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Investigation of bone reconstruction using an attenuated immunogenicity xenogenic composite scaffold fabricated by 3D printing

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Bio-Design and Manufacturing 2020年第4期3卷 396-409页

作者： Qiongxi Pan Chenyuan gao Yingying Wang Yili Wang cong Mao Quan Wang Sophia n.Economidou Dennis Douroumis f.ng Wen Lay Poh Tan Huaqiong Li School of Biomedical Engineering School of Ophthalmology and Optometry and Eye HospitalWenzhou Medical UniversityWenzhou 325035Zhejiang ProvincePeople’s Republic of China Engineering Research Center of Clinical f.nctional Materials and Diagnosis and Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011Zhejiang ProvincePeople’s Republic of China Key Laboratory of Orthopedics of Zhejiang Province Department of OrthopedicsThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvincePeople’s Republic of China Medway School of Pharmacy University of KentMedway CampusCentral AvenueChatham MaritimeChathamKent ME44TBUK CIPER Centre for Innovation and Process Engineering ResearchKent ME44TBUK School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore 637459Singapore School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore

Bone is known to have a natural f.nction to heal ***,if the bone damage is beyond a critical degree,intervention such as bone grafting may be *** this work,the fabrication of a novel bone scaffold composed of.natural bone components and polycaprolactone(PCL)using 3D printing is put forward.α1,3-galactosyltransferase deficient pigs were used as the donor source of a *** porcine bone(DCB)with attenuated immunogenicity was used as the natural component of the scaffold with the aim to promote bone *** 3D printed DCB-PCL scaffolds combined essential advantages such as uniformity of the interconnected macropores and high porosity and enhanced compressive *** biological properties of the DCB-PCL scaffolds were evaluated by studying cell adhesion,viability,alkaline phosphatase activity and osteogenic gene expression of human bone marrow-derived mesenchymal stem *** in vitro results demonstrated that the DCB-PCL scaffolds exhibit an enhanced performance in promoting bone differentiation,which is correlated to the DCB ***,critical-sized cranial rat defects were used to assess the effect of DCB-PCL scaffolds on bone regeneration in *** results confirm that in comparison with PCL scaffolds,the DCB-PCL scaffolds can significantly improve new bone formation in cranial ***,the proposed 3D printed DCB-PCL scaffolds emerge as a promising regeneration alternative in the clinical treatment of large bone defects.

关键词： Polycaprolactone 3D printing Decellularized porcine bone Cranial bone regeneration Attenuated immunogenicity

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改良的复方聚乙二醇电解质溶液剂量分配方案应用于肠道准备的效果评价

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消化肿瘤杂志（电子版） 2024年第2期16卷 244-249页

作者：丛雪韦键班燕高林英张静首都医科大学附属北京友谊医院消化分中心北京100050 首都医科大学附属北京友谊医院护理部北京100050

目的肠道准备标准方案中3L复方聚乙二醇电解质溶液(polyethyleneglycol electrolyte solution,PEG-ES)的服用方法为结肠镜检查前1晚服用1LPEG-ES、检查当天早晨服用2L PEG-ES。由于部分患者对于晨起服用2LPEG-ES的耐受性较差,本研究设... 详细信息

目的肠道准备标准方案中3L复方聚乙二醇电解质溶液(polyethyleneglycol electrolyte solution,PEG-ES)的服用方法为结肠镜检查前1晚服用1LPEG-ES、检查当天早晨服用2L PEG-ES。由于部分患者对于晨起服用2LPEG-ES的耐受性较差,本研究设计交换检查前1晚和当天早晨两次服用剂量的改良方案,旨在比较患者行改良方案与标准方案的肠道准备质量和耐受性差异。方法本研究为单中心单盲随机对照试验,选取2022年1月1日至2023年4月30日在首都医科大学附属北京友谊医院行结肠镜下息肉切除的206例住院患者为研究对象,采用随机数字表法将其按1:1分为对照组(n=103)和试验组(n=103)。对照组执行标准方案,分别于结肠镜检查前1晚19:00服用1LPEG-ES,结肠镜检查当天早4:00服用2LPEG-ES。试验组则交换两次服用PEG-ES的剂量。观察两组患者的肠道准备质量评分、肠道气泡评分、结肠镜检查操作时间、新发息肉检出率、患者不良反应、睡眠质量及再次行同样肠道准备的意愿。结果两组患者的性别、年龄、学历、体重指数的差异无统计学意义(P>0.05),且均顺利完成肠道准备和结肠镜检查。试验组与对照组的肠道准备质量评分分别为(6.45±1.06)分和(6.61±1.36)分,差异无统计学意义(P=0.333),并且两组肠道准备充分率(P=0.372)、肠道气泡评分(P=0.191)、结肠镜检查操作时长(P=0.629)及新发息肉检出率(P=0.460)差异均无统计学意义,但两组患者不良反应发生率(P=0.009)、睡眠质量(P<0.001)及再次行同样肠道准备的意愿(P<0.001)的差异有统计学意义。结论改良的PEG-ES剂量分配方案对于晨起服用PEG-ES耐受性较差、睡眠质量不佳的患者,具有可根据个人耐受度、服药习惯自主选择PEG-ES剂量分配方案的优点,改良方案具有安全性、可行性。

关键词：复方聚乙二醇电解质溶液结肠镜肠道准备剂量分配

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A novel superhard tungsten nitride predicted by machine-learning accelerated crystal structure search

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Science Bulletin 2018年第13期63卷 817-824页

作者： Kang Xia Hao gao cong Liu Jianan Yuan Jian Sun Hui-Tian Wang Dingyu Xing national Laboratory of Solid State Microstructures School of Physics and Collaborative Innovation Center of Advanced MicrostructuresNanjing University

Transition metal nitrides have been suggested to have both high hardness and good thermal stability with large potential application value, but so far stable superhard transition metal nitrides have not been synthesized. Here, with our newly developed machine-learning accelerated crystal structure searching method, we designed a superhard tungsten nitride, h-Wn6, which can be synthesized at pressure around 65 GPa and quenchable to ambient pressure. This h-Wn6 is constructed with single-bonded armchair-like n6 rings and presents ionic-like features, which can be formulated as W^2.4＋n^2.4-. It has a band gap of 1.6 eV at 0GPa and exhibits an abnormal gap broadening behavior under pressure. Excitingly, this h-Wn6 is found to be the hardest among transition metal nitrides known so far （Vickers hardness around 57 GPa） and also has a very high melting temperature （around 1,900 K）. Additionally, the good gravimet- ric （3.1 kJ/g/and volumetric （28.0 kJ/cm3） energy densities make this nitrogen-rich compound a potential high-energy-density material, These predictions support the designing rules and may stimulate future experiments to synthesize superhard and high-energy-density material.

关键词： Tungsten nitride Transition metal nitrides Machine-learning accelerated crystal structure searching method Superhard tungsten nitride

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黄河流域河南段浮游藻类功能群分布特征及影响因子

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水生生物学报 2024年第3期48卷 513-523页

作者：王飞虎杨越张洋秦祥朝陈玉环袁杰郭聪慧董静李学军张曼高云霓高肖飞河南师范大学水产学院新乡453007 生态环境部黄河流域生态环境监督管理局生态环境监测与科学研究中心郑州450000

为研究黄河流域藻类功能群分布及关键环境驱动因子,于2021年6—7月在黄河河南段设置16个采样位点,对黄河流域河南段浮游藻类群落组成、藻类功能群分布特征、不同空间环境因子特征及藻类-环境因子相关性进行分析,(1)共鉴定浮游藻类7门65... 详细信息

为研究黄河流域藻类功能群分布及关键环境驱动因子,于2021年6—7月在黄河河南段设置16个采样位点,对黄河流域河南段浮游藻类群落组成、藻类功能群分布特征、不同空间环境因子特征及藻类-环境因子相关性进行分析,(1)共鉴定浮游藻类7门65属154种,在物种数上,绿藻门类(68种)>硅藻门类(60种)>蓝藻门类(11种),以小环藻(Cyclotella sp.)、颗粒沟链藻极窄变种(Aulacoseira granulata ***)、束丝藻(Aphanizomenon sp.)、假鱼腥藻(Pseudanabaena sp.)为流域内主要优势种(优势度≥0.02);(2)黄河流域河南段浮游藻类共划分为23个功能群,分别是功能群B、C、D、E、f、G、H1、J、LM、Lo、M、MP、n、P、S1、T、W1、W2、X1、X2、X3、X_(ph)和Y,所调查流域功能群空间分布差异较大,其中干流功能群种类最少,支流种类最多;从优势度来看,以适应富营养化、混动水体的功能群C、D、MP、P和J占优势;(3)RDA分析结果表明,优势功能群C与Tn呈负相关;功能群MP与TP、nH_(4)^(+)-n、WT、pH和CODMn呈负相关;功能群P与nH_(4)^(+)-n、WT和CODMn呈正相关;功能群D与Tn呈正相关,功能群J与nTU呈正相关,与DO呈强负相关,其中CODMn是驱动藻类功能群分布的关键因子;(4)结合地表水环境评价、基于功能群的Q指数与Qr指数评价、生物多样性指数评价,此次调查流域水体呈重度氮污染,水库呈轻度磷污染,洛河流域相对其他支流水质偏差。

关键词：黄河浮游藻类优势度功能群空间分布

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基于多种机器学习算法的人血浆辐射敏感脂质代谢物模型探索

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中华放射医学与防护杂志 2024年第6期44卷 457-463页

作者：陈琦赵骅蔡恬静高义哲高玲刘青杰中国疾病预防控制中心辐射防护与核安全医学所辐射防护与核应急中国疾病预防控制中心重点实验室北京100088 湖北省疾病预防控制中心传染病防治所急性传染病预防控制部武汉430079

目的通过脂质组学方法联合机器学习(ML)多种算法,探索人外周血辐射敏感脂质代谢物分类模型。方法收集2023年3—9月北京市某综合医院准备接受骨髓移植的25例白血病放射治疗病例,照射前和照射后外周血样本97份,其中对照组24份,为照射前血... 详细信息

目的通过脂质组学方法联合机器学习(ML)多种算法,探索人外周血辐射敏感脂质代谢物分类模型。方法收集2023年3—9月北京市某综合医院准备接受骨髓移植的25例白血病放射治疗病例,照射前和照射后外周血样本97份,其中对照组24份,为照射前血液样本;辐射组73份,为4、8、12 Gy照射剂量下的24、25和24份血液样本。采用基于超高效液相色谱-串联质谱(UPLC⁃MS/MS)平台的靶向脂质组学方法,分析辐射组与对照组差异脂质。线性回归筛选0~12 Gy的剂量范围内辐射剂量响应脂质。采用5种机器学习方法构建训练集辐射分类模型,验证集进行模型的验证和评价。结果与对照组相比,辐射组敏感的脂质代谢物中62个脂质浓度变化差异有统计学意义(t=-4.91~4.74,Pf)、K最邻近(Knn)这5种机器学习训练模型拟合均较好(f1=0.69~1.00),灵敏度较高。通过评价验证指标,辐射分类判定效果最好的模型为随机森林(灵敏度1.00、准确率0.72、f1值0.80)。结论通过靶向脂质组学分析,发现人类样本中辐射响应的脂质代谢物和辐射剂量响应的脂质。机器学习方法中的Rf模型可以为探索人类辐射脂质代谢物模型提供新的思路。

关键词：电离辐射脂质组学机器学习随机森林

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The role of halogen bonding in improving OfET performance of a naphthalenediimide derivative

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Chinese Chemical Letters 2018年第3期29卷 423-428页

作者： Jing Li Yong-Hui Hu cong-Wu Ge He-Gui Gong Xi-Ke gao Department of Chemistry College of Science Shanghai University Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic f.nctional Molecules Shanghai Institute of Organic Chemistry Chinese Academy of Sciences

Controlling microstructure and thin film morphology of organic semiconductors by supramolecular arrangement is critical to improving their device performance. To realize well-controlling supramolecular assembly, a core-expanded naphthalene diimides derivative （1） was designed and synthesized as an n-type organic semiconductor and also as a halogen bonding （XB） donor that could form complementary XBs with 2,2-dipyridine or 2,2-bipyrimidine acceptor. The XB interactions in the solid state of 1/2,2- dipyridine and 1/2,2-bipyrimidine were confirmed by a series of characterization methods, such as thermal gravimetric analysis （TGA）, X-ray photoelectron spectroscopy （XPS）, nuclear magnetic resonance （nMR） involving 13f.nMR and solid-state 13C nMR. Organic field-effect transistors （OfETs） based on XB complexes 1/2,2-dipyridine or 1/2,2-bipyrimidine showed better device performance than that of devices based on pure 1, with the average electron mobility increased more than doubled （from 0.027cm2V-1 s-1 to 0.070cm2V-1 s-1）.

关键词： Supramolecular assembly Halogen bond naphthalene diimide Organic semiconductor Organic field-effect transistor

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Microstructure and wear resistance of AlCrf.niMo_(0.5)Si_(x) high-entropy alloy coatings prepared by laser cladding

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China foundry 2022年第6期19卷 473-480页

作者： Xiao-cong Li Hui Liang Yan-zhou Zhao Li gao Li Jiang Zhi-qiang Cao Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024LiaoningChina School of Physics and Electronic Technology Liaoning Normal UniversityDalian 116029LiaoningChina

In recent years,the coating prepared by laser cladding has attracted much attention in the field of wear *** this work,AlCrf.niMo_(0.5)Si_(x)(x=0,0.5,1.0,1.5,2.0)high-entropy alloy coatings were designed and prepared on Q235 steel by laser *** effect of Si content on microstructure,microhardness and wear resistance of the coatings was studied in *** results indicate that the AlCrf.niMo_(0.5)Si_(x) highentropy alloy coatings show an excellent bonding between substrate and the cladding *** AlCrf.niMo_(0.5)Si_(x) coatings are composed of.nano-precipitated phase with BCC structure and matrix with ordered B2 *** the addition of Si,the white phase(Cr,Mo)_(3)Si with cubic structure appears in the interdendritic,and the morphology of the coating(x=2.0)transforms into lamellar eutectic-like *** addition of Si enhances the microhardness and significantly improves the wear resistance of the *** x increases from 0 to 2.0,the average hardness of the cladding zone increases from 632 HV to 835 HV,and the wear rate decreases from 1.64×10^(-5) mm^(3)·(n·m)^(-1) to 5.13×10^(-6) mm^(3)·(n·m)^(-1).When x≥1.5,the decreasing trend of the wear rate gradually slows *** wear rates of Si1.5 and Si2.0 coatings are 5.85×10^(-6) mm^(3)·(n·m)^(-1) and 5.13×10^(-6) mm^(3)·(n·m)^(-1),respectively,which is an order of magnitude lower than that of Q235 steel.

关键词： high-entropy alloy coatings laser cladding microstructure wear resistance

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Heterosis and combining ability evaluation for growth traits of blunt snout bream(Megalobrama amblycephala)when crossbreeding three strains

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Chinese Science Bulletin 2014年第9期59卷 857-864页

作者： Wei Luo cong Zeng Shaokui Yi nicholas Robinson Weimin Wang Zexia gao College of fisheries Key Laboratory of Agricultural Animal Genetics Breeding and Reproduction of Ministry of Education/Key Laboratory of Freshwater Animal Breeding Ministry of Agriculture Huazhong Agricultural University nofima PO Box 5010 1432 s Norway Collaborative Innovation Center for Healthy freshwater Aquaculture of Hubei Province

The blunt snout bream(Megalobrama amblycephala)is a major aquaculture species in the Chinese freshwater polyculture *** this study,complete diallel crossing of three strains(i.e.,Liangzi[LZ],Poyang[PY]and Yuni[Yn])was used to evaluate the combining ability and heterosis effect of intraspecific crossbreeding on the growth performance(i.e.,body weight,total length,body length,body height,and fulton’s coefficient of condition).The offspring produced from the three strains were reared in a communal pond for 20 months,and nine microsatellites were used to assess their *** the749 offspring,708(94.53%)could be assigned directly to a single parental *** differences were observed in body weight(BW)among the different combinations,indicating that the combining ability of BW from each strain was significantly *** general combining ability(GCA)of BW from the sire was much higher than that from the *** GCA for the dam and sire of the LZ and Yn were the largest and the smallest,*** special combining ability of Yn$9 PY#was the largest,and Yn$9 PY#showed significantly positive heterosis effects on all f1growth traits,except for fulton’s condition coefficient(K)(P\0.05).In addition,significant positive linear correlations were found between the mean BW of corresponding progeny and the H E of the parental generation(y=600.7x-29.472,r=0.8651,P=0.0026),H O(y=1206.9x-518.14,r=0.7436,P=0.0216),and the polymorphism information content(y=1021.3x-331.31,r=0.8245,P=0.0063)as determined by a correlative *** f.ndings obtained from the study will be important for future considerations of *** stock improvement programs.

关键词：杂种优势效应特殊配合力生长性状双列杂交团头鲂平均体重评价线性相关关系

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Lipocalin-2 Test in Distinguishing Acute Lung Injury Cases from Septic Mice Without Acute Lung Injury

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Chinese Medical Sciences Journal 2014年第2期29卷 65-77页

作者： gao Zeng cong-wei Jia Jie Liu Shu-bin Guo Department of Emergency Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Objective To explore whether the amount of lipocalin-2 in the biofluid could reflect the onset of sepsis-induced acute lung injury(ALI) in mice. Methods Lipopolysaccharide(LPS, 10 mg/kg) injection or cecal ligation and puncture(CLP) was performed to induce severe sepsis and ALI in C57 BL/6 male mice randomly divided into 5 groups(n=10 in each group): group A(intraperitoneal LPS injection), group B(intravenous LPS injection via tail vein), group C(CLP with 25% of the cecum ligated), group D(CLP with 75% of the cecum ligated), and the control group(6 sham-operation controls plus 4 saline controls). All the mice received volume resuscitation. Measurements of pulmonary morphological and f.nctional alterations were used to identify the presence of experimental ALI. The expressions of lipocalin-2 and interleukin(IL)-6 in serum, bronchoalveolar lavage fluid(BALf), and lung tissue were quantified at both protein and mRnA levels. The overall abilities of lipocalin-2 and IL-6 tests to diagnose sepsis-induced ALI were evaluated by generating receiver operator characteristic curves(ROC) and computing area under curve(AUC). Results In both group B and group D, most of the "main features" of experimental ALI were reproduced in mice, while group A and group C showed septic syndrome without def.nite evidence for the presence of ALI. Compared with septic mice without ALI(group A+group C), lipocalin-2 protein expression in septic mice with ALI(group B+group D) was significantly up-regulated in BALf(Pnd in serum(Pnd mRnA expression boosted in lung tissues(all Pn-2 tests performed better than IL-6 tests in recognizing sepsis-induced ALI cases, evidenced by the larger AUC of the former(BALf tests, 0.8800 versus 0.6625; serum tests, 0.8500 versus 0.7000). Using a dual cutoff system to diagnose sepsis-induced ALI, BALf lipocalin-2 test exhibited the highest positive likelihood ratio(13.000) and the lowest negative likelihood ratio(0.077) among the tests of

关键词： lipocalin-2 acute lung injury biomarker sepsis neutrophil gelatinase associatedlipocalin

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Isolation and characterization of a high-efficiency marine diesel oil-degrading bacterium

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Petroleum Science 2021年第2期18卷 641-653页

作者： Jin gao Jie Ming Meng Xu Xinge fu Liang-f.ng Duan cong-Chao Xu Yu gao Jian-Liang Xue Xin-f.ng Xiao College of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdao266590China College of Chemical Engineering China University of PetroleumBeijing102249China

In the recent 50 years,marine oil spills had resulted in severe environmental pollution problems *** this study,12 petroleum-degrading strains named MJ1 to MJ12,which can use diesel oil as the sole carbon source for growth,were isolated from the seawater in Jiaozhou Bay,*** MJ4 has the highest diesel-degrading rate which is up to 26.54%in 5 days with the diesel oil concentration of 10 g/*** to the BLAST research,16SrRnA sequence of MJ4 showed 99%similarity to Bacillus megaterium ***-factor experiments and response surface methodology were carried out to optimize the environmental factors and their reciprocal action for affecting the diesel oil degradation process of Bacillus *** of single-factor experiments revealed that the highest degradation rate was obtained with temperature of 28°C,pH of 8.8,diesel oil concentration of 25 g/L,P/n ratio of 0.56,nitrogen and phosphorus dosage quantity of 0.35 g/L and 0.18 g/L,respectively.A nonlinear regression equation of diesel oil degradation rate and pH,temperature,P/n ratio was *** model predicted the maximum degradation rate of 72.21%with temperature of 28°C,pH of 8.88,P/n ratio of 0.31,respectively.

关键词： Bioremediation Bacillus megaterium MJ4 Environmental factors Marine oil spill Response surface methodology

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