检索结果-南通市图书馆

chinese Science Bulletin 2002年第7期47卷 578-581页

作者： duan yi & wang zhipingstate key laboratory of gas geochemistry, lanzhou institute of geology,{2., lanzhou 73.000, China institute of Environmental Science, Beijing Normal University, Beijing 100875, China 1. State key laboratory of {2. geochemistry Lanzhou Institute of Geology Chinese Academy of Sciences 730000 Lanzhou China 2. institute of Environmental Science Beijing Normal University 100875 Beijing China

Carbon isotopes are measured for individual long-chain n-alkanes in sediments from the Nansha Sea. The features of carbon isotopic compositions of individual n-alkanes and their origins are studied. The results show that the long-chain n-alkanes have a light carbon isotopic composition and a genetic feature of mixing sources, and low-latitude higher plants and microbes are considered to be their main end member sources. Based on the abundances and carbon isotopic compositions of individual n-alkanes, the fractional contributions of the two end member sources to individual n-alkanes are quantitatively calculated by using a mixing model. The obtained data indicate that the fractional contributions of the two biological sources are different in the three samples. A trend is that the contribution of microbes increases with the depth. These results provide the theory basis and quantitatively studied method for carbon isotopic applied research of individual n-alkanes.

关键词： modern marine sediment individual n-alkane carbon isotopic composition biological source.

Relationship Between Short-chain Fatty Acids and Parkinson’s Disease:A Review from Pathology to Clinic

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第4期40卷 500-516页

作者： Wen-Xiang duan Fen wang Jun-{2. Liu Chun-Feng Liu Department of Neurology and Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow UniversitySuzhou215004China Department of Neurology Dushu Lake Hospital affiliated to Soochow UniversitySuzhou215125China Jiangsu key laboratory of Neuropsychiatric Diseases and {2. of Neuroscience Soochow UniversitySuzhou215123China

Parkinson’s disease(PD)is a complicated neurodegenerative disease,characterized by the accumulation ofα-synuclein(α-syn)in Lewy bodies and neurites,and massive loss of midbrain dopamine *** evidence suggests that gut microbiota and microbial metabolites are involved in the development of *** these,short-chain fatty acids(SCFAs),the most abundant microbial metabolites,have been proven to play a key role in brain-gut *** this review,we analyze the role of SCFAs in the pathology of PD from multiple dimensions and summarize the alterations of SCFAs in PD patients as well as their correlation with motor and non-motor *** research should focus on further elucidating the role of SCFAs in neuroinflammation,as well as developing novel strategies employing SCFAs and their derivatives to treat PD.

关键词： Parkinson’s disease Short-chain fatty acids Microbial metabolites Brain-gut-microbiota axis

Robust tantalum tuned perovskite oxygen electrode for reversible protonic ceramic electrochemical cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第7期43卷 3055-3065页

作者： Yu-Shi Feng Yu Shen Fang wang Chuan Tian Qin-yi Hu Qian {2. Jing-Wei Li Di Bao School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China Zhongshan institute of Changchun University of Science and Technology Zhongshan528437China State key laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022China key laboratory of Preparation and Applications of Environmental Friendly Materials Ministry of EducationJilin Normal UniversityChangchun 130103China

Perovskite oxides with diverse composition and structure have exhibited grand advances in boosting the oxygen reduction and evolution reaction(ORR/OER),which are essential for the reversible protonic ceramic electrochemical cell(R-PCEC)toward the sustainable hydrogen production and ***,enhancement of their activity and stability remains ***,we develop the Ta-regulated BaCo_(0.7)Fe_(0.3)O_(3-δ)perovskite oxygen electrode(Ba(Co_(0.7)Fe_(0.3))_(1-x)Ta_xO_(3-δ))with abundant oxygen defects and achieve the simultaneous enhancement in the electrocatalytic activity and stability toward ORR and ***-fabricated R-PCEC with(Ba(Co_(0.7)Fe_(0.3))_(0.9)Ta_(0.1)O_(3-δ))(BCFT10)oxygen electrode performs high power density of 1.47 W·cm^(-2.at 650℃in fuel cell mode,and the current density is up to-2.11 A·cm^(-2.at 1.4 V at 650℃in electrolysis mode,as well as the good stability in both the fuel cell and electrolysis ***,the cell also demonstrates a stable cycling operation between fuel cell and electrolysis mode,suggesting a great potential of BCFT10 as oxygen electrode material for R-PCECs.

关键词： Reversible protonic ceramic electrochemical cells Perovskite oxide Oxygen electrode Ta element doping Oxygen defects

A possible probe to neutron-skin thickness by fragment parallel momentum distribution in projectile fragmentation reactions

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第6期35卷 114-119页

作者： Chun-wang Ma yi-Jie {2. Ya-Fei Guo Chun-Yuan Qiao Yu-Ting wang Jie Pu Kai-Xuan Cheng Hui-Ling Wei College of Physics Henan Normal UniversityXinxiang 453007China institute of Nuclear Science and Technology Henan Academy of SciencesZhengzhou 450015China

Neutron-skin thickness is a key parameter for a neutron-rich nucleus;however,it is difficult to *** the framework of the lanzhou Quantum Molecular Dynamics(LQMD)model,a possible probe for the neutron-skin thickness(δ_(np))of neutron-rich ^(48)Ca was studied in the 140A MeV ^(48)Ca+^(9)Be projectile fragmentation reaction based on the parallel momentum distribution(p∥)of the residual fragments.A Fermi-type density distribution was employed to initiate the neutron density distributions in the LQMD simulations.A combined Gaussian function with different width parameters for the left side(Γ_(L))and the right side(Γ_(R))in the distribution was used to describe the p∥of the residual *** neutron-rich sulfur isotopes as examples,Γ_(L) shows a sensitive correlation withδ_(np) of ^(48)Ca,and is proposed as a probe for determining the neutron skin thickness of the projectile nucleus.

关键词： Neutron-skin thickness Projectile fragmentation Parallel momentum distribution Neutron-rich nucleus Quantum molecular dynamics model

Mitochondria-targeted nanoparticles overcome chemoresistance via downregulating BACH1/CD47 axis in ovarian carcinoma

在线全文

学校读者我要写书评

暂无评论

chinese Chemical Letters 2024年第5期35卷 344-350页

作者： Ke Gong Jinghan Liao Jiangtao Lin Quan wang Zhihua Wu Liting wang Jiali Zhang {2. Dong Yourong {2. Jianhua Chen State key laboratory of Systems Medicine for Cancer Shanghai Cancer InstituteRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200032China Department of Ultrasound Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Department of Oncology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

The platinum-based chemotherapy is a routine strategy for the treatment of ovarian cancer,while it is prone to chemoresistance in clinical,which hinders the ***,it is urgently needed to elucidate the underlying mechanism of drug resistance and form the appropriate *** sequencing results showed that cisplatin(DDP)resistant ovarian cancer overexpressed BTB and CNC homology 1(BACH1),and up-regulated the“don’t eat me”signal *** identified that hemin,a BACH1 inhibitor,could effectively down-regulate BACH1 and simultaneously inhibit ***,hemin has a synergistic effect with *** designed a pH-responsive nanoparticle(H/D@FA-CaP-NPs)in which folic acid(FA)ensured targeting of ovarian cancer cells,while hemin inhibited BACH1 as well as down-regulated CD47,achieving the promotion of apoptosis of tumor cells and inducing phagocytosis of tumors by ***,hemin has a synergistic effect with DDP to promote apoptosis of tumor ***,hemin and DDP was encapsulated within hydrophobic 1,2.distearoyl-sn-glycero-3-phosphoethanolamine(DSPE)to form a tight core,and hydrophilic polyethylene glycol 2.00(PEG2.00)and calcium phosphate(CaP)formed the outside shell,and FA was modified on the surface of *** terms of function,(a)FA enhanced the active targeting of nanoparticles to tumors;(b)NPs targeted mitochondria to induce reactive oxygen species(ROS)production;(c)hemin encapsulated in nanoparticles could specifically target BACH1,thereby down regulating CD47;(d)hemin had a synergistic effect with DDP,thus augmenting the ***,mitochondria-targeted nanoparticles H/D@FA-CaP-NPs promoted tumor apoptosis and mobilized phagocytosis to treat tumor,providing a novel scheme for clinical treatment of cisplatin-resistant ovarian carcinoma.

关键词： Cisplatin-resistant Hemin BACH1 CD47 Phagocytosis ROS Synergistic effect

Sclerodermus alternatusi(Hymenoptera:Bethylidae),a new species from China,parasitizing Monochamus alternatus(Coleoptera:Cerambycidae)

在线全文

学校读者我要写书评

暂无评论

Zoological Systematics 2024年第3期49卷 258-266页

作者： Zhongqi Yang Xiaoyi wang Zhaoyao {2. Yanlong Zhang yi’nanZhang Liangming Cao Ke Wei key Lab of Forest Protection National Forestry and Grassland AdministrationEcology and Nature Conservation InstituteChinese Academy of ForestryBeijing 100091China Research institute of Biological Control Beijing Vocational College of AgricultureBeijing 102442China Research institute of Forest Protection Yunnan Academy of Forestry and GrasslandKunming 650201China

A new species,Sclerodermus alternatusi Yang,***.(Hymenoptera:Bethylidae),is described and *** cerambycid host,Monochamus alternatus Hope,a severe wood borer attacking many pine trees(Pinus spp.),is also a vector of pine wood nematode,Bursaphelencus xylophilus,which cause severe damages to pine forests in *** new species is a gregarious ectoparasitoid of junior larva of *** number of adult wasps reared from a single host larva ranges from 6 to *** ratio of female to male is 2.:*** new parasitoid species has a high potential in using as a biocontrol agent for the wood *** of the new species with comparisons to its related species,*** Yang&Yao and a key to known species of Sclerodermus from China is provided.

关键词： Ectoparasitoid larval parasitoid taxonomy biological control

Facile and effective synthesis strategy for terbium-doped hydroxyapatite toward photoelectric devices and flexible functional fibers

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第4期43卷 1713-1723页

作者： Xiao-Dong Zhang Kun Nie Zi-Yao Hu Ran-Ran Zhou Xiu-Qiang duan Wu-Bin Dai Song-Song Nie Song-Jun Yao Luo-Xin wang Le-Fu Mei Hua wang yi-yi Yao Xiao-Xue Ma Hubei key laboratory for New Textile Materials and Applications and State key laboratory of New Textile Materials and Advanced Processing Technology School of Materials Science and EngineeringWuhan Textile UniversityWuhan430200China key laboratory of Testing and Tracing of Rare Earth Products for State Market Regulation Jiangxi University of Science and TechnologyGanzhou341000China Hubei key laboratory of Plasma Chemistry and Advanced Materials and key laboratory of Green Chemical Engineering Process of Ministry of Education Wuhan Institute of TechnologyWuhan430205China

As a material with good biocompatibility,hydroxyapatite(HAP)can have optical properties after doping with various rare earth *** a biocompatible fluorescent material,doped HAP could have broad applications in biological probes,drug delivery,optoelectronic materials,fluorescence anti-counterfeiting,and other *** this paper,we put forward the preparation of HAP doped with terbium(Ⅲ)ions(Tb^(3+))by hydrothermal *** controlling the Tb^(3+)doping content in reaction and the reaction time,the changes in HAP's structure,morphology,and luminescence properties under different conditions were *** the doping amount of Tb^(3+)reached an optimal value,the dipole-quadrupole would occur and the concentration would be *** control experiment showed that the optimal Tb3+content was 7.5×10^(-5)mol,which showed the best fluorescence ***,a non-luminous material,was rarely used in the field of fluorescent anti-counterfeiting and photoelectric *** proposed to prepare a luminescent aramid/polyphenylene sulfide(ACFs/PPS)fiber paper and a new light-emitting diode(LED)using the Tb-doped HAP *** composite sample exhibited an excellent stability and fluorescence performance,which also demonstrated a possibility of HAP applications in anticounterfeiting and *** introduction of Tb3+dopant HAP was done to give HAP optical properties and broaden the application range of HAP.

关键词： Hydroxyapatite Rare earth luminescence Photoelectric device Aramid Polyphenylene sulfide fiber paper Luminescent fiber

Plateau Marsh Methane Oxidation as affected by Inorganic N

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2004年第2期14卷 195-204页

作者： wangZhi-Ping duan{2. YANGJu-Rong LILing-Hao HANXing-Guo laboratoryofQuantitativeVegetationEcology InstituteofBotanyChineseAcademyofSciencesBeijing100093（China）／E-mail：wangzp5@*** Statekeylaboratoryof{2.geochemistry LanzhouInstituteofGeology.ChineseAcademyofSciencesLanzhou730000（China） CollegeofResourceandEnvironment BEijingNormailUniversityBeijing100875（China）

In a series of laboratory incubations using soils of two contrasting sitesfrom a temperate marsh on the Qinghai-Tibet Plateau, potential methane (CH_4) oxidation rates weremeasured to study the effects of inorganic N inputs on CH_4 oxidation. For adrained site, subsurfacepeat (5--15 cm) at an initial 2. mu L CH_4 L^(-1) showed a significantly different (P 2..9 ng CH_4 gDW (dryweight)^(-1) h^(-1); the underlying mineral soil layers (15--30 and 30--50 cm) also had a strongCH_4 oxidation capacity at about an initial 2.000 mu L CH_4 L^(-1). With a waterlogged site, theCH_4 oxidation rate in an aerobic incubation was significantly greater (P 2.O_4, NH_4Cl and NH_4NO_3, exhibited strong inhibitions, which varied as a function of theadded salts and the initial CH_4 level Increasing NH_4^+ usually resulted in greater inhibition andincreasing initial CH_4 concentrations resulted in less NH_4^+ inhibition on CH4 oxidation innatural high-altitude, low-latitude wetlands could be as important as has been reported foragricultural and forest soils. The NH_4^+ effects on the CH_4 oxidation rate need to be furtherinvestigated in a wide range of natural wetland soil types.

关键词： ammonium inhibition inorganic N methane oxidation plateau marsh

Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第2期9卷 738-750页

作者： Yun Zhang Lijun Du Chenxi wang Zhangsheng Jiang Qingchi duan {2.ping Li Zhijun Xie Zhixing He {2. Sun Lin Huang Liwei Lu Chengping Wen key laboratory of {2. medicine rheumatology of Zhejiang Province Research Institute of Chinese Medical Clinical Foundation and ImmunologyCollege of Basic Medical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Cancer institute(key {2. of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Department of Pathology and Shenzhen institute of Research and Innovation The University of Hong KongHong KongChina Chongqing International institute for Immunology Chongqing 400038China

Systemic lupus erythematosus(SLE),a severe autoimmune disorder,is characterized by systemic inflammatory response,autoantibody accumulation and damage to *** dysregulation of double-negative(DN)T cells is considered as a crucial commander during ***,a significant type of protein post-translational modification(PTM),has been well-proved to regulate T cell-mediated immune ***,the function of neddylation in SLE is still ***,we reported that neddylation inactivation with MLN492.,a specific inhibitor of NEDD8-activating enzyme E1(NAE1),or genetic abrogation of Ube2. in T cells decreased DN T cell accumulation and attenuated murine lupus *** investigations revealed that inactivation of neddylation blocked Bim ubiquitination degradation and maintained Bim level in DN T cells,contributing to the apoptosis of the accumulated DN T cells in lupus *** double knockout(KO)lupus-prone mice(Ube2.-/-Bim-/-lpr)were generated and results showed that loss of Bim reduced Ube2. deficiency-induced apoptosis in DN T cells and reversed the alleviated lupus *** findings identified that neddylation inactivation promoted Bim-mediated DN T cell apoptosis and attenuated lupus ***,we also found that in SLE patients,the proportion of DN T cells was raised and their apoptosis was ***,compared to healthy groups,SLE patients exhibited decreased Bim levels and elevated Cullin1 neddylation ***,the inhibition of neddylation induced Bim-dependent apoptosis of DN T cells isolated from SLE ***,our findings provide the direct evidence about the function of neddylation during lupus,suggesting a promising therapeutic approach for this disease.

关键词： inactivation double finding

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

煤岩生气热模拟及其对煤层气形成的示踪意义

天然气工业 2005年第1期25卷 66-69页

作者：段毅吴保祥郑朝阳王传远陶明信中国科学院兰州地质研究所气体地球化学重点实验室

煤岩热解模拟实验为认识含煤盆地的成烃演化、煤层气地球化学特征的成因及其资源预测提供了科学依据。文章在336.8～600℃温度和50MPa压力及2.℃/h和2./h升温速率条件下,对沁水盆地上古生界煤岩进行了热解生气模拟实验。结果表明... 详细信息

煤岩热解模拟实验为认识含煤盆地的成烃演化、煤层气地球化学特征的成因及其资源预测提供了科学依据。文章在336.8～600℃温度和50MPa压力及2.℃/h和2./h升温速率条件下,对沁水盆地上古生界煤岩进行了热解生气模拟实验。结果表明,煤岩热模拟气体产物主要由甲烷(CH4)、C2.5烃类气体和二氧化碳(CO2. 非烃气体组成,氢气(H2.和硫化氢(H2.)含量极低;随着模拟温度的增加,气体产物中甲烷和大部分氢气(H2.的相对百分含量呈单向增加,二氧化碳表现为单向降低,C2.5烃类气体和硫化氢(H2.)气体先增加后降低;低温速率有利于甲烷、C2.5气体、氢气和二氧化碳气体的生成,并且它们的形成表现为多阶段性;相同升温速率下二氧化碳和氢气的相对产率与甲烷的相对产率变化表现为正相关,反映了它们与甲烷同是煤岩热解过程中同步进行的平行反应产物;相同模拟温度和温速条件下,山西组煤岩比太原组煤岩具有较高的产甲烷和C2.5烃类气体能力,这意味着在实际的地质环境中,山西组煤岩更有利于煤层气的形成。并且对煤岩生气热模拟实验结果在煤层气形成方面的示踪意义进行了探讨。

关键词：煤层气热模拟升温速率示踪意义煤岩生气