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Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings

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Light(Science & Applications) 2021年第1期10卷 71-85页

作者： Elisabet A.Rank Ryan Sentosa danielle j.harper Matthias Salas Anna Gaugutz Dana Seyringer Stefan Nevlacsil Alejandro Maese-Novo Moritz Eggeling Paul Muellner Rainer Hainberger Martin Sagmeister jochen Kraft Rainer ALeitgeb Wolfgang Drexler Center for Medical Physics and Biomedical Engineering Medical University of ViennaWaehringer Guertel 18-20/4 L1090 ViennaAustria Research Centre for Microtechnology Vorarlberg University of Applied SciencesHochschulstrasse 16850 DornbirnAustria AIT Austrian Institute of Technology GmbH Gieffinggasse 41210 ViennaAustria ams AG Tobelbader Strasse 308141 PremstaettenAustria

In this work,we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated *** diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide *** arrayed waveguide grating designs with 256 channels were tested,which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal *** 1 supports a bandwidth of 22nm,with which a sensitivity of up to 91 dB(830μW) and an axial resolution of 10.7 pm was *** 2 supports a bandwidth of 48 nm,with which a sensitivity of 90 dB(480μW) and an axial resolution of 6.5μm was *** silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process,which allows their monolithic co-integration on top of an optoelectronic silicon *** a benchmark for chip-based optical coherence tomography,tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip *** similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.

关键词： waveguide arrayed optical

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Weight regain after intragastric balloon for pre-surgical weight loss

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World journal of Gastrointestinal Surgery 2024年第7期16卷 2040-2046页

作者： danielle Abbitt Kevin Choy Alexandra Kovar Teresa S jones Krzysztof j Wikiel Edward L jones Department of Surgery University of ColoradoAuroraCO 80045United States Department of Surgery Rocky Mountain Regional Veteran Affairs Medical CenterAuroraCO 80045United States

BACKGROUND Over one-third of Americans carry the diagnosis of obesity,many also with obesity-related *** can place patients at increased risk of operative and postoperative *** intragastric balloon has been shown to aid in minor weight loss,however its weight recidivism in patients requiring short interval weight loss has not been well *** To evaluate weight loss,ability to undergo successful elective surgery after intragastric balloon placement,and weight management after balloon *** This study is a retrospective review of patients in a single academic institution undergoing intragastric balloon placement from 2019-2023 to aid in weight loss prior to undergoing elective *** outcomes including weight loss,duration of balloon placement,successful elective surgery,weight regain postballoon and post-procedure complications were *** criteria included those with balloon in place at time of *** Thirty-three patients completed intragastric balloon therapy from 2019-2023 as a bridge to elective *** patients were required to participate in a 12-month weight management program to be eligible for balloon *** surgeries included incisional hernia repair,umbilical hernia repair,inguinal hernia repair,and knee and hip *** average age at placement was 53 years±11 years,majority(91%)were *** average duration of intragastric balloon therapy was 186 days±41 *** average weight loss was 14.0 kg±7.4 kg and with an average percent excess body weight loss of 30.0%(7.9%-73.6%).Over half of the patients(52.0%)achieved the goal of 30-50 lbs(14-22 kg)weight ***-one patients(64%)underwent their intended elective surgery,2 patients(6%)deferred surgery due to symptom relief with weight loss ***-one of the patients(64%)have documented weights in 3 months after balloon removal,in these patients the majority(76%)gained weight after balloon *** pat

关键词： Intragastric balloon Weight loss Obesity Bariatric Body mass index

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Biodiversity responses to insular fragmentation in Amazonia: Two decades of research in the Balbina Hydroelectric Reservoir

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 106-116页

作者： Ana Filipa Palmeirim Maíra Benchimol danielle Storck-Tonon Anderson SBueno Isabel Ljones Gilmar Klein Carlos APeres CIBIO Research Centre of Biodiversity and Genetic ResourcesInBIO Associated LabVairão CampusUniversity of PortoVairão 4485-661Portugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOVairão CampusUniversity of PortoVairão 4485-661Portugal Laboratório de Ecologia AplicadaàConservação Universidade Estadual de Santa CruzIlhéusBahia 45662-900Brazil Programa de Pós-Graduação em Ambiente e Sistemas de Produção Agrícola(PPGASP) Universidade do Estado de Mato GrossoTangaráda SerraMato Grosso 78301-532Brazil Instituto Federal de Educação Ciência e Tecnologia FarroupilhaJúlio de CastilhosRio Grande do Sul 98130-000Brazil Biological and Environmental Sciences University of StirlingStirling FK94LAUK REBIO Uatumã/ICMBio Presidente FigueiredoAmazonas 69736-000Brazil Centre for Ecology Evolution and ConservationSchool of Environmental SciencesUniversity of East AngliaNorwich NR47TJUK juruáInstitute ManausAmazonas 69057-060Brazil

As hydropower development expands across lowland tropical forests,flooding and concomitant insular fragmentation have become important threats to *** created insular landscapes serve as natural laboratories to investigate biodiversity responses to *** of these most iconic landscapes is the Balbina Hydroelectric Reservoir in Brazilian Amazonia,occupying>400000 ha and comprising>3500 forest ***,we synthesise the current knowledge on responses of a wide range of biological groups to insular fragmentation at *** has largely concentrated on a set of 22 islands and three mainland *** total,39 studies were conducted over nearly two decades,covering 17 vertebrate,invertebrate,and plant *** species responses varied according to taxonomic group,island area was consistently included and played a pivotal role in 66.7%of all studies examining patterns of species *** persistence was further affected by species traits,mostly related to species capacity to use/traverse the aquatic matrix or tolerate habitat degradation,as noted for species of vertebrates and orchid *** research is needed to improve our understanding of such effects on wider ecosystem *** Impact Assessments must account for changes in both the remaining habitat amount and configuration,and subsequent long-term species losses.

关键词： Habitat loss Hydropower dams Landbridge Local extinctions Species-area relationships Species diversity Tropical forests

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Environmental determinants of social wasp diversity and assemblage structure in an Amazonian archipelagic landscape

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 121-129页

作者： jose Victor Alves Ferreira Alexandre Somavilla Maíra Benchimol Ana Filipa Palmeirim Carlos APeres danielle Storck-Tonon Laboratório de Ecologia Aplicada àConservação Universidade Estadual de Santa CruzIlhéus 45662-900Brazil Instituto Nacional de Pesquisas da Amazônia Coordenação de BiodiversidadeManaus 69067-001Brazil CIBIO Centro de Investigação em Biodiversidade e Recursos GenéticosInBIO Laboratório AssociadoCampus de VairãoUniversidade do PortoVairão 4485-661Portugal BIOPOLIS Program in Genomics Biodiversity and Land PlanningCIBIOCampus de VairãoVairão 4485-661Portugal School of Environmental Sciences University of East AngliaNorwich NR47TJUK Instituto juruá Manaus69057-060Brazil Programa de Pós-Graduação em Ambiente e Sistemas de Produção Agrícola(PPGASP) Universidade do Estado de Mato GrossoTangaráda Serra 78300-970Brazil

Hydropower development has become an important driver of habitat loss and fragmentation across lowland tropical *** ample evidence on the detrimental effects of insular habitat fragmentation on biodiversity,invertebrate taxa,that may be critical to ecosystem functioning,have been *** assessed the assemblage-level responses of social wasps to forest insularization induced by the Balbina Hydroelectric Dam in Central Brazilian *** Malaise trapping,we captured wasps on 27 forest islands and three continuous *** constructed Generalized Linear Models and employed a model selection approach to examine the impact of local variables(fire severity(FIRE)and basal area of pioneer tree species(PIONEER))and landscape-scale variables(amount of habitat(COVER))on patterns of species richness,composition,and body size of wasps.A total of 374 individuals(29 species)were collected across all sampling *** was the main predictor of species richness,while PIONEER was the only variable that explained variation in community composition,with a negative effect on body *** results add evidence to the pervasive impacts of large hydroelectric dams on tropical forest biodiversity,and suggest that social wasps,among other invertebrates,can be used as bioindicators in infrastructure development projects.

关键词： Habitat amount hypothesis Habitat fragmentation Habitat loss Hydroelectric dams Invertebrates

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Drought can offset potential water use efficiency of forest ecosystems from rising atmospheric CO2

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journal of Environmental Sciences 2020年第4期32卷 262-274页

作者： Ning Liu jatin Kala Shirong Liu Vanessa Haverd Bernard Dell Keith R.j.Smettem Richard j.harper Environmental and Conservation Sciences Murdoch UniversityMurdochWA 6150 Australia Research Institute of Forest Ecology Environment and ProtectionChinese Academy of ForestryBeijing 10091 China CSIRO Oceans&Atmosphere ACT 2600 Australia

Increasing atmospheric CO2 is both leading to climate change and providing a potential fertilisation effect on plant ***,southern Australia has also experienced a significant decline in rainfall over the last 30 years,resulting in increased vegetative water *** better understand the dynamics and responses of Australian forest ecosystems to drought and elevated CO2,the magnitude and trend in water use efficiency(WUE)of forests,and their response to drought and elevated CO2 from 1982 to 2014 were analysed,using the best available model estimates constrained by observed fluxes from simulations with fixed and time-varying *** ratio of gross primary productivity(GPP)to evapotranspiration(ET)(WUEe)was used to identify the ecosystem scale WUE,while the ratio of GPP to transpiration(Tr)(WUEc)was used as a measure of canopy scale *** increased significantly in northern Australia(p<0.001)for woody savannas(WSA),whereas there was a slight decline in the WUE of evergreen broadleaf forests(EBF)in the southeast and southwest of *** lag of WUEc to drought was consistent and relatively short and stable between biomes(<3 months),but notably varied for WUEe,with a long time-lag(mean of 10 months).The dissimilar responses of WUEe and WUEc to climate change for different geographical areas result from the different proportion of Tr in ***2 fertilization and a wetter climate enhanced WUE in northern Australia,whereas drought offset the CO2 fertilization effect in southern Australia.

关键词： Water use efficiency Elevated CO2 Carbon sequestration,drought Forest Australia

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Ecological factors influencing the beneficial endosymbionts of the hemlock woolly adelgid (Hemiptera:Adelgidae)

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Insect Science 2019年第1期26卷 97-107页

作者： Angela M.Mech Sherilyn j.harper Nathan P.Havill Carol D.von Dohlen Gaelen R.Burke Department of Entomology University of GeorgiaAthensGeorgiaUSA School of Environmental and Forest Sciences University of WashingtonSeattleWashingtonUSA USDA Forest Service Northern Research StationHamdenConnecticutUSA Department of Biology Utah State UniversityLoganUtahUSA

Bacterial endosymbionts of sap-sucking insects provide their host with a num- ber of beneficial qualities,including the supply of nutrition,defense against parasitoids, and protection from heat *** to these bacterial associates can therefore have a negative impact on the fitness of their insect *** evaluated observational and experi- mental factors regarding the normative hemlock woolly adelgid (Adelges tsugae Annand) (Hemiptera:Adelgidae)to help understand the roles of its three recently identified symbionts,including under heat stress *** prevalence of ***'s facultafive symbiont (Serratia symbiotica)was examined at different spatial scales to determine how variable infection rates are for this *** was no significant difference found in infection rates between adelgids on a tree,within a plot,or within a ***, significantly more adelgids in Georgia (95%)had *** compared to those in New York (68%).Microsatellite genotyping of the adelgids found that this difference was most likely not the result of a second introduction *** into eastern North *** *** proportions between first and fourth instars showed that symbiont absence did not affect the ability *** to survive *** of sym- biont densities within each adelgid found that when *** was absent,the density of obligate symbionts was significantly *** to heat stress (32.5℃)was not consistently correlated with changes in symbiont densities over a 4-d ***,we have shown that symbiont prevalence and densities vary within the broad population of *** in eastern North America,with potentially significant effects upon the ecology of this important pest.

关键词： Adelges tsugae Anncindia adelgestsuga bacterial endosymbionts Serratia symbiotica Pseudomonas adelgestsugas

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早期复发缓解型多发性硬化症的脑定量T1成像：病灶随时间的演变、病灶异质性与临床残疾

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国际医学放射学杂志 2024年第4期 502-502页

作者： j.G.harper E.N.York R.Meijboom A.Kampaite M.j.Thrippleton P.K.A.Kearns 杨程

摘要目的通过纵向T1值的测量来量化近期诊断的复发缓解型多发性硬化症（RRMS）病人大脑微观结构的变化，及其与临床残疾之间的关系。方法从一项单中心队列子研

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Muscle energy technique for chronic obstructive pulmonary disease:A feasibility study

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journal of Integrative Medicine 2023年第3期21卷 245-253页

作者： danielle A.Baxter Meaghan E.Coyle Catherine j Hill Christopher Worsnop johannah L.Shergis School of Health and Biomedical Sciences Royal Melbourne Institute of Technology UniversityBundooraVictoria 383Australia Department of Physiotherapy Austin HealthHeidelbergVictoria 3084Australia Institute for Breathing and Sleep HeidelbergVictoria 3084Australia

Objective:This study aimed to investigate the feasibility of implementing a manual therapy technique(muscle energy technique,MET)protocol in a hospital pulmonary rehabilitation(PR)program for patients with moderate to severe chronic obstructive pulmonary disease(COPD).Methods:Participants aged 40 years and over,with moderate to severe COPD,were recruited into this 12-week *** primary outcome measures were feasibility(acceptability of the intervention and attendance/adherence to the trial)and safety(adverse events,AEs).All participants received the MET and PR *** and assessors were ***-standardized MET was delivered on 6 occasions(a maximum of once per week)at the hospital directly before a PR *** undertook PR sessions as per the hospital program at a frequency of two days per week for 8 *** were contacted 4 weeks after their final MET treatment via a telephone call to assess acceptability of the ***:Thirty-three participants were enrolled,with a median age of 74 years(range 45-89 years).The median number of MET sessions that participants attended was 5(range O-6)out of a possible 6 sessions(83%attendance).At follow-up,participants overwhelmingly enjoyed the MET treatment with some subjectively reporting improved *** were no major AEs related to the intervention,with the majority of AEs classified as expected events related to COPD ***:It is feasible to implement a manual therapy protocol using MET as an adjunct to PR in a hospital *** rates were satisfactory and there were no AEs related to the MET component of the intervention.

关键词： Manual therapy Pulmonary rehabilitation Chronic obstructive pulmonary disease

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Soil ecosystem changes by vegetation on old-field sites over five decades in the Brazilian Atlantic forest

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journal of Forestry Research 2022年第2期33卷 667-677页

作者： danielle Cristina Ortiz Tancredo Augusto Feitosa de Souza Tatiani Maria Pech Marie Luise Carolina Bartz Dilmar Baretta Alexandre Siminski júlia Carina Niemeyer Federal University of Santa Catarina Ulysses Gaboardikm 3CuritibanosSC 89520-000Brazil Postgraduate Programme in Agricultural and Natural Ecosystems(PPGEAN) Federal University of Santa CatarinaUlysses Gaboardikm 3CuritibanosSC 89520-000Brazil Centre for Functional Ecology Department of Life SciencesUniversity of Coimbra3000-456 CoimbraPortugal Department of Animal Science UDESC OesteSanta Catarina State UniversityChapecóSC 89815-630Brazil

Vegetation types alter soil ecosystems by changing soil fauna community activities and soil physi-cal-chemical ***,it is unclear how tree species(natural forest,native and exotic tree plantations)promote changes in the soil ecosystem,and if these changes alter functional groups of soil fauna and ecosystem *** determine the effects of five decades of old-field veg-etation on soil ecosystems in the Brazilian Atlantic Forest,field sampling of three ecosystems(exotic tree species Pinus elliottii ***,endangered tree species Arau-caria angustifolia(Bertol.)Kuntze plantation,and a natural ecosystem)were carried out,as well using bait-lamina tests and bioassays with collembolans,earthworms and seeds of Lactuca sativa *** sampling evaluated the soil fauna community and soil physical-chemical *** bait-lamina test in situ was carried out for 14-days to deter-mine fauna feeding activity,and the bioassays evaluated the reproduction of Folsomia candida,the avoidance of Eisenia andrei,and germination of *** in the soil from each *** results are:(1)vegetation type altered the soil fauna community composition;(2)soil fauna feeding was reduced in the plantations compared to the natural eco-system;(3)a physical barrier was created by recalcitrant litter that compromised fauna community structure and seed bank germination in situ;and,(4)changes in soil physical-chemical properties promoted decomposers.

关键词： Endangered tree species Exotic tree species Forest ecosystem Soil fauna functional groups Soil invertebrates

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Genitourinary melanoma:An overview for the clinician

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Asian journal of Urology 2022年第4期9卷 407-422页

作者： danielle K.DePalo Kelly M.Elleson Michael j.Carr Philippe E.Spiess jonathan S.Zager Department of Cutaneous Oncology Moffitt Cancer CenterTampaFLUSA Department of Surgery University of LouisvilleLouisvilleKYUSA Department of Genitourinary Oncology Moffitt Cancer CenterTampaFLUSA

Genitourinary (GU) melanoma is a rare presentation of melanoma accounting for approximately 0.5% of all *** melanomas include primary melanomas of the vulva,vagina,uterine cervix,ovary,penis,scrotum,urethra,bladder,ureter,and *** melanomas are often diagnosed in advanced stages and stigma is thought to contribute to delays in *** the likely diagnosing provider,it is imperative that dermatologists,urologists,and gynecologists are aware of these uncommon sites of *** there have been major advances in the treatment of melanomas as a whole in the last 10 years,their applications to GU melanomas have often been *** melanomas have not been included in many of the major phase II clinical trials which brought contemporary advanced treatments to market and the prognoses for GU melanomas remain *** to the rarity of GU melanomas,much of the literature provides gener alized recommendations across multiple different organs affected by GU melanomas or omits certain topics,making it difficult to appreciate the funda-mentals of the individual *** review aimed to provide background information on the pathogenesis and epidemiology of the different sites of GU melanomas and categorize data specific to the presentation,staging,treatment,and prognosis of each type of GU melanoma to guide the *** was also meant to encourage a multidisciplinary approach to the management of these patients as it spans the expertise of surgical oncologists,medical oncologists,radiation oncologist,dermatologists,urologists,and gynecologists.

关键词： Genitalia Female Male Melanoma Rare diseases Staging Treatment Urinary tract

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