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Design and evaluation of nicorandil extended-release tablet

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Asian Journal of Pharmaceutical Sciences 2015年第2期10卷 108-113页

作者： Ju-Young Kim chun-Woong park Beom-Jin Lee Eun-Seok park Yun-Seok Rhee College of Pharmacy Woosuk UniversityWanju-gun 565-701Republic of Korea College of Pharmacy Chungbuk National UniversityCheongju 361-763Republic of Korea College of Pharmacy Ajou UniversitySuwon 443-749Republic of Korea School of Pharmacy Sungkyunkwan UniversitySuwon 440-746Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Gyeongsang National UniversityJinju 660-701Republic of Korea

The aim of this study was to design and evaluate extended-release formulations of a model drug,nicorandil,in order to achieve the desired steady-state plasma concentration of drug in *** was employed to estimate optimum dissolution and absorption rate of *** dissolution test was employed using pH 1.2,4.0,6.8 buffer solution,or water,to measure the in vitro release behaviors of nicorandil formulations.A single dose(15 mg)of each formulation was orally administered to four beagle dogs under fasted conditions,and the pharmacokinetic parameters were *** in vitro/in vivo relationship of the extended-release formulation was confirmed using in vitro dissolution profiles and plasma concentrations of drug in beagle *** was released completely within 30 min from the immediate-release tablets and released for 24 h from the extended-release *** nicorandil plasma concentration could be modified by adjusting the drug release rate from the extended-release *** release rate of nicorandil was the rate-limiting step in the overall absorption of drug from the extendedrelease *** results highlight the potential of a nicorandil extended-release formulation in the treatment of angina pectoris.

关键词： Nicorandil In vitro In vivo Pharmacokinetic Extended-release

基于动态电-碳需求响应的综合能源系统日前多元低碳交易方法

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电力系统自动化 2024年第12期48卷 24-35页

作者：李伊竹林韩肖清李廷钧周鑫肖春太原理工大学电气与动力工程学院山西省太原市030024 国网山西省电力公司营销服务中心山西省太原市030001

随着电力行业碳减排任务的推进,电-碳耦合愈加紧密,为综合能源系统优化运行带来了新机遇、新挑战。根据新型电力系统多能互补、清洁低碳、安全可控、灵活高效、开放互动的基本特征,提出需求侧动态电-碳双响应的日前多级市场交易方法。首... 详细信息

随着电力行业碳减排任务的推进,电-碳耦合愈加紧密,为综合能源系统优化运行带来了新机遇、新挑战。根据新型电力系统多能互补、清洁低碳、安全可控、灵活高效、开放互动的基本特征,提出需求侧动态电-碳双响应的日前多级市场交易方法。首先,基于碳排放流理论,将源侧碳排放信息传递至各园区,实现差异运行方式下电力系统源-网-荷的精细化“电-碳”联动。然后,构建需求侧电-碳-绿证多元交易市场,鼓励更多主体参与市场,充分挖掘需求侧在经济、环境等方面的价值。最后,建立主网与各园区间的双层综合能源系统优化调度模型。上层主网发布动态电价与动态碳排放因子,下层需求侧的各园区生成有效的减排方案,使得源荷双侧形成有效互动,综合能源系统整体实现低碳经济运行。仿真结果表明,所提策略能够在较为精确表征碳排放的基础上,通过完善需求侧多元交易市场,深度挖掘园区的碳减排潜力,提高新能源的消纳率,有效平衡系统的经济性、安全性和低碳性。

关键词：需求响应碳排放碳交易绿证交易综合能源系统

Improving ionic conductivity of von-Alpen-type NASICON ceramic electrolytes via magnesium doping

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Journal of Advanced Ceramics 2023年第5期12卷 1058-1066页

作者： Il-Seop Jang Wooseok Go Bo-Ye Song Hayoung park Yun Chan Kang Jinyoung chun Emerging Materials R&D Division Korea Institute of Ceramic Engineering and Technology(KICET)Jinju 52851Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Energy Storage and Distribution Resources Division Lawrence Berkeley National LaboratoryBerkeley 94720USA

NASICON (sodium (Na) superionic conductor) compounds have attracted considerable attention as promising solid electrolyte materials for advanced Na-based batteries. In this study, we investigated the improvement in ionic conductivities of von-Alpen-type NASICON (vA-NASICON) ceramic electrolytes by introducing a magnesium ion (Mg^(2+)) as a heterogeneous element. The optimal Mg-doped vA-NASICON exhibited a high ionic conductivity of 3.64×10^(−3) S·cm^(−1), which was almost 80% higher than that of un-doped vA-NASICON. The changes in physicochemical properties of the vA-NASICONs through the Mg introduction were systematically analyzed, and their effects on the ionic conductivities of the vA-NASICON were studied in detail. When the optimal ratio of Mg^(2+) was used in a synthetic process, the relative density (96.6%) and grain boundary ionic conductivity (σgb) were maximized, which improved the total ionic conductivity (σt) of the vA-NASICON. However, when Mg^(2+) was introduced in excess, the ionic conductivity decreased because of the formation of an undesired sodium magnesium phosphate (NaxMgyPO_(4)) secondary phase. The results of this study are expected to be effectively applied in the development of advanced sodium-based solid electrolytes with high ionic conductivities.

关键词： NASICON solid electrolyte von-Alpen-type magnesium(Mg)doping ionic conductivity

Dipole-assisted carrier transport in bis(trifluoromethane) sulfonamide-treated O-ReS_(2) field-effect transistor

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Nano Research 2021年第7期14卷 2207-2214页

作者： Jae Young park SangHyuk Yoo Byeongho park Taekyeong Kim Young Tea chun Jong Min Kim Keonwook Kang Soo Hyun Lee Seong Chan Jun Department of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea Center for Biomicrosystem Brain Science InstituteKorea Institute of Science and TechnologySeoul 02792Republic of Korea Sensor System Research Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Physics Hankuk University of Foreign StudiesYongin 17035Republic of Korea Division of Electronics and Electrical Information Engineering Korea Maritime and Ocean UniversityBusan 49112Republic of Korea Electrical Engineering Division Engineering Department University of CambridgeCambridgeCB3 OFAUK

We demonstrate the dipole-assisted carrier transport properties of bis(trifluoromethane)sulfonamide(TFSI)-treated O-ReS_(2) field-effect *** ReS_(2) was compared with defect-mediated ReS_(2) to confirm whether the presence of defects on the interface enhances the interaction between O-ReS_(2) and TFSI *** to the experiment,density functional theory(DFT)calculation was performed,and the result indicated that the charge transfer between TFSI and O-ReS_(2) is more sensitive to external electric fields than that between TFSI and pristine ReS_(2).After TFSI treatment,the drain current of O-ReS_(2) FET was significantly increased up to 1,113.4 times except in the range of−0.32–0.76 V owing to Schottky barrier modulation from dipole polarization of TFSI molecules,contrary to a significant degradation in device performance in pristine ReS_(2) ***,in the treated O-ReS_(2) device,the dipole direction was highly influenced by the voltage sweep direction,generating a significant area of hysteresis in I–V and transfer characteristics,which was further verified by the surface potential ***,the dipole state was enhanced according to the wavelength of the light source and *** results indicate that TFSI-treated ReS_(2) FET has large potential for use as next-generation memristor,memory,and photodetector.

关键词： Two-dimensional material ReS_(2) field-effect transistor TFSI superacid dipole

高地应力硬质砂岩断裂特征及岩爆孕育过程研究

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岩石力学与工程学报 2024年第1期43卷 50-58页

作者：张志强张康健许佳磊罗春西南交通大学极端环境岩土与隧道工程智能建养全国重点实验室四川成都610031 西南交通大学土木工程学院四川成都610031

为研究高地应力下硬质砂岩隧道岩爆破坏特性,真实模拟高地应力深部岩体的损伤破坏特性,建立基于PPR势能函数的Ⅰ/Ⅱ混合型黏聚力模型。通过紧凑拉伸试验和贯穿剪切试验,对硬质砂岩Ⅰ和Ⅱ型断裂特性进行研究,获得模型参数,然后建立高地... 详细信息

为研究高地应力下硬质砂岩隧道岩爆破坏特性,真实模拟高地应力深部岩体的损伤破坏特性,建立基于PPR势能函数的Ⅰ/Ⅱ混合型黏聚力模型。通过紧凑拉伸试验和贯穿剪切试验,对硬质砂岩Ⅰ和Ⅱ型断裂特性进行研究,获得模型参数,然后建立高地应力下硬质砂岩隧道岩爆数值分析模型,对岩爆过程中的应力、能量进行追踪,分析硬质砂岩隧道岩爆孕育过程及破坏特性。研究结果表明:(1)硬质砂岩剪切强度和Ⅱ型断裂能均随围压的增大而增大,当围压超过30 MPa时,硬岩砂质Ⅱ型断裂性能趋于稳定。(2)当竖向应力远大于水平应力时,硬质砂岩隧道主要以层状剥落或楔形爆裂形式发生张裂–倾倒式的岩爆;反之,主要发生以岩体内部贯通性剪切破坏为特征的剪切–爆裂式岩爆;当水平应力与竖向应力均较大时,岩体卸荷破坏形式多表现出张剪性复合型破坏特征,主要发生张裂–剥落式岩爆。

关键词：岩石力学岩爆高地应力硬质砂岩断裂特征黏聚力模型

Evaluation of characteristics on titanium surface treatment for absorption of functional groups

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Chinese Medical Journal 2010年第21期123卷 3132-3136页

作者： JIN Guang-chun park Rl-song park Hyeoung-ho SEO Jae-min LEE Sook-jeong LEE Min-ho School of Stomatology Binzhou Medical University Binzhou Shandong 264003 China Department of Dental Biomaterials and Institute of Oral Bioscience School of Dentistry BK21 Project Chonbuk National University Jeonju Korea Neural Injury Research Lab Department of Neurology Asan Life Science Institute University of Ulsan College of Medicine Seoul Korea

Background In order to bind or fix bioactive materials directly to the surface of a Ti implant, the prior binding process of functional groups （FGs, -COOH and -OH） to the implant surface is necessary. Conventional binding processes are so high-cost and complex, so it is essential to find a simple and effective procedure for Ti-FG *** Various electrolyte compositions and electrochemical processing were adopted in this study to develop a relatively simple and effective Ti-FG binding process. The ability of Ti-FG binding and calcium （Ca）/phosphorous （P）absorption and corrosion resistance were evaluated according to various titanium surface treatment in electrolyte involving -COOH and -OH ion by using X ray photoelectron spectroscopy （XPS）, field emission scanning electron microscope （FE-SEM） and potentiodynamic scan method *** In cases of -COOH, the anodic oxidation process （AN） showed an effective binding ability between -COOH and Ti surface. On the other hand, in cases of -OH, there were no significant differences in the result between the conditions used. In regard to the absorption of Ca and P on Ti surface, there was a minimal amount of Ca absorbed but no P was absorbed. The anodic oxidation series showed homogenous corrosion, whereas the electrolyte immersion （EL）series showed unstable corrosion. Although EL-OH showed a novel corrosion potential, the EL-COOH series showed good corrosion resistance over the anodic potential *** The ability of binding between FG and the Ti surface and Ca/P absorption were strongly associated with the surface potential （ξ, potential）, which was dependent on the pH of the electrolyte. Accordingly, in order to achieve the effective absorption of various FGs on the Ti surface, it is needed to develop the combination process in addition to the electric affinity, relation with the ξ, potential.

关键词： titanium plate anodic oxidation ξpotential Ecorr icorr

Polyurethane-based Actuators with Various Polyols

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Journal of Materials Science & Technology 2010年第8期26卷 763-768页

作者： Nam-Ju Jo Do-Hee Lim Gyeong-Mi Bark Ho-Hwan chun In-Won Lee Hyun park Department of Polymer Science and Engineering Pusan National University Advanced Ship Engineering Research Center Pusan National University

This study dealt with the electrostrictive responses of polyurethane （PU） actuators with different microphase separation structure, which was a promising candidate for a material used in polymer actuators. In order to construct PUs with different higher-order structure, PUs with various types of polyol were synthesized： poly（neopentyl glycol adipate）（PNAD）, poly（tetramethylene glycol）（PTMG）, and poly（dimethyl siloxnae）（PDMS）. Synthesized PU was characterized by Fourier transform-infrared （FT-IR） spectroscopy and gel per- meation chromatography （GPC）. Thermal analysis and mechanical properties of PU films were carried out with differential scanning calorimetry （DSC） and UTM （universal testing machine）, respectively. And PU actuator was formed in a type of monomorph, which was made by carbon black electrodes on the both surfaces of PU film by spin coating method. Actuation behavior was mainly influenced on microphase separation struc- ture and mechanical property of PU. In result, PU actuator with PNAD, polyester urethane, had the largest field-induced displacement.

关键词： Electroactive polymer Polyurethane actuator Polyol type Maxwell stress effect Electrostriction effect

Down-scaled regional ocean modeling system (ROMS) for high-resolution coastal hydrodynamics in Korea

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Acta Oceanologica Sinica 2013年第9期32卷 50-61页

作者： LIM Hak-Soo KIM Chang S park Kwang-Soon SHIM Jae Seol chun Insik Korea Institute of Ocean Science and Technology Konkuk University

A down-scaled operational oceanographic system is developed for the coastal waters of Korea using a re- gional ocean modeling system （ROMS）. The operational oceanographic modeling system consists of at- mospheric and hydrodynamic models. The hydrodynamic model, ROMS, is coupled with wave, sediment transport, and water quality modules. The system forecasts the predicted results twice a day on a 72 h basis, including sea surface elevation, currents, temperature, salinity, storm surge height, and wave information for the coastal waters of Korea. The predicted results are exported to the web-GIS-based coastal informa- tion system for real-time dissemination to the public and validation with real-time monitoring data using visualization technologies. The ROMS is two-way coupled with a simulating waves nearshore model, SWAN, for the hydrodynamics and waves, nested with the meteorological model, WRE for the atmospheric surface forcing, and externally nested with the eutrophication model, CE-QUAL-ICM, for the water quality. The op- erational model, ROMS, was calibrated with the tidal surface observed with a tide-gage and verified with current data observed by bottom-mounted ADCP or AWAC near the coastal waters of Korea. To validate the predicted results, we used real-time monitoring data derived from remote buoy system, HF-radar, and geostationary ocean color imager （GOCI）. This down-scaled operational coastal forecasting system will be used as a part of the Korea operational oceanographic system （KOOS） with other operational oceanographic systems.

关键词： down-scaled operational oceanographic system regional ocean modeling system wave coupledmodel real-time monitoring system

Enhanced wear and fatigue properties of Ti-6AI-4V alloy modified by plasma carburizing/CrN coating

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材料与冶金学报 2005年第2期4卷 102-108页

作者：魏明镛 park Yong-gwon IKENAGA Masaru 韩国忠北大学校 Department of Materials Engineering Chungbuk National University Cheongju 361-763 Korea Lecturer Ibaraki National University Hitachi Japan

In this study, a newly developed duplex coating method incorporating plasma carburization and CrN coating was applied to Ti-6Al-4V and its effects on the wear resistance and fatigue life were investigated. The carburized layer with approximately150 μm in depth and CrN coating film with 7.5 μm in thickness were formed after duplex coating. Hard carbide particles such as TiC And V4C3 were formed in the carburized layer. XRD diffraction pattern analysis revealed that CrN film had predominant [111] and [200] textures. The hardness （Hv） was significantly improved up to about 1960 after duplex coating while the hardness value of original Ti-6Al-4V was 402. The threshold load for the modification and/or failure of CrN coating was measured to be 32N using the acoustic emission technique. The wear resistance and fatigue life of duplex coated Ti-6Al-4V improved significantly compared to those of un-treated specimen. The enhanced wear resistance can be attributed to the excellent adhesion and improved hardness of CrN coating film for the duplex coated Ti-6Al-4V. The initiation of fatigue cracks is likely to be retarded by the presence of hard and strong layers on the surface, resulting in the enhanced fatigue life.

关键词：等离子渗碳 CrN覆层 Ti-6Al-4V合金耐磨性抗疲劳