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Intestinal anti-inflammatory activity of Ground Cherry(Physalis angulata L.)standardized CO2 phytopharmaceutical preparation

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World Journal of Gastroenterology 2017年第24期23卷 4369-4380页

作者： luiz domingues almeida junior ana elisa valencise quaglio celso acácio rodrigues de almeida costa Luiz claudio Di Stasi laboratory of phytomedicines pharmacology and biotechnology(phytopharmatech)department of pharmacologyinstitute of biosciencesuniversidade estadual paulista unespbotucatusao paulocep 18618-970

AIM To investigate the effects of Ground Cherry(Physalis angulata L.)standardized supercritical CO_2 extract in trinitrobenzenesulphonic acid(TNBS)model of rat intestinal *** The animals were divided into groups that received vehicle or *** extract(PACO_2)orally at the doses 25,50 and 100 mg/kg daily by 5 d before TNBS *** effects of PACO_2 were assessed by macroscopic analysis,biochemical determinations of the levels of myeloperoxidase(MPO),alkaline phosphatase(ALP),glutathione and cytokines(such as INF-γ,IL-1β,IL-6,IL-10 and TNF-α),gene expression evaluation(including Hsp70,heparanase,NF-κB,mitogenactivated protein kinases(Mapk)1,3,6 and 9,and the mucins genes Muc 1,2,3 and 4)and histopathological studies using optical,and electronic(transmission and scanning)*** PACO2 extract promoted a significant reduction in MPO and ALP activities,reducing oxidative stress and neutrophil *** effects were accompanied by significant reduction of colonic levels of IFN-γand IL-6 and down-regulation of heparanase,Hsp70,Mapk3,Mapk9,Muc1 and Muc2 genes expression when compared with TNBS-control *** addition,protective effects were also evidenced by reduced neutrophil infiltration,recovery of cell architecture and replacement of mucin by histopathological and ultrastructural *** Physalis angulata supercritical CO2 extract is an intestinal anti-inflammatory product that modulates oxidative stress,immune response and expression of inflammatory mediators,with potentially utility for treating inflammatory bowel disease.

关键词： Intestinal disease Inflammatory bowel disease Physalis angulata L.trinitrobenzenesulphonic acid

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Crucial steps in the natural history of inflammatory bowel disease

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World Journal of Gastroenterology 2012年第29期18卷 3790-3799页

作者： Giovanni Latella claudio Papi Gastroenterology Unit Department of Internal Medicine and Public HealthUniversity of L'Aquila67100 L'AquilaItaly Gastroenterology and Hepatology Unit S.Filippo Neri Hospital00135 RomeItaly

Inflammatory bowel diseases(IBD),including ulcerative colitis(UC) and Crohn's disease(CD),are chronic,progressive and disabling *** the last few decades,new therapeutic approaches have been introduced which have led not only to a reduction in the mortality rate but also offered the possibility of a favorable modification in the natural history of *** identification of clinical,genetic and serological prognostic factors has permitted a better stratification of the disease,thus allowing the opportunity to indicate the most appropriate *** treatment with immunosuppressive drugs and biologics has offered the opportunity to change,at least in the short term,the course of the disease by reducing,in a subset of patients with IBD,hospitalization and the need for *** this review,the crucial steps in the natural history of both UC and CD will be discussed,as well as the factors that may change their clinical *** methodological requirements for high quality studies on the course and prognosis of IBD,the true impact of environmental and dietary factors on the clinical course of IBD,the clinical,serological and genetic predictors of the IBD course(in particular,which of these are rel-evant and appropriate for use in clinical practice),the impact of the various forms of medical treatment on the IBD complication rate,the role of surgery for IBD in the biologic era,the true magnitude of risk of colorectal cancer associated with IBD,as well as the mortality rate related to IBD will be stressed;all topics that are extensively discussed in separate reviews included in this issue of World Journal of Gastroenterology.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn's disease Natural history Clinical course Complications Therapy Surgery Mortality

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Etiopathogenesis of inflammatory bowel diseases

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World Journal of Gastroenterology 2006年第30期12卷 4807-4812页

作者： Silvio Danese claudio Fiocchi Division of Gastroenterology Istituto Clinico Humanitas-IRCCS in Gastroenterology Milan Italy Department of Pathobiology and Department of Gastroenterology and Hepatology the Cleveland Clinic Foundation Cleveland Ohio United States

Theories explaining the etiopathogenesis of inflammatory bowel disease （IBD） have been proposed ever since Crohn＇s disease （CD） and ulcerative colitis （UC） were recognized as the two major forms of the disease. Although the exact cause（s） and mechanisms of tissue damage in CD and UC have yet to be completely understood, enough progress has occurred to accept the following hypothesis as valid： IBD is an inappropriate immune response that occurs in genetically susceptible individuals as the result of a complex interaction among environmental factors, microbial factors, and the intestinal immune system. Among an almost endless list of environmental factors, smoking has been identified as a risk factor for CD and a protective factor for UC. Among microbial factors, no convincing evidence indicates that classical infectious agents cause IBD, while mounting evidence points to an abnormal immune response against the normal enteric flora as being of central importance. Gut inflammation is mediated by cells of the innate as well as adaptive immune systems, with the additional contribution of non-immune cells, such as epithelial, mesenchymal and endothelial cells, and platelets.

关键词： Inflammatory bowel disease Chronic inflammation Mucosal immunity Innate immunity Adaptive immunity Environment Commensal flora

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Conjugate Heat Transfer Characterization in Cooling Channels

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Journal of Thermal Science 2012年第3期21卷 286-294页

作者： Beni Cukurel Tony Arts claudio Selcan von Karman Institute for Fluid Dynamics Turbomachinery Department Chaussée de Waterloo

Cooling technology of gas turbine blades,primarily ensured via internal forced convection,is aimed towards withdrawing thermal energy from the *** promote heat exchange,the walls of internal cooling passages are lined with repeated geometrical flow disturbance elements and surface *** the heat transfer at the expense of increased pressure loss;the goal is to obtain the highest possible cooling effectiveness at the lowest possible pressure drop *** cooling channel heat transfer problem involves convection in the fluid domain and conduction in the *** coupled behavior is known as conjugate heat *** experimental study models the effects of conduction coupling on convective heat transfer by applying iso-heat-flux boundary condition at the external side of a scaled serpentine *** involve local temperature measurements performed by Infrared Thermography over flat and ribbed slab *** number distributions along the wetted surface are obtained by means of heat flux distributions,computed from an energy balance within the metal *** the flat plate experiments,the effect of conjugate boundary condition on heat transfer is estimated to be in the order of 3%.In the ribbed channel case,the normalized Nusselt number distributions are compared with the basic flow *** the findings with other conjugate and convective iso-heat-flux literature,a high degree of overall correlation is evident.

关键词： conjugate heat transfer turbine cooling channel convection infrared thermography

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Amine-rich carbon nitride nanoparticles:Synthesis,covalent functionalization with proteins and application in a fluorescence quenching assay

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Nano Research 2019年第8期12卷 1862-1870页

作者： Gabriele Capilli Simone Cavalera Laura Anfossi Cristina Giovannoli Marco Minella claudio Baggiani claudio Minero Department of Chemistry and NIS Center of Excellence University of Torino10125 TorinoItaly

Carbon nitride nanoparticles (CNNPs) have been employed as fluorescent sensing tools owing to their unique features, e.g. low cost production, high stability in water and high photoluminescence quantum yield. Here, an easy and versatile synthetic approach was exploited to design fluorescent nanoparticles with surface functionalities suitable for covalent binding to bioligands. High hydrophilic, brightly fluorescent CNNPs, rich of superficial amines, were obtained from the thermal condensation of urea and lysine (CNNP^Lys) and by tuning the precursor ratio and the heating time. Structure and size of the functionalized nanoparticles were characterized through infrared (IR) spectroscopy, transmission electron microscopy (TEM) and dynamic light scattering (DLS). Their optical properties were studied by ultraviolet-visible (UV-Vis) and fluorescence spectroscopy. The superficial primary amino groups, furnished by the lysine co-precursor, enabled for covalently linking CNNP^Lys to model proteins. The CNNP^Lys-protein conjugates excited under UV irradiation emit in the 400-450 nm visible range (quantum yield 24%). The applicability of CNNP^Lys as novel fluorescent probes was demonstrated by a fluorescence quenching assay, in which gold nanoparticles (GNPs) were attached to Staphylococcal protein A and employed to quench the CNNP^Lys fluorescence by Forster resonant energy transfer (FRET). The quenching occurred upon formation of the specific binding between the GNP-linked protein A and CNNP^Lys-tagged immunoglobulins, while the inhibition of the binding resulted in the recovery of CNNP^Lys luminescence. The synthetic strategy, based on combining a "conjugated polymer"-forming unit (urea) and a co-precursor able to provide the desired functional group (lysine), allows designing innovative materials for the development of new generation fluorescence biosensors in which easily functionalized fluorophores are needed.

关键词： fluorescent probe carbon nitride nanoparticles quenching assay fluorescent materials g-C3N4 Forster resonant energy transfer (FRET)

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The evolution of available pharmacological treatments for variceal bleeding secondary to portal hypertension: A scope review

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iLIVER 2023年第3期2卷 170-176页

作者： Eduarda Raisa Coser Raphael Bernardo neto Izabel Cristina Meister Martins Coelho Norma Possa Marroni claudio Augusto Marroni Camila Moraes Marques Faculdades Pequeno Principe Brazil Universidade Federal de Ciencias da Saude de Porto Alegre Brazil

The texts analyzed in full totaled 110,of which 36 articles published between 2001 and 2020 were selected,with quantitative approaches,case reviews,liter-ature reviews,meta-analyses,and *** is concluded that beta-blockers are the drugs of choice for primary prophylaxis of variceal *** for secondary prophylaxis,there is an association of these with nitrates and endoscopic *** regard to acute bleeding,the use of vasoactive drugs is chosen,especially ***,it is important to emphasize that there is a shortage of clinical studies and a need for investment in new therapies.

关键词： Portal hypertension Clinical treatment pharmacology and variceal bleeding

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G protein-coupled estrogen receptor 1(GPER) activation triggers different signaling pathways on neurons and astrocytes

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Neural Regeneration Research 2019年第12期14卷 2069-2070页

作者： claudio Roque Graca Baltazar CICS-UBI - Health Sciences Research Centre University of Beira Interior Covilh. Portugal Faculty of Health Sciences University of Beira Interior Covilh. Portugal

Estradiol (E2) is the most potent and prevalent form of estrogen, a well-known hormone that regulates multiple tissues and functions in humans. In the brain, E2 regulates processes as diverse as learning, memory, cognition, mood, as well as neurodevelopment and neurodegeneration. The actions of E2 are mediated by classical estrogen receptors (ERs;α and β), and by the G protein-coupled estrogen receptor 1 (GPER or GPR30)(Prossnitz and Arterburn, 2015). Classical ER are predominantly present in the nucleus and cytoplasm, with less than 2% present on the plasma membrane, and mediate genomic cellular effects that occur in the time frame of hours to days (Prossnitz and Arterburn, 2015).

关键词： multiple tissues functions astrocytes

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Why do we have to review our experience in managing cases with idiopathic fistula-in-ano regularly?

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World Journal of Gastroenterology 2011年第28期17卷 3297-3299页

作者： claudio Fucini Iacopo Giani Department of Medical and Surgical Critical Care Section of General SurgeryUniversity of Florence Department of Medicine and Surgery-USL8 Arezzo Section of General Surgery Valdichiana

"Why do we have to review our experience in managing idiopathic fistula-in-ano regularly?" In order to answer this apparently simple question,we reviewed our clinical and surgical cases and most important relevant literature to find a rational and scientific *** would appear that whatever method you adopt in fistula management,there is a price to pay regarding either rate of recurrence (higher with conservative methods) or impairment of continence (higher with traditional surgery).Since,at the moment,reliable data to identify a treatment as a gold standard in the management of anal fistulas are lacking,the correct approach to this condition must consider all the anatomic and clinicopathological aspects of the disease;this knowledge joined to an eclectic attitude of the surgeon,who should be familiar with different types of treatment,is the only guarantee for a satisfactory *** a conclusion,it is worthwhile to remember that adequate initial treatment significantly reduces recurrence,which,when it occurs,is usually due to failure to recognise the tract and primary opening at the initial operation.

关键词： Anal fistula treatment Surgery of fistulain-ano Anal cryptoglandular infections Anal abscess Recurrent fistula-in-ano

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Modelling the test, trace and quarantine strategy to control the COVID-19 epidemic in the state of São Paulo, Brazil

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Infectious Disease Modelling 2021年第1期6卷 46-55页

作者： Marcos Amaku Dimas Tadeu Covas Francisco Antonio Bezerra Coutinho Raymundo Soares Azevedo neto claudio Struchiner Annelies Wilder-Smith Eduardo Massad School of Medicine University of Sao Paulo and LIM01-HCFMUSPSao PauloBrazil Instituto Butantan Sao PauloBrazil School of Applied Mathematics Fundacao Getulio VargasRio de JaneiroBrazil School of Veterinary Medicine University of Sao PauloSao PauloBrazil Department Public Health and Clinical Heidelberg Institute of Global HealthUniversity of HeidelbergGermany Medicine Epidemiology and Global HealthUmeåUniversitySE-90185UmeåSweden Department of Disease Control London School of Hygiene and TropicalMedicineUK

Testing for detecting the infection by SARS-CoV-2 is the bridge between the lockdown and the opening of *** this paper we modelled and simulated a test-trace-andquarantine strategy to control the COVID-19 outbreak in the State of São Paulo,*** State of São Paulo failed to adopt an effective social distancing strategy,reaching at most 59%in late March and started to relax the measures in late June,dropping to 41%in 08 ***,São Paulo relies heavily on a massive testing strategy in the attempt to control the *** alternative strategies combined with economic evaluations were *** strategy included indiscriminately testing the entire population of the State,reaching more than 40 million people at a maximum cost of 2.25 billion USD,that would reduce the total number of cases by the end of 2020 by 90%.The second strategy investigated testing only symptomatic cases and their immediate contacts e this strategy reached a maximum cost of 150 million USD but also reduced the number of cases by 90%.The conclusion is that if the State of São Paulo had decided to adopt the simulated strategy on April the 1st,it would have been possible to reduce the total number of cases by 90%at a cost of 2.25 billion US dollars for the indiscriminate strategy but at a much smaller cost of 125 million US dollars for the selective testing of symptomatic cases and their contacts.

关键词： COVID-19 SARS-CoV-2 Testing Cost-analysis Modelling

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Potential therapeutic effects of polyphenols in Parkinson's disease:in vivo and in vitro pre-clinical studies

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Neural Regeneration Research 2021年第2期16卷 234-241页

作者： claudio Giuliano Silvia Cerri Fabio Blandini Laboratory of Cellular and Molecular Neurobiology IRCCS Mondino FoundationPaviaItaly

Parkinson's disease is a neurodegenerative disorder characterized by a combination of severe motor and non-motor *** the years,several factors have been discovered to play a role in the pathogenesis of this disease,in particular,neuroinflammation and oxidative *** date,the pharmacological treatments used in Parkinson's disease are exclusively *** this reason,in recent years,the research has been directed towards the discovery and study of new natural molecules to develop potential neuroprotective therapies against Parkinson's *** this context,natural polyphenols have raised much attention for their important anti-inflammatory and antioxidant properties,but also for their ability to modulate protein *** this review,we propose to summarize the relevant in vivo and in vitro studies concerning the potential therapeutic role of natural polyphenols in Parkinson's disease.

关键词： alpha-synuclein anti-inflammatory antioxidants natural molecules neuroprotection Parkinson's disease polyphenols syntomatic effect

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