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Semen microbiota in normal and leukocytospermic males

Asian Journal of Andrology 2022年第4期24卷 398-405页

作者： Ye Yao Xin-Jian Qiu Dong-Sheng Wang Jie-Kun Luo Tao Tang Yun-hui Li chun-hu zhang Hao Liu Lu Zhou Lin-Lin Zhao Health Management Center The Third Xiangya HospitalCentral South UniversityChangsha 410013China Institute of Integrated Traditional Chinese and Western Medicine Xiangya HospitalCentral South UniversityChangsha 410005China Department of Nephrology Integrated Hospital of Traditional Chinese and Western MedicineSouthern Medical UniversityGuangzhou 510220China Department of Traditional Chinese Medicine Guangdong Second Provincial General HospitalGuangzhou 510220China

Large numbers of microbes can be present in seminal fluid,and there are differences in the semen microbiota between normal and abnormal semen samples.To evaluate the semen microbiota in patients with leukocytospermia,87 seminal fluid samples,including 33 samples with a normal seminal leukocyte count and 54 samples with leukocytospermia,were obtained for a cross-sectional analysis.Twenty samples with a normal seminal leukocyte count had normal sperm parameters(Control group),and 13 samples with a normal seminal leukocyte count were from asthenozoospermia patients(Ast group).However,32 samples with leukocytospermia were from asthenozoospermia patients(LA group),and only 22 samples with leukocytospermia had normal sperm parameters(Leu group).The 16S ribosomal RNA(rRNA)gene sequencing method was used to sequence the microbiota in the seminal fluid,and multiple bioinformatics methods were utilized to analyze the data.Finally,the results showed that the worse sperm parameters were observed in the leukocytospermia-related groups.Semen microbiota analysis found that there was increased alpha diversity in the leukocytospermia-related groups.Firmicutes,Proteobacteria,Actinobacteria,and Bacteroidetes were the primary phyla in the seminal fluid.Two microbiota profiles,namely,Lactobacillus-enriched and Streptococcus-enriched groups,were identified in this study.The majority of the samples in the groups with a normal seminal leukocyte count could be categorized as Lactobacillus-enriched,whereas the majority of the leukocytospermia samples could be categorized as Streptococcus-enriched.Our study indicated that males with leukocytospermia have worse sperm parameters and a different semen microbiota composition compared to males with a normal seminal leukocyte count.

关键词： 16S rRNA gene sequencing asthenozoospermia leukocytospermia semen microbiota sperm motility

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Genome-wide analysis of hippocampal transfer RNA-derived small RNAs identifies new potential therapeutic targets of Bushen Tiansui formula against Alzheimer’s disease

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Journal of Integrative Medicine 2021年第2期19卷 135-143页

作者： Zhe-yu zhang chun-hu zhang Jing-jing Yang Pan-pan Xu Peng-ji Yi Mu-li hu Wei-jun Peng Department of Integrated Traditional Chinese&Western Medicine the Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Department of Integrated Traditional Chinese&Western Medicine Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of Scientific Research the Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

Objective:Bushen Tiansui formula(BSTSF),a traditional Chinese medicine prescription,has been widely used to treat Alzheimer’s disease(AD).However,the mechanisms underlying its effects remain largely unknown.In this study,a rat AD model was used to study the effects of BSTSF on cognitive performance and expression of transfer RNA-derived small RNAs(tsRNAs)in the hippocampus,to determine whether treatment of AD with BSTSF could regulate the expression of tsRNAs,a novel small non-coding RNA.Methods:To generate a validated AD model,oligomeric amyloid-β_(1-42)(Aβ_(1-42))was injected intracerebroventricularly into rats.The Morris water maze(MWM)test was used to evaluate rat cognitive performance,and tsRNA-sequencing was conducted to examine tsRNA expression in the rat hippocampus.Potential targets were validated by quantitative real-time polymerase chain reaction(qRT-PCR).Bioinformatic analyses were conducted to investigate the biological function of candidate tsRNAs.Results:The learning and memory deficits of Aβ_(1-42)-induced AD rats,assessed by MWM tests,were clearly ameliorated by BSTSF treatment.A total of 387 tsRNAs were detected in the rat hippocampus.Among them,13 were significantly dysregulated in AD rats compared with sham control rats,while 57 were markedly altered by BSTSF treatment,relative to untreated AD rats(fold change>2 and P<0.05).Moreover,six BSTSF treatment-related tsRNAs were identified and validated by qRT-PCR.Bioinformatic analyses indicated that the six treatment-related tsRNAs had potential therapeutic roles,via multiple signaling pathways and Gene Ontology biological functions,including cyclic adenosine monophosphate and retrograde endocannabinoid signaling.Conclusion:This study identified a previously uncharacterized mechanism underlying the effects of BSTSF in alleviating the learning and memory deficits in Aβ_(1-42)-induced AD rats,demonstrating that tsRNAs are potential therapeutic targets of BSTSF in the treatment of AD.

关键词： Traditional Chinese medicine Alzheimer’s disease Endocannabinoids Hippocampus Small non-coding RNAs Transfer RNA

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Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury

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Neural Regeneration Research 2018年第8期13卷 1417-1424页

作者： Lin Zhu Tao Tang Rong Fan Jie-Kun Luo Han-Jin Cui chun-hu zhang Wei-Jun Peng Peng Sun Xin-Gui Xiong Yang Wang Laboratory of Ethnopharmacology Institute of Integrated Traditional Chinese and Western Medicine Xiangya Hospital Central South University Changsha Hunan Province China Department of-Integrated Traditional Chinese and Western Medicine Second Xiangya Hospital Central South University Changsha Hunan Province China College of Pharmacy Shandong University of Traditional Chinese Medicine Jinan Shandong Province China

Xuefu Zhuyu decoction has been used for treating traumatic brain injury and improving post-traumatic dysfunction, but its mechanism of action needs further investigation. This study established rat models of traumatic brain injury by controlled cortical impact. Rat models were intragastrically administered 9 and 18 g/kg Xuefu Zhuyu decoction once a day for 14 or 21 days. Changes in neurological function were assessed by modified neurological severity scores and the Morris water maze. Immunohistochemistry, western blot assay, and re- verse-transcription polymerase chain reaction were used to analyze synapsin protein and mRNA expression at the injury site of rats. Our results showed that Xuefu Zhuyu decoction visibly improved neurological function of rats with traumatic brain injury. These changes were accompanied by increased expression of synaptophysin, synapsin I, and postsynaptic density protein-95 protein and mRNA in a dose-de- pendent manner. These findings indicate that Xuefu Zhuyu decoction increases synapsin expression and improves neurological deficits alder traumatic brain injury.

关键词： nerve regeneration traumatic brain injury Xuefu Zhuyu decoction neurological dysfunction synapsin synaptophysin synapsin I posts vnaptic density protein-95 neuroprotection neural regeneration

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The role of innate immunity in diabetic nephropathy and their therapeutic consequences

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Journal of Pharmaceutical Analysis 2024年第1期14卷 39-51页

作者： Min Yang chun zhang Department of Nephrology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Diabetic nephropathy (DN) is an enduring condition that leads to inflammation and affects a substantial number of individuals with diabetes worldwide. A gradual reduction in glomerular filtration and emergence of proteins in the urine are typical aspects of DN, ultimately resulting in renal failure. Mounting evidence suggests that immunological and inflammatory factors are crucial for the development of DN. Therefore, the activation of innate immunity by resident renal and immune cells is critical for initiating and perpetuating inflammation. Toll-like receptors (TLRs) are an important group of receptors that identify patterns and activate immune responses and inflammation. Meanwhile, inflammatory responses in the liver, pancreatic islets, and kidneys involve inflammasomes and chemokines that generate pro-inflammatory cytokines. Moreover, the activation of the complement cascade can be triggered by glycated proteins. This review highlights recent findings elucidating how the innate immune system contributes to tissue fibrosis and organ dysfunction, ultimately leading to renal failure. This review also discusses innovative approaches that can be utilized to modulate the innate immune responses in DN for therapeutic purposes.

关键词： Innate immunity Diabetic nephropathy Inflammation Toll-like receptor Inflammasomes

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Effect of Central Multiphase Microstructure of Thick Plates on Work Hardening and Crack Propagation

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 325-338页

作者： Lei hu Liqin zhang Feng hu Kuan Zheng Guohong zhang Collaborative Innovation Center for Advanced Steels Wuhan University of Science and TechnologyWuhan430081China Department of Applied Physics Wuhan University of Science and TechnologyWuhan430081China Analysis and Testing Center Wuhan University of Science and TechnologyWuhan430081China

The effect of multiphase microstructure in the center segregation zones(CSZ)of high-strength steel thick plates on work hardening characteristics and crack initiation/propagation were studied.Microstructure was correlated with deformation damage behavior by using Taylor factor(TF)gradients,kernel average misorientation(KAM),and geometric necessary dislocation(GND)density.The results show that the segregation leads to a mixed structure of ferrite(soft phase)and martensite/bainite(hard phase)in the center of the thick plate.Compared to the 1/4 thickness(1/4 T)region,grain refinement occurred in the CSZ,with KAM values increasing from 0.24 to 0.49 and a decrease in the proportion of high-angle grain boundaries(>15°)from 77.4 to 51.8%.In the process of deformation,due to the influence of grain refinement and adjacent martensite/bainite,ferrite grains were divided into structural units with different TF values.The higher KAM value and GND density at the interface between soft/hard phases resulted in severe work hardening.In addition,the presence of micron-sized inclusions in the CSZ caused local strain concentration and non-continuous deformation of the matrix,which induced crack initiation.The fracture surface showed a mixed mode of brittle cleavage fracture and ductile fracture.

关键词： Thick plate Center segregation zone Multiphase microstructure Taylor factor Crack propagation

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Layered Structural PBAT Composite Foams for Efficient Electromagnetic Interference Shielding

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Nano-Micro Letters 2024年第2期16卷 273-286页

作者： Jianming Yang hu Wang Yali zhang Hexin zhang Junwei Gu School of Chemistry and Chemical Engineering Anhui University of TechnologyMa’anshanAnhui 243032People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072ShaanxiPeople’s Republic of China School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003JiangsuPeople’s Republic of China

The utilization of eco-friendly,lightweight,high-efficiency and high-absorbing electromagnetic interference(EMI)shielding composites is imperative in light of the worldwide promotion of sustainable manufacturing.In this work,magnetic poly(butyleneadipate-coterephthalate)(PBAT)microspheres were firstly synthesized via phase separation method,then PBAT composite foams with layered structure was constructed through the supercritical carbon dioxide foaming and scraping techniques.The merits of integrating ferroferric oxideloaded multi-walled carbon nanotubes(Fe3O4@MWCNTs)nanoparticles,a microcellular framework,and a highly conductive silver layer have been judiciously orchestrated within this distinctive layered configuration.Microwaves are consumed throughout the process of“absorption-reflection-reabsorption”as much as possible,which greatly declines the secondary radiation pollution.The biodegradable PBAT composite foams achieved an EMI shielding effectiveness of up to 68 dB and an absorptivity of 77%,and authenticated favorable stabilization after the tape adhesion experiment.

关键词： Electromagnetic interference shielding Layered structure Supercritical carbon dioxide foaming Poly(butyleneadipateco-terephthalate) Microcellular

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Enhanced Fenton-like process over Cu/L(+)-ascorbic acid co-doping mesoporous silica for toxicity reduction of emerging contaminants

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 49-60页

作者： Yuhang Liu Wenxuan Deng Xiaojun Wu chun hu Lai Lyu Key Laboratory for Water Quality and Conservation of the Pearl River Delta(Ministry of Education) Institute of Environmental Research at Greater BayGuangzhou UniversityGuangzhou 510006China

Effective removal of emerging contaminants(ECs)to minimize their impacts on human health and the natural environment is a global priority.For the removal of ECs in water,we fabricated a seaweed spherical microsphere catalyst with Cu cation-πstructures by in situ doping of Cu species and ascorbic acid in mesoporous silica(Cu-C-MSNs)via a hydrothermal method.The results indicate that bisphenol A(BPA)is substantially degraded within 5 min under natural conditions,with its biological toxicity considerably weakened.Moreover,industrial wastewater could also be effectively purified by Cu-C-MSNs/H2O2 system.The presence of metal sites and the complexation of ECs via cation-πinteraction andπ-πstacking on the catalyst surface were directly responsible for the polarization distribution of electrons,thus activating H2O2 and dissolved oxygen(DO).The removal of contaminants could be attributed primarily to 1)the activation of H2O2 into•OH to attack the contaminants and 2)self-cleavage because of the transfer of electrons from the contaminants to the catalysts.This study provides an innovative solution for the effective treatment of ECs and has positive implications for easing global environmental crises.

关键词： Cation-πstructures Polarization electric field Fenton-like process Contaminants cleavage

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Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora

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Chinese Chemical Letters 2024年第6期35卷 380-384页

作者： Ji zhang Tong zhang Qiao An Peng zhang Cai-Yan Tian chun-Mao Yuan Ping Yi Zhan-Xing hu Xiao-Jiang Hao State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Natural Products Research Center of Guizhou Province Guiyang 550014China School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang 550025China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of ScienceKunming 650201China Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesKunming 650201China

Three novel matrine-type alkaloids(1-3)and two unprecedented aloperine-type alkaloids(4 and 5)were isolated from the root of Sophora tonkinensis and the seeds of Sophora alopecuroides respectively.Notably,compound 1 possessed an unprecedented 6/5/6 tricyclic skeleton,while compounds 2 and 3 characterized by rare 6/6/5/6 tetracyclic system and 6/6/6/6/6 pentacyclic system respectively.Moreover,compound 4 possessed an unprecedented 6/7/6/6 tetracyclic core,and compound 5 characterized by rare 6/6/6/6tetracyclic skeleton.Their structures were elucidated by comprehensive spectroscopic data analysis and electronic circular dichroism(ECD)calculations.Biological tests indicated that compound 5 displayed significant anti-tobacco mosaic virus(TMV)activity compared with the positive control ningnanmycin.

关键词： Matrine-type alkaloids Aloperine-type alkaloids Sophora tonkinensis Sophora alopecuroides Anti-tobacco mosaic virus

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Efficacy and safety of Usights UC100 illuminated microcatheter in microcatheter-assisted trabeculotomy

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 272-277页

作者： Shuo Yu Ke Xu chun zhang Department of Ophthalmology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory of Restoration of Damaged Ocular Nerve Peking University Third HospitalBeijing 100191China

AIM:To evaluate the efficacy and safety of Usights UC100 illuminated microcatheter in microcatheter-assisted trabeculotomy(MAT).METHODS:Totally 10 eyes of 10 patients with primary open angle glaucoma(POAG)who underwent MAT facilitated by Usights UC100(5 eyes)or iTrack(5 eyes)were reviewed.The success of this surgery was defined as intraocular pressure(IOP)30%reduction,without oral glaucoma medications,or additional glaucoma surgery.RESULTS:The mean pre-operative IOP was 25.38±10.22 mm Hg in the Usights UC100 group and 19.98±3.87 mm Hg in the iTrack group.MAT was achieved in all eyes in both groups.The success rates for the Usights UC100 group and iTrack groups were in all and 4 eyes,respectively.Both microcatheters produced a statistically significant reduction in IOP,and eyes using Usights UC100 achieved a lower IOP than the iTrack group at 3mo followup(12.58±1.52 and 14.84±1.89 mm Hg,respectively),but no statistical significance was there.No severe side effects were observed in either group.CONCLUSION:MAT using Usights UC100 or iTrack both achieve significant pressure reduction in cases of POAG,and Usights UC100 is as safe as iTrack.

关键词： illuminated microcatheter microcatheterassisted trabeculotomy primary open angle glaucoma

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Synergically regulated silver species and surface oxygen on manganese oxide for promoted activity of formaldehyde oxidation

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Journal of Environmental Sciences 2024年第4期138卷 709-718页

作者： Shuo hu Jianghao zhang Xueyan Chen Xiaoxiao Qin Jinshui Yao Changbin zhang School of Materials Science&Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Formaldehyde(HCHO)is a common indoor pollutant that is detrimental to human health.Its efficient removal has become an urgent demand to reduce the public health risk.In this work,Ag-MnO_(x)-based catalysts were prepared and activated under different atmosphere(i.e.,air,hydrogen(H_(2))and carbon monoxide(CO))for efficient oxidation of HCHO.The catalyst activated with CO(Ag/Mn-CO)displayed the highest activity among the tested samples with 90% conversion at 100℃ under a gas space velocity of 75,000 mL/(g_(cat)·hr).Complementary characterizations demonstrate that CO reduction treatment resulted in synergically regulated content of surface oxygen on support to adsorb/activate HCHO and size of Ag particle to dissociate oxygen to oxidize the adsorbed HCHO.In contrast,other catalysts lack for either abundant surface oxygen species or metallic silver with the appropriate particle size,so that the integrate activity is limited by one specific reaction step.This study contributes to elucidating the mechanisms regulating the oxidation activity of Ag-based catalysts.

关键词： HCHO oxidation Ag-MnO_(x)-based catalyst Activation condition Synergic regulation Surface oxygen Oxidized Ag

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