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HP30-2, a mitochondrial PRAT protein for import of signal sequence-less precursor proteins in Arabidopsis thaliana

Journal of Integrative Plant Biology 2017年第8期59卷 535-551页

作者： claudia Rossig John Gray Oscar Valdes Sachin Rustgi Diter von Wettstein Christiane Reinbothe Steffen Reinbothe Laboratory of Plant Molecular Genetics and Laboratory of Environmental and Systems Biology Grenoble-Alpes-University Grenoble France Department of Biological Sciences University of Toledo 2801 West Bancroft Street Toledo OH 43606 USA Department of Plant and Environmental Sciences Pee Dee Research and Education Center Clemson University Florence SC 29506 USA Department of Crop and Soil Sciences Washington State University Pullman WA 99164-6420 USA

Chloroplasts and mitochondria contain a family of putative preprotein and amino acid transporters designated PRAT. Here, we analyzed the role of two previously characterized PRAT protein family members, encoded by At3g49560 （HP30） and At5g24650 （HP30-2）, in planta using a combination of genetic, cell biological and biochemical approaches. Expression studies and green fluorescent protein tagging identified HP30-2 both in chloroplasts and mitochondria, whereas HP30 was located exclusively in chloroplasts. Biochemical evidence was obtained for an association of mitochondrial HP30-2 with two distinct protein complexes, one containing the inner membrane translocase TIM22 and the other containing an alternative NAD（P）H dehydrogenase subunit （NDCI） implicated in a respiratory complex 1-1ike electron trans- port chain. Through its association with TIM22, HP30-2 is involved in the uptake of carrier proteins and other, hydrophobic membrane proteins lacking cleavable N H2-terminal presequences, whereas HP30-2＇s interaction with NDC1 may permit controlling mitochondrial biogenesis and activity.

关键词： of as et in HP30-2,a mitochondrial PRAT protein for import of signal sequence-less precursor proteins in Arabidopsis thaliana for Figure NDC were TIM RNAi that

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Non-compliant and compliant balloons for endovascular rescue therapy of cerebral vasospasm after spontaneous subarachnoid haemorrhage: experiences of a single- centre institution with radiological follow- up of the treated vessel segments

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Stroke & Vascular Neurology 2021年第1期6卷 16-24页

作者： Alexander Neumann Jan Küchler claudia Ditz Kara Krajewski Jan Leppert Peter Schramm Hannes Schacht Neuroradiology University Medical Center Schleswig Holstein Lubeck CampusLubeckGermany Neurosurgery University Medical Center Schleswig Holstein Lubeck CampusLubeckGermany

Background For endovascular rescue therapy(ERT)of cerebral vasospasm(CVS)due to spontaneous subarachnoid haemorrhage(sSAH),non-compliant(NCB)and compliant(CB)balloons are used with both balloon types bearing the risk of vessel injury due to specific mechanical *** severe delayed arterial narrowing after transluminal balloon angioplasty(TBA)for CVS has sporadically been described,valid data concerning incidence and relevance are *** aim was to analyse the radiological follow-up(RFU)of differently TBA-treated arteries(CB or NCB).Methods Twelve patients with utilisation of either NCB or CB for CVS were retrospectively analysed for clinical characteristics,ERT,functional outcome after 3 months and *** with the initial angiogram,we classified delayed arterial narrowing as mild,moderate and severe(60% calibre reduction).Results Twenty-three arteries were treated with CB,seven with *** median first RFU was 11 months after TBA with CB and 10 after *** was performed with catheter angiography in 18 arteries(78%)treated with CB and in five(71%)after NCB;magnetic resonance angiography was acquired in five vessels(22%)treated with CB and in two(29%)after *** arterial narrowing was detected in three arteries(13%)after CB and in one(14%)after *** or severe findings were neither detected after use of CB nor *** We found no relevant delayed arterial narrowing after TBA for CVS after *** previous assumptions that CB provides for more dilatation in segments adjacent to CVS,we observed no disadvantages concerning long-term adverse *** data support TBA as a low-risk treatment option.

关键词： balloon cerebral after

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Adalimumab-induced interstitial pneumonia in a patient with Crohn's disease

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World Journal of Gastroenterology 2015年第7期21卷 2260-2262页

作者： María José Casanova María Chaparro claudia Valenzuela Carolina Cisneros Javier P Gisbert Gastroenterology Department Hospital Universitario de La Princesa Instituto de Investigación Sanitaria Princesa (IIS-IP) Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD) Pneumology Department Hospital Universitario de La Princesa

There are several reports of anti-tumor necrosis factor(TNF)-induced lung disease,especially in patients with rheumatologic *** is an antiTNF drug used to induce and maintain remission in patients with immune-mediated diseases,such as Crohn’s *** pulmonary disorders could be an extra-intestinal manifestation of inflammatory bowel disease,biologic therapy could also be a cause of lung *** few cases of adalimumab-induced lung toxicity have been reported,and the majority of them were in patients with rheumatologic *** injury secondary to anti-TNF therapy should,after ruling out other etiologies,be considered in patients who have a temporal association between the onset of respiratory symptoms and the exposure to these drugs.A compatible pattern in the biopsy and the clinical improvement after discontinuation of the anti-TNF drug would strongly support the diagnosis.

关键词： Adalimumab Anti-tumor necrosis factor Crohn’s dise

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Contrast-enhanced guided endoscopic ultrasound procedures

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World Journal of Gastroenterology 2024年第17期30卷 2311-2320页

作者： Marcel Ioan Gheorghiu Andrada Seicean Cristina Pojoga claudia Hagiu Radu Seicean Zeno Sparchez Department of Gastroenterology “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and Hepatology"Iuliu Hatieganu"University of Medicine and PharmacyCluj-Napoca 400162ClujRomania Department of Clinical Psychology and Psychotherapy International Institute for Advanced Study of Psychotherapy and Applied Mental HealthBabeș-Bolyai UniversityCluj-Napoca 400375ClujRomania The First Surgical Clinic "Iuliu Hatieganu"University of Medicine and PharmacyCluj Napoca 400006ClujRomania

Contrast-enhanced endoscopic ultrasound(CH-EUS)can overcome the limi-tations of endoscopic ultrasound-guided acquisition by identifying microvessels inside inhomogeneous tumours and improving the characterization of these *** the initial enthusiasm that oriented needle sampling under CH-EUS guidance could provide better diagnostic yield in pancreatic solid lesions,further studies did not confirm the supplementary values in cases of tissue acquisition guided by *** review details the knowledge based on the available data on contrast-guided *** indications for CH-EUS tissue acquisition include isoechoic EUS lesions with poor visible delineation where CH-EUS can differentiate the lesion vascularisation from the surrounding parenchyma and also the mural nodules within biliopancreatic cystic lesions,which occur in select ***,the roles of CH-EUS-guided therapy in patients whose pancreatic fluid collections or bile ducts that have an echogenic content have indications for drainage,and patients who have nonvisualized vessels that need to be highlighted via Doppler EUS are *** indication is represented if there is a need for an immediate assessment of the post-radiofrequency ablation of pancreatic neuroendocrine tumours,in which case CH-EUS can be used to reveal the incomplete tumour destruction.

关键词： Endosonography Contrast-enhanced endoscopic ultrasound Tissue acquisition Fine needle aspiration Fine needle biopsy Drainage Pancreatic fluid collections Biopsy Pancreas

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Clinical Research on Acupuncture-Concepts and Guidance on Efficacy and Effectiveness Research

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Chinese Journal of Integrative Medicine 2011年第2期17卷 166-172页

作者： claudia M Witt Institute for Social Medicine Epidemiology and Health EconomicsCharite University Medical Center10098 BerlinGermany

Over the last few years a number of large acupuncture trials have been carried out in western countries. The following article draws on the experience from these recent large-scale trials on acupuncture to outline the way randomized trials could be used to answer questions on efficacy, effectiveness and efficiency. It will provide guidance, firstly on the underlying concepts of both efficacy and effectiveness and secondly on designing both types of trials. In addition, the controversy over specific and non-specific effects of acupuncture, emerging from the results of the above-mentioned trials, will be highlighted. Suggestions for future clinical research on acupuncture include： greater reflection on the complex approach of Chinese medicine, and transparent and detailed reporting according to CONSORT and STRICTA guidelines. The current data on acupuncture point-specific effects do indeed have relevance, however for valid decision-making on acupuncture, further clinical trials on effectiveness and cost-effectiveness are required to provide realistic benefit estimates for future health care.

关键词： acupuncture efficacy effectiveness randomized controlled trial randomized pragmatic trial

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Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment

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World Journal of Gastroenterology 2014年第26期20卷 8377-8392页

作者： Nathalie C Leite Cristiane A Villela-Nogueira claudia R L Cardoso Gil F Salles Internal Medicine Department University Hospital Clementino Fraga FilhoSchool of MedicineUniversidade Federal do Rio de Janeiro

Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type 2diabetes are at a particularly high risk for developing the progressive forms of NAFLD,non-alcoholic steatohepatitis and associated advanced liver ***,diabetes is an independent risk factor for NAFLD progression,and for hepatocellular carcinoma development and liver-related mortality in prospective ***,patients with NAFLD have an elevated prevalence of *** studies have shown that NAFLD presence predicts the development of type2 *** and NAFLD have mutual pathogenetic mechanisms and it is possible that genetic and environmental factors interact with metabolic derangements to accelerate NAFLD progression in diabetic *** diagnosis of the more advanced stages of NAFLD in diabetic patients shares the same challenges as in non-diabetic patients and it includes imaging and serological methods,although histopathological evaluation is still considered the gold standard diagnostic *** effective established treatment is not yet available for patients with steatohepatitis and fibrosis and randomized clinical trials including only diabetic patients are *** sought to outline the published data including epidemiology,pathogenesis,diagnosis and treatment of NAFLD in diabetic patients,in order to better understand the interplay between these two prevalent diseases and identify the gaps that still need to be fulfilled in the management of NAFLD in patients with diabetes mellitus.

关键词： Non-alcoholic fatty liver disease Diabetes mellitus Pathogenesis Diagnosis Treatment

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Different modes of foveal regeneration after closure of full-thickness macular holes by(re)vitrectomy and autologous platelet concentrate

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 36-48页

作者： Andreas Bringmann claudia Jochmann Jan Darius Unterlauft Renate Wiedemann Matus Rehak Peter Wiedemann Department of Ophthalmology and Eye Hospital University of Leipzig

AIM: To describe using spectral-domain optical coherence tomography the regeneration of the foveal morphology after pars plana(re)vitrectomy surgery and gas tamponade combined with injection of autologous platelet concentrate to treat full-thickness macular holes, and to describe different anatomical outcome. METHODS: A retrospective case series of 8 eyes of 8 patients was described. RESULTS: In all cases investigated, the plateletassisted closure of macular holes was associated with a rapid resolution of cystic cavities in the foveal walls. In two patients, there was a regular regeneration of the foveal morphology after hole closure;the regenerated central fovea had a regular structure with a foveola and photoreceptors. In three other patients, there was an irregular regeneration of the fovea;a foveola was not formed, photoreceptor cells were absent from the foveal center, and the center was composed of Müller and retinal pigment epithelial(RPE) cells. The foveal regeneration after hole closure may proceed with or without a temporary detachment of the foveal center from the RPE, and with or without a direct contact between the central outer nuclear layer(ONL) and the RPE. Contacts between the ONL and RPE were observed only in patients with an irregular foveal regeneration after hole ***: The data show that there are different modes of foveal regeneration after closure of macular holes with(re)vitrectomy and platelet concentrate. It is suggested that the regular regeneration of the foveal morphology proceeds by Müller cell-mediated tissue movements without cell proliferation, whereas the irregular foveal regeneration proceeds in part by proliferation of Müller and RPE cells.

关键词： macular hole platelet concentrate fovea Müller glia retinal pigment epithelium

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Challenges in and lessons learned during the implementation of the 1-3-7 malaria surveillance and response strategy in China: a qualitative study

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Infectious Diseases of Poverty 2016年第1期5卷 857-867页

作者： Guangyu Lu Yaobao Liu claudia Beiersmann Yu Feng Jun Cao Olaf Müller Department of Preventive Medicine Medical College of Yangzhou UniversityYangzhou University225001 YangzhouChina Institute of Public Health Medical SchoolThe Ruprecht-Karls-Universität HeidelbergINF 32469120 HeidelbergGermany Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Prevention Jiangsu Provincial Key Laboratory on Parasite and Vector Control TechnologyJiangsu Institute of Parasitic DiseasesWuxiChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Public Health Research Center Jiangnan UniversityWuxiChina

Background:China has made great progress in malaria control over the last century and now aims to eliminate malaria by *** 2012,the country launched its 1-3-7 surveillance and response strategy for malaria *** strategy involves to case reporting within 1 day,case investigation within 3 days,and focus investigation and public health actions within 7 *** aim of this study was to evaluate the challenges in and lessons learned during the implementation of the 1-3-7 strategy in China so ***:This qualitative study was conducted in two provinces in China:Gansu province(northwestern China)and Jiangsu province(southeastern China)in *** informant interviews(n=6)and in-depth interviews(n=36)about the implementation aspects of the 1-3-7 strategy were conducted with malaria experts,health staff,laboratory practitioners,and village doctors at the provincial,city,county,township,and village ***:Broad themes related to the challenges in and lessons learned during the implementation of the 1-3-7 strategy were identified according to:case reporting within 1 day,case investigation within 3 days,focus investigation within 7 days,and the overall *** major challenges outlined were related to respecting the timeline of surveillance procedures,the absence of or difficulties in following guidelines on conducting focus investigations,diagnostics,and the increasing number of returning migrant workers from malaria-endemic *** lessons learned revolve around the importance of continuous capacity building,supervision and motivation,quality control,information technology support,applied research,governmental commitment,and intersectoral ***:Surveillance is a key intervention in malaria elimination *** Chinese 1-3-7 strategy has already proven to be successful but still needs to be *** particular,dealing appropriately with imported malaria cases through the screening of migrant workers from

关键词： Malaria 1-3-7 surveillance and response strategy China Qualitative research

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Gut-liver axis and probiotics: Their role in non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第42期20卷 15518-15531页

作者： Giulia Paolella claudia Mandato Luca Pierri Marco Poeta Martina Di Stasi Pietro Vajro Department of Medicine and Surgery University of Salerno Pediatrics of AORN Santobono-Pausilipon ELFID European Laboratory for the Investigation of Food Induced Disease

The incidence of obesity and its related conditions, including non-alcoholic fatty liver disease (NAFLD), has dramatically increased in all age groups worldwide. Given the health consequences of these conditions, and the subsequent economic burden on healthcare systems, their prevention and treatment have become major priorities. Because standard dietary and lifestyle changes and pathogenically-oriented therapies (e.g., antioxidants, oral hypoglycemic agents, and lipid-lowering agents) often fail due to poor compliance and/or lack of efficacy, novel approaches directed toward other pathomechanisms are needed. Here we present several lines of evidence indicating that, by increasing energy extraction in some dysbiosis conditions or small intestinal bacterial overgrowth, specific gut microbiota and/or a “low bacterial richness” may play a role in obesity, metabolic syndrome, and fatty liver. Under conditions involving a damaged intestinal barrier (“leaky gut”), the gut-liver axis may enhance the natural interactions between intestinal bacteria/bacterial products and hepatic receptors (e.g., toll-like receptors), thus promoting the following cascade of events: oxidative stress, insulin-resistance, hepatic inflammation, and fibrosis. We also discuss the possible modulation of gut microbiota by probiotics, as attempted in NAFLD animal model studies and in several pilot pediatric and adult human studies. Globally, this approach appears to be a promising and innovative add-on therapeutic tool for NAFLD in the context of multi-target therapy.

关键词： Probiotics Gut-liver axis Intestinal microbiota Barrier function Small intestinal bacterial overgrowth Bacterial translocation Non-alcoholic fatty liver disease

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Mismatch repair proteins and microsatellite instability in solid pseudopapillary neoplasm of the pancreas

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Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 491-492页

作者： claudia Covelli Paola Parente Francesco Pepe Pasquale Pisapia Fabiola Fiordelisi Umberto Malapelle UOC di Anatomia Patologica Fondazione Casa Sollievo della SofferenzaViale Cappuccini 171013 San Giovanni RotondoFGItaly Department of Public Health University of Naples Federico ⅡVia Pansini 580131 NapoliItaly

Solid pseudopapillary neoplasms (SPNs) are rare solid pancreatic tumors mainly affecting young women. Despite the high percentage of favorable prognosis, they are considered as low grade malignant neoplasms, and metastases occur in 5%-15% of patients. Almost all SPNs (95%) have somatic activating mutations in the β-catenin gene [1].

关键词： Solid pseudopapillary neoplasms (SPNs) Mismatch repair proteins microsatellite instability

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