawei Zhang Dalian Polytechnic University Dalian116000PR China Tianjin Institutes of Industrial Biotechnology Chinese Academy of SciencesTianjin300308PR China Biodesign Center Tianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjin300308PR China Tianjin University of science and technology Tianjin300308PR China

Melatonin is a biogenic amine that can be found in plants,animals and *** metabolic pathway of melatonin is different in various organisms,and biosynthetic endogenous melatonin acts as a molecular signal and antioxidant protection against external *** synthesis pathways of melatonin are similar to those of animals but different from those of *** present,the method of using microorganism fermentation to produce melatonin is gradually prevailing,and exploring the biosynthetic pathway of melatonin to modify microorganism is becoming the mainstream,which has more advantages than traditional chemical ***,we review recent advances in the synthesis,optimization of melatonin pathway.L-tryptophan is one of the two crucial precursors for the synthesis of melatonin,which can be produced through a four-step *** involved in melatonin synthesis have low specificity and catalytic ***-directed mutation,directed evolution or promotion of cofactor synthesis can enhance enzyme activity and increase the metabolic flow to promote microbial melatonin *** the whole,the status and bottleneck of melatonin biosynthesis can be improved to a higher level,providing an effective reference for future microbial modification.

关键词： Melatonin Biosynthesis Plants Animals Microorganisms Metabolic modification Enzyme catalysis mechanism

Climate change in the Hongliujing area of Lop Nur over the past 200 years revealed by the stable oxygen isotopes of Tamarix cones

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Frontiers of Earth Science 2023年第4期17卷 970-980页

作者： Zhiguang LI Yaqing DONG Haoyu ZHANG Hongxiao sun danyang JIA Shikai SONG Yuanjie ZHAO Hebei Key Laboratory of Environmental Change and Ecological Construction College of Geographical SciencesHebei Normal UniversityShijiazhuang 050024China Hebei Center for Ecological and Environmental Geology Research Hebei GEO UniversityShijiazhuang 050031China

The layers of Tamarix cones within sedimentary deposits in arid regions have significant chronological and paleoenvironmental ***,we compare the δ^(18)O values of Tamarix cones in the Hongliujing area of Lop Nur with meteorological data for the Ruoqiang meteorological station for 1960-2019 *** regression analysis was used to reconstruct the average temperature for April and the precipitation for November in the Hongliujing area over the past 200 *** results showed that the δ^(18)O values were significantly negatively correlated with the temperature for February,April,May,August,December,and with the annual mean temperature;significantly negatively correlated with the precipitation for February and April;significantly negatively correlated with the sunshine hours for March and May;significantly positively correlated with the sunshine hours for February,July,August,October,and December,and with the annual mean values;and significantly correlated with the relative humidity for April,July,August,September,October,and November,and with the annual mean *** on the δ^(18)O record of the past 200 years,the Hongliujing area experienced two warm-wet periods(1874-1932 and 2004-2019 AD)and two cold-dry periods(1832–1873 and 1933-2003 AD).Thus,the climate was characterized by alternating warm-wet and cold-dry *** analysis revealed three main cycles:45 years,29 years,and 14 years.

关键词： Tamarix cones climate change δ^(18)O Lop Nur