Gut microbiota metabolites for sweetening type I diabetes

作     者：Thamer Aljutaily Marta Consuegra-Fernández Fernando Aranda Francisco Lozano Eduardo Huarte 

作者机构：Department of Health and Nutritional SciencesSouth Dakota State UniversityBrookingsSDUSA Group of Immunoreceptors of the Innate and Adaptive SystemInstitute d’Investigacions Biomédiques August pi i Sunyer(IDIBAPS)BarcelonaSpain Department of ImmunologyHospital Clínic of BarcelonaBarcelonaSpain Department de Biomedical SciencesUniversity of BarcelonaBarcelonaSpain 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2018年第15卷第2期

页      面：92-95页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：The work by FL is supported by grants from the Worldwide Cancer Research(14-1275) FundacióLa MaratóTV3(201319-30) and Spanish Ministerio de Economía y Competitividad(Plan Nacional I+D+i,SAF2013-46151-R and SAF2016-80535-R)-co-financed by European Development Regional Fund‘A way to achieve Europe’ERDF.FA holds Sara Borrell(CD15/00016)and M-AES(MV16/00002)fellowships from Instituto de Salud Carlos III.TA is supported by the Cultural Mission of the Royal Embassy of Saudi Arabia(Qassim University) 

主　　题：prevention striking linking 

摘      要：Type 1 diabetes(T1D),also referred to as insulin-dependent diabetes mellitus,is a debilitating disease that follows the destruction of pancreatic insulin-producingβcells by autologous T-cells.T1D primarily affects children and has a strong genetic component,with50 susceptibility loci identified,including HLA-DQβchains.1 However,the striking differences between European regions with similar genetic backgrounds and a sharp rise in T1D incidence in developed countries over the last several decades suggest that environmental factor(s)also play a relevant etiopathogenic role.2 Given the accumulating evidence linking the gut microbiota to protection against metabolic diseases,3 Mariño et al.4 recently tested the hypothesis that short-chain fatty acids(SCFAs),which are the end products of fermentation of dietary fibers by anaerobic intestinal microbiota,can protect genetically susceptible mice from developing ***,the authors found that diets enriched in acetate or butyrate(two of the main SCFAs)can protect animals from developing diabetes through different and complementary cellular *** findings significantly enhance our understanding of the role of diet and gut microbiota in the development of autoimmune diseases and indicate that the use of medicinal foods may be a cost-effective treatment against T1D and other autoimmune diseases with a cellular *** that current anti-T1D approaches(which focus on prevention or modulation of the adaptive specific immune response against autoantigens)have been generally disappointing,5 such a new and refreshing strategy has attracted a great deal of attention(reviewed in Ref.2).