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The paleoclimatic events and cause in the Okinawa Trough during 50 kaBP

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Chinese Science Bulletin 2001年第2期46卷 153-157页

作者： S.Berne Y.saito Key Laboratory of Marine Science and Numerical Modeling State Oceanic Administration (SOA) Qingdao China First Institute of Oceanography SOA Qingdao China Institute of Oceanology Chinese Academy of Sciences Qingdao China Taiwan University Taibei China French Oceanographic Institute IFREMER Plouzane France Geological Survey of Japan Tsukuba Japan

Planktonic foraminiferal δ18O record for core DGKS9603 from the Okinawa Trough shows a series of climatic fluctuations and sudden cooling events in short time scale during 50 kaBP, which appear to correlate closely tothe Younger Dryas and Heinrich events H1-5 recorded in Chinese loess, the South China Sea, the North Atlantic cores and the Greenland ice cores. Three polarity reversal events, correlating to Gothenburg, Mungo and Laschamp events, approximately correspond to Heinrich events H1, H3 and H5 respectively, which could be a cause of global climate changes. The δ18O curve of the Okinawa Trough is well associated with the grain size record of the Lijiayuan loess profile in northwestern China and is somewhat different from the climate fluctuations documented in the Greenland ice cores. These correlation results indicate that regional factors play an important role in controlling the climate changes in the East Asia, and the East Asian Monsoon could be the prominent regional controlling factor.

关键词： Okinawa Trough sudden paleoclimatic change events polarity reversal events Late Quaternary.

Enzymatic remodeling of heparan sulfate:a therapeutic strategy for systemic and localized amyloidoses?

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Neural Regeneration Research 2016年第3期11卷 408-409页

作者： Kazuchika Nishitsuji Hiroyuki saito Kenji Uchimura Department of Molecular Pathology Institute of Biomedical SciencesTokushima University Graduate School Department of Molecular Physical Pharmaceutics Institute of Biomedical SciencesTokushima University Graduate School Department of Biochemistry Nagoya University Graduate School of Medicine

In 1854,Rudolf Virchow introduced the term＂amyloid＂to indicate white waxy deposits that stained positive for iodine and that were found in many organs of patients with chronic inflammatory *** observed that these deposits stained pale blue after treatment with iodine and became dark blue or black after subsequent addition of sulfuric acid,in a similar manner to that of cellulose or carbohydrate.

关键词： heparan amyloid remodeling carbohydrate stained subsequent Virchow organs iodine cellulose

Characterization of Malalignment between Atrial and Ventricular Septa in Overriding/Straddling Tricuspid and Mitral Valves

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Congenital Heart Disease 2021年第1期16卷 1-16页

作者： Mika saito Dragulescu Andreea Shi-Joon Yoo The Labatt Family Heart Centre The Hospital for Sick ChildrenUniversity of TorontoTorontoCanada Division of Cardiology Department of PaediatricsThe Hospital for Sick ChildrenUniversity of TorontoTorontoCanada Department of Diagnostic Imaging The Hospital for Sick ChildrenUniversity of TorontoTorontoCanada

Objective:Overriding/straddling of an atrioventricular valve is a consequence of atrial-ventricular septal *** sought to characterize the malalignment by analogizing it to a flap-door and using structured ***:The echocardiograms and magnetic resonance images of 35 patients with overriding/straddling tricuspid or mitral valve were evaluated to assess the following modifiers;the malaligned part of the septum,the reference structure,and the mechanism,direction and severity of ***:The pathology included classic overriding tricuspid valve in 15,classic overriding mitral valve in 12,and overriding tricuspid valve with left juxtaposition of atrial appendages in *** classic overriding tricuspid valve,the ventricular septum was hinged to the anterior interventricular groove and its insertion to the posterior interventricular groove was displaced toward the right *** VSD primarily involved the inlet but also extended toward the anterior interventricular *** classic overriding mitral valve,the ventricular septum was hinged to the posterior interventricular groove and crux *** insertion to the anterior interventricular groove was displaced toward the left *** VSD primarily involved the anterior part but also extended toward the *** tricuspid valve with left juxtaposition of atrial appendages had a mild degree of malalignment with displacement/rotation of the atrioventricular *** spaced short-axis images were most helpful in characterizing the ***:Overriding/straddling atrioventricular valves can be easily understood by analogizing the atrial-ventricular septal malalignment to a flap-door and describing the pathology in a structured *** to what has previously been known,the VSD is not limited to the inlet or outlet part of the ventricular septum.

关键词： Malalignment ventricular septal defect overriding straddling tricuspid mitral

General Regulatory Patterns of Plant Mineral Nutrient Depletion as Revealed by serat Quadruple Mutants Disturbed in Cysteine Synthesis

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Molecular Plant 2010年第2期3卷 438-466页

作者： Mutsumi Watanabe Hans-Michael Hubberten Kazuki saito Rainer Hoefgen Graduate School of Pharmaceutical Sciences Chiba University 1-33 Yayoi-cho Inage-ku Chiba 263-8522 Japan Max-Planck-lnstitut fuer Molekulare Pflanzenphysiologie Wissenschaftspark Golm Am Muehlenberg 1 14476 Potsdam-Golm RIKEN Plant Science Center Tsurumi-ku Yokohama 230-0045 Japan

Sulfate is an essential macronutrient for plants. Plants have developed strategies to cope with sulfate deficiency, and other nutrient ion limitations. However, the regulation of these adaptive responses and the coordinating signals that underlie them are still poorly characterized. O-acetylserine （OAS） is a marker metabolite of sulfate starvation and has been speculated to have a signaling function. OAS is synthesized by the enzyme serine acetyltransferase （SERAT）, which is encoded by five distinct genes in Arabidopsis. We investigated quadruple knockout mutants of SERAT that retained only one functional isoform. These mutants displayed symptoms of sulfate starvation. Furthermore, some of them displayed phenotypes typical of prolonged sulfate starvation, in particular, developmental programs associated with senescence or stress responses. Thus, we compared metabolite and transcriptome data from these mutants with N-, P-, K-, and S-depleted plants. This revealed many similarities with general nutrient-depletion-induced senescence （NuDIS）, in- dicating the recruitment of existing regulatory programs for nutrient-starvation responses. Several candidate genes that could be involved in these processes were identified, including transcription factors and other regulatory proteins, as well as the functional categories of their target genes. These results outline components of the regulatory network controlling plant development under sulfate stress, forming a basis for further investigations to elucidate the complete network. In turn, this will advance our broader understanding of plant responses to a range of other nutrient stresses.

关键词： Abiotic/environmental stress ion/metabolite sensing senescence functional genomics Arabidopsis sulfur.

Geochemical and Grain-Sized Implications for Provenance Variations of the Central Yellow Sea Muddy Area Since the Middle Holocene

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Journal of Ocean University of China 2020年第3期19卷 577-588页

作者： AI Lina HAN Zongzhu WU Xiao saito Yoshiki WANG Houjie College of Marine Geosciences/Key Laboratory of Submarine Geosciences and Prospecting Techniques MOEOcean University of ChinaQingdao 266100China Laboratory of Marine Geology Qingdao National Laboratory of Marine Science and TechnologyQingdao 266237China Estuary Research Center Shimane UniversityMatsue 690-8504Japan Geological Survey of Japan AISTTsukuba 305-8567Japan

Based on high-resolution analysis to a 280-cm long sediment core obtained from the muddy area in the central Yellow Sea, we examined the provenance of muddy sediments and discussed the changing marine sedimentary environment since the middle Holocene. The results indicated that fine-grained sediments in the muddy area were mainly derived from the Huanghe(Yellow River) and Changjiang(Yangtze River) with considerable stepwise variations during the past 6.6 kyr. The Yellow Sea Warm Current was initiated at 6 kyr when the sea level was high together with the enhanced East Asian Winter Monsoon. These in combination established the framework of shelf circulation in the Yellow Sea that began to trap the river-derived fine-grained sediments. From 4.9 kyr to 2.8 kyr, both the Kushiro Current and East Asian Monsoon were significantly weakened, reducing the delivery of Changjiang sediments to the muddy area. As a result, the sediments were mainly originated from the Huanghe. From 2.8 kyr to 1.5 kyr the continuously weakened East Asian Winter Monsoon and enhanced Yellow Sea Warm Current entrapped more fine-grain sediments. Whereas the enhanced East Asian Winter Monsoon and the human caused increase in sediment load of the Huanghe since 1.5 kyr, and direct delivery of Huanghe sediments to the Yellow Sea during 1128–1855 AD might dominated the sedimentation in the study area. The stepwise variations of the sediment provenance and composition of the Central Yellow Sea muddy sediments are of importance to understanding the formation of muddy deposit in the central Yellow Sea and the associated variations of marine environment since the middle Holocene.

关键词： sediment provenance rare earth elements grain size central Yellow Sea mud middle Holocene

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

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Cancer Communications 2024年第2期44卷 287-293页

作者： Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu saito Akira saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno Division of Genome Biology National Cancer Center Research InstituteTokyoJapan Department of Clinical Genomics National Cancer Center Research InstituteTokyoJapan Laboratory for Statistical Analysis Center for Integrative Medical SciencesRIKENYokohamaJapan Department of Genomic Medicine Research InstituteNational Cerebral and Cardiovascular CenterOsakaJapan Laboratory for Genotyping Development Center for Integrative Medical SciencesRIKENYokohamaJapan Center for Antibody and Vaccine Therapy Research HospitalInstitute of Medical ScienceThe University of TokyoTokyoJapan Department of Medical Oncology and Cancer Center and Center for Advanced Medicine against CancerShiga University of Medical ScienceOtsuJapan Division of Medical AI Research and Development National Cancer Center Research InstituteTokyoJapan Center for Genomic Medicine Graduate School of MedicineKyoto UniversityKyotoJapan Department of Medical Oncology Japanese Red Cross Medical CenterTokyoJapan Department of Thoracic Oncology National Cancer Center Hospital EastJapan Department of Thoracic Oncology National Cancer Center HospitalTokyoJapan Department of Cellular and Organ Pathology Graduate School of MedicineAkita UniversityAkitaJapan Department of Respiratory Medicine Tokyo Medical and Dental UniversityBunkyo-kuTokyoJapan Division of General Thoracic Surgery Department of SurgeryShinshu University School of MedicineMatsumotoNaganoJapan Department of General Surgical Science Division of General Thoracic SurgeryGunma University Graduate School of MedicineIntegrative Center of General SurgeryGunma University HospitalGunmaJapan Department of Gastrointestinal Tract Surgery Fukushima Medical University School of MedicineFukushimaJapan StaGen Co. LtdTokyoJapan Division of Thoracic Surgery National Cancer Center HospitalTokyoJapan Department of Thoracic Surgery National Cancer Center Hospital EastChibaJapan Division of Translational Informatics Exploratory Oncology Research and Clinical Trial Center(EPOC

Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type.

关键词： adenocarcinoma lung Lung

Case of clear-cell hepatocellular carcinoma that developed in the normal liver of a middle-aged woman

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World Journal of Gastroenterology 2008年第1期14卷 129-131页

作者： Atsushi Takahashi Hironobu saito Yukiko Kanno Kazumichi Abe Junko Yokokawa Atsushi Irisawa Akira Kenjo Takuro saito Mitsukazu Gotoh Hiromasa Ohira Department of Internal Medicine Ⅱ Fukushima Medical University School of Medicine 1 Hikarigaoka Fukushima 960-1295 Japan Department of Surgery Ⅰ Fukushima Medical University School of Medicine 1 Hikarigaoka Fukushima 960-1295 Japan

A 36-year-old woman was admitted to our department for close examination of a liver tumor that was found during a medical checkup. Abdominal US, CT and MRI showed a tumor in segment 7 (S7) of the liver. Although imaging suggested hepatocellular carcinoma, laboratory tests showed no abnormality in liver function, hepatitis virus markers were negative, and tumor markers including protein induced by vitamin K absence or antagonist Ⅱ (PIVKA-Ⅱ), α-fetoprotein (AFP), carbohydrate antigen 19-9 (CA19-9), and carcinoembryonic antigen (CEA) were all within normal ranges. Upon aspiration biopsy of the liver, the histopathological diagnosis was moderately differentiated hepatocellular carcinoma. Therefore, right hepatectomy was performed. Although a part of the tumor was necrotic, about 60% of the viable part showed a clear-cell variant. Consequently, it was diagnosed as clear-cell hepatocellular carcinoma. It was noted that the background liver tissue was normal. This case is worthy of reporting because development of clear-cell hepatocellular carcinoma in the normal liver of a middle-aged woman is rarely seen.

关键词： Clear-cell hepatocellular carcinoma Liver Middle-aged

Stability improvement mechanism due to less charge accumulation in ternary polymer solar cells

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npj Flexible Electronics 2022年第1期6卷 194-203页

作者： Dong Xue Masahiko saito Itaru Osaka Kazuhiro Marumoto Division of Materials Science University of TsukubaTsukubaIbaraki 305-8573Japan Graduate School of Advanced Science and Engineering Hiroshima UniversityHigashihiroshimaHiroshima 739-8527Japan Tsukuba Research Center for Energy Materials Science(TREMS) University of TsukubaTsukubaIbaraki 305-8571Japan

Ternary polymer solar cells based on a thiazolothiazole-based polymer donor(PTzBT)and a fullerene acceptor(PC61BM)have attracted attention because they show high efficiency and stability by addition of a non-fullerene acceptor(ITIC).However,the performance improvement mechanism is not completely ***,we show the stability improvement mechanism due to less charge accumulation in the PTzBT cells with ITIC using operando electron spin resonance from a microscopic *** observed two correlations between device performance and number of spins(N_(spin))under solar *** correlation is the decrease in short-circuit current and the N_(spin) increase in electrons on PC_(61)BM and holes in PTzBT,where the ITIC addition causes the less these N_(spin).The other correlation is the increase in open-circuit voltage and the N_(spin) decrease in holes in *** findings explain the stability improvement mechanism,showing the correlation between less charge accumulation and higher stability,which is valuable for the development of further efficient and stable polymer solar cells.

关键词： charge stability polymer

Reduction behaviors of permanganate by microbial cells and concomitant accumulation of divalent cations of Mg2+, Zn2+, and Co2+

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Journal of Environmental Sciences 2019年第12期31卷 78-86页

作者： Tomoaki Kato Qianqian Yu Kazuya Tanaka Naofumi Kozai Takumi saito Toshihiko Ohnuki School of Environment and Society Tokyo Institute of Technology2-12-1 OofcayamaMeguro-fcuTokyo 152-8550Japan School of Earth Science China University of GeosciencesWuhan 430074China Advanced Science Research Center Japan Atomic Energy AgencyTokaiIbaraki 319-1195Japan Institute of Innovative Research Tokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo 152-8550Japan The University of Tokyo 7-3-1 HongoBunkyo-kuTokyo 113-8654Japan

Permanganate treatment is widely used for disinfection of bacteria in surface-contaminated *** this paper,the fate of the dissolved permanganate in aqueous solution after contact with cells of Pseudomonas fluorescens was *** accumulation of divalent cations of Mg2+,Zn2+,and Co2+during precipitation of Mn oxides was also *** time course of the Mn concentration in solution showed an abrupt decrease after contact of Mn(VII)with microbial cells,followed by an increase after^24 *** analysis of the precipitated Mn oxides,called biomass Mn oxides,showed the formation of low-crystalline *** spectroscopy and X-ray absorption near edge structure(XANES)analyses indicated that dissolved Mn(VII)was reduced to form biomass Mn oxides involving Mn(IV)and Mn(III),followed by reduction to soluble Mn(II).The numbers of electron transferred from microbial cells to permanganate and to biomass Mn oxides for 24 hr after the contact indicated that the numbers of electron transfer from microbial cell was approximately 50 times higher to dissolved permanganate than to the biomass Mn oxides in present experimental *** 24 hr accumulation of divalent cations during formation of biomass Mn oxides was in the order of Co2+>Zn2+>Mg2+.XANES analysis of Co showed that oxidation of Co2+to Co3+resulted in higher accumulation of Co than Zn and ***,treatment of surface water by KMnO4 solution is effective not only for disinfection of microorganisms,but also for the elimination of metal cations from surface water.

关键词： Permanganate Cobalt Zinc Biomass Mn oxides Birnessite XANES