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r.NKL inhibition r.duces lesional cellular.ty and Gαs var.ant expr.ssion and enables osteogenic matur.tion in fibr.us dysplasia

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Bone r.sear.h 2024年第1期12卷 165-179页

作者： Luis F.de Castr. Jar.ed M.Whitlock Zachar. Michel Kr.sten Pan Jocelyn Taylor.Vivian Szymczuk Br.ndan Boyce daniel Mar.in Var.it Kr.m r.beca Galisteo Kamr.n Melikov Leonid V.Cher.omor.ik Michael T.Collins Alison M.Boyce Skeletal Disor.er. and Miner.l Homeostasis Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Section on Membr.ne Biology Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institutes of HealthBethesdaMDUSA Metabolic Bone Disor.er. Unit National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA Depar.ment of Plastic and r.constr.ctive Sur.er. The Johns Hopkins Medical InstitutionsBaltimoreMDUSA Depar.ment of Pathology and Labor.tor. Medicine University of Rochester Medical CenterRochesterNYUSA NIDCr.Genomics and Computational Biology Cor. National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaMDUSA

Fibr.us dysplasia(FD)is a r.r.,disabling skeletal disease for.which ther. ar. no established tr.atments.Gr.wing evidence suppor.s inhibiting the osteoclastogenic factor.r.ceptor.activator.of nuclear.kappa-B ligand(r.NKL)as a potential tr.atment str.tegy.In this study,we investigated the mechanisms under.ying r.NKL inhibition in FD tissue and its likely indir.ct effects on osteopr.genitor. by evaluating human FD tissue pr.-and post-tr.atment in a phase 2 clinical tr.al of denosumab(NCT03571191)and in mur.ne in vivo and ex vivo pr.clinical models.Histological analysis of human and mouse tissue demonstr.ted incr.ased osteogenic matur.tion,r.duced cellular.ty,and r.duced expr.ssion of the pathogenic Gαs var.ant in FD lesions after.r.NKL inhibition.r.A sequencing of human and mouse tissue suppor.ed these findings.The inter.ction between osteoclasts and mutant osteopr.genitor. was fur.her.assessed in an ex vivo lesion model,which indicated that the pr.lifer.tion of abnor.al FD osteopr.genitor. was dependent on osteoclasts.The r.sults fr.m this study demonstr.ted that,in addition to its expected antiosteoclastic effect,denosumab r.duces FD lesion activity by decr.asing FD cell pr.lifer.tion and incr.asing osteogenic matur.tion,leading to incr.ased bone for.ation within lesions.These findings highlight the unappr.ciated r.le of cellular.cr.sstalk between osteoclasts and pr.osteoblasts/osteoblasts as a dr.ver.of FD pathology and demonstr.te a novel mechanism of action of denosumab in the tr.atment of bone disease.

关键词： dysplasia tr.atment finding

Association between Helicobacter.pylor. infection,mismatch r.pair.HEr. and tumor.infiltr.ting lymphocytes in gastr.c cancer

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Wor.d Jour.al of Gastr.intestinal Oncology 2024年第6期16卷 2487-2503页

作者： Car.os A Castaneda Miluska Castillo Luis A Ber.abe Joselyn Sanchez Matteo Fassan Kather.ne Tello Ignacio Ivan Wistuba Ivan Chavez Passiur. Eloy r.iz Juvenal Sanchez Fer.ando Bar.eda daniel Valdivia Yaqueline Bazan Milagr.s Abad-Licham Claudio Mengoa Hugo Fuentes Paola Montenegr. Eber. Poquioma r.ul Alatr.sta Claudio J Flor.s Luis Taxa Faculty of Health Sciences Universidad Cientifica del SurLima 15038Peru GECO PEr. Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Depar.ment of r.sear.h Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Medicine Universidad Ricardo PalmaLima 15039Peru Depar.ment of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Depar.ment of Tr.nslational Molecular.Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Depar.ment of Abdominal Sur.er. Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Depar.ment of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Depar.ment of Medical Specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Depar.ment of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Depar.ment of Sur.er. Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Depar.ment of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Depar.ment of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de Investigación Básica y Tr.slacional Oncosalud-AUNALima 15038Peru Faculty of Medicine Universidad San Martin de PorresLima 15008Peru

BACKGr.UND The influence of Helicobacter.pylor.(H.pylor.)infection and the char.cter.stics of gastr.c cancer.GC)on tumor.infiltr.ting lymphocyte(TIL)levels has not been extensively studied.Analysis of infiltr.ting-immune-cell subtypes as well as sur.ival is necessar. to obtain compr.hensive infor.ation.AIM To deter.ine the r.tes of deficient mismatch-r.pair.dMMr.,HEr.-status and H.pylor. infection and their.association with TIL levels in GC.METHODS Samples fr.m 503 r.sected GC tumor. wer. included and TIL levels wer. evaluated following the inter.ational-TILs-wor.ing-gr.up r.commendations with assessment of the intr.tumor.l(IT),str.mal(ST)and invasive-bor.er.IB)compar.ments.The density of CD3,CD8 and CD163 immune cells,and dMMr.and HEr.-status wer. deter.ined by immunohistochemistr.(IHC).H.pylor. infection was evaluated by r.utine histology and quantitative PCr.qPCr.in a subset of samples.r.SULTS dMMr.was found in 34.4%,HEr.+in 5%and H.pylor.-positive in 55.7%of samples.High IT-TIL was associated with gr.de-3(P=0.038),while ST-TIL with gr.de-1(Pr.cur.ence(P=0.003).dMMr.was associated with high TIL levels in the ST(P=0.019)and IB(P=0.01)compar.ments,and STCD3(P=0.049)and ST-CD8(P=0.05)densities.HEr.-was associated with high IT-CD8(P=0.009).H.pylor.negative was associated with high IT-TIL levels(P=0.009)when assessed by r.utine-histology,and with high TIL levels in the 3 compar.ments(P=0.002-0.047)and CD8 density in the IT and ST compar.ments(P=0.001)when assessed by qPCr.A longer.over.ll sur.ival was associated with low IT-CD163(P=0.003)and CD8/CD3(P=0.001 in IT and P=0.002 in ST)and high IT-CD3(P=0.021),ST-CD3(P=0.003)and CD3/CD163(P=0.002).CONCLUSION TIL levels wer. r.lated to dMMr.and H.pylor.-negativity.Low CD8/CD3 and high CD163/CD3 wer. associated with lower.r.cur.ence and longer.sur.ival.

关键词： Lymphocytes Macr.phages Gastr.c cancer Helicobacter.pylor. HEr. Mismatch r.pair

r.cent pr.gr.ss in MgB_(2)super.onducting joint technology

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镁合金学报(英文) 2023年第7期11卷 2217-2229页

作者： Hao Liang Dipak Patel Mahboobeh Shahbazi Andr.ej Mor.wski daniel Gajda Matt r.ndfleisch r.char. Taylor.Yusuke Yamauchi md Shahr.ar.A.Hossain School of Mechanical and Mining Engineer.ng The University of QueenslandSt LuciaQueensland 4072Australia QUT Centr. for.Mater.als Science and School of Chemistr. and Physics Queensland University of TechnologyBrisbaneQueensland 4001Australia Institute of High Pr.ssur. Physics Polish Academy of Sciences(PAS)Sokolowska 29/37Warsaw 01-142Poland Institute of Low Temper.tur. and Str.ctur. r.sear.h Polish Academy of Sciences(PAS)Okólna 2Wrocław 50-422Poland Hyper.Tech r.sear.h Inc.539 Industrial Mile RdColumbusOhio 43228USA Applied Super.onductivity Labor.tor. Queensland University of TechnologyBrisbaneQueensland 4001Australia Austr.lian Institute for.Bioengineer.ng and Nanotechnology(AIBN) The University of QueenslandSt LuciaQueensland 4072Australia Depar.ment of Mater.als Pr.cess Engineer.ng Graduate School of EngineeringNagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan The Commonwealth Scientific and Industr.al r.sear.h Or.anisation(CSIr.) LindfieldNew South Wales 2070Australia

Magnesium dibor.de(MgB_(2))magnets have the potential to be the next-gener.tion liquid-helium-fr.e magnet for.magnetic r.sonance imaging(Mr.)application due to their.r.latively high super.onducting tr.nsition temper.tur.,high cur.ent density and low r.w mater.al cost compar.d with cur.ent commer.ial niobium-titanium(Nb-Ti)magnets.A typical super.onducting magnet includes sever.l coils.To pr.duce an ultr.-stable magnetic field for.imaging in Mr.,a super.onducting electr.magnet oper.ting in a per.istent mode is cr.cial.Super.onducting coils of the electr.magnet in Mr. ar. shor.-cir.uited to oper.te in the per.istent mode by connecting coils with super.onducting joints.Per.sistent joints have been demonstr.ted for.in-situ and ex-situ wir.s of both mono-and multi-filamentar. str.ctur.s,made pr.dominantly by PIT techniques similar.to those used in wir. pr.duction.To r.alise fur.her.engagement of MgB_(2)in Mr. applications,enhancing the per.or.ance of MgB_(2)super.onducting joints is essential.This liter.tur. r.view summar.ses r.sear.h and development on MgB_(2)super.onducting joining technology.

关键词： MgB_(2) Super.onducting joints Per.istent-mode magnets Mr. application Field-decay measur.ment

An evolutionar. computational fr.mewor. for.capacity-safety tr.de-off in an air.tr.nspor.ation networ.

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Chinese Jour.al of Aer.nautics 2019年第4期32卷 999-1010页

作者： md.Mur.d HOSSAIN Sameer.ALAM daniel DELAHAYE School of Engineer.ng and Infor.ation Technology University of New South Wales School of Mechanical and Aer.space Engineer.ng Nanyang Technological University MAIAA Labor.tor. Ecole Nationale de l'Aviation Civile

Air.pace safety and air.or. capacity ar. two key challenges to sustain the gr.wth in Air.Tr.nspor.ation. In this paper. we model the Air.Tr.nspor.ation Networ. as two sub-networ.s of air.pace and air.or.s, such that the safety and capacity of the over.ll Air.Tr.nspor.ation networ. emer.e fr.m the inter.ction between the two. We pr.pose a safety-capacity tr.de-off appr.ach,using a computational fr.mewor., wher. the two networ.s can inter.act and the tr.de-off between capacity and safety in an Air.Tr.nspor. Networ. can be established. The fr.mewor. compr.se of an evolutionar. computation based air.tr.ffic scenar.o gener.tion using a flow capacity estimation module(for.capacity), Collision r.sk estimation module(for.safety) and an air.tr.ffic simulation module(for.evaluation). The pr.posed methodology to evolve air.tr.ffic scenar.os such that it minimizes collision r.sk for.given capacity estimation was tested on two differ.nt air.tr.nspor. networ. topologies(r.ndom and small-wor.d) with the same number.of air.or.s. Exper.mental r.sults indicate that though air.pace collision r.sk incr.ases almost linear.y with the incr.asing flow(flow intensity) in the cor.esponding air.or. networ., the cr.tical flow depend on the under.ying networ. configur.tion. It was also found that, in gener.l, the capacity upper.bound depends not only on the connectivity among air.or.s and their.individual per.or.ances but also the configur.tion of waypoints and mid-air.inter.ctions among conflicts. r.sults also show that air.or. networ. can accommodate mor. tr.ffic in ter.s of capacity but the cor.esponding air.pace networ. cannot accommodate the r.sulting tr.ffic flow due to the bounds on collision r.sk.

关键词： Air.or. networ. Air.pace capacity Air.pace safety Collision r.sk Flow intensity

Moldable and tr.nsfer.able conductive nanocomposites for.epider.al electr.nics

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npj Flexible Electr.nics 2022年第1期6卷 363-371页

作者： Myeong Namkoong Heng Guo md Saifur.r.hman daniel Wang Cassandr. Jane Pfeil Sophia Hager.Limei Tian Depar.ment of Biomedical Engineer.ng and Center for Remote Health Technologies and SystemsTexas A&M UniversityCollege StationTX 77843USA

Skin-inspir.d soft and str.tchable electr.nic devices based on functional nanomater.als have br.ad applications such as health monitor.ng,human-machine inter.ace,and the Inter.et of things.Solution-pr.cessed conductive nanocomposites have shown gr.at pr.mise as a building block of soft and str.tchable electr.nic devices.However.r.alizing conductive nanocomposites with high conductivity,electr.mechanical stability,and low modulus over.a lar.e ar.a at sub-100μm r.solution r.mains challenging.Her.,we r.por. a moldable,tr.nsfer.able,high-per.or.ance conductive nanocomposite compr.sed of an inter.enetr.ting networ. of silver.nanowir.s and poly(3,4-ethylenedioxythiophene):poly(styr.nesulfonate).The stacked str.ctur. of the nanocomposite syner.istically integr.tes the complementar. electr.cal and mechanical pr.per.ies of the individual components.We patter.ed the nanocomposite via a simple,low-cost micr.molding pr.cess and then tr.nsfer.ed the patter.ed lar.e-ar.a electr.des onto var.ous substr.tes to r.alize soft,skin-inter.aced electr.physiological sensor..Electr.physiological signals measur.d using the nanocomposite electr.des exhibit a higher.signal-to-noise r.tio than standar. gel electr.des.The nanocomposite design and fabr.cation appr.ach pr.sented her. can be br.adly employed for.soft and str.tchable electr.nic devices.

关键词： conductive tr.nsfer inter.ace

Tar.eted deliver. of r.Ai to cancer.cells using r.A-ligand displaying exosome

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Acta Phar.aceutica Sinica B 2023年第4期13卷 1383-1399页

作者： Nasir.Uddin daniel WBinzel Dan Shu Tian-Min Fu Peixuan Guo Center.for.r.A Nanobiotechnology and Nanomedicine Division of Pharmaceutics and PharmacologyCollege of Pharmacythe Ohio State UniversityColumbusOH 43210USA Dor.thy M.Davis Hear. and Lung r.sear.h Institute the Ohio State UniversityColumbusOH 43210USA James Compr.hensive Cancer.Center College of Medicinethe Ohio State UniversityColumbusOH 43210USA Depar.ment of Biological Chemistr.&Phar.acology College of Medicinethe Ohio State UniversityColumbusOH 43210USA

Exosome is an excellent vesicle for.in vivo deliver. of ther.peutics,including r.Ai and chemical dr.gs.The extr.mely high efficiency in cancer.r.gr.ssion can par.ly be attr.buted to its fusion mechanism in deliver.ng ther.peutics to cytosol without endosome tr.pping.However.being composed of a lipidbilayer.membr.ne without specific r.cognition capacity for.aimed-cells,the entr. into nonspecific cells can lead to potential side-effects and toxicity.Applying engineer.ng appr.aches for.tar.eting-capacity to deliver.ther.peutics to specific cells is desir.ble.Techniques with chemical modification in vitr. and genetic engineer.ng in cells have been r.por.ed to decor.te exosomes with tar.eting ligands.r.A nanopar.icles have been used to har.or.tumor.specific ligands displayed on exosome sur.ace.The negative char.e r.duces nonspecific binding to vital cells with negatively char.ed lipid-membr.ne due to the electr.static r.pulsion,thus lower.ng the side-effect and toxicity.In this r.view,we focus on the uniqueness of r.A nanopar.icles for.exosome sur.ace display of chemical ligands,small peptides or.r.A aptamer.,for.specific cancer.tar.eting to deliver.anticancer.ther.peutics,highlighting r.cent advances in tar.eted deliver. of sir.A and mir.A that over.omes the pr.vious r.Ai deliver. r.adblocks.Pr.per.under.tanding of exosome engineer.ng with r.A nanotechnology pr.mises efficient ther.pies for.a wide r.nge of cancer.subtypes.

关键词： r.A inter.er.nce r.A nanotechnology Endolysosome tr.pping Exosome engineer.ng Tar.eted deliver. Chemical dr.g deliver.

Functional pr.moter.r.189037 var.ant of ATM is associated with decr.ase in lung diffusing capacity after.ir.adiation for.nonesmall-cell lung cancer

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Chr.nic Diseases and Tr.nslational Medicine 2018年第1期4卷 59-66页

作者： Jose Luis Lopez Guer.a Yi-Peng Song Quynh-Nhu Nguyen daniel r. Gomez Zhongxing Liao Ting Xu Depar.ment of r.diation Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Depar.ment of r.diation Oncology Virgen del Rocío University HospitalSeville 41013Spain Depar.ment of r.diation Oncology Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantaiShandong 264000China

Objective: Single-nucleotide polymor.hisms (SNPs) in the ataxia telangiectasiaemutated gene ATM have been linked with pneumonitis after.r.diother.py for.lung cancer.but have not been evaluated in ter.s of pulmonar. function impair.ent. Her. we investigated potential associations between SNPs in ATM and changes in diffusing capacity of the lung for.car.on monoxide (DLCO) in patients with nonesmall-cell lung cancer.(NSCLC) after.r.diother.py. Methods: Fr.m November.1998 thr.ugh June 2009, 448 consecutive patients with inoper.ble pr.mar. NSCLC under.ent definitive (≥60 Gy) r.diother.py, with or.without chemother.py. After.excluding patients with a histor. of thor.cic sur.er., r.-diation, or.lung cancer. without DNA samples available for.analysis; or.without pulmonar. function testing within the 12 months befor. and the 12 months after.r.diother.py, 100 patients wer. identified who ar. the subjects of this study. We genotyped two SNPs of ATM pr.viously found to be associated with r.diation-induced pneumonitis (r.189037 and r.228590) and evaluated potential cor.elations between these SNPs and impair.ent (decr.ases) in DLCO by using logistic r.gr.ssion analysis. r.sults: Univar.ate and multivar.ate analyses showed that the AA genotype of ATM r.189037 was associated with decr.ased DLCO after.definitive r.diother.py than the GG/AG genotypes (univar.ate coefficient, -0.122; 95％ confidence inter.al (CI),-0.236 to -0.008; P = 0.037; and multivar.ate coefficient, -0.102; 95％ CI, -0.198 to -0.005; P = 0.038)No such cor.elations wer. found for.r.228590 (univar.ate coefficient, -0.096; 95％ CI, -0.208 to 0.017; P = 0.096). Conclusions: The AA genotype of ATM r.189037 was associated with higher.r.sk of lung injur. than wer. the GG/AG genotypes in patients with NSCLC tr.ated with r.diother.py. This finding should be validated pr.spectively with other.patient populations.

关键词： Nonesmall-cell lung cancer r.diation ther.py Ataxia telangiectasia-mutated gene Single-nucleotide polymor.hisms

Par.icles disper.ion on fluid-liquid inter.aces

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Par.icuology 2011年第1期9卷 1-13页

作者： Sathish Gur.patham Bhavin Dalal md.Shahadat Hossain Ian S.Fischer.Pushpendr. Singh daniel D.Joseph Depar.ment of Mechanical Engineer.ng New Jersey Institute of Technology Depar.ment of Aer.space Engineer.ng and Mechanics University of Minnesota Depar.ment of Mechanical and Aer.space Engineer.ng University of California Irvine

This paper.is concer.ed with the disper.ion of par.icles on the fluid-liquid inter.ace. In a pr.vious study we have shown that when small par.icles, e.g., flour. pollen, glass beads, etc., contact an air.liquid inter.ace, they disper.e r.pidly as if they wer. in an explosion. The r.pid disper.ion is due to the fact that the capillar. for.e pulls par.icles into the inter.ace causing them to acceler.te to a lar.e velocity. In this paper.we show that motion of par.icles nor.al to the inter.ace is iner.ia dominated; they oscillate ver.ically about their.equilibr.um position befor. coming to r.st under.viscous dr.g. This ver.ical motion of a par.icle causes a r.dially-outwar. later.l （secondar.） flow on the inter.ace that causes near.y par.icles to move away. The disper.ion on a liquid-liquid inter.ace, which is the pr.mar. focus of this study, was r.latively weaker.than on an air.liquid inter.ace, and occur.ed over.a longer.per.od of time. When falling thr.ugh an upper.liquid the par.icles have a slower.velocity than when falling thr.ugh air.because the liquid has a gr.ater.viscosity. Another.differ.nce for.the liquid-liquid inter.ace is that the separ.tion of par.icles begins in the upper.liquid befor. the par.icles r.ach the inter.ace. The r.te of disper.ion depended on the size of the par.icles, the densities of the par.icle and liquids, the viscosities of the liquids involved, and the contact angle. For.small par.icles, par.ial pinning and hyster.sis of the thr.e-phase contact line on the sur.ace of the par.icle dur.ng adsor.tion on liquid-liquid inter.aces was also impor.ant. The fr.quency of oscillation of par.icles about their.floating equilibr.um incr.ased with decr.asing par.icle size on both air.water.and liquid-liquid inter.aces, and the time to r.ach equilibr.um decr.ased with decr.asing par.icle size. These r.sults ar. in agr.ement with our.analysis.

关键词： Adsor.tion Inter.acial tension Par.icle disper.ion Fluid–liquid inter.ace Capillar. for.e Viscous dr.g

DNA r.pair.capacity cor.elates with standar.ized uptake values fr.m 18F-fluor.deoxyglucose positr.n emission tomogr.phy/CT in patients with advanced non-small-cell lung cancer

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Chr.nic Diseases and Tr.nslational Medicine 2018年第2期4卷 109-116页

作者： Xin (Er.c) Jiang Ting Xu Qingyi Wei Peng Li daniel r. Gomez Laur.nce E. Cour. Zhongxing Liao Depar.ment of r.diation Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Duke Univer.ity DurhamNC 27708USA Duke Cancer.Institute Duke University Medical CenterDurhamNC 27710USA Depar.ment of Medical Oncology Henan Cancer HospitalZhengzhouHenan 450008China Depar.ment of r.diation Physics The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Objective: The DNA r.pair.capacity (Dr.) of tumor.cells is an impor.ant contr.butor.to r.sistance to r.diation and platinum-based dr.gs. Because Dr. may be affected by tumor.cell metabolism, we measur.d Dr. in lymphocytes fr.m patients with non-small-cell lung cancer.(NSCLC) and compar.d the findings with the maximum standar.ized uptake value (SUVmax) on 18 F-fluor.deoxyglucose positr.n emission tomogr.phy (FDG PET) after.(chemo)r.diation ther.py. Methods: This study included 151 patients with stage IA-IV NSCLC who had FDG PET at a single institution and donated blood samples befor. chemother.py. We assessed the cor.elation of Dr., measur.d in per.pher.l T lymphocytes by a host-cell r.ac-tivation assay with SUVmax and their.associations with over.ll sur.ival (OS) time by hazar.s r.tios calculated with a Cox pr.-por.ional hazar.s r.gr.ssion model. r.sults: SUVmax of the pr.mar. tumor.at diagnosis was inver.ely associated with lymphocyte Dr. (r.－0.175, P＝0.032), par.icular.y among patients with advanced disease (r.＝－0.218, P ＝ 0.015). However. △SUVmax of pr.mar. tumor.was not significantly associated with Dr. (r.0.005, P＝0.968). SUVmax of r.gional lymph nodes at diagnosis (r.－0.307, P＝0.0008) and after.(chemo)r.diation tr.atment (r.－0.329, P＝0.034) and SUVmax of the pr.mar. tumor.after.(chemo)r.diation tr.atment (r.－0.253, P＝0.045) wer. also inver.ely associated with OS time. Conclusion: Dr. was inver.ely associated with pr.mar. tumor.SUVmax befor. tr.atment but not with △SUVmax after.(chemo)r.diation.

关键词： DNA r.pair capacity Standar.ized uptake value 18F-fluor.deoxyglucose positr.n emission tomogr.phy Outcome Non-small-cell lung cancer