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Direct laser writing of volumetric gradient index lenses and waveguides

Light(Science & Applications) 2020年第1期9卷 89-102页

作者： Christian R.Ocier Corey A.Richards daniel a.bacon-brown Qing Ding Raman Kumar Tanner J.Garcia Jorik van de Groep Jung-Hwan Song Austin J.Cyphersmith Andrew Rhode Andrea N.Perry Alexander J.Littlefield Jinlong Zhu Dajie Xie Haibo Gao Jonah F.Messinger Mark L.Brongersma Kimani C.Toussaint Jr Lynford L.Goddard Paul V.Braun Department of Materials Science and Engineering University of Illinois at Urbana-ChampaignUrbanaILUSA Materials Research Laboratory University of Illinois at Urbana-ChampaignUrbanaILUSA Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-ChampaignUrbanaILUSA Department of Electrical and Computer Engineering University of Illinois at Urbana-ChampaignUrbanaILUSA Department of Materials Science and Engineering Stanford UniversityStanfordCAUSA Carl R.Woese Institute for Genomic Biology University of Illinois at Urbana-ChampaignUrbanaILUSA Department of Mechanical Science and Engineering University of Illinois at Urbana-ChampaignUrbanaILUSA

Direct laser writing(DLW)has been shown to render 3D polymeric optical components,including lenses,beam expanders,and mirrors,with submicrometer ***,these printed structures are limited to the refractive index and dispersive properties of the ***,we present the subsurface controllable refractive index via beam exposure(SCRIBE)method,a lithographic approach that enables the tuning of the refractive index over a range of greater than 0.3 by performing DLW inside photoresist-filled nanoporous silicon and silica *** the laser exposure during printing enables 3D submicron control of the polymer infilling and thus the refractive index and chromatic *** SCRIBE’s unprecedented index range and 3D writing accuracy has realized the world’s smallest(15μm diameter)spherical Luneburg lens operating at visible ***’s ability to tune the chromatic dispersion alongside the refractive index was leveraged to render achromatic doublets in a single printing step,eliminating the need for multiple photoresins and writing *** also has the potential to form multicomponent optics by cascading optical elements within a *** a demonstration,stacked focusing structures that generate photonic nanojets were fabricated inside porous ***,an all-pass ring resonator was coupled to a subsurface 3D *** measured quality factor of 4600 at 1550 nm suggests the possibility of compact photonic systems with optical interconnects that traverse multiple *** is uniquely suited for constructing such photonic integrated circuits due to its ability to integrate multiple optical components,including lenses and waveguides,without additional printed supports.

关键词： index refractive render

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Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： daniel Adam Felix Langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

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Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions

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Neural Regeneration Research 2025年第1期20卷 191-192页

作者： Narek Manukjan daniel Fulton Zubair Ahmed WMatthijs Blankesteijn Sébastien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-School for Cardiovascular Diseases Maastricht UniversityMaastrichtThe Netherlands Neuroscience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirminghamUK MHeNs-School for Mental Health and Neuroscience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As the population ages,the burden of age-related diseases becomes ***,over 55 million people suffer from dementia worldwide,with Alzheimer’s disease being the most common ***,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10%-30%of the elderly population and 35%-90%of all dementia patients exhibit signs of *** term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming white

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Barriers to Insurance as a Flood Risk Management Tool:Evidence from a Survey of Property Owners

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International Journal of Disaster Risk Science 2020年第3期11卷 263-273页

作者： Jason Thistlethwaite daniel Henstra Craig brown daniel Scott School of Environment Enterprise and DevelopmentUniversity of WaterlooWaterlooON N2L 3G1Canada Department of Political Science University of WaterlooWaterlooON N2L 3G1Canada Climate Change and Health Adaptation Planning Vancouver Coastal HealthVancouverBC V5Z 4C2Canada Department of Geography and Environmental Management University of WaterlooWaterlooON N2L 3G1Canada

By using risk-adjusted price signals to transfer responsibility for property-level flood protection and recovery from governments to property owners,flood insurance represents a key tenet of the flood risk management(FRM)*** Government of Canada has worked with insurers to introduce flood insurance for the first time as a part of a broader shift towards FRM to limit the growing costs of *** viability of flood insurance in Canada,however,has been questioned by research that disputes the utility of purchasing coverage by property *** study tested this assumption by drawing on public opinion survey data to assess factors that influence decisions about the utility of *** findings reveal that Canadians have limited knowledge of flood insurance coverage,exhibit a low willingness-to-pay for both insurance and property-level flood protection measures,and expect governments to shoulder much of the financial burden of flood recovery through disaster assistance.

关键词： Flood insurance Flood risk management Risk-sharing Willingness-to-pay

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Droplet Collision Simulation by a Multi-Speed Lattice Boltzmann Method

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Communications in Computational Physics 2011年第5期9卷 1219-1234页

作者： daniel Lycett-brown Ilya Karlin Kai H.Luo Energy Technology Group School of Engineering SciencesUniversity of SouthamptonSO171BJUK Aerothermochemistry and Combustion Systems Lab ETH Zurich8092 ZurichSwitzerland

Realization of the Shan-Chen multiphase flow lattice Boltzmann model is considered in the framework of the higher-order Galilean invariant *** present multiphase lattice Boltzmann model is used in two-dimensional simu... 详细信息

关键词： Multiphase flow lattice Boltzmann method droplets

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Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.Spicer Jianqi Yang daniel Fu Alison N.DeVore Marisol Lauffer Nilufer S.Atasoy Deniz Atasoy Rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing ***,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGS6)

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Material transport in dip-pen nanolithography

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Frontiers of physics 2014年第3期9卷 385-397页

作者： Keith A. brown daniel J. Eichelsdoerfer Xing Liao Shu He Chad A. Mirkin Department of Chemistry Northwestern University 2145 Sheridan Road Evanston IL 60208 USA International Institute for Nanotechnology Northwestern University 2145 Sheridan Road Evanston IL 60208 USA Department of Materials Science and Engineering Northwestern University 2145 Sheridan Road Evanston IL 60208 USA

Dip-pen *** （DPN） is a useful method for directly printing materials on surfaces with sub-50nm resolution. Because it, involves the physical transport of materials from a scanning probe tip to a surface and the subsequent chemical interaction of that material with the surface, there are many factors to consider when attempting to understand DPN. In this review, we overview the physical and chemical processes that are known to play a role in DPN, Through a detailed review of the literature, we classify inks into three general categories based on their transport properties, and highlight the myriad ways that. DPN can be used to perform chemistry at the tip of a scanning probe.

关键词： dip-pen nanolithography scanning probe lithography materials transport

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Hepatobiliary Surgery and Nutrition 2024年第2期13卷 343-346页

作者： Meaghan S.Dendy Case daniel B.brown Department of Radiology and Radiologic Sciences Vanderbilt University Medical CenterNashvilleTNUSA

Hepatocellular carcinoma(HCC)remains the third most common cause of cancer-related deaths worldwide(1).Transarterial chemoembolization(TACE)has been established as a therapeutic option in those patients who are outside of surgical resection or transplant criteria for over four decades(2).Multiple expert panels have outlined the appropriate use criteria and recommendations for HCC treatment(3-5).These documents have focused on multiple treatment modalities including interventional radiology intra-arterial and ablative treatments as well as resection,transplant and systemic *** their recently published practice recommendations for the use of TACE in HCC patients,the Korean Liver Cancer Association(KLCA)has developed a comprehensive list of recommendations for this specific modality(6).The recommendations are a combination of evidence-based,expert consensus decisions and surveys of Korean experts in TACE for *** and contrasting this focused guideline on TACE to the recent HCC guidelines from the National Comprehensive Cancer Network(NCCN),American Association for the Study of Liver Diseases(AASLD)and Barcelona Clinic Liver Cancer(BCLC)is valuable to understand where methods are truly global and also to understand differences in treatment approach by region.

关键词： Hepatocellular carcinoma(HCC) therapeutic chemoembolization interventional radiology

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基于数字高程模型的鄱阳湖淹水范围制图研究

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武汉大学学报（信息科学版） 2010年第7期35卷 857-862页

作者：齐述华顾中宇 daniel brown 姜鲁光江西师范大学地理与环境学院南昌市紫阳大道99号330022 江西师范大学鄱阳湖湿地与流域研究教育部重点实验室南昌市紫阳大道99号330022 School of Natural Resources and Environment University of Michiganannarborusa48109 中国科学院地理科学与资源研究所北京市朝阳区大屯路甲11号100101

利用13幅Landsat TM/ETM+鄱阳湖区遥感影像,提取不同水位下的淹水范围,根据淹水面积与湖内7个水文站水位相关性,确定都昌水文站水位能够最好控制鄱阳湖水面范围。为了改善中低水位条件下淹水范围的制图精度,将遥感提取的水体边界作为水... 详细信息

利用13幅Landsat TM/ETM+鄱阳湖区遥感影像,提取不同水位下的淹水范围,根据淹水面积与湖内7个水文站水位相关性,确定都昌水文站水位能够最好控制鄱阳湖水面范围。为了改善中低水位条件下淹水范围的制图精度,将遥感提取的水体边界作为水位等值线,插值建立鄱阳湖基于水体边界的数字高程模型(taterline-based DEM,WL_DEM),利用WL_DEM和都昌水位实现中低水位淹水范围制图。结果表明,中低水位条件下,基于WL_DEM的淹水范围制图精度都有显著提高。

关键词：鄱阳湖淹水范围遥感 DEM

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