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Asian Journal of Andrology 2024年第1期26卷 67-70页

作者： Marcello Henrique Araujo da Silva Gabriela Faria Buys-Goncalves Joao Henrique Duque Reis Estrada Francisco Jose Barcellos Sampaio Diogo Benchimol de Souza Urogenital Research Unit Rio de Janeiro State UniversityRio de Janeiro 20551-030RJBrazil

the objective of this study was to investigate whether treatment with tribulus terrestris(tt)has any impact on the testicular morphology and function in a rodent *** male rats were divided into a control group and a group receiving 100 mg kg^(-1) body weight of tt *** 4o days of experiment,the animals were submitted to euthanasia;epididymal tail spermatozoa were collected;and spermatozoa concentration,motility,and viability were *** addition,testicles were collected and processed for histomorphometrical *** were compared using the Student's t-test and considered significant when Ptration,motility,and viability showed no difference between the ***,testicular weight and volume,seminiferous tubule diameter,tunica propria surface density,seminiferous epithelium surface density,and intertubular compartment surface density were statistically similar between the ***,seminiferous epithelium height and tubular lumen surface density were augmented in animals treated with *** with tt does not cause a major impact on testicular morphology,promoting only subtle *** difference on spermatozoa parameters was observed.

关键词： morphometry testicle tribulus terrestris

Immune Regulatory Networks and therapy of yδt Cells in Liver Cancer:Recent trends and Advancements

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Journal of Clinical and translational Hepatology 2024年第3期12卷 287-297页

作者： Kun-Li Yin Kai-Jian Chu Ming Li Yu-Xin Duan Yan-Xi Yu Mei-Qing Kang da Fu Rui Liao Department of Hepatobiliary Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqingChina Biliary Surgical Department I the Eastern Hepatobiliary Surgical HospitalNaval Medical UniversityShanghaiChina General Surgery Institute of Pancreatic DiseasesRuijin HospitalShanghai Jiaotong University School of MedicineShanghaiChina

the roles of γδ t cells in liver cancer,especially in the poten-tial function of immunotherapy due to their direct cytotoxic effects on tumor cells and secretion of important cytokines and chemokines,have aroused research *** re-view briefly describes the basic characteristics of γδ t cells,focusing on their diverse effects on liver *** particular,different subtypes of γδ t cells have diverse or even opposite effects on liver *** provide a detailed description of the immune regulatory network of γδ t cells in liver can-cer from two aspects:immune components and nonimmune *** interactions between various components in this immune regulatory network are dynamic and pluralis-tic,ultimately determining the biological effects of γδ t cells in liver *** also integrate the current knowledge of γδ t-cell immunotherapy for liver cancer treatment,emphasiz-ing the potential of these cells in liver cancer immunotherapy.

关键词： Liver cancer γδt cells Immunotherapy tumor microenvironment

Correlation between cerebral neurotransmitters levels by proton magnetic resonance spectroscopy and HbA1c in patients with type 2 diabetes

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World Journal of Diabetes 2024年第6期15卷 1263-1271页

作者： Xiang-Yu Gao Chen-Xia Zhou Hong-Mei Li Min Cheng da Chen Zi-Yi Li Bo Feng Jun Song Department of Endocrinology East HospitalTongji University School of MedicineShanghai 200120China Department of Endocrinology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266000Shandong ProvinceChina Department of Immunization Program Huangdao District Center for Disease Prevention and ControlQingdao 266400Shandong ProvinceChina

BACKGROUND Cognitive dysfunction is the main manifestation of central *** cognitive impairments tend to be overlooked in patients with diabetes mellitus(DM),there is a growing body of evidence linking DM to cognitive *** is closely related to neurological abnormalities,while often disregarded in clinical *** in cerebral neurotransmitter levels are associated with a variety of neurological abnormalities and may be closely related to blood glucose control in patients with type 2 DM(t2DM).AIM to evaluate the concentrations of cerebral neurotransmitters in t2DM patients exhibiting different hemoglobin A1c(HbA1c)*** A total of 130 t2DM patients were enrolled at the Department of Endocrinology of Shanghai East *** participants were divided into four groups according to their HbA1c levels using the interquartile method,namely Q1(data were collected and measured,including age,height,weight,neck/waist/hip circumferences,blood pressure,comorbidities,duration of DM,and biochemical ***,neurotransmitters in the left hippocampus and left brainstem area were detected by proton magnetic resonance *** the HbA1c level was significantly associated with urinary microalbumin(mALB),triglyceride,low-density lipoprotein cholesterol(LDL-C),homeostasis model assessment of insulin resistance(HOMA-IR),and beta cell function(HOMA-β),N-acetylaspartate/creatine(NAA/Cr),and NAA/choline(NAA/Cho).Spearman correlation analysis showed that mALB,LDL-C,HOMA-IR and NAA/Cr in the left brainstem area were positively correlated with the level of HbA1c(Ptively correlated with the HbA1c level(Ptiple logistic regression analysis showed that NAA/Cho[Odds ratio(OR):1.608,95%confidence interval(95%CI):1.004-2.578,P<0.05],LDL-C(OR:1.627,95%CI:1.119-2.370,P<0.05),and HOMA-IR(OR:1.107,95%CI:1.031-

关键词： type 2 diabetes mellitus Hemoglobin A1c Proton magnetic resonance spectroscopy Neurotransmitters Central neuropathy

Systemic inflammatory response index is a predictor of prognosis in gastric cancer patients: Retrospective cohort and meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 382-395页

作者： Jing-Yao Ren Meng Xu Xiang-Dong Niu Shi-Xun Ma Ya-Jun Jiao da Wang Miao Yu Hui Cai School of Clinical Medicine Ningxia Medical UniversityYinchuan 750000Ningxia Hui autonomous regionChina Gansu Provincial Hospital Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Medical College of Jiangsu University Jiangsu UniversityZhenjiang 212013Jiangsu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND the systemic inflammatory response index(SIRI)has been demonstrated to make a significant difference in assessing the prognosis of patients with different solid ***,research is needed to ascertain the accuracy and reliability of applying the SIRI to patients who undergo robotic radical gastric cancer *** to validate the applicability of the SIRI in assessing the survival of gastric cancer patients and evaluate the clinical contribution of preoperative SIRI levels to predicting long-term tumor outcomes in patients,who received robotic radical gastric cancer *** Initially,an exhaustive retrieval was performed in the PubMed,the Cochrane Library,EMBASE,Web of Science,and Scopus databases to identify relevant ***,a meta-analysis was executed on 6 cohort studies iden-tifying the value of the SIRI in assessing the survival of gastric cancer ***,the clinical data of 161 patients undergoing robotic radical gastric cancer surgery were retrospectively analyzed to evaluate their clinicopathological characteristics and relevant laboratory *** association between preoperative SIRI levels and 5-year overall survival(OS)and disease-free survival(DFS)was *** the findings demonstrated an extensive connection between SIRI values and the outcome of patients with gastric *** SIRI levels were identified as an independent hazard feature for both OS and DFS among those who received robotic surgery for gastric *** levels in gastric cancer patients were observed to be associated with the presence of comorbidities,t-stage,carcinoembryonic antigen levels,the development of early serious postoperative complications,and the rate of lymph node *** SIRI values are correlated with adverse in the gastric cancer population and have the potential to be utilized in predicting long-term oncological survival in patients who undergo robotic radical gastric canc

关键词： Systemic inflammatory response index Prognosis Gastric cancer Complications Meta-analysis

Detection of Novel BESt1 Variations in Autosomal Recessive Bestrophinopathy Using third-generation Sequencing

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Current Medical Science 2024年第2期44卷 419-425页

作者： Jia-xun LI Ling-rui MENG Bao-ke HOU Xiao-lu HAO da-jiang WANG Ling-hui QU Zhao-hui LI Lei ZHANG Xin JIN Department of Senior Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China Department of Ophthalmology the 74th Army Group HospitalGuangzhou 510318China

Objective:Autosomal recessive bestrophinopathy(ARB),a retinal degenerative disease,is characterized by central visual loss,yellowish multifocal diffuse subretinal deposits,and a dramatic decrease in the light peak on *** potential pathogenic mechanism involves mutations in the BESt1 gene,which encodes Ca2+-activated Cl−channels in the retinal pigment epithelium(RPE),resulting in degeneration of RPE and *** this study,the complete clinical characteristics of two Chinese ARB families were ***:Pacific Biosciences(PacBio)single-molecule real-time(SMRt)sequencing was performed on the probands to screen for disease-causing gene mutations,and Sanger sequencing was applied to validate variants in the patients and their family ***:two novel mutations,c.202t>C(chr11:61722628,p.Y68H)and c.867+97G>A,in the BESt1 gene were identified in the two Chinese ARB *** novel missense mutation BESt1 c.202t>C(p.Y68H)resulted in the substitution of tyrosine with histidine in the N-terminal region of transmembrane domain 2 of *** novel variant,BESt1 c.867+97G>A(chr11:61725867),located in intron 7,might be considered a regulatory variant that changes allele-specific binding affinity based on motifs of important transcriptional ***:Our findings represent the first use of third-generation sequencing(tGS)to identify novel BESt1 mutations in patients with ARB,indicating that tGS can be a more accurate and efficient tool for identifying mutations in specific *** novel variants identified further broaden the mutation spectrum of BESt1 in the Chinese population.

关键词： autosomal recessive bestrophinopathy BESt1 gene third-generation sequencing mutation

Analysis of Phenotypes Associated with Deficiency of PAX6 Haplotypes in Chinese Aniridia Families

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Current Medical Science 2024年第4期44卷 820-826页

作者： Xiao-lu HAO Ran CHEN Wei LIU Bao-ke HOU Ling-hui QU Zhao-hui LI da-jiang WANG Xin JIN Hou-bin HUANG Senior Department of Opthalmology the Third Medical Center of Chinese PLA General HospitalBeijing100039China Bolin Eye Care Group Beijing100098China Department of Ophthalmology Hainan Hospital of Chinese PLA General HospitalSanya572000China Department of Ophthalmology the 74th Army Group HospitalGuangzhou510318China

Objective to examine the clinical phenotype and genetic deficiencies present in Chinese aniridia families with PAX6 haplotype *** A comprehensive questionnaire and ophthalmological assessments were administered to both affected patients and unaffected *** clinical feature analysis included the evaluation of visual acuity,intraocular pressure,slit-lamp anterior segment examination,fundus photography,and spectral domain optical coherence *** identify the mutation responsible for aniridia,targeted next-generation sequencing was used as a beneficial *** A total of 4 mutations were identified,consisting of two novel frameshift mutations(c.314delA,p.K105Sfs*33 and c.838_845dup AACACACC,p.S283tfs*85),along with two recurring nonsense mutations(c.307C>t,p.R103X and c.619A>t,p.K207*).Complete iris absence,macular foveal hypoplasia,and nystagmus were consistent in these PAX6 haplotype-deficient Chinese aniridia families,while corneal lesions,cataracts,and glaucoma exhibited heterogeneity both among the families and within the same *** In our study,two novel PAX6 mutations associated with aniridia were identified in Chinese families,which expanded the phenotypic and genotypic spectrum of PAX6 *** also analyzed the clinical characteristics of PAX6 haplotype deficiency in Chinese aniridia families.

关键词： aniridia PAX6 mutation haplotype deficiency phenotype genotype

Seasonal variation and host sex affect bat–bat fly interaction networks in the Amazonian savannahs

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Integrative Zoology 2024年第3期19卷 400-416页

作者： Paulo MEJIA Gustavo Lima URBIEtA Bruna da Silva XAVIER IsaíJorge de CAStRO JoséJúlio DE tOLEDO Gustavo GRACIOLLI Lucio AndréVIANA DIAS William Douglas CARVALHO Programa de Pós-Graduação em Biodiversidade tropical Universidade Federal do Amapá(UNIFAP)MacapáAPBrazil Programa de Pós-Graduação em Ecologia Instituto de BiologiaCentro de Ciências da SaúdeUniversidade Federal do Rio de Janeiro(UFRJ)Rio de JaneiroRJBrazil Laboratório de Mamíferos Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá(IEPA)MacapáAPBrazil Programa de Pós-Graduação em Biologia Animal Laboratório de SistemáticaEcologia e Evolução(LSEE)Instituto de BiociênciasUniversidade Federal de Mato Grosso do Sul(UFMS)Campo GrandeMTBrazil terrestrial Ecology Group(tEG-UAM) Departamento de EcologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridMadridSpain

Bats are the second-most diverse group of mammals in the world,and bat flies are their main ***,significant knowledge gaps remain regarding these antagonistic interactions,especially since diverse factors such as seasonality and host sex can affect their network ***,we explore the influence of such factors by comparing species richness and composition of bat flies on host bats,as well as specialization and modularity of bat–bat fly interaction networks between seasons and adult host *** captured bats and collected their ectoparasitic flies at 10 sampling sites in the savannahs of AmapáState,northeastern region of the Brazilian *** female bats being more parasitized and recording greater bat fly species richness in the wet season,neither relationship was statistically *** pooled network could be divided into 15 compartments with 54 links,and all subnetworks comprised>12 *** total number of links ranged from 27 to 48(for the dry and wet seasons,respectively),and female and male subnetworks had 44 and 41 links,*** values were very low for the pooled network and for all *** results revealed higher bat fly species richness and abundance in the wet season,whereas specialization and modularity were higher in the dry ***,the subnetwork for female bats displayed higher specialization and modularity than the male ***,both seasonality and host sex contribute in different ways to bat–bat fly network *** studies should consider these factors when evaluating bat–bat fly interaction networks.

关键词： Amapá Amazon biome bat flies bats interaction networks

Gut microbiome:A revolution in typeⅡdiabetes mellitus

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World Journal of Diabetes 2024年第9期15卷 1874-1888页

作者： Madhan Jeyaraman tejaswin Mariappan Naveen Jeyaraman Sathish Muthu Swaminathan Ramasubramanian Gabriel Silva Santos Lucas Furtado da Fonseca JoséFábio Lana Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Brazilian Institute of Regenerative MedicineIndaiatuba 13334-170São PauloBrazil Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Community Medicine Government Stanley Medical College and HospitalChennai 600001Tamil NaduIndia Department of Orthopaedics Government Medical CollegeKarur 639004Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

typeⅡdiabetes mellitus(t2DM)has experienced a dramatic increase globally across countries of various income levels over the past three *** persistent prevalence of t2DM is attributed to a complex interplay of genetic and environmental *** numerous pharmaceutical therapies have been developed,there remains an urgent need for innovative treatment approaches that offer effectiveness without significant adverse *** this context,the exploration of the gut microbiome presents a promising *** has increasingly shown that the gut microbiome of individuals with t2DM exhibits distinct differences compared to healthy individuals,suggesting its potential role in the disease’s pathogenesis and *** emerging field offers diverse applications,particularly in modifying the gut environment through the administration of prebiotics,probiotics,and fecal microbiome *** interventions aim to restore a healthy microbiome balance,which could potentially alleviate or even reverse the metabolic dysfunctions associated with *** current results from clinical trials have not yet shown dramatic effects on diabetes management,the groundwork has been laid for deeper *** and future clinical trials are critical to advancing our understanding of the microbiome’s impact on *** further elucidating the mechanisms through which microbiome alterations influence insulin resistance and glucose metabolism,researchers can develop more targeted *** potential to harness the gut microbiome in developing new therapeutic strategies offers a compelling prospect to transform the treatment landscape of t2DM,potentially reducing the disease’s burden significantly with approaches that are less reliant on traditional pharmaceuticals and more focused on holistic,systemic health improvements.

关键词： typeⅡdiabetes Gut microbiome Probiotics Prebiotics Fecal microbiota transplantation

tinea of Vellus Hair Caused by trichophyton violaceum in a Child:A Case Report

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International Journal of Dermatology and Venereology 2024年第1期7卷 58-59页

作者： Ge Song Guan-Zhao Liang Wei-da Liu Department of Medical Mycology Hospital for Skin Diseases(Institute of Dermatology)Chinese Academy of Medical Sciences and Peking Union Medical College&Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIsNanjingJiangsu 210042China Center for Global Health School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China

Introduction:tinea of vellus hair is a rare dermatophytosis,caused by dermatophyte infection in the vellus *** clinical symptoms of tinea of vellus hair are more serious and the conventional topical treatment are often ***,we report a case of tinea of vellus hair caused by trichophyton violaceum in a *** presentation:A 7-year-old boy presented with a localized,scaly,and itchy erythema on his left cheek for two *** once used a topical corticosteroid but without any clinical improvement,the erythema was progressively enlarging and spread to the left *** denied any contact with *** microscopy found abundant spores and hyphae on the vellus hair;*** was identified by culture and PCR *** patient was diagnosed with tinea of vellus hair and cured after treating with oral terbinafine 125 mg/day and topical treatment for two *** was no recurrence during the follow-up ***:the clinical symptoms of tinea of vellus hair are often atypical and easy to be *** fungal examination is necessary for suspicious patients and confirmed patients should be treated with oral antifungal ***:the diagnosis and treatment of tinea of vellus hair need to be paid more attention in clinical works.

关键词： tinea vellus hair case report

tunnel entrance crossing spoil heap deformations control by micropile combine with coupling beams

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Geohazard Mechanics 2024年第1期2卷 21-28页

作者： Chunwei Wu Han Xia da Qin Junhui Luo Guangxi Beitou transportation Maintenance technology Group Co. Ltd.Nanning530029China School of transportation Southeast UniversityNanjing211189China Jiangsu Key Laboratory of Urban Underground Engineering and Environmental Safety Southeast UniversityNanjing211189China Guangxi Communications Design Group Co. Ltd.Nanning530029China Guangxi Beitou transportation Maintenance technology Group Co. LTD.Nanning530201China

Aiming at the deformation control problem of the tunnel entrance crossing the spoil heap at the Xialao junction,this paper adopts the micropile combined with the coupling beams method to treat the spoiled *** results show that the excavation of the tunnel after the construction of the micropile and coupling beam will cause vertical deformation of the tunnel and the slope *** main reason is that the soil layer structure is loose,and the tunnel excavation causes the whole displacement of the loose *** addition,the buried depth of the tunnel is shallow,so it cannot form an effective soil *** stability process after the construction of the micropile method is the process of stress redistribution,and the rock and soil are gradually compressed and *** is,the construction by the micropile method changes the surrounding rock level of the tunnel and reduces the height of the soil ***,it is suggested that the tunnel excavation should be carried out when the micropile is constructed after the soil layers are consolidated *** micropile method treats the loose spoiled soil at the tunnel entrance,which saves 73%of the total cost compared with the scheme of directly digging out the accumulation,and the economic beneﬁt is very obvious.

关键词： Micropile Coupling beams Spoil heap Deformation control