Changes in corneal nerve morphology and function in patients with dry eyes having type 2 diabetes

作     者：Wei Fang Zhong-Xi Lin Hui-Qing Yang Lei Zhao Da-Chuan Liu Zhi-Qiang Pan 

作者机构：Department of OphthalmologyXuanwu HospitalCapital Medical UniversityBeijing 100053China Department of OphthalmologyBeijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100005BeijingChina Department of NeurologyXuanwu HospitalCapital Medical UniversityBeijing 100053China Department of EndocrinologyXuanwu HospitalCapital Medical UniversityBeijing 100053China 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第10期

页      面：3014-3026页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100212[医学-眼科学] 10[医学] 

主　　题：Blink reflex Corneal nerve Diabetes mellitus Dry eye Tear secretion 

摘      要：BACKGROUND Dry eye syndrome(DES)is a common disease with various clinical *** had a significant association with *** reflex(BR)is also known as trigeminal nerve facial *** stimulation of corneal nerves is one of the origins of BR *** parasympathetic fibers sent out through the facial nerve are the outlet of tear *** can be used to assess the function of the corneal nerve closed-loop;however,whether the BR changes in these patients is *** To understand the morphology and function of the corneal nerve in patients with dry eyes having diabetes or *** This study enrolled 131 patients who visited the inpatient and outpatient services of ophthalmology and endocrinology departments between January 2019 to August 2020 with subjective symptoms of dry eyes and non-dry eye reasons,as well as volunteers such as *** patients were divided into four groups:DEwDM,with dry eyes having type 2 diabetes mellitus(T2DM);DMnDE,with T2DM not having dry eyes;DEnDM,with dry eyes not having diabetes;and nDMnDE,with neither dry eyes nor *** tear film break-up time,Schirmer I test,in vivo confocal microscopy,and BR were *** The DEwDM,DMnDE,DEnDM,and nDMnDE groups included 56,22,33,and 20 patients,*** and age were not statistically different among the four *** nerve fiber length(NFL)of patients in the DEwDM,DEnDM,and DMnDE groups reduced(P0.001,P=0.014,and P=0.001,respectively).No significant difference in corneal nerve fiber density(NFD)(P=0.083)and corneal nerve branch density(NBD)(P=0.195)was found among the four *** R1 Latency of blink reflexes increased only in the DEwDM group(P=0.008,P=0.001,P0.001,compared with the DMnDE,DEnDM,and nDMnDE groups,respectively).The NBD and R1 Latency were different between DEwDM and DEnDM groups in patients with moderate and severe dry *** The corneal nerve morphology changed in patients with dry eyes or diabetes,or