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Targeted genotyping for the prediction of celiac disease autoimmunity development in patients with type 1 diabetes and their family members

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World Journal of Diabetes 2019年第3期10卷 189-199页

作者： Maureen M Leonard Stephanie Camhi Victoria Kenyon Rebecca A Betensky craig Sturgeon Shu Yan Alessio Fasano Mucosal Immunology and Biology Research Center Mass General Hospital for Children Boston MA 02115 United States Center for Celiac Research and Treatment Mass General Hospital for Children Boston MA 02115 United States Department of Pediatric Gastroenterology and Nutrition Mass General Hospital for Children Boston MA 02114 United States Department of Biostatistics Harvard T.H. Chan School of Public Health Boston MA 02115 United States

BACKGROUND Patients with type 1 diabetes (T1D) and their first-degree relatives (FDRs) have an increased risk of developing celiac disease (CD) compared to the general population. This is largely explained by the shared association with major histocompatibility class II human leukocyte antigen (hLA) DQ2 and/or DQ8 between the two disease states. AIM To describe the frequency of CD autoimmunity (CDA) and the distribution of hLA and haptoglobin genotypes in patients with T1D and their FDRs. Additionally, we aimed at identifying predictors associated with an increased risk of developing CDA in patients with T1D and their family members. METhODS We obtained clinical information and blood samples from 1027 participants (302 with T1D and 725 FDRs) over a five-year period. Samples were tested for autoantibodies associated with CD, hLA-DQ alleles, and haptoglobin *** fit univariate and multiple logistic regression models for CDA separately for subjects with T1D and for FDRs of subjects with T1D. RESULTS Implementation of a screening program increased the frequency of CDA by 2- fold in participants with T1D and 2.8-fold in their FDRs. Multivariate analysis found that, in participants with T1D, having both DR7-DQ2 and DR4-DQ8 was associated with an increased frequency of CDA. In FDRs of T1D patients, reported CD in the family was associated with an increased frequency of CDA during screening. haptoglobin 2 genotype was not associated with developing CDA in the multivariate analysis. CONCLUSION Patients with T1D and their FDRs have a high frequency of CDA. Carrying both DR7-DQ2 and DR4-DQ8 was associated with development of CDA in patients with T1D.

关键词： Screening Gluten Diabetic Coeliac haptoglobin human leukocyte antigen

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Analysis of a ten step protocol to decrease postoperative spinal wound infections

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World Journal of Orthopedics 2018年第11期9卷 271-284页

作者： hossein Elgafy craig J Raberding Megan L Mooney Kyle A Andrews Joan M Duggan Department of Orthopedics and Infectious Diseases University of Toledo Medical Center

AIM To define a ten-step protocol that reduced the incidence of surgical site infection in the spine surgery practice of the senior author and evaluate the support for each step based on current *** In response to unexplained increased infection rates at our institution following spine surgery,a ten-step protocol was implemented:(1) preoperative glycemic management based on hemoglobin A1 c(hbA1 c);(2) skin site preoperative preparation with 2% chlorhexidine gluconate disposable cloths;(3) limit operating room traffic;(4) cut the number of personnel in the room to the minimum required;(5) absolutely no flash sterilization of equipment;(6) double-gloving with frequent changing of outer gloves;(7) local application of vancomycin powder;(8) re-dosing antibiotic every 4 h for prolonged procedures and extending postoperative coverage to 72 h for high-risk patients;(9) irrigation of subcutaneous tissue with diluted povidone-iodine solution after deep fascial closure; and(10) use of Dura Prep skin preparation at the end of a case before skin closure. Through an extensive literature review,the current data available for each of the ten steps was *** Use of vancomycin powder in surgical wounds,routine irrigation of surgical site,and frequent changing of surgical gloves are strongly supported by the literature. Preoperative skin preparation with chlorhexidine wipes is similarly supported. The majority of current literature supports control of hbA1 c preoperatively to reduce risk of infection. Limiting the use of flash sterilization is supported,but has not been evaluated in spine-specific surgery. Limiting OR traffic and number of personnel in the OR are supported although without level 1 evidence. Prolonged use of antibiotics postoperativelyis not supported by the literature. Intraoperative use of Dura Prep prior to skin closure is not yet *** The ten-step protocol defined herein has significantly helped in decreasing surgical site

关键词： Wound infections Spine Ten step protocol Surgical site infections

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Fish vaccines:current state and future trends

Fish vaccines:current state and future trends

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中国工程院第77场工程科技论坛·2008水产科技论坛——渔业现代化与可持续发展

作者： Phillip h.Klesius craig A.Shoemaker Joyce J.Evans Aquatic Animal health Research Laboratory Agricultural Research ServiceU.S.Department of AgricultureAuburnAlabama 36832 and ChestertownMaryland 21620U.S.A.

A vaccine is a preventive tool used in a health management strategy for the control of infectious diseases in *** more than 100 years,vaccines have proved to be an effective tool for preventing infectious disease outbreaks in humans,poultry and other food *** aquaculture, the development and use of vaccines is now making rapid progress to achieve its full potential as effective disease prevention *** objective of vaccination is to provide a strong immune response to an administered antigen able to provide acquired long-term protection against a *** achieve this objective either a killed or modified live vaccine needs to be developed and licensed for use in fresh or marine water *** type of immunity needed,antibody and/or cell-mediated against,a particular pathogen is among the deciding factors in the development of a *** with a killed bacterial vaccine produces an antibody-mediated protection,but not cell-mediated *** and/or antibody-mediated immunity can be provided only by immunization with a modified live ***,antibody-mediated immunity provided by killed vaccines is relatively short lived in terms of protection(3-5 months).Longer protection(≥12 months)is provided by modified live *** duration of protection may be increased by the addition of an adjuvant to the killed *** adjuvant is a substance that increases specific immune responses against the co-inoculated *** vaccines are usually administered by intraperitonal and/or intramuscular injection of individual *** is the least cost effective in terms of labor and time. Modified live vaccines may be administered by bath immersion to large numbers of fish(fry and/or eggs)which is a more cost effective method of mass vaccination in both labor and *** vaccines are considered to be safer than modified live vaccines which may revert to ***, future trends include oral del

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Expression of miR-15/107 Family MicroRNAs in human Tissues and Cultured Rat Brain Cells

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Genomics, Proteomics & Bioinformatics 2014年第1期12卷 19-30页

作者： Wang-Xia Wang Robert J.Danaher craig S.Miller Joseph R.Berger Vega G.Nubia Bernard S.Wilfred Janna h.Neltner Christopher M.Norris Peter T.Nelson Sanders-Brown Center on Aging University of KentuckyLexingtonKY 40536USA College of Dentistry University of KentuckyLexingtonKY 40536USA Department of Neurology University of KentuckyLexingtonKY 40536USA Department of Pathology University of KentuckyLexingtonKY 40536USA Department of Molecular and Biomedical Pharmacology University of KentuckyLexingtonKY 40536USA

The miR-15/107 family comprises a group of 10 paralogous microRNAs （miRNAs）,sharing a 5＇ AGCAGC *** miRNAs have overlapping *** order to characterize the expression of miR-15/107 family miRNAs,we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members,and other selected miRNAs,in 11 human tissues obtained at autopsy including the cerebral cortex,frontal cortex,primary visual cortex,thalamus,heart,lung,liver,kidney,spleen,stomach and skeletal ***-103,miR-195 and miR-497 were expressed at similar levels across various tissues,whereas miR-107 is enriched in brain *** also examined the expression patterns of evolutionarily conserved miR-15/107 miRNAs in three distinct primary rat brain cell preparations （enriched for cortical neurons,astrocytes and microglia,respectively）.In primary cultures of rat brain cells,several members of the miR-15/107 family are enriched in neurons compared to other cell types in the central nervous system （CNS）.In addition to mature miRNAs,we also examined the expression of precursors （pri-miRNAs）.Our data suggested a generally poor correlation between the expression of mature miRNAs and their *** summary,we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of miRNA genes.

关键词： miR-16 miR-424 miR-503 miR-15 Normalization Target prediction

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医院生命安全管理的思考

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中国医院建筑与装备 2006年第5期7卷 60-61页

作者： craig h.Kampmier 美国防火协会

实现'绿色环境+环境科技'是21世纪人类社会追求的目标.在科学技术飞速发展的今天,环境工程学被广泛应用在环境空间建设与管理领域.作为保障人类健康的医疗机构,医院对环境空间建设与安全管理有着特殊要求.

关键词：医院环境安全管理绿色环境生命环境工程技术计算机模拟人类社会 21世纪

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Surgical management of osteonecrosis of the femoral head in patients with sickle cell disease

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World Journal of Orthopedics 2015年第10期6卷 776-782页

作者： Atul F Kamath Michael h McGraw craig L Israelite Department of Orthopedic Surgery the Center for Hip PreservationPenn MedicineUniversity of Pennsylvania

Sickle cell disease is a known risk factor for osteonecrosis of the *** within the femoral head may cause severe pain,functional limitations,and compromise quality of life in this patient *** stages of avascular necrosis of the hip may be managed surgically with core decompression with or without autologous bone *** hip arthroplasty is the mainstay of treatment of advanced stages of the disease in patients who have intractable pain and are medically fit to undergo the *** management of hip pathology in sickle cell disease presents numerous medical and surgical challenges,and the careful perioperative management of patients is *** there is an increased risk of medical and surgical complications in patients with sickle cell disease,total hip arthroplasty can provide substantial relief of pain and improvement of function in the appropriately selected patient.

关键词： Sickle cell disease Total hip arthroplasty Core decompression Orthopedic Osteonecrosis Avascular necrosis hip

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Introduction to Applied Geophysics

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2006年

作者： Burger, henry Robert/ Sheehan, Anne F./ Jones, craig h.

ISBN: (纸本)9780393926378

"Introduction to Applied Geophysics" covers the fundamental principles and common methods of exploration geophysics, preparing students for field study of the shallow subsurface. Offering a chapter on each of the most common methods of exploration, the book explains in detail how each method is performed and discusses that method's geologic, engineering and environmental applications. In addition to ample examples, illustrations and applications throughout, each chapter concludes with a problem set. The book is accompanied by the Field Geophysics Software Suite, an innovative CD-ROM that allows students to experiment with refraction and reflection seismology, gravity, magnetics, electrical resistivity and ground-penetrating radar methods of exploration.

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The Effects of a School-Based Injury Prevention Program on Injury Incidence in Young Females

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Journal of Science in Sport and Exercise 2021年第1期3卷 47-55页

作者： Lesley M.Sommerfield Chris S.Whatman craig B.harrison Peter S.Maulder Sports Performance Research Institute New Zealand AUT UniversityMillennium Campus17 Antares PlaceMairangi BayAuckland 0632New Zealand Centre for Sport Science and human Performance Waikato Institute of TechnologyTristram StreetWhitioraHamilton 3200New Zealand

Purpose To examine the effects of a progressive injury prevention(IP)program,embedded into school curriculum,on injury rates in young *** One hundred and three physical education(PE)students[mean±SD;age= 14.0±0.6 years;height= 162.6±5.8 cm;mass = 57.4±9.8 kg,intervention(INT)n = 53,control(CON)n = 50]from a girls'secondary school participated in this *** INT group(competitive athletes)completed a 23-week(three phase)IP program whereas the CON group con-tinued normal PE *** online questionnaire recorded training and competition exposure and self-reported *** The INT group reported significantly more weekly training and competition hours than the CON group(4.15±4.78 vs.2.19±3.22,Phours and 0.77±1.42 vs.0.55±1.10,Phours).There was no differ-ence in any injury rate between the two *** was a significant reduction in injury rate between phase 1 and phase 3 of the IP program for the INT group[injury rate ratio = 0.63(95%CI = 0.41-0.96);P = 0.02].Injury rates in competition were higher than in training(40.1 and 36.3 injuries per 1000 h competition vs.13.7 and 9.5 injuries per 1000 h training).Conclusion Although there was no difference in injury rates between groups,the IP program did significantly reduce rates with-in the INT group over the duration of the school year and may be protective against increased injury incidence for young females engaged in competitive sports.

关键词： Neuromuscular training Youth Girls Injury rates

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阿尔泰铁木尔特铅锌矿床的碳质流体组合及其地质意义

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岩石学报 2008年第9期24卷 2094-2104页

作者：徐九华单立华丁汝福 craig J hART 王琳琳卫晓锋北京科技大学资源工程系北京100083 北京矿产地质研究院北京100012 Dept.of Geology and Geophysics University of West Australia

铁木尔特铅锌矿是阿尔泰克兰盆地内最主要的 VMS 型矿床。矿床受控于阿巴宫—库尔提断裂,铅锌矿体分布于该断裂 NE 逆冲盘的下泥盆统康布铁堡组地层绿泥石英片岩、大理岩或层状矽卡岩中。矿体形态多呈透镜状、似层状,并整合产于变质岩系... 详细信息

铁木尔特铅锌矿是阿尔泰克兰盆地内最主要的 VMS 型矿床。矿床受控于阿巴宫—库尔提断裂,铅锌矿体分布于该断裂 NE 逆冲盘的下泥盆统康布铁堡组地层绿泥石英片岩、大理岩或层状矽卡岩中。矿体形态多呈透镜状、似层状,并整合产于变质岩系中,发育多个矿化层。金属矿物有方铅矿、闪锌矿、黄铜矿、黄铁矿和磁黄铁矿等。铁木尔特铅锌矿床晚期发育多金属硫化物石英脉,至少可识别出3个流体包裹体组合(FIA)。FI0为高盐度流体包裹体组合,主要为含子矿物的多相包裹体(L-V-S 型),部分为气液两相包裹体(L-V 型),局限于单个石英颗粒内,包裹体呈无序分布,或呈孤立的单个包裹体分布, 包裹体的最终均一温度322～422.5℃。FI1为次生的CO_2-h_2O 流体包裹体组合,主要由单相(L_(CO_2))和两相(L_(CO_2)-L_(h_2O))的富CO_2包裹体组成,呈线性分布,穿透石英颗粒边界,明显属于次生包裹体范畴、FI2为碳质(CO_2-Ch_4)流体包裹体组合,广泛发育,包裹体主要由单相(L_(CO_2)、L_(CO_2-Ch_4)或 L_(CO_2-N_2))、少量两相(LCO,-Lh'O)富CO。包裹体组成,大小5μm～20μm,成群定向分布,穿透石英颗粒边界并切断 FI1,是晚于 FI1的次生包裹体组合,反映晚期较大的构造—流体活动。对 FI2的详细研究表明,L_(CO_2)型包裹体的 T_(mCO_2)=-63.3～-57.7℃,T_(hCO_2)=-27.5～+29.7℃;L_(CO_2-Ch_4)型或 L_(CO_2-N_2)型包裹体的 T_(mCO_2)=-80.5～-65.5℃,T_(hCO_2)=-56.0～-25.0℃;L_(CO_2)-L_(h_2O)型包裹体 CO_2相的 T_(mCO_2)=-66.9～-60.9℃,T_(hCO_2)=-13.3～+2.3℃,包裹体的最终均一温度 T_(h,total)=243.1～361.1℃。铁木尔特次生碳质流体组合,萨热阔布金矿主成矿阶段、赛都—多拉纳含金剪切带中早期透镜状石英脉碳质流体组合,以及阿舍勒等矿床的次生碳质流体组合,都具有相似的流体性质,均为高密度的CO_2-Ch_2-N_2流体,其来源与石炭—二叠造山作用主期的区域动力热流变质作用有关。

关键词：碳质流体包裹体铁木尔特矿床阿尔泰

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瓦楞纸箱性能测试

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国外造纸 1990年第3期9卷 14-17页

作者： craig h.Leake 樊辉

我们公司除了把自己的产品供应给瓦楞加工业外,也是瓦楞纸箱的用户之一,正是由于这一原因。我们关注着诸如纸箱式样、结构、性能及经济性等方面的问题。在讨论降低成本的方法时,针对所购买的纸箱类型出现了这样一个问题:在不影响纸箱性... 详细信息

我们公司除了把自己的产品供应给瓦楞加工业外,也是瓦楞纸箱的用户之一,正是由于这一原因。我们关注着诸如纸箱式样、结构、性能及经济性等方面的问题。在讨论降低成本的方法时,针对所购买的纸箱类型出现了这样一个问题:在不影响纸箱性能的前提下,能否用较便宜的126.9g/m^2的瓦楞芯纸替代目前所使用的161.1g/m^2的瓦楞芯纸。

关键词：瓦楞纸箱性能测试

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