Alcoholism: A systemic proinflammatory condition
Alcoholism: A systemic proinflammatory condition作者机构：Servicio de Medicina Interna Hospital Universitario de Canarias Universidad de La Laguna Tenerife 38320 Canary Islands Spain
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2014年第20卷第40期
页 面：14660-14671页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Alcoholism Cytokines Brain Bone Muscle Oxidative damage Atherosclerosis Sepsis Lung Chronic pancreatitis Alcoholic liver disease
摘 要：Excessive ethanol consumption affects virtually any organ,both by indirect and direct *** research in the last two decades has widened the knowledge about the paramount importance of proinflammatory cytokines and oxidative damage in the pathogenesis of many of the systemic manifestations of *** cytokines derive primarily from activated Kupffer cells exposed to Gram-negative intestinal bacteria,which reach the liver in supra-physiological amounts due to ethanol-mediated increased gut *** oxygen species(ROS)that enhance the inflammatory response are generated both by activation of Kupffer cells and by the direct metabolic effects of *** effects of this increased cytokine secretion and ROS generation lie far beyond liver *** addition to the classic consequences of endotoxemia associated with liver cirrhosis that weredescribed several decades ago,important research in the last ten years has shown that cytokines may also induce damage in remote organs such as brain,bone,muscle,heart,lung,gonads,peripheral nerve,and *** effects are even seen in alcoholics without significant liver ***,alcoholism can be viewed as an inflammatory condition,a concept which opens the possibility of using new therapeutic weapons to treat some of the complications of this devastating and frequent *** this review we examine some of the most outstanding consequences of the altered cytokine regulation that occurs in alcoholics in organs other than the liver.
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