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导师对住院医师规范化培训的认知与思考

卫生职业教育 2023年第13期41卷 117-119页

作者：杨晓清林肖肖薛万江唐东羌建锋彭亮亮朱春玉周庆南通大学附属医院江苏南通226001 南通大学医学院江苏南通226001

分析导师在对现有课程设置与轮转安排的认知情况等,结果发现,不同任职年限、不同专业技术职称的导师对课程设置、轮转安排等的认同有差异。临床教学管理部门应与学校研究生管理部门共同研讨,优化课程设置,采用多样化的教学模式,提高专... 详细信息

分析导师在对现有课程设置与轮转安排的认知情况等,结果发现,不同任职年限、不同专业技术职称的导师对课程设置、轮转安排等的认同有差异。临床教学管理部门应与学校研究生管理部门共同研讨,优化课程设置,采用多样化的教学模式,提高专业学位研究生培养质量。

关键词：住院医师规范化培训临床医学专业学位硕士研究生研究生导师

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无痛分娩联合助产全程陪伴对产妇分娩的影响

中国继续医学教育 2020年第6期12卷 73-76页

作者：王晓莉杜爱飞张芳李永恒张华朱春玉程道静陈敏山东省聊城市东昌府区妇幼保健院家化病房山东聊城252000 山东省聊城市东昌府区妇幼保健院分娩室山东聊城252000

目的探讨无痛分娩联合助产全程陪伴对产妇分娩的影响。方法选取本院2018年6月-2018年12月656例产妇,随机数字表法分为观察组、对照组,每组328例。观察组给予无痛分娩联合助产全程陪伴,对照组给予常规护理。比较抑郁量表评分和焦虑量表... 详细信息

目的探讨无痛分娩联合助产全程陪伴对产妇分娩的影响。方法选取本院2018年6月-2018年12月656例产妇,随机数字表法分为观察组、对照组,每组328例。观察组给予无痛分娩联合助产全程陪伴,对照组给予常规护理。比较抑郁量表评分和焦虑量表评分、分娩的方式、新生儿Apgar评分、视觉模拟疼痛评分(VAS)、分娩出血量及产程时间。结果分娩前两组SDS和SAS评分差异均无统计学意义(P>0.05);分娩后两组SDS和SAS评分均下降,且观察组SDS和SAS评分均低于对照组(P<0.05)。观察组顺产率83.54%(274/328)高于对照组52.44%(172/328)(P<0.05)。观察组新生儿Apgar评分高于对照组,观察组VAS评分、出血量均低于对照组(P<0.05)。观察组第一产程、第二产程和第三产程时间均低于对照组(P<0.05)。结论无痛分娩联合助产全程陪伴缩短产程,有利于顺利生产,提高自然分娩率。

关键词：产科分娩助产全程陪伴无痛抑郁

Scalable salt-templated directed synthesis of high-quality MoS_(2) nanosheets powders towards energetic and environmental applications

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Nano Research 2020年第11期13卷 3098-3104页

作者： Lijie zhu Pengfei Yang Yahuan Huan Shuangyuan Pan Zhaoqian Zhang Fangfang Cui Yuping Shi Shaolong Jiang chunyu Xie Min Hong Jiatian Fu Jingyi Hu Yanfeng Zhang Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China

Two-dimensional(2D)transition metal dichalcogenides(TMDCs)have emerged as perfect platforms for developing applications in nano-electronics,catalysis,energy storage and environmental-related fields due to their superior ***,the low-cost,batch production of high-quality 2D TMDCs remains a huge challenge with the existing synthetic ***,we present a scalable chemical vapor deposition(CVD)approach for the batch production of high-quality MoS_(2) nanosheet powders,by using naturally abundant,water-soluble and recyclable NaCl crystal powders as *** high-quality MoS_(2) nanosheets powders are achieved by a facile water dissolution-filtration process,by virtue of the excellent dispersibility of the as-grown products in *** internal mechanism for the scalable synthesis strategy is *** applications of the MoS_(2) nanosheets powders are also demonstrated as catalysts or adsorbents in hydrogen evolution reaction(HER)and organic dyes adsorption,*** work should hereby pave ways for the mass production and application of powdery TMDCs in energetic and environmental related fields.

关键词： mass production salt-templated molybdenum disulfide chemical vapor deposition green transfer

ENPP1/PC-1 Gene K121Q Polymorphism Is Associated with Obesity in European Adult Populations: Evidence from A Meta-Analysis Involving 24 324 Subjects

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Biomedical and Environmental Sciences 2011年第2期24卷 200-206页

作者： WANG RuoQi ZHOU DongHao XI Bo GE XiuShan zhu Ping WANG Bo ZHOU MingAi HUANG YuBei LIU JunTing YU Yang WANG chunyu Department of Cardiology Affiliated Hospital of Youjiang Medical College for Nationalities Baise 533000 Guangxi China Department of Endocrinology Linyi People's Hospital Linyi 276002 Shandong China Department of Maternal and Child Health Care School of Public Health Shandong University Jinan 250012 Shandong China Department of Genetics Capital Institute of Pediatrics Beijing 100020 China Guangdong Cardiovascular Institute Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou 510100 Guangdong China Publishing House Chinese Academy of Medical Sciences Beijing 100730 China Department of Internal Medicine Linyi Hospital of Traditional Chinese Medicine Linyi 276002 Shandong China Department of Epidemiology and Biostatistics School of Public Health Peking University Health Science Center Beijing 100083 China Department of Epidemiology Capital Institute of Pediatrics Beijing 100020 China Department of Molecular and Cellular Biology Baylor College of Medicine Houston Texas 77030 USA The University of Texas M. D. Anderson Cancer Center Houston Texas 77030 USA

Objective Findings from the previous studies have suggested a relationship between ectonucleotide pyrophosphatase /phosphodiesterase 1 （ENPP‐1） or plasma cell membrane glycoprotein 1 （PC‐1） gene single nucleotide polymorphism （K121Q, rs1044498） and genetic susceptibility to obesity. However, such relationship is not reproduced by some currently available studies. In this context, the present study is aimed to quantitatively analyze the association of K121Q variant with obesity in all published case‐control studies in European adult populations. Methods Published literature from PubMed, EMBASE, and ISI web of science databases were retrieved. The studies evaluating the association of ENPP1/PC1 gene K121Q polymorphism with obesity were included, in which sufficient data were presented to calculate the odds ratio （OR） with 95% confidence intervals （CIs）. Results Ten case‐control studies meeting the inclusion criteria identified a total of 24,324 subjects including 11,372 obese and 12,952 control subjects. The meta‐analysis results showed a statistically significant association of K121Q with obesity [OR （95%CI）： 1.25 （1.04‐1.52） P=0.021] under a recessive model of inheritance （QQ vs. KK＋KQ） without heterogeneity or publication bias. Conclusions The results from the present study have indicated that ENPP1/PC1 Q121 variant may increase the risk of obesity and that more well‐designed studies based on a larger population will be required to further evaluate the role of ENPP1/PC1 gene K121Q polymorphism in obesity and other related metabolic syndromes.

关键词： Ectonucleotide pyrophosphatase /phosphodiesterase 1 (ENPP1) Plasma cell membrane glycoprotein 1 (PC1) K121Q Single nucleotide polymorphism (SNP) Obesity

Cadmium accumulation and tolerance of two castor cultivars in relation to antioxidant systems

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Journal of Environmental Sciences 2014年第10期26卷 2048-2055页

作者： Hanzhi Zhang Qingjun Guo Junxing Yang Tongbin Chen Guangxu zhu Marc Peters Rongfei Wei Liyan Tian chunyu Wang Deyun Tan Jie Ma Gangming Wang Yingxin Wan Center for Environmental Remediation Institute of Geographical Sciences and Natural Resources Chinese Academy of Sciences University of Chinese Academy of Sciences Zibo Academy of Agricultural Sciences China University of Geosciences College of Applied Arts and Science of Beijing Union University

To investigate the effects of Cd on tolerance and antioxidant activities of castor, two different castor（Ricinus communis L.） cultivars（Zibo No. 5 and Zibo No. 8） were used for a hydroponic experiment（0, 1 and 2 mg/L Cd） and a pot experiment using Cd-contaminated soil（34 mg/kg） with the addition of ethylenedinitrilotetraacetic acid（EDTA）. The results indicated that there were significant differences between the two cultivars with respect to Cd uptake in shoots（113–248 mg/kg for Zibo No. 5 and 130–288 mg/kg Zibo No. 8）, biomass tolerance indexes（64.9%–74.6% for Zibo No. 5 and 80.1%–90.9% for Zibo No. 8） in the hydroponic experiment and survival rates（0% for Zibo No. 5 and 100% for Zibo No. 8）determined by the addition of EDTA in the pot experiment, suggesting that Zibo No. 8 has higher tolerance than Zibo No. 5. Moreover, the castor cultivars have low bioconcentration factors（4.80% for Zibo No. 5 and 5.43% for Zibo No. 8） and low translocation factors（〈1%）.Consequently, Zibo No. 8 can participate in Cd phytostabilization in highly Cd-polluted areas. The results indicated that glutathione（GSH） as a non-enzymatic antioxidant, and antioxidant enzymes including superoxide dismutase（SOD）, catalase（CAT） and guaiacol peroxidase（GPX）, were cultivar- and dose-dependent. The higher tolerance of Zibo No. 8compared with Zibo No. 5 can be attributed to the higher GSH levels in the root and higher GPX activity in the leaf.

关键词： Cadmium Castor Antioxidant activity Tolerance Phytoremediation

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季铵盐类防霉抗菌功能化硅橡胶的制备

山东交通学院学报 2020年第1期28卷 46-53页

作者：董福营李帅杰朱春雨郝家文秦雪梅贾天松韩德昌崔如心山东交通学院交通土建工程学院山东济南250357

为制备季铵盐类防霉抗菌功能化硅橡胶,采用氢氧化钾(KOH)甲醇溶液对硅橡胶表面进行活化,通过偶联反应将季铵盐基团接枝到硅橡胶表面。测定KOH质量分数不同的KOH甲醇溶液对硅橡胶表面的活化程度,观察活化后硅橡胶表观形貌,并测定硅橡胶... 详细信息

为制备季铵盐类防霉抗菌功能化硅橡胶,采用氢氧化钾(KOH)甲醇溶液对硅橡胶表面进行活化,通过偶联反应将季铵盐基团接枝到硅橡胶表面。测定KOH质量分数不同的KOH甲醇溶液对硅橡胶表面的活化程度,观察活化后硅橡胶表观形貌,并测定硅橡胶表面季铵盐的质量浓度。测定硅烷偶联剂二甲基十八烷基(3-三甲氧基硅丙基)氯化铵(TPOAC)甲醇溶液中TPOAC的质量分数、反应时间及反应温度对硅橡胶表面材料中季铵盐质量分数的影响。得到制备此类硅橡胶的最优条件为:KOH溶液中KOH的质量分数为1%,TPOAC溶液中TPOAC的质量分数为15%,反应时间为5 h,反应温度为50℃。

关键词：硅橡胶硅季铵盐防霉抗菌表面修饰

Biocompatible Chemically Fueled Transient Polymer Nanoparticles for Temporally Programmable in Vivo Imaging

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CCS Chemistry 2023年第3期5卷 669-681页

作者： chunyu Pan Jiajun Xu Liang Wang Yiyang Jia Jiahui Li Guancheng Liu Shoujun zhu Bai Yang Yunfeng Li State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012

Chemically fueled dissipative self-assembly paves the way for innovative materials with lifelike properties and *** of nonequilibrium systems with biocompatibility and biofunctions remains an important and challenging ***,we present biocompatible chemically fueled transient polymer nanoparticles and their applications in temporally programmable in vivo *** lifetime of the transient polymer nanoparticles can be tuned by varying the concentration of polymer,adenosine triphosphate,and ***,the transient assembly of polymer nanoparticles can be paused for storage and then subsequently *** transient polymer nanoparticles exhibit good ***,we implement in vivo imaging in a temporally programmable fashion by using an autonomous fluorescence modulator of transient nanoparticles assembled from polymers with a fluorescence *** results in this work provide a valuable way to achieve nonequilibrium self-assembly of synthetic systems with good biocompatibility and programmable biofunctions,accelerating innovative developments of nonequilibrium soft biomaterials.

关键词： polymer self-assembly nonequilibrium self-assembly polymer nanoparticles biocompatibility programmable bioimaging

Supplementation with yak (Bos grunniens) bone collagen hydrolysate altered the structure of gut microbiota and elevated short-chain fatty acid production in mice

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Food Science and Human Wellness 2023年第5期12卷 1637-1645页

作者： Zitao Guo Dalong Yi Bo Hu Lingyu zhu Ji Zhang Yuliang Yang chunyu Liu Yi Shi Zhenghua Gu Yu Xin Huaigao Liu Liang Zhang National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing Jiangnan UniversityWuxi 214122China Jiangsu Provincial Research Center for Bioactive Product Processing Technology Jiangnan UniversityWuxi 214122China Anhui Guotai Biotechnology Co. LtdXuancheng 242100China National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

In this study, yak bone collagen hydrolysate(YBCH)was produced by mixed proteases and provided to standard-diet mice at a different dose(low dose(LD), medium dose(MD), and high dose(HD))to investigate its effects on the composition of gut microbiota and short-chain fatty acids(SCFA)production. It was found that YBCH was mainly composed of small molecular peptides whose molecular weight below 2 000 Da. Notably, supplementation with different doses of YBCH could significantly downregulate the ratio of Firmicutes to Bacteroidetes in the fecal microbiota. At the family level, the Lachnospiraceae abundance was significantly reduced in the YBCH gavage groups(mean reduction ratio 41.7 %, 35.2%, and 36.4% for LD, MD, and HD group, respectively). The predicted functions of gut microbes in the MD group were significantly increased at “lipid metabolism” and “glycan biosynthesis and metabolism”. Moreover, the SCFA production in the YBCH groups was elevated. Especially, the concentration of acetic acid, propionic acid, and butyric acid in the MD group was separately increased 79.7%, 89.2%, and 78.8% than that in the NC group. These results indicated that YBCH might be applied in the development of functional food for intestinal microecological regulation.

关键词： Yak bone collagen hydrolysate Peptides Gut microbiota Short-chain fatty acid Lachnospiraceae

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Topological transformation and free-space transport of photonic hopfions

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Advanced Photonics 2023年第1期5卷 1-7页

作者： Yijie Shen Bingshi Yu Haijun Wu chunyu Li Zhihan zhu Anatoly V.Zayats University of Southampton Optoelectronics Research Centre and Centre for Photonic MetamaterialsSouthamptonUnited Kingdom Harbin University of Science and Technology Wang Da-Heng CenterHeilongjiang Key Laboratory of Quantum ControlHarbinChina King’s College London London Centre for NanotechnologyDepartment of PhysicsLondonUnited Kingdom

Structured light fields embody strong spatial variations of polarization,phase,and ***,characterization,and exploitation of such fields can be achieved through their topological ***-dimensional(3D)topological solitons,such as hopfions,are 3D localized continuous field configurations with nontrivial particle-like structures that exhibit a host of important topologically protected ***,we propose and demonstrate photonic counterparts of hopfions with exact characteristics of Hopf fibration,Hopf index,and Hopf mapping from real-space vector beams to homotopic hyperspheres representing polarization *** experimentally generate photonic hopfions with on-demand high-order Hopf indices and independently controlled topological textures,including Néel-,Bloch-,and antiskyrmionic *** also demonstrate a robust free-space transport of photonic hopfions,thus showing the potential of hopfions for developing optical topological informatics and communications.

关键词： topology skyrmions hopfions structured light spin-orbital interaction