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MOF-based magnetic microrobot swarms for pH-responsive targeted drug delivery

Science China Chemistry 2024年第4期67卷 1216-1223页

作者： Qinyi Cao Yifan Zhang Yanping Tang Changjin Wu Jizhuang Wang dan Li College of Chemistry and Materials Science Jinan UniversityGuangzhou 510632China Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications Jinan UniversityGuangzhou 510632China Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction The Fifth Affiliated Hospital(Heyuan Shenhe People’s Hospital)Jinan UniversityHeyuan 517000China JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research College of PharmacyJinan UniversityGuangzhou 510632China Department of Chemistry The University of Hong KongHong KongChina

Metal-organic frameworks(MOFs)hold significant potential as vehicles for drug delivery due to their expansive specific surface area,biocompatibility,and versatile ***,magnetically actuated micro/nano-robots(MNRs)offer distinct advantages,such as untethered and precise *** fusion of these technologies presents a promising avenue for achieving non-invasive targeted drug ***,we report a MOF-based magnetic microrobot swarm(MMRS)for targeted *** approach overcomes limitations associated with a single MNR,including limited drug loading and the risk of loss during *** select Zeolitic Imidazolate Framework-8(ZIF-8)as the drug vehicle for its superior loading potential and p H-sensitive *** design incorporates magnetic responsive components into the one-pot synthesis of Fe@ZIF-8,enabling collective behaviors under *** the yaw angle of alternating magnetic fields and nanoparticles'amount,the MMRSs with controllable size achieve instantaneous transformation among different configurations,including vortex-like swarms,chain-like swarms,and elliptical swarms,facilitating adaptation to environmental *** to the subcutaneous T24 tumor site,the MMRSs with encapsulated doxorubicin(DOX)automatically degrade and release the drug,leading to a dramatic reduction of the tumor in *** investigation signifies a significant advancement in the integration of biodegradable MOFs into microrobot swarms,ushering in new avenues for accurate and non-invasive targeted drug delivery.

关键词： magnetic microrobot swarm MOF nanoparticles magnetic propulsion pH-responsive drug release targeted drug delivery

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KSKV:Key-Strategy for Key-Value Data Collection with Local Differential Privacy

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3063-3083页

作者： dan Zhao Yang You Chuanwen Luo Ting Chen Yang Liu Artificial Intelligence Development Research Center Institute of Scientific and Technical Information of ChinaBeijing100038China Industry Development Department NSFOCUS Inc.BeijingChina School of Information Science and Technology Beijing Forestry UniversityBeijing100083China School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu610054China Institute of Computing Technology China Academy of Railway Sciences Corporation LimitedBeijing10081China

In recent years,the research field of data collection under local differential privacy(LDP)has expanded its focus fromelementary data types to includemore complex structural data,such as set-value and graph ***,our comprehensive review of existing literature reveals that there needs to be more studies that engage with key-value data *** studies would simultaneously collect the frequencies of keys and the mean of values associated with each ***,the allocation of the privacy budget between the frequencies of keys and the means of values for each key does not yield an optimal utility *** the importance of obtaining accurate key frequencies and mean estimations for key-value data collection,this paper presents a novel framework:the Key-Strategy Framework forKey-ValueDataCollection under ***,theKey-StrategyUnary Encoding(KS-UE)strategy is proposed within non-interactive frameworks for the purpose of privacy budget allocation to achieve precise key frequencies;subsequently,the Key-Strategy Generalized Randomized Response(KS-GRR)strategy is introduced for interactive frameworks to enhance the efficiency of collecting frequent keys through group-anditeration *** strategies are adapted for scenarios in which users possess either a single or multiple key-value ***,we demonstrate that the variance of KS-UE is lower than that of existing *** claims are substantiated through extensive experimental evaluation on real-world datasets,confirming the effectiveness and efficiency of the KS-UE and KS-GRR strategies.

关键词： Key-value local differential privacy frequency estimation mean estimation data perturbation

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Laser manufacturing of spatial resolution approaching quantum limit

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Light(Science & Applications) 2024年第3期13卷 421-428页

作者： Xiao-Jie Wang Hong-Hua Fang Zhen-Ze Li dan Wang Hong-Bo Sun State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin University2699 Qianjin StreetChangchun 130012China

Atomic and close-to-atom scale manufacturing is a promising avenue toward single-photon emitters,single-electron transistors,single-atom memory,and quantum-bit devices for future communication,computation,and sensing *** manufacturing is outstanding to this end for ease of beam manipulation,batch production,and no requirement for *** is,however,suffering from optical diffraction ***,we report a spatial resolution improved to the quantum limit by exploiting a threshold tracing and lock-in method,whereby the two-order gap between atomic point defect complexes and optical diffraction limit is surpassed,and a feature size ofsingle colour centres in the regular array are deterministically created with a unity yield and high positional accuracy,serving as a step forward for integrated quantum technological applications.

关键词： quantum limit resolution

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Phosphine-catalyzed acyl-transfer of heteroaryl ketones for the construction of N-fused heterocycles

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Chinese Chemical Letters 2024年第3期35卷 252-256页

作者： Yu Zhang De-Rui Han dan Ye Hong Lu Hao Wei Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry&Materials ScienceNorthwest UniversityXi'an 710069China

An inexpensive phosphine catalyst was used effectively for a transition-metal-free acyl-transfer of N-containing heteroaryl ketones for the rapid synthesis of N-fused *** key pre-aromatic spirocyclic intermediate initialized by the single electron transfer(SET)process of Togni's reagentⅡpromoted by the tertiary phosphine resulted in an intriguing and alternative tactic for the cleavage of C–C *** using inexpensive tertiary phosphine as the catalyst,this skeleton-reorganizing approach of N-containing heteroaryl ketones allows a streamlined assembly of complex N-fused heterocycles with broad functional group tolerance.

关键词： Phosphine catalysis Acyl-transfer N-Fused heterocycles C–C bond activation Aromatization

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Recent progress in single crystal perovskite X-ray detectors

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Science China(Information Sciences) 2024年第3期67卷 5-19页

作者： Xiao LIU Jun REN Yu-Ang CHEN Xiangshun GENG dan XIE Tian-Ling REN School of Integrated Circuits Tsinghua University Beijing National Research Center for Information Science and Technology (BNRist)

Perovskites have attracted extensive attention as radiation detection material due to their long carrier diffusion length and lifetime, high absorption coefficient, and flexible manufacturing process. Compared with polycrystalline structures, single crystal perovskites improve the performance of optoelectronic devices due to their low defect state density, better photoelectric characteristics, and chemical ***, we review the recent progress of single crystal perovskite X-ray detectors. First, we briefly introduced the basic concepts, detection mechanisms, figure of merits of perovskite X-ray detectors, and the preparation methods of single crystal perovskites. Then, we summarized the significant advancements in single crystal perovskite X-ray detectors in recent times. Finally, we discussed the critical challenges and some practicable solutions for developing high-performance X-ray detectors.

关键词： single crystal perovskites carrier transport radiation detection X-ray detectors X-ray imaging

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Recent progress on mechanisms,principles,and strategies for high-activity and high-stability non-PGM fuel cell catalyst design

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Carbon Energy 2024年第5期6卷 25-52页

作者： Yuping Yuan Yun Zheng dan Luo Weibin Qiu Jiantao Wang Xin Wang Zhongwei Chen GRINM(Guangdong)Institute of New Materials Technology FoshanChina Department of Chemical Engineering Waterloo Institute for NanotechnologyWaterloo Institute for Sustainable EnergyUniversity of WaterlooWaterlooOntarioCanada Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices School of Information and Optoelectronic Science and EngineeringSouth China Normal UniversityGuangdongChina National Power Battery Innovation Center GRINM Group Co.Ltd.BeijingChina

The commercialization of a polymer membrane H2-O2 fuel cell and its widespread use call for the development of cost-effective oxygen reduction reaction(ORR)nonplatinum group metal(NPGM)***,to meet the requests for the real-world fuel cell application and replacing platinum catalysts,it still needs to address some challenges for NPGM catalysts regarding the sluggish ORR kinetics in the cathode and their poor durability in acidic *** response to these issues,numerous efforts have been made to study NPGM catalysts both theoretically and experimentally,developed these into the atomically dispersed coordinated metal-nitrogen-carbon(M-N-C)form over the past *** this review,we present a comprehensive summary of recent advancements on NPGM catalysts with high activity and *** design strategies in terms of optimizing active-site density and enhancing catalyst stability against demetalization and carbon corrosion are *** is also emphasized the importance of understanding the mechanisms and principles behind those strategies through a combination of theoretical modeling and experimental ***,further understanding the mechanisms related to the active-site structure and the formation process of the single-atom active site under pyrolysis conditions is critical for active-site *** the active-site distance is the basic principle for improving catalyst activity through increasing the catalyst active-site *** studies for the catalyst deactivation mechanism and modeling stable active-site structures provide both mechanisms and principles to improve the NPGM catalyst ***,currently remained challenges and perspectives in the future on designing high-performance atomically dispersed NPGM catalysts toward fuel cell application are discussed.

关键词： batteries electrocatalysis energy storage and conversion fuel cells

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Rational design of practical layered transition metal oxide cathode materials for sodium-ion batteries

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 121-140页

作者： Yan Wang Ning Ding Rui Zhang Guanhua Jin dan Sun Yougen Tang Haiyan Wang Hunan Provincial Key Laboratory of Chemical Power Sources College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China College of Energy and Chemical Engineering Xinjiang Institute of TechnologyAksu Prefecture 843100China

Sodium-ion batteries (SIBs), which serve as alternatives or supplements to lithium-ion batteries, have been developed rapidly in recent years. Designing advanced high-performance layered NaxTMO_(2) cathode materials is beneficial for accelerating the commercialization of SIBs. Herein, the recent research progress on scalable synthesis methods, challenges on the path to commercialization and practical material design strategies for layered NaxTMO_(2) cathode materials is summarized. Co-precipitation method and solid-phase method are commonly used to synthesize NaxTMO_(2) on mass production and show their own advantages and disadvantages in terms of manufacturing cost, operative difficulty, sample quality and so on. To overcome drawbacks of layered NaxTMO_(2) cathode materials and meet the requirements for practical application, a detailed and deep understanding of development trends of layered NaxTMO_(2) cathode materials is also provided, including high specific energy materials, high-entropy oxides, single crystal materials, wide operation temperature materials and high air stability materials. This work can provide useful guidance in developing practical layered NaxTMO_(2) cathode materials for commercial SIBs.

关键词： sodium-ion batteries layered oxide industrialization development prospect

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F-doped orthorhombic Nb_(2)O_(5) exposed with 97% (100) facet for fast reversible Liþ-Intercalation

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Green Energy & Environment 2024年第4期9卷 723-731页

作者： Xiaodi Liu Yufeng Tang dan Zhang Guangyin Liu Xinwei Luo Yi Shang Xiu Li Jianmin Ma College of Chemistry and Pharmaceutical Engineering Nanyang Normal UniversityNanyang473061China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu611731China

Orthorhombic Nb_(2)O_(5)(T-Nb_(2)O_(5))is attractive for fast-charging Li-ion batteries,but it is still hard to realize rapid charge transfer kinetics for Li-ion ***,F-doped T-Nb_(2)O_(5) microﬂowers(F-Nb_(2)O_(5))are rationally synthesized through topotactic ***,F-Nb_(2)O_(5) are assembled by single-crystal nanoﬂakes with nearly 97%exposed(100)facet,which maximizes the exposure of the feasible Li^(+)transport pathways along loosely packed 4g atomic layers to the electrolytes,thus effectively enhancing the Li^(+)-intercalation ***,the band gap of F-Nb_(2)O_(5) is reduced to 2.87 eV due to the doping of F atoms,leading to enhanced electrical *** synergetic effects between tailored exposed crystal facets,F-doping,and ultrathin building blocks,speed up the Li^(+)/electron transfer kinetics and improve the pseudocapacitive properties of F-Nb_(2)O_(5).Therefore,F-Nb_(2)O_(5) exhibit superior rate capability(210.8 and 164.9 mAh g^(-1) at 1 and 10 C,respectively)and good long-term 10 C cycling performance(132.7 mAh g^(-1) after 1500 cycles).

关键词： Exposed facets Orthorhombic Nb_(2)O_(5) F-doping Pseudocapacitive intercalation anode Li-ion storage

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Optimized air-ground data fusion method for mine slope modeling

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Journal of Mountain Science 2024年第6期21卷 2130-2139页

作者： LIU dan HUANG Man TAO Zhigang HONG Chenjie WU Yuewei FAN En YANG Fei State Key Laboratory for Tunnel Engineering China University of Mining and Technology(Beijing)Beijing 100083China Department of Civil Engineering Shaoxing UniversityShaoxing 312000China Department of Computer Science and Engineering Shaoxing UniversityShaoxing 312000China

Refined 3D modeling of mine slopes is pivotal for precise prediction of geological *** at the inadequacy of existing single modeling methods in comprehensively representing the overall and localized characteristics of mining slopes,this study introduces a new method that fuses model data from Unmanned aerial vehicles(UAV)tilt photogrammetry and 3D laser scanning through a data alignment algorithm based on control ***,the mini batch K-Medoids algorithm is utilized to cluster the point cloud data from ground 3D laser ***,the elbow rule is applied to determine the optimal cluster number(K0),and the feature points are ***,the nearest neighbor point algorithm is employed to match the feature points obtained from UAV tilt photogrammetry,and the internal point coordinates are adjusted through the distanceweighted average to construct a 3D ***,by integrating an engineering case study,the K0 value is determined to be 8,with a matching accuracy between the two model datasets ranging from 0.0669 to 1.0373 ***,compared with the modeling method utilizing K-medoids clustering algorithm,the new modeling method significantly enhances the computational efficiency,the accuracy of selecting the optimal number of feature points in 3D laser scanning,and the precision of the 3D model derived from UAV tilt *** method provides a research foundation for constructing mine slope model.

关键词： Air-ground data fusion method Mini batch K-Medoids algorithm Ebow rule Optimal cluster number 3D laser scanning UAV tilt photogrammetry

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Research on Driver’s Fatigue Detection Based on Information Fusion

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Computers, Materials & Continua 2024年第4期79卷 1039-1061页

作者： Meiyan Zhang Boqi Zhao Jipu Li Qisong Wang dan Liu Jinwei Sun Jingxiao Liao Harbin Institute of Technology School of Instrument Science and EngineeringHarbin150036China Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityHong Kong100872China

Driving fatigue is a physiological phenomenon that often occurs during *** the driver enters a fatigued state,the attentionis lax,the response is slow,and the ability todeal with emergencies is significantly reduced,which can easily cause traffic ***,studying driver fatigue detectionmethods is significant in ensuring safe ***,the fatigue state of actual drivers is easily interfered with by the external environment(glasses and light),which leads to many problems,such as weak reliability of fatigue driving ***,fatigue is a slow process,first manifested in physiological signals and then reflected in human face *** improve the accuracy and stability of fatigue detection,this paper proposed a driver fatigue detection method based on image information and physiological information,designed a fatigue driving detection device,built a simulation driving experiment platform,and collected facial as well as physiological information of drivers during ***,the effectiveness of the fatigue detection method was *** movement feature parameters and physiological signal features of drivers’fatigue levels were *** driver fatigue detection model was trained to classify fatigue and non-fatigue states based on the extracted *** rates of the image,electroencephalogram(EEG),and blood oxygen signals were 86%,82%,and 71%,*** fusion theory was presented to facilitate the fatigue detection effect;the fatigue features were fused using multiple kernel learning and typical correlation analysis methods to increase the detection accuracy to 94%.It can be seen that the fatigue driving detectionmethod based onmulti-source feature fusion effectively detected driver fatigue state,and the accuracy rate was higher than that of a single information *** summary,fatigue drivingmonitoring has broad development prospects and can be used in traffic accident prevention and wearable dr

关键词： Driving fatigue information fusion EEG blood oxygen

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