Melatonin biosynthesis pathways in nature and its production in engineered microorganisms
作者机构：Dalian Polytechnic UniversityDalian116000PR China Tianjin Institutes of Industrial BiotechnologyChinese Academy of SciencesTianjin300308PR China Biodesign CenterTianjin Institute of Industrial BiotechnologyChinese Academy of SciencesTianjin300308PR China Tianjin University of science and technologyTianjin300308PR China
出 版 物：《Synthetic and Systems Biotechnology》 (合成和系统生物技术（英文）)
年 卷 期：2022年第7卷第1期
页 面：544-553页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：the National Key R&D Program of China(2021YFC2100900) National Nature Science Foundation of China(32100062) Youth Innovation Promotion Association,CAS(2020182) Tianjin Synthetic Biotechnology Inno-vation Capacity Improvement Project(TSBICIP-CXRC-029)
主 题：Melatonin Biosynthesis Plants Animals Microorganisms Metabolic modification Enzyme catalysis mechanism
摘 要：Melatonin is a biogenic amine that can be found in plants,animals and *** metabolic pathway of melatonin is different in various organisms,and biosynthetic endogenous melatonin acts as a molecular signal and antioxidant protection against external *** synthesis pathways of melatonin are similar to those of animals but different from those of *** present,the method of using microorganism fermentation to produce melatonin is gradually prevailing,and exploring the biosynthetic pathway of melatonin to modify microorganism is becoming the mainstream,which has more advantages than traditional chemical ***,we review recent advances in the synthesis,optimization of melatonin pathway.L-tryptophan is one of the two crucial precursors for the synthesis of melatonin,which can be produced through a four-step *** involved in melatonin synthesis have low specificity and catalytic ***-directed mutation,directed evolution or promotion of cofactor synthesis can enhance enzyme activity and increase the metabolic flow to promote microbial melatonin *** the whole,the status and bottleneck of melatonin biosynthesis can be improved to a higher level,providing an effective reference for future microbial modification.
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