Tamoxifen:an FDA approved drug with neuroprotective effects for spinal cord injury recovery

作     者：Jennifer M.Colón Jorge D.Miranda 无

作者机构：Department of PhysiologySchool of MedicineUniversity of Puerto Rico Medical Sciences Campus 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第8期

页      面：1208-1211页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：partially supported by COBRE(P20-GM103642) the MBRS-RISE Program(R25 GM061838) NIH-MARC(5T34GM007821-35) the RCMI program(5G12MD007600) 

主　　题：selective estrogen receptor modulator trauma antioxidant anti-inflammatory regeneration reactive gliosis demyelination, estradiol 

摘      要：Spinal cord injury（SCI） is a condition without a cure,affecting sensory and/or motor *** physical trauma to the spinal cord initiates a cascade of molecular and cellular events that generates a non-permissive environment for cell survival and axonal *** these complex set of events are damage of the blood-brain barrier,edema formation,inflammation,oxidative stress,demyelination,reactive gliosis and *** multiple events activated after SCI require a multi-active drug that could target most of these events and produce a permissive environment for cell survival,regeneration,vascular reorganization and synaptic ***,a selective estrogen receptor modulator,is an FDA approved drug with several neuroprotective properties that should be considered for the treatment of this devastating *** investigators using different animal models and injury parameters have demonstrated the beneficial effects of this drug to improve functional locomotor recovery after *** suggest that the mechanism of action of Tamoxifen administration is to modulate anti-oxidant,anti-inflammatory and anti-gliotic responses.A gap of knowledge exists regarding the sex differences in response to Tamoxifen and the therapeutic window available to administer this *** addition,the effects of Tamoxifen in axonal outgrowth or synapse formation needs to be *** review will address some of the mechanisms activated by Tamoxifen after SCI and the results recently published by investigators in the field.