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Direct interaction of DNMT inhibitors to PrP^C suppresses pathogenic process of prion

Acta Pharmaceutica Sinica B 2019年第5期9卷 952-959页

作者： dae-Hwan kim Chunyan Ren Chongsuk Ryou Jiaojie Li Institute of Pharmaceutical Science and Technology Hanyang UniversityAnsan15588Republic of Korea School of Undergraduate Studies College of Transdisciplinary StudiesDaegu Gyeongbuk Institute of Science and TechnologyDaegu42988Republic of Korea Boston Children’s Hospital Harvard Medical SchoolBostonMA02115USA Department of Pharmacy Hanyang UniversityAnsan15588Republic of Korea Department of Chemistry Gwangju Institute of Science and TechnologyGwangju61005Republic of Korea

The conversion of the normal cellular prion protein(PrP^C) to the misfolded pathogenic scrapie prion protein(Pr PSc) is the biochemical hallmark of prion replication. So far, various chemical compounds that inhibit this conformational conversion have been identified. Here, we report the novel anti-prion activity of SGI-1027 and its meta/meta analogue(M/M), previously known only as potent inhibitors of DNA methyltransferases(DNMTs). These compounds effectively decreased the level of Pr PSc in cultured cells with permanent prion infection, without affecting PrP^Cat the transcriptional or translational levels. Furthermore, SGI-1027 prevented effective prion infection of the cells. In a Pr P aggregation assay, both SGI-1027 and M/M blocked the formation of misfolded Pr P aggregates, implying that binding of these compounds hinders the Pr P conversion process. A series of binding and docking analyses demonstrated that both SGI-1027 and M/M directly interacted with the C-terminal globular domain of PrP^C, but only SGI-1027 bound to a specific region of PrP^C with high affinity, which correlates with its potent antiprion efficacy. Therefore, we report SGI-1027 and related compounds as a novel class of potential antiprion agents that preferentially function through direct interaction with PrP^C.

关键词： Prion DNMT Therapeutic compounds PrP^C Epigenetic regulation

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FEA technique of hot plate forming process using cell-typed die with cooling device

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中国有色金属学会会刊：英文版 2012年第S3期22卷 831-837页

作者： Jung-Min LEE In-Kyu LEE Kyung-Hun LEE dae-Soon kim Byung-Min kim Dongnam Regional Division Korea Institute of Industrial Technology School of Mechanical Engineering Pusan National University Industrial Technology Division Hyundai Heavy Industries

Hot plate forming using a cell-typed die is a process for forming a large thick plate with a spherical shape for the manufacture of a large spherical LNG ***-typed upper and lower dies made of a framework of steel plates fitted to make a grid pattern are used in this process,and an air-cooling device is separately installed inside the lower die.A finite element analysis (FEA) technique was developed,which included hot forming,air flow,cooling and thermal deformation analysis for the hot plate forming process using the cell-typed ***,the convective and interface heat transfer coefficients were used to reproduce analytically the effects of the cooling device in the hot plate forming analysis.A small-scale model test of the process was conducted to verify the FEA *** analysis results show that the curvature of the final plate agrees well with that of the designed experiment within a maximum relative error of 0.03% at the corner of the plate.

关键词： cell-typed die hot plate forming spherical LNG tank heat transfer coefficient

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Comparative study of tensile and high-cycle fatigue properties of extruded AZ91 and AZ91-0.3Ca-0.2Y alloys

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Journal of Materials Science & Technology 2021年第34期93卷 41-52页

作者： Ye Jin kim Young Min kim Seong-Gu Hong dae Woong kim Chong Soo Lee Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Division of Industrial Metrology Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Energy Infra Material Measure Team Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Graduate Institute of Ferrous Technology Pohang University of Science and Technology.Pohang 37673Republic of Korea

Mg-Al-Zn-Ca-Y alloys with excellent ignition and corrosion resistances—termed SEN alloys(where the letters"S,""E,"and"N"stand for stainless,environmentally friendly,and non-flammable,respectively)—have been developed *** this study,the microstructure,tensile properties,and high-cycle fatigue properties of an extruded Mg-9.0Al-0.8Zn-0.1Mn-0.3Ca-0.2Y(SEN9)alloy are investigated and compared with those of a commercial Mg-9.0Al-0.8Zn-0.1Mn(AZ91)alloy extruded under the same *** the extruded SEN9 alloy and the extruded AZ91 alloy have a fully recrystallized structure comprising equiaxed grains,but the former has a smaller average grain size owing to the promoted dynamic recrystallization during *** extruded AZ91 alloy contains coarse Mg_(17)Al_(12) discontinuous precipitate(DP)bands parallel to the extrusion direction,which are formed during its cool down after *** contrast,the extruded SEN9 alloy contains relatively fine undissolved Al_(2)Ca,Al_(8)Mn_(4)Y,and Al_(2)Y second-phase particles,which are formed during the solidification stage of the casting *** tensile strength of the extruded SEN9 alloy,which has finer grains and more abundant particles,is slightly higher than that of the extruded AZ91 ***,the difference in their strengths is relatively small because the stronger solid-solution hardening and precipitation hardening effects in the extruded AZ91alloy offset the stronger grain-boundary hardening and dispersion hardening effects in the extruded SEN9alloy to some *** tensile elongation of the extruded AZ91 alloy is significantly lower than that of the extruded SEN9 alloy because the large cracks formed in the DP bands in the former cause its premature *** the extruded SEN9 alloy has higher tensile properties than the extruded AZ91alloy,the high-cycle fatigue life and fatigue strength of the former are shorter and lower,respectively,than those of the *** DP bands in the extruded

关键词： Mg-Al-Zn-Ca-Y alloy Extrusion Tensile properties High-cycle fatigue Crack source

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60 years of Rabinowicz' criterion for adhesive wear

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Friction 2018年第3期6卷 341-348页

作者： Elena POPOVA Valentin L.POPOV dae-Eun kim Institute of Mechanics Technische Universit?t Berlin School of Mechanical Engineering Yonsei University Center for Nano-Wear Yonsei University

60 years ago, in 1958, Ernest Rabinowicz published a 5 page paper titled "The effect of size on the looseness of wear fragments" where he suggested a criterion determining the minimum size of wear particles. The criterion of Rabinowicz is based on the consideration of the interplay of elastic energy stored in "asperities" and the work of separation needed for detaching a wear particle. He was probably the first researcher who explicitly emphasized the role of adhesion in friction and wear. In a recent paper in Nature Communications, Aghababaei, Warner and Molinari confirmed the criterion of Rabinowicz by means of quasi-molecular dynamics and illustrated the exact mechanism of the transition from plastic smoothing to formation of wear debris. This latter paper promoted the criterion of Rabinowicz to a new paradigm for current studies of adhesive wear. The size arguments of Rabinowicz can be applied in the same form also to many other problems, such as brittle-ductile transition during indentation, cutting of materials or ultimate strength of nano-composites.

关键词： adhesion plasticity wear Archard's law of wear Rabinowicz criterion surface topography history of Tribology

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Development of twin wheel creep-feed grinding machine using continuous dressing for machining of aircraft rotary wing

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Journal of Central South University 2011年第3期18卷 704-710页

作者： kim Jin-seob HWANG Jong-dae JUNG Yoon-gyo School of Mechatronics Changwon National University

The purpose of this study is to develop a twin wheel creep-feed grinding machine using continuous dressing to machine precise axisymmetric turbine blades that have been difficult to machine using a conventional creep-feed *** order to develop such a machine,3D-modeling and machine simulations were performed and a twin wheel creep-feed grinding machine was ***,the axisymmetric precision of the machined workpieces through practical machining was evaluated and the quality of the continuous dressing effect of the developed machine was *** addition,experimental considerations for a proper dresser-to-wheel speed ratio and proper feed rate of the dresser were carried *** a result,a twin wheel creep-feed grinding machine with continuous dressing is developed through machine simulation,manufacturing and performance *** condition for the dresser feed rate is 0.3μm/*** cases of large dressor-to-wheel speed ratio,grinding efficiency can be enhanced,but the surface roughness shows a conflicting *** twin wheel creep-feed grinding machine has satisfactory appraisal with regard to surface roughness,flatness,and *** surface roughness below 0.1μm can be obtained for the blade of ***,in order to perform precise machining,it is necessary to improve the structure of the twin wheel creep-feed grinding machine.

关键词： creep-feed grinding twin wheel surface roughness grinding force continuous dressing flatness parallelism

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Effects of ozonation and coagulation on effluent organic matter characteristics and ultrafiltration membrane fouling

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Journal of Environmental Sciences 2014年第6期26卷 1325-1331页

作者： Kwon Jeong dae-Sung Lee Do-Gun kim Seok-Oh Ko Department of Civil Engineering Kyung Hee UniversityYongin 446-701 Korea Institute of Construction Technology KUMHO Engineering & ConstructionYongin 449-822 Korea

Effluent organic matter （EfOM） is the major cause of fouling in the low pressure membranes process for wastewater reuse. Coagulation and oxidation of biological wastewater treatment effluent have been applied for the fouling control of microfiltration membranes. However, the change in EfOM structure by pre-treatments has not been clearly identified. The changes of EfOM characteristics induced by coagulation and ozonation were investigated through size exclusion chromatography, UV/Vis spectrophotometry, fluorescence spectrophotometry and titrimetric analysis to identify the mechanisms in the reduction of ultrafiltration （UF） membrane fouling. The results indicated that reduction of flux decline by coagulation was due to modified characteristics of dissolved organic carbon （DOC） content. Total concentration of DOC was not reduced by ozonation. However, the mass fraction of the molecules with molecular weight larger than 5 kDa, fluorescence intensity, aromaticity, highly condensed chromophores, average molecular weight and soluble microbial byproducts decreased greatly after ozonation. These results indicated that EfOM was partially oxidized by ozonation to low molecular weight, highly charged compounds with abundant electron- withdrawing functional groups, which are favourable for alleviating UF membrane flux decline.

关键词： effluent organic matter fouling ultrafiltration oxidation molecular weight distribution acidity

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A Study of BERT-Based Classification Performance of Text-Based Health Counseling Data

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Computer Modeling in Engineering & Sciences 2023年第4期135卷 795-808页

作者： Yeol Woo Sung dae Seung Park Cheong Ghil kim Namseoul University CheonanChungcheongnam-doKorea

The entry into a hyper-connected society increases the generalization of communication using ***,research to analyze big data accumulated in SNS and extractmeaningful information is being conducted in various *** particular,with the recent development of Deep Learning,the performance is rapidly improving by applying it to the field of Natural Language Processing,which is a language understanding technology to obtain accurate contextual *** this paper,when a chatbot system is applied to the healthcare domain for counseling about diseases,the performance of NLP integrated withmachine learning for the accurate classification ofmedical subjects from text-based health counseling data becomes *** the various algorithms,the performance of Bidirectional Encoder Representations from Transformers was compared with other algorithms of CNN,RNN,LSTM,and *** this purpose,the health counseling data of Naver Q&A service were crawled as a *** was used to classify medical subjects according to symptoms and the accuracy of classification results was *** simulation results show that KoBERTmodel performed high performance by more than 5%and close to 18%as large as the smallest.

关键词： BERT NLP deep learning healthcare machine learning

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Home Range Size and Overlap of the Small Nocturnal Schlegel’s Japanese Gecko (Gekko japonicus), Introduced into a City Park in Korea

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Asian Herpetological Research 2019年第4期10卷 261-269页

作者： Il-Kook PARK dae-In kim Jonathan JFONG daesik PARK Department of Biology Kangwon National UniversityChuncheonKangwon 24341South Korea Science Unit Lingnan UniversityTuen MunNew TerritoriesHong KongChina Division of Science Education Kangwon National UniversityChuncheonKangwon 24341South Korea

Studying the home range of an organism is important in understanding its ecology. Due to being cryptic, few studies have been conducted on the home range studies of small, nocturnal geckos. We conducted radio-tracking surveys for 23 individuals to estimate the home range size and home range overlap of the Schlegel’s Japanese gecko(Gekko japonicus) previously introduced into a suburban city park. Individuals were commonly found in artificial structures(buildings and accessory structures) and on nearby natural trees. Daily moved distance was positively correlated with home range size. Minimum convex polygon(MCP) home range was 97.8 m^2 for females and 99.5 m^2 for males, on average. Gekko japonicus moved farther daily distances and used wider MCP and Kernel 95 home ranges in breeding season compared to non-breeding season, while the size of Kernel 50 home range did not differ between seasons. Both daily moved distance and home range size were not significantly different between sexes. In the breeding season, MCP and Kernel 50 home ranges of each gecko overlapped with 32.4% and 13.8% of remaining geckos, respectively. Our results not only show that 1) G. japonicus uses both artificial structures and adjacent natural trees as microhabitat, but also suggest that 2) G. japonicus is non-territorial, but has a core habitat that is shared with few other individuals, and 3) the reproductive system of G. japonicus is polygamous.

关键词： radio telemetry invasive species territory lizard Korea

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Remote Navigation of Turtle by Controlling Instinct Behavior via Human Brain-computer Interface

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Journal of Bionic Engineering 2016年第3期13卷 491-503页

作者： Cheol-Hu kim Bongjae Choi dae-Gun kim Serin Lee Sungho Jo Phill-Seung Lee Department of Mechanical Engineering Korea Advanced Institute of Science and Technology (KAIST) 373-1 Guseong-dong Yuseong-gu Daejeon 34141 Republic of Korea School of Computing Science Korea Advanced Institute of Science and Technology (KAIST) 373-1 Guseong-dong Yuseong-gu Daejeon 34141 Republic of Korea Instituteforlnfocomm Research 1 Fusionopolis Way #21-01 Connexis (South Tower) 138632 Singapore

Brain-Computer Interface （BCI） techniques have advanced to a level where it is now eliminating the need lor hand-based activation. This paper presents a novel attempt to remotely control an animal＇s behavior by human BCI using a hybrid of Event Related Desynchronization （ERD） and Steady-State Visually Evoked Potential （SSVEP） BCI protocols. The turtle was chosen as the target animal, and we developed a head-mounted display, wireless communication, and a specially designed stimulation device for the turtle. These devices could evoke the turtle＇s instinctive escape behavior to guide its moving path, and turtles were remotely controlled in both indoor and outdoor environments. The system architecture and design were presented. To demon- strate the feasibility of the system, experimental tests were performed under various conditions. Our system could act as a framework for future human-animal interaction systems.

关键词： brain-computer interface turtle (Trachemys scripta elegans) remote navigation instinct behaviour escape be- havior

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Identifying the relationships between subsurface absorber defects and the characteristics of kesterite solar cells

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Carbon Energy 2023年第8期5卷 42-54页

作者： dae-Ho Son Dong-Hwan Jeon dae-Hwan kim Jin-Kyu Kang Shi-Joon Sung Jaebaek Lee Taeseon Lee Enkhjargal Enkhbayar JunHo kim Kee-Jeong Yang Division of Energy Technology DGISTDaeguRepublic of Korea Research Center for Thin Film Solar Cells DGISTDaeguRepublic of Korea Department of Physics Incheon National UniversityIncheonRepublic of Korea

Understanding the defect characteristics that occur near the space-charge regions(SCRs)of kesterite(CZTSSe)solar cells is important because the recombination loss at the CZTSSe/CdS interface is considered the main cause of their low *** surfaces with different elemental compositions were formed without polishing(C00)and with polishing for 20 s(C20)and 60 s(C60).For C60,a specific region near the SCR was excessively Cu-rich and Zn-poor compared to C00 and *** charged defects formed where the elemental variation was *** the main deep acceptor defect energy level(E_(a2))near the SCR increased,the efficiency,open-circuit voltage deficit,and current density degraded,and this phenomenon was especially rapid for large E_(a2) *** the E_(a2) near the SCR became deep,the carrier diffusion length decreased more for the CZTSSe solar cells with a low carrier mobility than for the CuInGaSe_(2)(CIGSe)solar *** large amplitude of the electrostatic potential fluctuation in the CZTSSe solar cells induced a high carrier recombination and a short carrier ***,the properties of the CZTSSe solar cells were more strongly degraded by defects with deep energy levels near the SCR than those of the CIGSe solar cells.

关键词： defect density defect energy level elemental variation kesterite space charge region

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