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Molecular Plant 2013年第5期6卷 1707-1710页

作者： dagan sade Yariv Brotman Assa f Eybishtz Alvaro Cuadros-lnostroza Alisdair R. Fernie Lothar Willmitzer Henry Czosnek Institute of Plant Sciences and Genetics in Agriculture The Robert H. Smith Faculty of Agriculture Food and Environment The Hebrew University of Jerusalem Rehovot 76100 Israel Max-Planck Institute of Molecular Plant Physiology Am Muhlenberg 1 14476 Potsdam-Golm Germany

Dear Editor, Tomato yellow leaf curl virus （TYLCV） is a whitefly-trans- mitted geminivirus infecting tomato crops （Czosnek, 2007）. TYLCV-resistant （R） and susceptible （S） lines with the same genetic background have been bred using Solanum habro- chaites as the resistance source. The gene（s） conferring resist- ance are unknown. Previously, we demonstrated that the hexose transporter gene LeHT1 is up-regulated upon infec- tion in R plants and its silencing in R plants （RH） leads to the collapse of resistance （Eybishtz et al., 2010）. To uncover the role of LeHT1 in resistance, we （1） analyzed the transcriptome reprogramming in leaves of S, R, and RH plants using a home- designed microarray, before and 7 d after TYLCV inoculation （0, 7 dpi）, and （2） measured the concentration of sugars and their derivatives in S, R, and RH leaves at 1 and 7 dpi because LeHT1 is transporting both glucose and fructose （McCurdy et al., 2010）.

关键词： curl virus whitefly-transmitted geminivirus TYLCV inoculation

Assessment of spermatogenesis in camels via seminiferous tubule staging and testosterone profiling

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Asian pacific Journal of Reproduction 2024年第3期13卷 133-142页

作者： Saif Ullah Abdul Quddus Quanwei Wei Wael Ennab Sheeraz Mustafa Jiahao Sun Rahmani Mohammad Malyar Abdul Baseer dagan Mao Fangxiong Shi College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China Faculty of Veterinary and Animal Sciences Lasbela University of Agriculture Water and Marine SciencesBalochistanPakistan Faculty of Veterinary and Animal Sciences Ziaddin University Karachi Pakistan

Objective:To investigate the successive morphological stages of spermatogenesis,hormonal regulation,and testosterone profile in dromedary camel ***:Testicular tissue samples were obtained from 12 dromedary bull camels aged 7 to 8 at a local *** histological assessment involved tissue processing,hematoxylin and eosin(H&E)staining,and examination under a *** analysis,germ cell identification,and assessment of seminiferous tubules and maturation were *** assay was performed by radioimmunoassay using blood samples collected at regular ***:The study revealed 12 phases of the dromedary camel's seminiferous epithelium cycle,highlighting distinct morphological characteristics and cellular *** migration,maturation,cap formation,and the Golgi-mediated synthesis of proacrosomal vesicles were also explained in dimension,as were the steps of acrosome *** and mature sperm cells were present when spermatogenesis phases were *** analysis of the dimensions of seminiferous tubules revealed specific measures for diameter,area,and epithelial height about luminal ***,there were noticeable variations in the serum testosterone concentrations during the study period,indicating temporal ***:This study outlines the spermatogenesis process in dromedary camels across 12 stages,emphasizing cellular dynamics and acrosomal *** also provides seminiferous tubule measurements and observes seasonal testosterone fluctuations,offering insights into reproductive regulation and potential strategies for camel breeding conservation.

关键词： Spermatogenesis Camel Testosterone profile Morphological staging

REDISSE in Benin and Lessons Learned for the Management of Public Health Emergencies after Five Years of Implementation

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Open Journal of Epidemiology 2024年第3期14卷 493-507页

作者： Fidelia Hinson Arthur dagan Dorine Laura Danmitondé Blaise Hounyo Isidore Domanou David Houéto REDISSE Project Cotonou Benin School of Public Health University of Parakou Parakou Benin

Introduction: Benin was embarked on phase 3 of the REDISSE Benin project (Regional Disease Surveillance Systems Enhancement) which began in 2018. The objectives were in five key components namely, Surveillance and health information;Laboratory capacity building;Emergency preparedness and response;Human resources management for effective disease surveillance and epidemic preparedness;and Institutional Capacity Building, Project Management, Coordination and Advocacy. After five years of implementation, this study aimed at the documentation of lessons learned and best practices. Methods: A descriptive cross-sectional study. Apart from individual semi-structured interviews, a thematic workshops bringing together the project’s main stakeholders recruited on an exhaustive way by component to identify and validate lessons learned, good practices and propose improvement mechanisms to be taken into account by the sector. Criteria were set up and used to validate best practices and lessons learned. Results: A total 54 (Surveillance workshop), 47 (Preparedness & response workshop), 53 (Human Resources workshop), 26 (Laboratories workshop) participated to the thematic workshops, and five interviews. The good practices (33: 9 for animal health, 7 for human health and 17 crosscutting) and lessons learned (10: 3 for animal health and 7 for human health) have been identified and have been the subject, depending on the case, of proposals for improvement or conditions necessary for their maintenance. Discussion: The richness of a project lies not only in the immediate achievement of its results, but also and above all, in its usefulness for similar interventions, whether in the local, regional, national or international context. It is in this context that the REDISSE project has set out to make public the various lessons learned and best practices from the implementation of its activities over a period of some five consecutive years.

关键词： Public Health Emergency Events Preparedness and Response Capitalization REDISSE Benin

A Transformer-Assisted Cascade Learning Network for Choroidal Vessel Segmentation

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Journal of Computer Science & Technology 2024年第2期39卷 286-304页

作者：温阳吴依林毕磊石武祯刘潇骁许毓鹏许迅曹文明冯大淦 Guangdong Provincial Key Laboratory of Intelligent Information Processing School of Electronics and Information EngineeringShenzhen UniversityShenzhen 518060China Institute of Translational Medicine Shanghai Jiao Tong UniversityShanghai 200240China Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China School of Information Technologies The University of SydneySydney 2006Australia

As a highly vascular eye part,the choroid is crucial in various eye disease ***,limited research has focused on the inner structure of the choroid due to the challenges in obtaining sufficient accurate label data,particularly for the choroidal ***,the existing direct choroidal vessel segmentation methods for the intelligent diagnosis of vascular assisted ophthalmic diseases are still unsatisfactory due to noise data,while the synergistic segmentation methods compromise vessel segmentation performance for the choroid layer segmentation *** cascaded structures grapple with error propagation during *** address these challenges,we propose a cascade learning segmentation method for the inner vessel structures of the choroid in this ***,we propose TransformerAssisted Cascade Learning Network(TACLNet)for choroidal vessel segmentation,which comprises a two-stage training strategy:pre-training for choroid layer segmentation and joint training for choroid layer and choroidal vessel *** also enhance the skip connection structures by introducing a multi-scale subtraction connection module designated as MSC,capturing differential and detailed information ***,we implement an auxiliary Transformer branch named ATB to integrate global features into the segmentation *** results exhibit that our method achieves the state-of-the-art performance for choroidal vessel ***,we further validate the significant superiority of the proposed method for retinal fluid segmentation in optical coherence tomography(OCT)scans on a publicly available *** these fully prove that our TACLNet contributes to the advancement of choroidal vessel segmentation and is of great significance for ophthalmic research and clinical application.

关键词： choroidal vessel segmentation optical coherence tomography(OCT) Transformer-assisted cascade learning retinal fluid segmentation multi-scale feature extraction

围产期日粮添加姜黄素对山羊生产性能、血液指标及炎症因子基因表达的影响

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中国农业科学 2024年第12期57卷 2483-2496页

作者：陈恒光裴晓蒙夏雨婷刘静茆达干南京农业大学动物科技学院

【背景】山羊繁殖力对肉羊产业有直接影响，而围产期是山羊繁殖过程中特殊的生理时期，此时母畜采食量减少，能量摄入降低，同时子代的营养需求急剧增加，母羊在此阶段容易进入能量负平衡状态，诱发一系列不良反应，如代谢疾病，炎症... 详细信息

【背景】山羊繁殖力对肉羊产业有直接影响，而围产期是山羊繁殖过程中特殊的生理时期，此时母畜采食量减少，能量摄入降低，同时子代的营养需求急剧增加，母羊在此阶段容易进入能量负平衡状态，诱发一系列不良反应，如代谢疾病，炎症反应，造成免疫抑制甚至流产等问题。【目的】通过对围产期日粮添加姜黄素缓解母羊能量负平衡状态，从山羊生产性能、血液指标和炎症因子基因表达等方面入手，为改善围产期山羊健康提出可行路径。【方法】选择18只妊娠122 d（即产前28 d）的经产苏白母山羊，分为对照组（无添加，Con）和姜黄素组(Curcumin, 下文缩写Cur补充Cur 800 mg·kg-1DMI)。采集母羊产前21 d(d-21)、产后0（d0）和21 d(d21)的血液，测定生产性能、血液指标及炎症因子基因表达。【结果】Cur处理不影响母羊采食量、羔羊出生体重体尺和日增重；两组母羊分娩前后采食量均表现为先下降后升高的趋势，在分娩当日采食量最低（P=0.097）。Cur处理有提高血清葡萄糖含量的趋势（P=0.075）。Cur处理显著降低d0和d21的血清游离脂肪酸（NEFA）含量（P0.05）。 Cur处理有提高d21总抗氧化能力（T-AOC）水平的趋势（P=0.073），显著降低了d0丙二醛（MDA）含量，但不影响超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）水平（P>0.05）。Cur处理不影响免疫球蛋白A（Ig A）、免疫球蛋白G（Ig G）和免疫球蛋白M（Ig M）含量（P>0.05）。Cur处理显著升高d21核转录因子红系2（Nrf2）表达量（P0.05）。【结论】围产期日粮添加姜黄素能在一定程度上降低围产期母羊的血清游离脂肪酸水平，增强抗氧化性能，降低炎症反应。

关键词：围产期山羊生产性能脂代谢免疫炎症抗氧化

Maternal Burnout: Prevalence and Associated Factors in Northern Benin (2023)

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Open Journal of Psychiatry 2024年第1期14卷 29-44页

作者： Ireti Nethania Elie Ataigba Guy Gérard Aza Gnandji David Sinet Koivogui Owèrè Charlotte dagan Coovi Ignace Tokpanoude Kwamé Abdias Adoufou Anselme Djidonou Francis Tognon Tchegnonsi Prosper Gandaho Institut de Formation en Soins Infirmiers et Obstétricaux Faculté de Médecine Université de Parakou Parakou Bénin Service de Psychiatrie Centre Hospitalier Universitaire Départemental du Borgou Alibori Parakou Bénin Organisation Non Gouvernementale de Soutien Réhabilitation Insertion et Réinsertion (SouRIR ONG) Parakou Bénin Faculté des Sciences de la Santé Université d’Abomey-Calavi Cotonou Bénin Service de Psychiatrie Centre National Hospitalier Universitaire Hubert Koutoucou Maga de Cotonou Cotonou Bénin Faculté des Sciences et Techniques de la Santé Université Gamal Abdel Nasser de Conakry Conakry Guinée

Introduction: Also known as maternal burnout syndrome, maternal burnout is a state of physical, emotional and mental exhaustion generated by prolonged stress in the family environment. It is experienced by women in their role as mothers. Those affected can develop psychological disorders, sleep disturbances, etc., all of which impair their day-to-day lives, and thus their maternal role. The repercussions affect both the child and other family members. Objective: The aim of the present study was to investigate maternal burnout among female users of public and private health facilities in the commune of Parakou in 2023. Methods: Descriptive cross-sectional study was conducted from December 2022 to July 2023 among all mothers using public and private health facilities in the commune of Parakou. All healthy mothers with at least one biological or adoptive child fully dependent on them and living at home, who came for a consultation in one of the health facilities or for an appointment at the Expanded Program on Immunization (EPI) and gave their free and informed consent. Sampling was done for non-exhaustive convenience were included in the study. Burnout was assessed using the Parental Burnout Assessment (PBA) scale. Results: A total of 888 mothers meeting the inclusion criteria were surveyed. The prevalence of burnout calculated using the Parental Burnout Assessment (PBA) scale was 6.19%. The risk factors for maternal burnout were poor relationships with family and friends (OR = 8.90;p = 0.045), moderate (OR = 11.71;p = 0.020) and severe depression (OR = 40.85;p = 0.001), followed by the presence of repeated nocturnal awakening (OR = 5.14;p = 0.014). Conclusion: This is a subject that is almost never discussed in African society, but whose reality is revealed by the present study, which provided statistical data on maternal burnout. From now on, the risk of burnout will no longer be discussed solely in the family context. It will also need to be explored within the fam

关键词： Burnout Maternal Benin 2023

Responsive Janus Structural Color Hydrogel Micromotors for Label-Free Multiplex Assays

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Research 2021年第1期2021卷 1183-1191页

作者： Huan Wang Lijun Cai dagan Zhang Luoran Shang Yuanjin Zhao Department of Clinical Laboratory Institute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210002China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Shanghai Xuhui Central Hospital Zhongshan-Xuhui Hospitaland The Shanghai Key Laboratory of Medical EpigeneticsThe International Co-Laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032China Chemistry and Biomedicine Innovation Center Nanjing UniversityNanjing 210023China

Micromotors with self-propelling ability demonstrate great values in highly sensitive *** novel micromotors to achieve label-free multiplex assay is particularly intriguing in terms of detection ***,structural color micromotors(SCMs)were developed and employed for this *** SCMs were derived from phase separation of droplet templates and exhibited a Janus structure with two distinct sections,including one with structural colors and the other providing catalytic selfpropelling ***,the SCMs were functionalized with ion-responsive aptamers,through which the interaction between the ions and aptamers resulted in the shift of the intrinsic color of the *** was demonstrated that the SCMs could realize multiplex label-free detection of ions based on their optical coding capacity and responsive ***,the detection sensitivity was greatly improved benefiting from the autonomous motion of the SCMs which enhanced the ion-aptamer *** anticipate that the SCMs can significantly promote the development of multiplex assay and biomedical fields.

关键词： template autonomous structural

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非常规油气储层智能压裂技术研究进展与展望

天然气工业 2024年第9期44卷 13-26页

作者：郭建春张宇曾凡辉胡大淦白小嵩龚高彬任文希油气藏地质与开发工程全国重点实验室·西南石油大学

非常规储层油气资源丰富,压裂是释放非常规储层油气的必要手段,但压裂优化是一个多模态、高维度、大尺度、细时空的复杂大系统问题。为实现非常规储层压裂系统开发,梳理了油气压裂人工智能3个应用场景:透明油气藏数智化构建和压裂双甜... 详细信息

非常规储层油气资源丰富,压裂是释放非常规储层油气的必要手段,但压裂优化是一个多模态、高维度、大尺度、细时空的复杂大系统问题。为实现非常规储层压裂系统开发,梳理了油气压裂人工智能3个应用场景:透明油气藏数智化构建和压裂双甜点智能优选、机理—数据联合驱动的压裂工艺参数智能优化和压裂风险预警及在线监控智能调控,然后明确了智能压裂3个方面技术特征,并展望了智能压裂未来5个方面的技术攻关方向。研究结果表明:(1)形成了地质多源数据、建模迭代更新精准化技术,助力了优选地质工程压裂双甜点;(2)建立了机理数据驱动多目标优化压裂参数方法,促进了裂缝均衡扩展、扩大体积和提高产量;(3)开发了压裂动态监测及在线调控流程,支撑了压裂高效、可持续开发,提高压裂效率和油气采收率;(4)提出了“甜点选择数智化—压裂参数智能化—在线监测调控精准化—四维可视化”的地质—工程“动态一体化”智能压裂新理念。结论认为,强化数字孪生智能压裂可视化技术、构建生成式智能压裂大数据生态系统、融合机理数据的工艺参数优化方法、开发压裂动态智能预测监测技术、创新远程智能压裂决策控制系统,可为智能压裂革新发展提供理论指导和技术支撑,为未来压裂人机交互智能决策和闭环调控的实现指明了方向。

关键词：非常规储层智能压裂透明油气藏数智化机理数据驱动风险预警与在线调控数字孪生

A Review of Predictive and Contrastive Self-supervised Learning for Medical Images

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Machine Intelligence Research 2023年第4期20卷 483-513页

作者： Wei-Chien Wang Euijoon Ahn dagan Feng Jinman Kim Biomedical and Multimedia Information Technology(BMIT)Research Group School of Computer ScienceThe University of SydneySydneyNSW2006Australia College of Science and Engineering James Cook UniversityCairnsQLD4811Australia

Over the last decade, supervised deep learning on manually annotated big data has been progressing significantly on computer vision tasks. But, the application of deep learning in medical image analysis is limited by the scarcity of high-quality annotated medical imaging data. An emerging solution is self-supervised learning (SSL), among which contrastive SSL is the most successful approach to rivalling or outperforming supervised learning. This review investigates several state-of-the-art contrastive SSL algorithms originally on natural images as well as their adaptations for medical images, and concludes by discussing recent advances, current limitations, and future directions in applying contrastive SSL in the medical domain.

关键词： Self-supervised learning(SSL) contrastive learning deep learning medical image analysis computer vision

ISO 15189:2012和ISO 15189:2022的不符合对照分析及换版策略

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临床检验杂志 2024年第4期42卷 304-307页

作者：何菁胡长爱杨大干绍兴文理学院附属医院检验科浙江绍兴312000 浙江大学医学院附属第一医院检验科杭州310003

目的通过分析ISO 15189:2012与ISO 15189:2022版标准的不符合项,为实验室换版工作提供改进策略。方法收集24家实验室32次现场评审的522项ISO 15189:2012不符合项目,并将其对应到ISO 15189:2022版标准的相关条款。基于标准要求、文献研... 详细信息

目的通过分析ISO 15189:2012与ISO 15189:2022版标准的不符合项,为实验室换版工作提供改进策略。方法收集24家实验室32次现场评审的522项ISO 15189:2012不符合项目,并将其对应到ISO 15189:2022版标准的相关条款。基于标准要求、文献研究和实验室现状,探讨ISO 15189换版的工作策略。结果每次现场评审平均16条不符合项,最少8条,最多31条。这些不符合项主要集中在ISO 15189:2022版7.3检验过程(165条)、6.5设备校准和计量学溯源(43条)、6.6试剂和耗材(40条)等条款要求。而对于风险管理、患者相关要求、即时检验等新增或加强的条款要求,不符合项相对较少。结论ISO 15189:2022版标准的不符合项主要集中在检验过程环节,建议实验室利用数字化、智能化技术手段,加强这一环节的管理,以顺利实施新版标准要求,并通过组织培训、差距分析、文件修订、全员参与实施、加强风险管理和持续改进等策略,确保换版工作的顺利推进。

关键词：医学实验室认可不符合项风险管理 ISO 15189:2022