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Changes in corneal nerve morphology and function in patients with dry eyes having type 2 diabetes

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World Journal of Clinical Cases 2022年第10期10卷 3014-3026页

作者： Wei Fang Zhong-Xi Lin Hui-Qing Yang Lei Zhao da-Chuan Liu Zhi-Qiang pan Department of Ophthalmology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100005BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Endocrinology Xuanwu HospitalCapital Medical UniversityBeijing 100053China

BACKGROUND Dry eye syndrome(DES)is a common disease with various clinical *** had a significant association with *** reflex(BR)is also known as trigeminal nerve facial *** stimulation of corneal nerves is one of the origins of BR *** parasympathetic fibers sent out through the facial nerve are the outlet of tear *** can be used to assess the function of the corneal nerve closed-loop;however,whether the BR changes in these patients is *** To understand the morphology and function of the corneal nerve in patients with dry eyes having diabetes or *** This study enrolled 131 patients who visited the inpatient and outpatient services of ophthalmology and endocrinology departments between January 2019 to August 2020 with subjective symptoms of dry eyes and non-dry eye reasons,as well as volunteers such as *** patients were divided into four groups:DEwDM,with dry eyes having type 2 diabetes mellitus(T2DM);DMnDE,with T2DM not having dry eyes;DEnDM,with dry eyes not having diabetes;and nDMnDE,with neither dry eyes nor *** tear film break-up time,Schirmer I test,in vivo confocal microscopy,and BR were *** The DEwDM,DMnDE,DEnDM,and nDMnDE groups included 56,22,33,and 20 patients,*** and age were not statistically different among the four *** nerve fiber length(NFL)of patients in the DEwDM,DEnDM,and DMnDE groups reduced(pp=0.014,and p=0.001,respectively).No significant difference in corneal nerve fiber density(NFD)(p=0.083)and corneal nerve branch density(NBD)(p=0.195)was found among the four *** R1 Latency of blink reflexes increased only in the DEwDM group(p=0.008,p=0.001,ppared with the DMnDE,DEnDM,and nDMnDE groups,respectively).The NBD and R1 Latency were different between DEwDM and DEnDM groups in patients with moderate and severe dry *** The corneal nerve morphology changed in patients with dry eyes or diabetes,or

关键词： Blink reflex Corneal nerve Diabetes mellitus Dry eye Tear secretion

preventive effects of autologous bone marrow mononuclear cell implantation on intrahepatic ischemic-type biliary lesion in rabbits

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Hepatobiliary & pancreatic Diseases International 2010年第6期9卷 593-599页

作者： Qu, Zhao-Wei Chen, da-Zhi Sheng, Qin-Song Lang, Ren He, Qiang Wang, Ming-Feng Capital Med Univ Beijing Chaoyang Hosp Dept Hepatobiliary & Pancreaticosplen Surg Beijing 100020 Peoples R China Harbin Med Coll Tumor Hosp Dept Hepatobiliary Surg Harbin 150086 Peoples R China Zhejiang Univ Sch Med Affiliated Hosp 1 Dept Colorectal & Anal Surg Hangzhou 310003 Zhejiang Peoples R China

BACKGROUND: The ischemic-type biliary lesion (ITBL) is one of the most serious biliary complications of liver transplantation. This study aimed to investigate the effects of autologous bone marrow mononuclear cell (BM-MNC) implantation on neovascularization and the prevention of intrahepatic ITBL in a rabbit model. METHODS: The rabbits were divided into control, experimental model, and cell implantation groups, with 10 in each group. The model of intrahepatic ITBL was established by clamping the hepatic artery and common bile duct. Autologous BM-MNCs were isolated from the tibial plateau by density gradient centrifugation and were implanted through the common hepatic artery. Changes in such biochemical markers as aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyltranspeptidase, total bilirubin and direct bilirubin were measured. Four weeks after operation, cholangiography, histopathological manifestations, differentiation of BM-MNCs, microvessel density and the expression of vascular endothelial growth factor were assessed. RESULTS: Compared with the experimental model group, the BM-MNC implantation group showed superiority in the time to recover normal biochemistry. The microvessel density and vascular endothelial growth factor expression of the implantation group were significantly higher than those of the control and experimental model groups. The ITBL in the experimental model group was more severe than that in the implantation group and fewer new capillary blood vessels occurred around it. CONCLUSIONS: Implanted autologous BM-MNCs can differentiate into vascular endothelial cells, promote neovascularization and improve the blood supply to the ischemic bile duct, and this provides a new way to diminish or prevent intrahepatic ITBL after liver transplantation. (Hepatobiliary pancreat Dis Int 2010; 9:593-599)

关键词： bone marrow mononuclear cell intrahepatic ischemic-type biliary lesion liver transplantation bile duct angiogenesis

An Improved Heuristic Recursive Strategy Based on Genetic Algorithm for the Strip Rectangular packing problem

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自动化学报 2007年第9期33卷 911-916页

作者： ZHANG De-Fu CHEN Sheng-da LIU Yan-Juan Department of Computer Science Xiamen University Xiamen 361005 P. Ft. China

与基因算法结合的改进启发式的递归的策略在这份报纸被介绍。第一，这个方法寻找一些矩形，它有一样的长度或宽度，到没有浪费空间，形成一些层，然后，计算留下包装顺序的高度使用启发式的递归的策略并且使用基因算法的进化能力减少高... 详细信息

与基因算法结合的改进启发式的递归的策略在这份报纸被介绍。第一，这个方法寻找一些矩形，它有一样的长度或宽度，到没有浪费空间，形成一些层，然后，计算留下包装顺序的高度使用启发式的递归的策略并且使用基因算法的进化能力减少高度。基准问题的几个班上的计算结果证明了介绍算法能与已知的进化启发规则竞争。它特别为大测试问题更好表现。

关键词：改良式启发式递归策略遗传算法矩形封装

Mean-Square Exponential Input-to-State Stability of Numerical Solutions for Stochastic Control Systems

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自动化学报 2013年第8期39卷 1360-1365页

作者： Qiao ZHU Jia-Rui CUI Guang-da HU School of Automation and Electrical Engineering University of Science and Technology Beijing Beijing 100083 China

这份报纸处理随机的控制系统(SCS ) 的数字解决方案的吝啬平方的指数的 input-to-state 稳定性(expbe ) 。第一，一个有限时间的强壮的集中条件成立为，这被显示出随机 ? SCS 上的方法。那么，如果并且仅当，我们能看到 SCS 的吝啬平方... 详细信息

这份报纸处理随机的控制系统(SCS ) 的数字解决方案的吝啬平方的指数的 input-to-state 稳定性(expbe ) 。第一，一个有限时间的强壮的集中条件成立为，这被显示出随机 ? SCS 上的方法。那么，如果并且仅当，我们能看到 SCS 的吝啬平方的 expbe 成立的随机 ? 方法(为足够地小的步尺寸) 在有限时间的强壮的集中条件下面被保存。为有片面 Lipschitz 飘移的 SCS 的一个班，第二，它被证明那二含蓄的 Euler 方法(为任何步尺寸) 能继承 SCS 的吝啬平方的 expbe 性质。最后，数字例子证实在这研究介绍的定理的正确性。

关键词：随机控制系统状态稳定性数值解输入 Lipschitz 隐式Euler方法有限时间收敛条件

Visualization of hydraulic fracture interacting with pre-existing fracture

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petroleum Science 2023年第6期20卷 3723-3735页

作者： Zi-Xiao Xie Xiao-Guang Wu Teng-da Long Zhong-Wei Huang Gen-Sheng Li Wen-Chao Zou Zhao-Wei Sun State Key Laboratory of petroleum Resources and prospecting China University of Petroleum-BeijingBeijing102249China

Hydraulic fracturing is considered the main stimulation method to develop shale gas reservoirs. Due to its strong heterogeneity, the shale gas formation is typically embedded with geological discontinuities such as bedding planes and natural fractures. Many researchers realized that the interaction between natural fractures and hydraulic fractures plays a crucial role in generating a complex fracture network. In this paper, true tri-axial hydraulic fracturing tests were performed on polymethyl methacrylate (pMMA), on which pre-existing fracture was pre-manufactured to simulate natural fracture. A cohesive model has been developed to verify the results of the experimental tests. The key findings demonstrate that the experimental results agreed well with the numerical simulation outcomes where three main interaction modes were observed: crossing;being arrested by opening the pre-existing fracture;being arrested without dilating the pre-existing fracture. Crossing behavior is more likely to occur with the approaching angle, horizontal stress difference, and injection rate increase. Furthermore, the higher flow rate might assist in reactivating the natural fractures where both sides of the pre-existing fractures were reactivated as the injection rate increased from 5 to 20 mL/min. Additionally, hydraulic fractures show a tendency to extend vertically rather than along the direction of maximum horizontal stress when they are first terminated at the interface. This research may contribute to the field application of hydraulic fracturing in shale gas formation.

关键词： Hydraulic fracturing Natural fracture Fracture propagation Interaction mode pMMA

Distributed fault-tolerant strategy for electric swing system of hybrid excavators under communication errors

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Frontiers of Information Technology & Electronic Engineering 2017年第7期18卷 941-954页

作者： da-hui GAO Qing-feng WANG Yong LEI State Key Laboratory of FluM power and Meehatronie Systems Zhejiang University Hangzhou 310027 China Beijing Electro-Mechanical Engineering Institute Beijing 100074 China

A distributed fault-tolerant strategy for the controller area network based electric swing system of hybrid excavators is proposed to achieve good performance under communication errors based on the adaptive compensation of the delays and packet dropouts. The adverse impacts of communication errors are effectively reduced by a novel delay compensation scheme, where the feedback signal and the control command are compensated in each control period in the central controller and the swing motor driver, respectively, without requiring additional network bandwidth. The recursive least-squares algorithm with forgetting factor algorithm is employed to identify the time-varying model parameters due to pose variation, and a reverse correction law is embedded into the feedback compensation in consecutive packet dropout scenarios to overcome the impacts of the model error. Simulations and practical experiments are conducted. The results show that the proposed fault-tolerant strategy can effectively reduce the communication-error-induced overshoot and response time variation.

关键词： Fault tolerant Delay compensation Controller area network Communication errors Electric swing system ofhybrid excavator

Generalized Nonlinear Implicit Variational-Like Inequalities

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Journal of Mathematical Research and Exposition 2010年第2期30卷 291-296页

作者： da peng GAO Zhong Quan HE Shi Qiang FENG School of Mathematics and Information China West Normal University Siehuan 637002 P. R. China

A new class of generalized nonlinear implicit variational-like inequality problems （for short, GNIVLIp） in the setting of locally convex topological vector spaces is introduced and studied in this paper. Under suitable conditions, some existence theorems of solutions for （GNIVLIp） are presented by using some fixed point theorems.

关键词： generalized nonlinear implicit variational-like inequality upper semicontinuity fixed point theorem multifunction.

Robust Leader-follower Formation Control of Mobile Robots Based on a Second Order Kinematics Model

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自动化学报 2007年第9期33卷 947-955页

作者： LIU Shi-Cai TAN da-Long LIU Guang-Jun Robotics Laboratory Shenyang Institute of Automation Chinese Academy of Sciences Shenyang 110016 P. R. China Graduate University of Chinese Academy of Sciences Beijing 100049 P. R. China Department of Aerospace Engineering Ryerson University Toronto M5B 2K3 Canada

在这份报纸，我们学习为活动机器人的领导人追随者形成建模并且控制的问题。首先，为领导人追随者机器人形成的一个新奇 kinematics 模型基于在机器人和追随者机器人的本地运动之间的相对运动状态被提出。用这个模型，向心的亲戚和在机... 详细信息

在这份报纸，我们学习为活动机器人的领导人追随者形成建模并且控制的问题。首先，为领导人追随者机器人形成的一个新奇 kinematics 模型基于在机器人和追随者机器人的本地运动之间的相对运动状态被提出。用这个模型，向心的亲戚和在机器人之间的 Coriolis 加速被测量相对、本地的运动传感器直接计算，并且利用了线性化非线性的系统方程。一个形成控制器，由反馈 linearization 部分和一个滑动模式赔偿者组成，被设计包括内部动力学稳定全面系统。控制获得被解决坚韧性不平等决定并且假定满足保证形成系统的零动力学的稳定性的一个合作协议。建议控制器为追随者机器人产生命令的加速并且使形成控制系统柔韧到领导人机器人的无节制的加速的效果。而且，一个柔韧的适应控制器被开发在系统处理参量的无常。模拟和试验性的结果表明了建议控制方法的有效性。

关键词：鲁棒性自适应控制移动式遥控装置二阶运动学模型结构控制

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经导管三尖瓣缘对缘修复术的应用现状

中国介入心脏病学杂志 2024年第1期32卷 45-50页

作者：谢春梅沈梦奇朱达王首正骆志玲潘湘斌云南省阜外心血管病医院昆明医科大学附属心血管医院麻醉科云南昆明650102 云南省阜外心血管病医院昆明医科大学附属心血管医院结构性心脏病中心云南昆明650102 国家心血管病中心北京协和医学院中国医学科学院阜外医院结构性心脏病中心北京100037 云南省阜外心血管病医院昆明医科大学附属心血管医院超声科云南昆明650102

三尖瓣反流(TR)是常见的心脏瓣膜病变。根据发病机制,TR可分为原发性(器质性)和继发性(功能性)反流,其中功能性TR占比超过90%。重度TR患者预后差,药物治疗效果差,外科手术(瓣环成形)是主要治疗手段。目前,经导管三尖瓣缘对缘修复术(T-TE... 详细信息

三尖瓣反流(TR)是常见的心脏瓣膜病变。根据发病机制,TR可分为原发性(器质性)和继发性(功能性)反流,其中功能性TR占比超过90%。重度TR患者预后差,药物治疗效果差,外科手术(瓣环成形)是主要治疗手段。目前,经导管三尖瓣缘对缘修复术(T-TEER)已成为TR经导管治疗的重要方案,为广大无法接受外科手术或手术高风险的TR患者提供了微创治疗方式。T-TEER通过夹闭瓣叶进而降低反流程度,目前处于早期研发探索和临床验证阶段,主要用于功能性TR。T-TEER相关器械也取得了明显的进步(TriClip,pASCAL),我国独立研发的T-TEER器械也正在进行临床试验(DragonFly-TTM,SQ-Kyrin-TTM,NeoBlazarTM)。本文对T-TEER的应用现状和研究进展进行综述。

关键词：三尖瓣反流经导管三尖瓣缘对缘修复术介入治疗