检索结果-南通市图书馆

Brain-derived neurotrophic factor as a potential biomarker of cognitive recovery in schizophrenia

World Journal of Psychiatry 2013年第4期3卷 93-102页

作者： Rafael Penadés Rosa Catalán Irene López-Vílchez Bárbara Arias Alexandre González-Rodríguez Ana M Galán cristóbal gastó Psychiatry and Psychology ClinicalInstitute of Neurosciences (ICN) Hospital Clínic 08036 Barcelona Spain Departmentof Psychiatry and Psychobiology University of Barcelona 08036 Barcelona Spain Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) 08036 Barcelona Spain Centro Investigación en Red Salud Mental (CIBER-SAM) 28007 Madrid Spain Hemotherapy and Hemo-stasis Centre for Biomedical Diagnosis Hospital Clínic 08036 Barcelona Spain Department of Anthropology Faculty of Biol-ogy and Biomedicine Institute University of Barcelona 08036 Barcelona Spain

Brain-derived neurotrophic factor(BDNF) has been proposed as a biomarker of schizophrenia and, more specifically, as a biomarker of cognitive recovery. Evidence collected in this review indicates that BDNF is relevant in the pathophysiology of schizophrenia and could play a role as a marker of clinical response. BDNF has been shown to play a positive role as a marker in antipsychotic treatment, and it has been demonstrated that typical antipsychotics decrease BDNF levels while atypical antipsychotics maintain or increase serum BDNF levels. Furthermore, BDNF levels have been associated with severe cognitive impairments in patients with schizophrenia. Consequently, BDNF has been proposed as a candidate target of strategies to aid the cognitive recovery process. There is some evidence suggesting that BDNF could be mediating neurobiological processes underlying cognitive recovery. Thus, serum BDNF levels seem to be involved in some synaptic plasticity and neurotransmission processes. Additionally, serum BDNF levels significantly increased in schizophrenia subjects after neuroplasticity-based cognitive training. If positive replications of those findings are published in the future then serum BDNF levels could be definitely postulated as a peripheral biomarker for the effects of intensive cognitive training or any sort of cognitive recovery in schizophrenia. All in all, the current consideration of BDNF as a biomarker of cognitive recovery in schizophrenia is promising but still premature.

关键词： Schizophrenia Brain-derived neurotrophic factor Cognition Biomarkers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Comprehensive Approach to Investigate CO_(2)Reduction Electrocatalysts at High Current Densities

引用

Accounts of Materials Research 2021年第4期2卷 220-229页

作者： gastón O.Larrazábal Ming Ma Brian Seger Section for Surface Physics and Catalysis(SurfCat) Department of PhysicsTechnical University of Denmark2800 Kgs LyngbyDenmark School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China

As electrochemical CO_(2)reduction studies progress from beaker or H-cell devices operating at low current densities to gas diffusion electrode(GDE)-based devices that sustain high reaction rates and provide an avenue toward commercialization,the overall system becomes significantly more *** the current densities may vary for the different approaches,it is essential to maintain the same scientific rigor when analyzing these *** mass transfer optimizations used in GDE based approaches necessarily add complexity and provide new challenges that need to be analyzed and overcome in terms of both engineering as well as analysis *** Account puts into perspective our recent works analyzing high current density CO_(2)electrolysis performance via a comprehensive investigation of the entire *** particular,we show the importance of monitoring(i)the gas flow rates at the outlet of the cathodic compartment,(ii)the anodic gas composition for CO_(2)/O_(2)ratio,and(iii)pH variations in the electrolyte.A rigorous analysis of these parameters allows us to achieve a complete carbon balance,in addition to accounting for a total of 100%Faradaic *** analyzing both the cathode outlet and anodic CO_(2):O_(2)ratio,we demonstrate that these methods can be used to self-validate results providing *** show that this analysis approach holds for both a zero-gap membrane electrode assembly device and a flowing-catholyte *** addition,a comprehensive monitoring approach reveals that having an alkaline environment in the vicinity of the cathode can absorb substantial amounts of CO_(2),which may greatly distort Faradaic efficiencies if not accounted *** monitoring the outlet flow rate of a reactor appears a simple task,the mixed gases and small flow rates in lab-scale reactors can add challenges and we discuss various methods to measure these flow *** pH is well-known to play a role in the activity and selectivity of CO_(2)redu

关键词： outlet necessarily electrolyte

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

COVID-19 and neurologic manifestations:a synthesis from the child neurologist’s corner

引用

World Journal of Pediatrics 2022年第6期18卷 373-382页

作者： Carolina Valderas gastón Méndez Alejandra Echeverría Nelson Suarez Katherin Julio Francisca Sandoval Department of Neurology Hospital Dr.Exequiel González CortésGran Avenida JoséMiguel Carrera 33008900085SantiagoRegión MetropolitanaChile

Background Since December 2019,the SARS-CoV-2 virus has been a global health *** main clinical presentation of this virus is a flu-like disease;however,patients with diverse neurologic manifestations have also been *** this review,we attempt to summarize,discuss and update the knowledge of the neurologic manifestations in the pediatric population affected by SARS-CoV-2 infection and the pandemic’s effects in children with neurologic *** sources This review analyzes studies found on the PubMed database using the following keywords:Neurologic manifestations COVID-19,Neurological COVID-19,coronavirus,SARS-CoV-2,pediatric COVID-19,COVID-19 in children,MIS-C,Pediatric Inflammatory Multisystem Syndrome,Guillain BarréSyndrome,Stroke,ADEM,and Anti-NMDA *** studies cited were published between 2004 and 2022,and represent the most relevant articles in the *** World Health Organization COVID-19 online dashboard was assessed to obtain updated epidemiological *** The most common neurologic symptoms in the pediatric population are headache,seizures,encephalopathy,and muscle *** can be present during COVID-19 or weeks after recovering from *** who presented with multi-system inflammatory syndrome had a higher incidence of neurologic manifestations,which conferred a greater risk of morbidity and *** neuro-pathophysiological mechanisms have been proposed,including direct virus invasion,hyper-inflammatory reactions,multi-systemic failure,prothrombotic states,and immune-mediated *** the other hand,the COVID-19 pandemic has affected patients with neurologic diseases,making it challenging to access controls,treatment,and *** Various neurologic manifestations have been associated with children’s SARS-CoV-2 *** is important to identify and give them proper and opportune treatment because they can be potentially grave and life-threatening;some can lead to long-lasting se

关键词： Coronavirus COVID-19 Neurologic Pediatric SARS-CoV-2 MIS-C

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Copper-indium hydroxides derived electrocatalysts with tunable compositions for electrochemical CO_(2) reduction

引用

Journal of Energy Chemistry 2021年第12期30卷 278-284,I0006页

作者： Qixian Xiea gaston O.Larrazabal Ming Ma Ib Chorkendorff Brian Seger Jingshan Luo Institute of Photoelectronic Thin Film Devices and Technology Solar Energy Research CenterKey Laboratory of Photoelectronic Thin Film Devices and Technology of TianjinMinistry of Education Engineering Research Center of Thin Film Photoelectronic TechnologyRenewable Energy Conversion and Storage CenterNankai UniversityTianjin 300350China Surface Physics and Catalysis(Surf Cat)Section Department of PhysicsTechnical University of Denmark2800 Kgs.LyngbyDenmark School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'an 710049Shaanxi.China

Bimetallic Cu-In hybrid electrocatalysts are promising noble metal-free catalysts for selective electrochemical CO_(2) reduction reaction(ECO_(2) RR).Most reports show Cu-In catalysts are selective towards CO evolutio ***,few show similarly high selectivity towards *** we fabricated composition tunable Cu-In hydroxides(Cu_xIn_y-OH) by the hydrothermal method and studied their composition effect on electrochemical CO_(2) reduction in detail. We found that the selectivity of CO_(2) reduction products shifted from CO to formate when the content of In increased in the Cu_xIn_y-OH *** Cu rich electrocatalyst mostly produced CO,which could achieve a Faradaic efficiency(FE) to 75.8% at-0.59 V ***(Cu_(76)In_(24)based electrocatalysts).In comparison,the In rich electrocatalysts selectively produced formate,which possessed the FE of formate up to 85% at-1.01 V *** work systematically illustrates the composition effect on hybrid catalysts,and provides insights into the design of highly selective catalysts for ECO_(2) RR.

关键词： Electrochemical CO_(2)reduction Bimetallic Cu-In hybrid electrocatalysts Carbon monoxide Formate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metformin and colorectal cancer

引用

BIOCELL 2022年第1期46卷 51-59页

作者： gastÓN AMABLE EDUARDO MARTÍNEZ-LEÓN MARÍA E.PICCO OSVALDO REY Consejo Nacionalde Investigaciones Científicas y Técnicas Universidad de Buenos AiresInstituto de InmunologíaGenética y MetabolismoFacultadde Farmacia y BioquímicaHospital de Clínicas“Joséde San Martín”Ciudad Autónoma de Buenos AiresCP1120Argentina

Colorecal cancer(CRC)is one of the main causes of cancer-related mortality in the deweloped world despite recent developments in detection and treatment Several epidemiologial studis indicate that metformin,a widdy prescribed antidiabetic drug,exerts a protective effect on different cancers incuding ***,a recent double blind placebo controlled,randomized trial showed that metformin significantly decreased colorectal adenoma *** exploring the medhanism of action of metformin in cells derived from different types of ancers reported many efects including rapiratory chain complex 1 inhibition,Akt phosphorylation inhibition,ATP depltion,PKA activation and Wnt signaling ***,many of these results were obtained employing metformin at concentrations several fold higher than those achieved in target tissuas in diabetic patients receiving therapeutic recommended doses of *** contrast,recent studies obtained with metformin at concentrations compatible with those detected in human intestins revealed that metformin dicit responses that targetβ-catenin,PI3KAkt,E-adherin,pl20-catenin and focal adhesion kinase which are key molecules and signaling pathways associated to colorectal cancar *** brief review revisit several know aspects as well as nowd ones on the effects of metformin on cancer cells.

关键词： Metformin β-Catenin E-Cadherin Colorectal cancer AMPK PI3K/AKT FAK

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Brazilian savanna re-establishment in a monoculture forest:diversity and environmental relations of native regenerating understory in Pinus caribaea Morelet. stands

引用

Journal of Forestry Research 2015年第3期26卷 571-579页

作者： gasto Viegas de Pinho Júnior AndréR. Terra Nascimento Barbara Tahara Valverde Lucas H. Clemente Elementary/High Schools in Uberlndia UberlndiaMinas Gerais 38412-436 Brazil Universidade Federal de Uberlndia UberlndiaMinas Gerais 38412-436 Brazil Avenida Ortizio Borges 2836 Bairro Santa MnicaUberlndia Minas Gerais 38412-436 Brazil

In this paper we analyze and compare natural regeneration in shrub-tree community in three areas below Pinus caribaea stands and a natural area （cerrado sensu stricto）. We also analyze the influence of biophysical and environmental variables on the distribution of regenerating shrub-tree species. The areas were analyzed and compared in relation to dispersal syndromes as well, being zoochory and anemochory the prevailing syndroms in the four areas. The sites below P. caribaea show a heterogeneous regen- eration with the number of species ranging from 18 to 42. We analyzed the influence of the biophysical and envi- ronmental variables performing a canonical correspon- dence analyses, being found significant values for variables distance from remnant and basal area. The species Si- paruna guianensis, Miconia albicans, Xylopia aromatica, Sclerolobium paniculatum, Casearia sylvestris and P. caribaea were the most importante ones in the four areas,

关键词： Native regeneration Cerrado Commercialforests Multivariate analysis Plant ecology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On a Dual to the Properties of Hurwitz Polynomials I

引用

American Journal of Computational Mathematics 2021年第1期11卷 31-41页

作者： gastón Vergara-Hermosilla Université de Bordeaux Talence France

In this work we develop necessary and sufficient conditions for describing the family of anti-Hurwitz polynomials, introduced by Vergara-Hermosilla et al. in [1]. Specifically, we studied a dual version of the Theorem of Routh-Hurwitz and present explicit criteria for polynomials of low order and derivatives. Another contribution of this work is establishing a dual version of the Hermite-Biehler Theorem. To this aim, we give extensions of the boundary crossing Theorems and a zero exclusion principle for anti-Hurwitz polynomials.

关键词： Hurwitz Polynomials Anti-Hurwitz Polynomials Hermite-Biehler Theo-rem Exclusion Principle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hydrocarbon biodegradation and dynamic laser speckle for detecting chemotactic responses at low bacterial concentration

引用

Journal of Environmental Sciences 2013年第3期25卷 613-625页

作者： Melina Nisenbaum Gonzalo Hernn Sendra gastón Alfredo Cerd Gilbert Marcelo Scagliola Jorge Froiln Gonzlez Silvia Elena Murialdo National University of Mar del Plata Faculty of EngineeringDepartment of ChemistryBiochemical Engineering Group.Juan B.Justo 4302(7600)Mar del PlataArgentina National University of Mar del Plata Faculty of EngineeringLaser Laboratory7600Mar del PlataArgentina and Optical Research CenterCONICETLa Plata-CIC.PO Box No.3 1897GonnetLa PlataArgentina OSSE.Obras Sanitarias Mar del Plata-Batn S.E.Quality Management Water Laboratory.French 67377600Mar del PlataArgentina

We report on the biodegradation of pure hydrocarbons and chemotaxis towards these compounds by an isolated chlorophenol degrader,Pseudomonas strain *** biochemical and phylogenetic analysis of the 16S rDNA sequence identified Pseudomonas strain H as having 99.56% similarity with *** *** strain was able to degrade n-hexadecane,1-undecene,1-nonene,1-decene,1-dodecene and *** grew in the presence of 1-octene,while this hydrocarbons is toxic to other hydrocarbons *** strain H was also chemotactic towards n-hexadecane,kerosene,1-undecene and *** results show that this Pseudomonas strain H is an attractive candidate for hydrocarbon-containing wastewater bioremediation in controlled *** the classical standard techniques for detecting chemotaxis are not efficient at low bacterial concentrations,we demonstrate the use of the dynamic speckle laser method,which is simple and inexpensive,to confirm bacterial chemotaxis at low cell concentrations （less than 105 colony-forming unit per millilitre （CFU/mL）） when hydrocarbons are the attractants.

关键词： dynamic laser speckle microorganisms biodegradation chemotaxis hydrocarbons

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A comparative pattern of lectin-binding in the endometrial glands of the uterus and placenta of healthy buffaloes and bovines at early gestation

引用

BIOCELL 2021年第2期45卷 331-337页

作者： SERGIO gastÓN CASPE JOSÉLUIS KONRAD DADIN PRANDO MOORE JUAN MANUEL SALA LILIAN LISCHINSKY CARLOS MANUEL CAMPERO CLAUDIO GUSTAVO BARBEITO Laboratory of Pathology Experimental Station MercedesInstituto Nacional de Tecnología AgropecuariaCorrientes3470Argentina Laboratory of Theriogenology School of Veterinary SciencesUniversidad Nacional del NordesteCorrientesW3402BKGArgentina Animal Health Group Experimental Station BalcarceInstituto Nacional de Tecnología AgropecuariaBalcarceB7620EMAArgentina Laboratory of Histology and Embryology School of Veterinary SciencesUniversidad Nacional de La PlataLa Plata1900Argentina

Water buffalo(Bubalus bubalis)and domestic cattle(Bos taurus)are closely related ***,embryo transfer interspecies has been attempted without any *** failure in hybrid embryo-implantation is associated with the glycocode in the maternal-fetal *** patterns have been studied in different species of ruminants;however,in ***,only the binucleated cells(BNC)have been *** glycocode is essential for a successful embryo-implantation and can be defined by Lectin-Histochemistry(LHC).The aim of this study is to compare the glycosylation pattern of placenta and uterus in water buffaloes and cattle by *** samples of placenta and uterus from pregnant Mediterranean female water buffaloes(Buf1)and Angus cows(Bov1)were *** animals were euthanized at 98 days of *** was carried out using twelve lectins(Con A,LCA,PSA,sWGA,PHA-e,SBA,UEA-1,WGA,RCA-1,PNA,DBA,BSA-1).The intensity of lectin binding was semiquantitatively scored using a scale of 0(negative)to 3(strongly positive).Difference between species was found in trophoblast layer by PSA,SWGA,PNA and BSA-1,in BNC,and in the mononuclear cells by LCA,PSA,PHA-e,DBA,BSA-1,*** utero,differences in the apical cellular membrane and the secretion of glands were identified by DBA and RCA-1,and in the cytoplasm of those glandular epithelial cells by PHA-e,BSA-1,WGA,and *** both species,BNC presented a strong positive reaction with DBA and SBA,a moderate response by LCA,PHA-e,BSA-1 and PNA lectin,and a low reaction by PSA,UEA-1,SWGA,WGA,Con A and *** results found in this study suggest that although both species are closely related,glycosylation patterns in the placenta and uterus are different,thus providing a possible reason for embryo transfer not being possible between these species.

关键词： Lectin-histochemistry Water buffalo Placenta Glycosylation pattern

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cyclic heptapeptides with metal binding properties isolated from the fungus Cadophora malorum from Antarctic soil

引用

Natural Products and Bioprospecting 2022年第1期12卷 393-402页

作者： Guidmar C.Donalle María Martha Martorell gastón E.Siless Lucas Ruberto Gabriela M.Cabrera Facultad de Ciencias Exactas y Naturales Departamento de Química OrgánicaUniversidad de Buenos AiresBuenos AiresArgentina Unidad de Microanálisis y Métodos Físicos Aplicados a la Química Orgánica(UMYMFOR) CONICET-Universidad de Buenos AiresBuenos AiresArgentina Instituto Antártico Argentino Instituto NanobiotecCONICET-Universidad de Buenos AiresBuenos AiresArgentina

The Antarctic fungus Cadophora malorum produces previously undescribed cyclic heptapeptides(cadophorin A and B)containing an anthranilic acid *** planar structure of these peptides was determined by high-resolution mass spectrometry combined with extensive 1D and 2D NMR *** absolute configuration of the amino acids was determined by Marfey’s method,with HPLC analysis of FDVA(Nα-(2,4-dinitro-5-fluorphenyl)-l-valinamide)derivatives making use of a PFP ***,cadophorin 2 possesses both the uncommon d-Ile and d-allo-Ile in its *** peptides have metal binding properties as shown by LCMS with post column addition of metal salt *** results were supported by DFT calculations.

关键词： Cyclic peptide Cadophora malorum Metal binding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：