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Hydrogels for neuroprotection and functional rewiring: a new era for brain engineering

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Neural Regeneration Research 2020年第5期15卷 783-789页

作者： Rocío fernández-Serra Rebeca Gallego Paloma Lozano daniel González-Nieto Center for Biomedical Technology Universidad Politécnica de Madrid. MadridSpain departamento de Tecnología Fotónica y Bioingeniería ETSI TelecomunicacionesUniversidad Politécnica de MadridMadridSpain Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN) MadridSpain

The neurological devastation of neurodegenerative and cerebrovascular diseases reinforces our perseverance to find advanced treatments to deal with these fatal ***-performance preclinical results have failed at clinical level,as it has been the case for a wide variety of neuroprotective agents and cell-based therapies employed to treat high prevalent brain pathologies such as stroke,Alzheimer’s and Parkinson’s *** unquestionable reality is the current absence of effective therapies to neuroprotect the brain,to arrest neurodegeneration and rewire the impaired brain *** of the problem might arise from the lack of adequate in vitro and in vivo models and that most of the underlying pathophysiological mechanisms are not yet *** contributing factor is the lack of efficient systems to sustain drug release at therapeutic concentrations and enhance the survival and function of grafted cells in transplantation *** medical applications the use of biomaterials of different compositions and formats has experienced a boom in the last *** the greater complexity of central nervous system has probably conditioned their extensive use with respect to other organs,the number of biomaterials-based applications to treat the injured brain or in the process of being damaged has grown ***-based biomaterials have constituted a turning point in the treatment of cerebral disorders using a new form of advanced *** show mechanical properties in the range of cerebral tissue resulting very suitable for local implantation of drugs and *** is also possible to fabricate three-dimensional hydrogel constructs with adaptable mesh size to facilitate axonal guidance and *** this article,we review the current trends in this area highlighting the positive impact of hydrogel-based biomaterials over the exhaustive control of drug delivery,cell engraftment and axonal reinnervation in brain p

关键词： advanced therapies Alzheimer’s disease biomaterials brain hydrogels neurological diseases Parkinson’s disease polymers stroke

Shaken not stirred: A molecular contribution to the systematics of genus Mugil (Teleostei, Mugilidae)

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Integrative Zoology 2016年第4期11卷 263-281页

作者： Sandra HERAS Ferruccio MALTAGLIATI Maria Victoria fernÁndez María Inés ROLdÁN Laboratory of Genetic Ichthyology University of GironaGironaSpain department of Biology University of PisaPisaItaly

With this work we addressed some molecular systematic issues within the Mugil cephalus species ***ticular attention was paid to the debated situations of:(i)Mugil liza,occurring in partial sympatry with Mugil cephalus in the northwestern Atlantic,and(ii)Mugil platanus,considered by some authors a synonymy of the former species and distributed in the southwestern *** sequenced 79 individuals of a 465-bp portion of the mitochondrial control region(CR)from 8 western Atlantic and 2 Mediterranean *** addition,all CR sequences available from GenBank for the studied taxa were added to our dataset,for a total of 323 indi***,229 haplotypes corresponding to 8 divergent monophyletic lineages were *** of phylogenetic analyses were consistent with the occurrence of past speciation events producing the observed lin*** these lineages,7 correspond to cryptic species and one is constituted by *** and *** a matter of fact,these 2 taxa constitute a single lineage within the *** species ***,individuals of ***/*** lineage analyzed by means of the 18 mitochondrial markers available in GenBank exhibited a degree of genetic diversity consistent with highly divergent *** the 8 lineages detected,the Mediterraean one(type locality)corresponds to ***;the lineage ***/*** should be named ***,under the priority principle,and the left 6 lineages need formal description.

关键词： cryptic species historical demography molecular phylogeny Mugil systematics

Controlling Molecular Packing in Aqueous Metallosupramolecular Self-assembly by Ligand Geometry

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Precision Chemistry 2023年第5期1卷 332-340页

作者： Papri Sutar Torsten dunnebacke Zulema fernández Timo Krüer Christina Rest Gustavo fernández Organisch-Chemisches Institut Westfälische-Wilhelms Universität Münster48149 MünsterGermany

The coordination geometry of d8 transition metal complexes has been successfully exploited as a tool to tune photophysical properties and self-assembly pathways of supramolecular polymerization processes,with a focus being primarily placed on organic *** such controlled supramolecular and photophysical properties to assemblies in aqueous media by molecular design is,however,still challenging due to the difficulty in programming noncovalent interactions in ***,we tackle this challenge by analyzing the aqueous self-assembly of amphiphilic Pt(II)complexes of different molecular geometry in order to control self-assembly and metal−metal interactions in aqueous *** this end,we have designed two Pt(II)complexes,1 and 2,containing an identical oligophenyleneethynylene(OPE)-based aromatic scaffold that differ in the molecular geometry(linear vs V-shaped)imposed by ligand substitution and studied their comparative self-assembly behavior in aqueous *** though both molecules follow the isodesmic mechanism of self-assembly,their structural difference strongly influences the molecular packing in aqueous media,which in turn impacts the photophysical properties(*** or presence of MMLCT)and the self-assembly *** the molecular geometry for 2 enforces short Pt…Pt contacts driven by an efficient face-to-face stacking of the OPE backbone,the antiparallel packing of 1 with slight translational offset does not allow the formation of short Pt…Pt *** a distinct interplay of interactions for 1 and 2 in aqueous media leads to significant differences in photoluminescence.

关键词： Self-assembly supramolecular polymerization amphiphilic systems π-conjugated systems Pt(II)complexes

CHARACTERISATION OF RATIONAL ANd NURBS dEVELOPABLE SURFACES IN COMPUTER AIdEd dESIGN

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Journal of Computational Mathematics 2021年第4期39卷 556-573页

作者： Leonardo fernandez-Jambrina ETSI Navales Universidad Politecnica de Madrid28040-MadridSpain

In this paper we provide a characterisation of rational developable surfaces in terms of the blossoms of the bounding curves and three rational functions∧,M,ν.Properties of developable surfaces are revised in this *** particular,a closed algebraic formula for the edge of regression of the surface is obtained in terms of the functions∧,M,ν,which are closely related to the ones that appear in the standard decomposition of the derivative of the parametrisation of one of the bounding curves in terms of the director vector of the rulings and its *** is also shown that all rational developable surfaces can be described as the set of developable surfaces which can be constructed with a constant∧,M,ν.The results are readily extended to rational spline developable surfaces.

关键词： NURBS Bezier Rational Spline NURBS developable surfaces

Genomic patterns of homozygosity and inbreeding depression in MurcianoGranadina goats

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Journal of Animal Science and Biotechnology 2022年第3期13卷 721-734页

作者： María Gracia Luigi-Sierra Almudena fernández Amparo Martínez dailu Guan Juan Vicente delgado Javier fernándezÁlvarez Vincenzo Landi Francesc Xavier Such Jordi Jordana María Saura Marcel Amills Centre for Research in Agricultural Genomics(CRAG) CSIC-IRTA-UAB-UBUniversitat Autònoma de Barcelona08193 BellaterraSpain departamento de Mejora Genética Animal INIACarretera de la Coruña km 7528040 MadridSpain departamento de Genética Universidad de Córdoba14071 CórdobaSpain department of Veterinary Medicine University of Bari“Aldo Moro”62 per Casamassima km.370010 ValenzanoSPItaly Group of Research in Ruminants(G2R) Department of Animal and Food ScienceUniversitat Autònoma de Barcelona(UAB)BellaterraBarcelonaSpain departament de Ciència Animal i dels Aliments Facultat de VeterinàriaUniversitat Autònoma de Barcelona08193 BellaterraSpain

Background:Inbreeding depression can adversely affect traits related to fitness,reproduction and productive *** current research suggests that inbreeding levels are generally low in most goat breeds,the impact of inbreeding depression on phenotypes of economic interest has only been investigated in a few studies based on genealogical ***:We genotyped 1040 goats with the Goat SNP50 *** information was used to estimate different molecular inbreeding coefficients and characterise runs of homozygosity and homozygosity *** detected38 genomic regions with increased homozygosity as well as 8 ROH hotspots mapping to chromosomes 1,2,4,6,14,16 and *** hundred seventeen goats with available records for dairy traits were analysed to evaluate the potential consequences of inbreeding depression on milk *** regions on chromosomes 8 and 25were significantly associated with inbreeding depression for the natural logarithm of the somatic cell ***,these regions contain several genes related with immunity,such as SYK,IL27,CCL19 and ***,one region on chromosome 2 was significantly associated with inbreeding depression for milk ***:Although genomic inbreeding levels are low in Murciano-Granadina goats,significant evidence of inbreeding depression for the logarithm of the somatic cell count,a phenotype closely associated with udder health and milk yield,have been detected in this *** inbreeding would be expected to augment economic gain by increasing milk yield and reducing the incidence of mastitis,which is one of the main causes of dairy goat culling.

关键词： Goat Inbreeding Milk yield Murciano-Granadina Somatic cell score

Seasonal influence and local factors affecting macroinvertebrate structure in a high-altitude Andean stream

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Journal of Mountain Science 2020年第6期17卷 1374-1386页

作者： SCHEIBLER Erica E fernández CAMPóN Florencia LAGOS SILNIK Susana WELLNITZ Todd Laboratorio de Entomologia IADIZACCT CONICET MendozaAvenida Ruiz Leal s/nParque Gral.San MartinCC 5075500MendozaArgentina Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET) Avenida Rivadavia 1917C1033AAJCABAArgentina Facultad de Ciencias Exactas y Naturales Universidad Nacional de CuyoPadre Jorge Contreras 1300M5502JMA MendozaArgentina Biology department University o f Wisconsin-Eau Claire105 Garfield Avenue54701Eau ClaireWisconsinUSA

Small water bodies are critical for maintaining freshwater biodiversity,but are among the least investigated aquatic *** examined physical and chemical variables at two reaches in Arroyo Tambillos,a small,high-elevation Andean stream,in NW Mendoza province,Argentina,across four seasons to examine how local factors and seasonality affected the structure of the macroinvertebrate *** Arroyo Tambillos community was numerically dominated by ephemeropterans(mainly Massartellopsis irarrazavali)while the dipteran Chironomidae were the most species *** macroinvertebrate abundance was highest in summer,driven mainly by taxa that were secondary in dominance(Austrelmis *** Andesiops peruvianus),while richness did not differ between ***,benthic composition was different in Fall 2013(March)compared to other seasons,largely because of the increased abundance of *** correspondence analysis discriminated Chironomidae species distributions in Fall 2013 by substrate type(i.e.,big and small boulder substrate).By contrast,discharge,velocity,and depth were the variables which most affected the macroinvertebrate abundance and *** to our expectations,most community changes observed occurred in fall instead of ***-kryal stream communities like the one described here have become increasingly important for conserving mountain stream biodiversity as anthropogentic impacts and climate change increasingly impact lower stream ***,monitoring high-altitude streams like the Arroyo Tambillos may be critical for preventing the future loss of unique and sensitive stream biota.

关键词： Ephemeroptera dominance Chironomidae richness Mountain small stream Physical variables Biodiversity Ecosystem

Alcoholism: A systemic proinflammatory condition

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World Journal of Gastroenterology 2014年第40期20卷 14660-14671页

作者： Emilio González-Reimers Francisco Santolaria-fernández María Candelaria Martín-González Camino María fernández-Rodríguez Geraldine Quintero-Platt Servicio de Medicina Interna Hospital Universitario de Canarias Universidad de La Laguna Tenerife 38320 Canary Islands Spain

Excessive ethanol consumption affects virtually any organ,both by indirect and direct *** research in the last two decades has widened the knowledge about the paramount importance of proinflammatory cytokines and oxidative damage in the pathogenesis of many of the systemic manifestations of *** cytokines derive primarily from activated Kupffer cells exposed to Gram-negative intestinal bacteria,which reach the liver in supra-physiological amounts due to ethanol-mediated increased gut *** oxygen species(ROS)that enhance the inflammatory response are generated both by activation of Kupffer cells and by the direct metabolic effects of *** effects of this increased cytokine secretion and ROS generation lie far beyond liver *** addition to the classic consequences of endotoxemia associated with liver cirrhosis that weredescribed several decades ago,important research in the last ten years has shown that cytokines may also induce damage in remote organs such as brain,bone,muscle,heart,lung,gonads,peripheral nerve,and *** effects are even seen in alcoholics without significant liver ***,alcoholism can be viewed as an inflammatory condition,a concept which opens the possibility of using new therapeutic weapons to treat some of the complications of this devastating and frequent *** this review we examine some of the most outstanding consequences of the altered cytokine regulation that occurs in alcoholics in organs other than the liver.

关键词： Alcoholism Cytokines Brain Bone Muscle Oxidative damage Atherosclerosis Sepsis Lung Chronic pancreatitis Alcoholic liver disease

Recent advances in liver preconditioning: Thyroid hormone, n-3 long-chain polyunsaturated fatty acids and iron

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World Journal of Hepatology 2012年第4期4卷 119-128页

作者： Virginia fernández Gladys Tapia Luis A Videla Molecular and Clinical Pharmacology Program Institute of Biomedical Sciences Faculty of Medicine University of Chile Casilla 70000 Santiago-7 Chile

Liver preconditioning (PC), defined as an enhanced tolerance to injuring stimuli induced by previous specific maneuvers triggering beneficial functional and molecular changes, is of crucial importance in human liver transplantation and major hepatic resection. For these reasons, numerous PC strategies have been evaluated in experimental models of ischemia-reperfusion liver injury, which have not been transferred to clinical application due to side effects, toxicity and difficulties in implementation, with the exception of the controversial ischemic PC. In recent years, our group has undertaken the assessment of alternate experimental liver PC protocols that might have application in the clinical setting. These include thyroid hormone (T3), n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA), or iron, which suppressed liver damage due to the 1 h ischemia-20 h reperfusion protocol. T3, n-3 LCPUFA and iron are hormetic agents that trigger biologically beneficial effects in the low-dose range, whose multifactorial mechanisms of action are discussed in the work.

关键词： Liver preconditioning Thyroid hormone n-3 polyunsaturated fatty acids Iron

Gut microbiota metabolites for sweetening type I diabetes

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Cellular & Molecular Immunology 2018年第2期15卷 92-95页

作者： Thamer Aljutaily Marta Consuegra-fernández fernando Aranda Francisco Lozano Eduardo Huarte department of Health and Nutritional Sciences South Dakota State UniversityBrookingsSDUSA Group of Immunoreceptors of the Innate and Adaptive System Institute d’Investigacions Biomédiques August pi i Sunyer(IDIBAPS)BarcelonaSpain department of Immunology Hospital Clínic of BarcelonaBarcelonaSpain department de Biomedical Sciences University of BarcelonaBarcelonaSpain

Type 1 diabetes(T1d),also referred to as insulin-dependent diabetes mellitus,is a debilitating disease that follows the destruction of pancreatic insulin-producingβcells by autologous T-cells.T1d primarily affects children and has a strong genetic component,with>50 susceptibility loci identified,including HLA-dQβchains.1 However,the striking differences between European regions with similar genetic backgrounds and a sharp rise in T1d incidence in developed countries over the last several decades suggest that environmental factor(s)also play a relevant etiopathogenic role.2 Given the accumulating evidence linking the gut microbiota to protection against metabolic diseases,3 Mariño et al.4 recently tested the hypothesis that short-chain fatty acids(SCFAs),which are the end products of fermentation of dietary fibers by anaerobic intestinal microbiota,can protect genetically susceptible mice from developing ***,the authors found that diets enriched in acetate or butyrate(two of the main SCFAs)can protect animals from developing diabetes through different and complementary cellular *** findings significantly enhance our understanding of the role of diet and gut microbiota in the development of autoimmune diseases and indicate that the use of medicinal foods may be a cost-effective treatment against T1d and other autoimmune diseases with a cellular *** that current anti-T1d approaches(which focus on prevention or modulation of the adaptive specific immune response against autoantigens)have been generally disappointing,5 such a new and refreshing strategy has attracted a great deal of attention(reviewed in Ref.2).

关键词： prevention striking linking