Responsive Janus Structural Color Hydrogel Micromotors for Label-Free Multiplex Assays

作     者：Huan Wang Lijun Cai Dagan Zhang Luoran Shang Yuanjin Zhao Huan Wang;Lijun Cai;Dagan Zhang;Luoran Shang;Yuanjin Zhao

作者机构：Department of Clinical LaboratoryInstitute of Translational MedicineThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210002China The Eighth Affiliated HospitalSun Yat-Sen UniversityShenzhen 518033China State Key Laboratory of BioelectronicsSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Shanghai Xuhui Central HospitalZhongshan-Xuhui Hospitaland The Shanghai Key Laboratory of Medical EpigeneticsThe International Co-Laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)Institutes of Biomedical SciencesFudan UniversityShanghai 200032China Chemistry and Biomedicine Innovation CenterNanjing UniversityNanjing 210023China 

出 版 物：《Research》 (研究（英文）)

年 卷 期：2021年第2021卷第1期

页      面：1183-1191页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 

基　　金：supported by the National Key Research and Development Program of China(2020YFA0908200) the National Natural Science Foundation of China(52073060,61927805,82102511,and 22002018) the Guangdong Basic and Applied Basic Research Foundation(2019A1515011750) the Shenzhen Fundamental Research Program(JCYJ20190813152616459 and JCYJ20190808120405672) 

主　　题：template autonomous structural 

摘      要：Micromotors with self-propelling ability demonstrate great values in highly sensitive *** novel micromotors to achieve label-free multiplex assay is particularly intriguing in terms of detection ***,structural color micromotors(SCMs)were developed and employed for this *** SCMs were derived from phase separation of droplet templates and exhibited a Janus structure with two distinct sections,including one with structural colors and the other providing catalytic selfpropelling ***,the SCMs were functionalized with ion-responsive aptamers,through which the interaction between the ions and aptamers resulted in the shift of the intrinsic color of the *** was demonstrated that the SCMs could realize multiplex label-free detection of ions based on their optical coding capacity and responsive ***,the detection sensitivity was greatly improved benefiting from the autonomous motion of the SCMs which enhanced the ion-aptamer *** anticipate that the SCMs can significantly promote the development of multiplex assay and biomedical fields.