Enzymatic remodeling of heparan sulfate:a therapeutic strategy for systemic and localized amyloidoses?

作     者：Kazuchika Nishitsuji Hiroyuki Saito Kenji Uchimura 

作者机构：Department of Molecular PathologyInstitute of Biomedical SciencesTokushima University Graduate School Department of Molecular Physical PharmaceuticsInstitute of Biomedical SciencesTokushima University Graduate School Department of BiochemistryNagoya University Graduate School of Medicine 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第3期

页      面：408-409页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：partly supported by Grant-in-Aid for Scientific Research B-25293006(to HS) Grant-in-Aid for Young Scientists B-15K19488(to KN)from the Japan Society for the Promotion of Science the Research Program for Development of Intelligent Tokushima Artificial Exosome(i TEX)from Tokushima University 

主　　题：heparan amyloid remodeling carbohydrate stained subsequent Virchow organs iodine cellulose 

摘      要：In 1854,Rudolf Virchow introduced the term＂amyloid＂to indicate white waxy deposits that stained positive for iodine and that were found in many organs of patients with chronic inflammatory *** observed that these deposits stained pale blue after treatment with iodine and became dark blue or black after subsequent addition of sulfuric acid,in a similar manner to that of cellulose or carbohydrate.