Relationship Between Short-chain Fatty Acids and Parkinson’s Disease:A Review from Pathology to Clinic
作者机构：Department of Neurology and Clinical Research Center of Neurological DiseaseThe Second Affiliated Hospital of Soochow UniversitySuzhou215004China Department of NeurologyDushu Lake Hospital affiliated to Soochow UniversitySuzhou215125China Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of NeuroscienceSoochow UniversitySuzhou215123China
出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)
年 卷 期：2024年第40卷第4期
页 面：500-516页
核心收录：
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
基 金：supported by the Jiangsu Provincial Key R&D Program(BE2018658) Jiangsu Provincial Medical Key Discipline(ZDXK202217) the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
主 题：Parkinson’s disease Short-chain fatty acids Microbial metabolites Brain-gut-microbiota axis
摘 要：Parkinson’s disease(PD)is a complicated neurodegenerative disease,characterized by the accumulation ofα-synuclein(α-syn)in Lewy bodies and neurites,and massive loss of midbrain dopamine *** evidence suggests that gut microbiota and microbial metabolites are involved in the development of *** these,short-chain fatty acids(SCFAs),the most abundant microbial metabolites,have been proven to play a key role in brain-gut *** this review,we analyze the role of SCFAs in the pathology of PD from multiple dimensions and summarize the alterations of SCFAs in PD patients as well as their correlation with motor and non-motor *** research should focus on further elucidating the role of SCFAs in neuroinflammation,as well as developing novel strategies employing SCFAs and their derivatives to treat PD.
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