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Lithium bis(trifluoromethanesulfonyl)imide blended in polyurethane acrylate photocurable solid polymer electrolytes for lithium-ion batteries

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Journal of Energy Chemistry 2021年第11期30卷 485-496,I0011页

作者： Cristian Mendes-Felipe J.C.Barbosa R.Gonsalves d.miranda C.M.Costa J.L.Vilas-Vilela S.Lanceros-Mendez BCMaterials Basque Center for MaterialsApplications and NanostructuresUPV/EHU Science Park48940 LeioaSpain Macromolecular Chemistry Group(LABQUIMAC) Department of Physical ChemistryFaculty of Science and TechnologyUniversity of the Basque Country(UPV/EHU)Barrio Sarriena s/nE-48940 LeioaSpain Center of Physics University of MinhoCampus of Gualtar4710-057 BragaPortugal Center of Chemistry University of MinhoCampus of Gualtar4710-057 BragaPortugal Ai–School of Technology IPCABarcelosPortugal Ikerbasque Basque Foundation for Science48009 BilbaoSpain

The increased demand of electronic devices promotes the development of advanced and more efficient energy storage devices, such as batteries. Lithium-ion batteries (LIBs) are the most studied battery systems due to their high performance. Among the different battery components, the separator allows the control of lithium ion diffusion between the electrodes. To overcome some drawbacks of liquid electrolytes, including safety and environmental issues, solid polymer electrolytes (SPEs) are being developed. In this work, a UV photocurable polyurethane acrylate (PUA) resin has been blended with lithium bis(trifluoromethanesulfonyl) imide (LiTFSI) up to 30 wt% LiTFSI content to reach a maximum ionic conductivity of 0.0032 mS/cm at room temperature and 0.09 mS/cm at 100 ℃. Those values allowed applying the developed materials as photocurable SPE in Swagelok type Li/C-LiFePO_(4) half-cells, reaching a battery discharge capacity value of 139 mAh.g^(−1) at C/30 rate. Those results, together with the theoretical studies of the discharge capacity at different C-rates and temperatures for batteries with LiTFSI/PUA SPE demonstrate the suitability of the developed photocurable SPE for LIB applications.

关键词： Solid polymer electrolytes Photocuring Polyurethane acrylate LiTFSI Li-ion batteries

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Tamoxifen:an FdA approved drug with neuroprotective effects for spinal cord injury recovery

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Neural Regeneration Research 2016年第8期11卷 1208-1211页

作者： Jennifer M.Colón Jorge d.miranda department of Physiology School of MedicineUniversity of Puerto Rico Medical Sciences Campus

Spinal cord injury（SCI） is a condition without a cure,affecting sensory and/or motor functions.The physical trauma to the spinal cord initiates a cascade of molecular and cellular events that generates a non-permissive environment for cell survival and axonal regeneration.Among these complex set of events are damage of the blood-brain barrier,edema formation,inflammation,oxidative stress,demyelination,reactive gliosis and apoptosis.The multiple events activated after SCI require a multi-active drug that could target most of these events and produce a permissive environment for cell survival,regeneration,vascular reorganization and synaptic formation.Tamoxifen,a selective estrogen receptor modulator,is an FdA approved drug with several neuroprotective properties that should be considered for the treatment of this devastating condition.Various investigators using different animal models and injury parameters have demonstrated the beneficial effects of this drug to improve functional locomotor recovery after SCI.Results suggest that the mechanism of action of Tamoxifen administration is to modulate anti-oxidant,anti-inflammatory and anti-gliotic responses.A gap of knowledge exists regarding the sex differences in response to Tamoxifen and the therapeutic window available to administer this treatment.In addition,the effects of Tamoxifen in axonal outgrowth or synapse formation needs to be investigated.This review will address some of the mechanisms activated by Tamoxifen after SCI and the results recently published by investigators in the field.

关键词： selective estrogen receptor modulator trauma antioxidant anti-inflammatory regeneration reactive gliosis demyelination, estradiol

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Tamoxifen and Src kinase inhibitors as neuroprotective/neuroregenerative drugs after spinal cord injury

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Neural Regeneration Research 2015年第3期10卷 385-390页

作者： Iris K.Salgado Aranza I.Torrado Jose M.Santiago Jorge d.miranda department of Physiology School of MedicineUniversity of Puerto Rico Medical Sciences Campus University of Puerto Rico Carolina Campus Department of Natural Sciences

Spinal cord injury （SCI） is a devastating condition that produces significant changes in the life- style of patients. Many molecular and cellular events are triggered after the initial physical impact to the cord. Two major phases have been described in the field of SCI： an acute phase and late phase. Most of the therapeutic strategies are focused on the late phase because this provides an opportunity to target cellular events like apoptosis, demyelination, scar formation and axonal outgrowth. In this mini-review, we will focus on two agents （tamoxifen and a Src kinase family inhibitor known as PP2） that have been shown in our laboratory to produce neuroprotective （increase cell survival） and/or regenerative （axonal outgrowth） actions. The animal model used in our laboratory is adult female rat （N250 g） with a moderate contusion （12.5 mm） to the spinal cord at the T10 level, using the MASCIS impactor device. Tamoxifen or PP2 was administered by implantation of a 15 mg pellet （Innovative Research of America, Sarasota, FL, USA） or by intraperitoneal injections （1.5 mg/kg, every 3 days）, respectively, to produce a long-term effect （28 days）. Tamoxifen and the Src kinase inhibitor, PP2, are drugs that in rats with a moderate spinal cord injury promote functional locomotor recovery, increase spared white matter tissue, and stimulate axonal outgrowth. Moreover, tamoxifen reduces the formation of reactive oxygen species. Therefore, these drugs are possible therapeutic agents that have a neuroprotective/regen- erative activity in vertebrates with SCI.

关键词： tamoxifen Src kinase PP2 trauma regeneration neuroprotection

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3 T MR扩散加权成像描述前列腺癌的最佳b值是什么?

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国际医学放射学杂志 2012年第3期 296-297页

作者： T.Metens d.miranda J.Absil C.Matos 范璐 Resonance Magnetique Hpital ErasmeUniversité Libre de Bruxelles808 Route de Lennik1070 BruxellesBelgiqueBelgium

目的确定3TMR扩散加权成像显示前列腺癌的最佳b值。方法41例经活检证实前列腺癌的病人用16通道线圈采用5个b值(0、1000、1500、2000、2500s/mm2)的3TMR扩散加权成像检查。对比不同b值影像的最佳病灶显

关键词：前列腺癌 MRI 扩散高b值高场MRI

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Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue

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Neural Regeneration Research 2014年第24期9卷 2164-2173页

作者： Odrick R.Rosas Aranza I.Torrado Jose M.Santiago Ana E.Rodriguez Iris K.Salgado Jorge d.miranda department of Physiology School of Medicine University of Puerto Rico Medical Sciences Campus department of Natural Sciences University of Puerto Rico Carolina Campus

The spinal cord has the ability to regenerate but the microenvironment generated after trauma reduces that capacity. An increase in Src family kinase （SFK） activity has been implicated in neuropathological conditions associated with central nervous system trauma. Therefore, we hypothesized that a decrease in SFK activation by a long-term treatment with 4-amino-5-（4- chlorophenyl）-7-（t-butyl）pyrazolo[3,4-d]pyramidine （PP2）, a selective SFK inhibitor, after spinal cord contusion with the New York University （NYU） impactor device would generate a permissive environment that improves axonal sprouting and/or behavioral activity. Results demonstrated that long-term blockade of SFK activation with PP2 increases locomotor activity at 7, 14, 21 and 28 days post-iniury in the Basso, Beattie, and Bresnahan open field test, round and square beam crossing tests. In addition, an increase in white matter spared tissue and serotonin fiber density was observed in animals treated with PP2. However, blockade of SFK activity did not change the astrocytic response or infiltration of cells from the immune system at 28 days post-injury. Moreover, a reduced SFK activity with PP2 diminished Ephexin （a guanine nudeotide exchange factor） phosphorylation in the acute phase （4 days post-injury） after trauma. Together, these findings suggest a potential role of SFK in the regulation of spared tissue and/or axonal outgrowth that may result in functional locomotor recovery during the pathophysiology generated after spinal cord injury. Our study also points out that ephexinl phosphorylation （activation） by SFK action may be involved in the repulsive microenvironment generated after spinal cord injury.

关键词： nerve regeneration trauma regeneration Src family kinase Eph receptors ephexin spared tissue locomotor recovery GFAP Ed1 serotonin fibers neural regeneration

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Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben Chung-Lap Chan Grace Gar-Lee Yue LI Pei-ting Sharon Sze-Man Hon HUANG dan-qi miranda Sin-Man Tsang Clara Bik-San Lau Ping-Chung Leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li dak Sum Yip Yio Chin R&d Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary glands.Sixty-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,Ld 4HF(low dose 4HF),Hd 4HF(high dose 4HF),Ld 4HF+d(low dose and doxorubicin),and d(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat pads.Starting from the day of tumor cell inoculation,tumors were grown for 6 days.The Ld and Hd groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,respectively.The Ld 4HF+d group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The d group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a week.The control group received daily oral gavage of 0.2 mL double-distilled water.The treatment period was 30 days.At the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota analysis.Results Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(Pd the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological activities.Moreover,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(Pdoxorubicin combination treatment demonstrated synergetic activities and was most effective in activating the anti-tumor immune response(P<

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

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Therapies for Tau-associated neurodegenerative disorders:targeting molecules,synapses,and cells

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Neural Regeneration Research 2023年第12期18卷 2633-2637页

作者： miranda Robbins MRC Laboratory of Molecular Biology Cambridge Biomedical CampusFrancis Crick AveTrumpingtonCambridgeUKUniversity of CambridgeDepartment of ZoologyCambridgeUK

Advances in experimental and computational technologies continue to grow rapidly to provide novel avenues for the treatment of neurodegenerative disorders. despite this, there remain only a handful of drugs that have shown success in late-stage clinical trials for Tau-associated neurodegenerative disorders. The most commonly prescribed treatments are symptomatic treatments such as cholinesterase inhibitors and N-methyl-d-aspartate receptor blockers that were approved for use in Alzheimer's disease. As diagnostic screening can detect disorders at earlier time points, the field needs pre-symptomatic treatments that can prevent, or significantly delay the progression of these disorders(Koychev et al., 2019). These approaches may be different from late-stage treatments that may help to ameliorate symptoms and slow progression once symptoms have become more advanced should early diagnostic screening fail. This mini-review will highlight five key avenues of academic and industrial research for identifying therapeutic strategies to treat Tau-associated neurodegenerative disorders. These avenues include investigating(1) the broad class of chemicals termed “small molecules”;(2) adaptive immunity through both passive and active antibody treatments;(3) innate immunity with an emphasis on microglial modulation;(4) synaptic compartments with the view that Tau-associated neurodegenerative disorders are synaptopathies. Although this mini-review will focus on Alzheimer's disease due to its prevalence, it will also argue the need to target other tauopathies, as through understanding Alzheimer's disease as a Tau-associated neurodegenerative disorder, we may be able to generalize treatment options. For this reason, added detail linking back specifically to Tau protein as a direct therapeutic target will be added to each topic.

关键词： Alzheimer's disease antibody frontotemporal dementia immunotherapy small molecules synapses tau therapeutics

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Magnitude of the contralateral efferent olivocochlear effect as a function of the frequency

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Journal of Otology 2022年第2期17卷 67-71页

作者： Fernanda Anza miranda Enzo Aguilar-Vidal Laboratorio de Audiología y Percepcion Auditiva Facultad de MedicinaUniversidad de ChileChile Escuela de Tecnología Medica Facultad de MedicinaUniversidad de ChileChile departamento de Tecnología Medica Facultad de MedicinaUniversidad de ChileChile

Background:The activation of the medial olivocochlear reflex reduces the cochlear gain,which is manifested perceptually as decreased auditory sensitivity.However,it has remained unclear whether the extent of this suppression varies according to the cochlear region involved.Here we aims to assess the magnitude of contralateral efferent suppression across human cochlea,at low levels,and its impact on hearing sensitivity.Methods:Assuming that acoustic stimulation activates the contralateral medial olivocochlear reflex,we evaluated the magnitude of the suppressive effect as a function of frequency in 17 subjects with normal hearing.Absolute thresholds were measured for bursts tones of various durations(10,100,and 500 ms)and frequencies(250,500,1000,4000,and 8000 Hz)in the presence or absence of contralateral white noise at 60 d B SPL.Results:We found that contralateral noise raised the absolute threshold for the burst tones evaluated.The effect was greater at lower than higher frequencies(3.85 d B at 250 Hz vs.2.22 d B at 8000 Hz).Conclusions:Our findings suggest that in humans,the magnitude of this suppression varies according to the cochlear region stimulated,with a greater effect towards the apex(lower frequencies)than the base(higher frequencies)of the cochlea.

关键词： Auditory perception Efferent system Medial olivocochlear reflex Absolute threshold

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NiTi laser textured implants with improved in vivo osseointegration:An experimental study in rats

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Journal of Materials Science & Technology 2022年第19期114卷 120-130页

作者： M.M.Costa A.miranda F.Bartolomeu O.Carvalho S.Matos G.miranda F.S.Silva Center for MicroElectroMechanical Systems(CMEMS-UMinho) University of MinhoCampus de AzurémGuimarães 4800-058Portugal Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de GualtarBraga 4710-057Portugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal Center for Innovation and Research in Oral Sciences(CIROS) Faculty of MedicineUniversity of CoimbraFMUCPortugal CICECO Aveiro Institute of MaterialsDepartment of Materials and Ceramic EngineeringUniversity of AveiroAveiro 3810-193Portugal

Laser surface texturing is a versatile approach for manufacturing implants with suitable surfaces for os-seointegration.This work explores the use of laser to fabricate NiTi textured implants,testing two dif-ferent groove-based designs.Their performance was evaluated in vivo through implantation in Sprague dawley rats’femur,being then analyzed after 4 and 12 weeks of implantation.Push-out experiments and histological characterization allowed to assess bone-implant bond and osseointegration and to compare the laser textured solutions with non-textured NiTi.Histology showed that,at 4 weeks of implantation,mainly immature woven bone was present whilst at 12 weeks a more mature bone had developed.Con-sidering the largest implantation time(12 weeks),results showed extraction forces considerably higher for textured implants(G2 and G3).Moreover,when comparing G2 and G3,it was found that G2(having the highest textured surface area)displayed the maximum extraction force among all groups,with an increase of 212%when compared to non-textured implants(G1).These results prove that the design and manufacturing technology are effective to promote an im-proved bone-implant bond,aiming the development of orthopedic implants.

关键词： NiTi Laser surface texturing In vivo studies Osseointegration Implants

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悉尼宣言——从基本原则视角重新审视法庭科学的本质

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证据科学 2023年第4期31卷 498-512页

作者：克劳德·鲁丽贝卡·布赫弗兰克·克里斯皮诺彼得·德·福雷斯特克里斯·伦纳尔皮埃尔·玛格特米歇尔·米兰达纳娅姆·尼克达恩利奥利维尔·里博阿拉斯泰尔·罗斯希拉·威利斯何晓丹(译) 张保生(校) 澳大利亚悉尼科技大学法庭科学中心国际法庭科学协会芬兰国家调查局法庭科学实验室加拿大魁北克大学化学、生物化学和物理系犯罪调查实验室美国纽约市立大学约翰·杰伊刑事司法学院澳大利亚西悉尼大学理学院瑞士洛桑大学刑事科学学院美国纽约州立大学法明代尔州立学院英国邓迪大学利弗休姆法医学研究中心澳大利亚维多利亚法医学院中国政法大学司法文明协同创新中心中国政法大学司法鉴定科学研究院中国政法大学证据科学研究院/证据科学教育部重点实验室

与其他更成熟的学科不同,人们对法庭科学的本质尚缺乏共识和广泛认可,其目的和基本原则仍然缺失,甚至被歪曲。虽然许多法庭科学先辈都认识到这一点,并将其视为学科发展之关键所在,但这种基础研究却长期受到忽视。《悉尼宣言》试图超越... 详细信息

与其他更成熟的学科不同,人们对法庭科学的本质尚缺乏共识和广泛认可,其目的和基本原则仍然缺失,甚至被歪曲。虽然许多法庭科学先辈都认识到这一点,并将其视为学科发展之关键所在,但这种基础研究却长期受到忽视。《悉尼宣言》试图超越组织、技术和规程的视角,通过研究其基础理论,重新审视法庭科学的本质。它的内容包括法庭科学的定义和七项基本原则,强调了现场痕迹在案件调查中的关键作用。《悉尼宣言》还讨论了法庭科学家工作的关键特征,包括案情、时间不对称性、一系列不确定性、广泛的科学知识、伦理、批判性思维和逻辑推理等。《悉尼宣言》认为这些原则应成为法庭科学执业的基础,并指导其教育和研究方向。最终,这些原则将使法庭科学在整体上更加相关、有效和可靠。

关键词：痕迹原则符号线索案情时间不对称性不确定性伦理批判性思维逻辑推理

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