Non-alcoholic fatty liver disease and diabetes: From physiopathological interplay to diagnosis and treatment

作     者：Nathalie C Leite Cristiane A Villela-Nogueira Claudia R L Cardoso Gil F Salles 

作者机构：Internal Medicine DepartmentUniversity Hospital Clementino Fraga FilhoSchool of MedicineUniversidade Federal do Rio de Janeiro 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第26期

页      面：8377-8392页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Conselho Brasileiro de Desenvolvimento Científico e Tecnológico(CNPq-Brasil)and Fundao Carlos Chagas Filho de AmparoàPesquisa do Estado do Rio de Janeiro(FAPERJ-Brasil) 

主　　题：Non-alcoholic fatty liver disease Diabetes mellitus Pathogenesis Diagnosis Treatment 

摘      要：Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients with diabetes mellitus and increasing evidence suggests that patients with type 2diabetes are at a particularly high risk for developing the progressive forms of NAFLD,non-alcoholic steatohepatitis and associated advanced liver ***,diabetes is an independent risk factor for NAFLD progression,and for hepatocellular carcinoma development and liver-related mortality in prospective ***,patients with NAFLD have an elevated prevalence of *** studies have shown that NAFLD presence predicts the development of type2 *** and NAFLD have mutual pathogenetic mechanisms and it is possible that genetic and environmental factors interact with metabolic derangements to accelerate NAFLD progression in diabetic *** diagnosis of the more advanced stages of NAFLD in diabetic patients shares the same challenges as in non-diabetic patients and it includes imaging and serological methods,although histopathological evaluation is still considered the gold standard diagnostic *** effective established treatment is not yet available for patients with steatohepatitis and fibrosis and randomized clinical trials including only diabetic patients are *** sought to outline the published data including epidemiology,pathogenesis,diagnosis and treatment of NAFLD in diabetic patients,in order to better understand the interplay between these two prevalent diseases and identify the gaps that still need to be fulfilled in the management of NAFLD in patients with diabetes mellitus.