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Crosstalk between dietary patterns,obesity and nonalcoholic fatty liver disease

World Journal of Gastroenterology 2022年第27期28卷 3314-3333页

作者： danijela ristic-medic Joanna Bajerska Vesna Vucic Group for Nutritional Biochemistry and Dietology Centre of Research Excellence in Nutrition and MetabolismInstitute for Medical ResearchNational Institute of Republic SerbiaBelgrade PO Box 102Serbia Department of Human Nutrition and Dietetics PoznańUniversity of Life SciencesPoznań60-624Poland

The prevalence of nonalcoholic fatty liver disease(NAFLD)is rising worldwide,paralleling the epidemic of *** liver is a key organ for the metabolism of proteins,fats and *** types of fats and carbohydrates in isocaloric diets differently influence fat accumulation in the liver ***,nutrition can manage hepatic and cardiometabolic complications of *** moderately reduced caloric intake,which leads to a weight loss of 5%-10%of initial body weight,is effective in improving liver steatosis and surrogate markers of liver disease *** dietary patterns,the Mediterranean diet mostly prevents the onset of ***,this diet is also the most recommended for the treatment of NAFLD ***,clinical trials based on the dietary interventions in NAFLD patients are *** there are only a few studies examining dietary interventions in clinically advanced stages of NAFLD,such as active and fibrotic steatohepatitis,the optimal diet for patients in these stages of the disease must still be *** this narrative review,we aimed to critically summarize the associations between different dietary patterns,obesity and prevention/risk for NAFLD,to describe specific dietary interventions’impacts on liver steatosis in adults with NAFLD and to provide an updated overview of dietary recommendations that clinicians potentially need to apply in their daily practice.

关键词： Nonalcoholic fatty liver disease Dietary patterns Obesity Diet Mediterranean diet Nutrition Treatment Clinical guidance

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Liver disease and COVID-19:The link with oxidative stress,antioxidants and nutrition

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World Journal of Gastroenterology 2021年第34期27卷 5682-5699页

作者： danijela ristic-medic Snjezana Petrovic Aleksandra Arsic Vesna Vucic Group for Nutritional Biochemistry and Dietology Centre of Research Excellence in Nutrition and MetabolismNational Institute for Medical ResearchUniversity of BelgradeBelgrade 11129Serbia

Varying degrees of liver injuries have been reported in patients infected with the severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2).In general,oxidative stress is actively involved in initiation and progression of liver *** liver metabolizes various compounds that produce free *** the oxidative/antioxidative balance is important in coronavirus disease 2019(COVID-19)*** vitamins,essential trace elements and food compounds,such as polyphenols,appear to be promising agents,with effects in oxidative *** of these nutrients suppresses immune function and increases susceptibility to *** micronutrient intake is necessary to support anti-inflammatory and antioxidative effects but for immune function may be higher than current recommended dietary *** supplements(β-carotene,vitamin A,vitamin C,vitamin E,and selenium)could have a potential role in patients with liver *** evidence suggests that supplementing the diet with a combination of micronutrients may help to optimize immune function and reduce the risk of *** trials based on the associations of diet and SARS-CoV-2 infection are ***,it is not possible to definitively determine the dose,route of administration and best timing to intervene with antioxidants in COVID-19 patients because clinical trials are still *** then,hopefully,this review will enable clinicians to understand the impact of micronutrient dietary intake and liver status assessment in COVID-19 patients.

关键词： SARS-CoV-2 COVID-19 Liver injury Antioxidants Nutrients Treatment

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