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Flexible dopamine-sensing fiber based on potentiometric method for long-term detection in vivo

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Science China Chemistry 2021年第10期64卷 1763-1769页

作者： Liyuan Wang Jiawei chen Jiajia Wang Hongjian Li chuanrui chen Jianyou Feng Yue Guo Hongbo Yu Xuemei Sun Huisheng Peng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Scienceand Laboratory of Advanced MaterialsFudan UniversityShanghai 200438China Vision Research Laboratory School of Life SciencesState Key Laboratory of Medical NeurobiologyCollaborative Innovation Centre for Brain ScienceFudan UniversityShanghai 200438China

Achieving real-time,continuous and long-term monitoring of dopamine(DA)in vivo is essential for revealing brain functions and preventing and treating neurogenic ***,it remains challenging to achieve a low limit of detection(LOD)and high neuron-compatibility at the same time for the current microsensors,resulting in the failure of long-term and accurate detection of DA in vivo.A DA-sensing fiber was achieved by the potentiometric method to possess a low LOD of 5 nM,1-3 orders of magnitude lower than amperometry and differential-pulse *** sensing fiber showed a wide linear range from 5 to 185 nM that well matched the DA concentration(26-40 nM)in *** implantation,the sensing fiber showed no influence on the firing rates of neurons with the potentiometric test,indicating high *** was then integrated with electrophysiology to simultaneously monitor DA variation and electrical signal in the brain,with stable monitoring of DA change in vivo for 8 *** sensing fiber was flexible and stably worked after hundreds of bending,and it showed high sensitivity even after protein adsorption,thus offering a reliable tool for neuroscience.

关键词： carbon nanotube fiber potentiometric implantable long-term dopamine detection

Implantable Fiber Biosensors Based on Carbon Nanotubes

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Accounts of Materials Research 2021年第3期2卷 138-146页

作者： Jianyou Feng chuanrui chen Xuemei Sun Huisheng Peng Fudan University to pursue his Ph.D.degree Department of Macromolecular Science at Fudan University Department of Macromolecular Science and Laboratory of Advanced Materials at Fudan University

CONSPECTUS:Implantable biosensors represent a rapidly developing direction with a wide range of applications in biotechnology and life *** example,the detection of neurotransmitters in the brain has attracted a lot of attention because of their essential effects for neural *** in vivo acute detection of chemicals has been developed for decades,but there are few reports about in vivo chronic monitoring of chemicals probably due to two ***,it is difficult to form stable interfaces between biosensors and ***,most of implantable biosensors are based on stiff electrode materials such as carbon fibers,whose moduli are several orders of magnitude higher than these of soft biological *** mechanical mismatch between them will cause severe inflammatory response during chronic *** some flexible neural probes with mesh geometry consisting of polymer and metal and polymer composite fibers have been employed in chronic electrophysiological recording,they are rarely employed for chronic monitoring of ***,electrode deteriorations associated with degradation and fouling of functional materials make chemical recognitions difficult in dynamic ***,biosensors usually need to be modified with several functional materials including a recognition layer in order to identify specific chemicals from various untargeted *** nanomaterials with high surface areas are reported to enhance the loading and immobilization of recognition layers so as to improve the sensitivity of biosensors,nanostructured and soft microelectrodes with high specific surface areas are rarely employed for longterm monitoring of chemicals in *** this Account,we highlight our efforts toward flexible and miniaturized implantable fiber biosensors based on carbon nanotube(CNT)fibers for stable interfaces in *** first summarize the assembly structure of CNT fiber electrodes and their mechanical,electrical,

关键词： fibers electrode implantation

Fiber-shaped organic electrochemical transistors for biochemical detections with high sensitivity and stability

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Science China Chemistry 2020年第9期63卷 1281-1288页

作者： Xiaoying Wu Jianyou Feng Jue Deng Zhichang Cui Liyuan Wang Songlin Xie chuanrui chen chengqiang Tang Zhengqi Han Hongbo Yu Xuemei Sun Huisheng Peng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Scienceand Laboratory of Advanced MaterialsFudan UniversityShanghai 200438China Vision Research Laboratory School of Life SciencesState Key Laboratory of Medical NeurobiologyCollaborative Innovation Centre for Brain ScienceFudan UniversityShanghai 200438China

Precise and continuous monitoring of biochemicals by biosensors assists to understand physiological functions for various diagnostics and therapeutic *** implanted biosensors,small size and flexibility are essential for minimizing tissue damage and achieving accurate ***,the active surface area of sensor decreases as the sensor becomes smaller,which will increase the impedance and decrease the signal to noise ratio,resulting in a poor detection *** advantages of local amplification effect,organic electrochemical transistors(OECTs)constitute promising candidates for high-sensitive ***,their detections in deep tissues are rarely ***,we report a family of implantable,fiber-shaped all-in-one OECTs based on carbon nanotube fibers for versatile biochemical detection including H2O2,glucose,dopamine and *** fiber-shaped OECTs demonstrated high sensitivity,dynamical stability in physiological environment and antiinterference *** implantation in mouse brain,7-day dopamine monitoring in vivo was realized for the first *** fiber-shaped OECTs could be great additions to the"life science"tool box and represent promising avenue for biomedical monitoring.

关键词： carbon nanotube fiber flexible organic electrochemical transistor

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基于交错反激光伏微逆的无功与谐波补偿

电力自动化设备 2015年第5期35卷 51-57页

作者：陈川瑞牟龙华朱国锋同济大学电子与信息工程学院上海201804

针对目前光伏微型逆变器只具备单一并网发电功能、利用率低下以及单相有源滤波器成本较高的不足,结合光伏微型逆变器和单相电流型有源滤波器的运行特点、结构和控制原理,提出了一种针对单块太阳能电池板的新型小功率交错双反激光伏微型... 详细信息

针对目前光伏微型逆变器只具备单一并网发电功能、利用率低下以及单相有源滤波器成本较高的不足,结合光伏微型逆变器和单相电流型有源滤波器的运行特点、结构和控制原理,提出了一种针对单块太阳能电池板的新型小功率交错双反激光伏微型逆变器,能够同时实现并网发电及适度无功和谐波补偿功能。详细分析了该系统的工作过程,提出了适用于该系统的相应控制策略,给出有功入网电流指令和无功谐波电流指令的计算方法。PSIM仿真和实验结果验证了系统结构和控制策略的合理性和有效性。

关键词：光伏发电并网光伏微型逆变器无功补偿谐波补偿电力滤波器逆变器

An intuitive parameterization method with inherently high-order differentiability for compressor blade sections based on ellipse hierarchical deformation

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Chinese Journal of Aeronautics 2023年第8期36卷 74-90页

作者： chuanrui SI Jinxin chenG Zhengqing ZHU Zhitong chen Qinglong HAO School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China Zaozhuang Beihang Machine Tool Innovation Research Institute Co. LtdZaozhuang 277500China Ningbo Institute of Technology Beihang UniversityNingbo 315832China

Shape parameterization has a crucial influence on the optimal solution of aerodynamic *** paper proposes a novel parameterization method for compressor blade sections based on the three-level deformation of the ellipse,which simultaneously satisfies the requirements of flexibility,smoothness,intuitiveness,and *** proposed method,the first-level deformation directly controls nine key geometric parameters to construct the blade section profile,and then the second-and third-level deformations are performed respectively to coarsely and finely modify the profile while keeping the key geometric parameters *** three levels of deformation effectively decompose the design space without destroying the ellipse’s infinite differentiability,allowing designers to work only with intuitive shape-related parameters to design blade sections with inherently high-order *** verify the effectiveness,six existing blade sections are first fitted and then one of them is selected for a three-level *** results show that the geometry and aerodynamic performance of the fitted and the original blade sections are in good agreement,and the loss coefficient of the optimized blade section is reduced by a total of 36.41%,with 27.34%,8.45%,and 0.62%reductions for the first to the third level,***,the proposed parameterization method facilitates the design of lower-loss and higher-load compressor blade sections.

关键词： Aerodynamics Blade sections Compressors Deformation Ellipse Parameterization

高职院校学前教育教师专业学习共同体:背景、涵义及特征

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吉林省教育学院学报 2024年第1期40卷 90-103页

作者：李安峰邹本杰徐仁海王敏朱传瑞陈文龙德州高级师范学校山东省教育科学研究院职教所

我国高职院校学前教育专业师资亟待依照中国教育现代化2035对创新型教师的高标准要求,强化职后教师教育的改革与创新。在分析我国高职院校学前教育专业的特殊性和教师专业发展实际基础上,跟踪国内外教师专业变革和发展的趋势,提出了构... 详细信息

我国高职院校学前教育专业师资亟待依照中国教育现代化2035对创新型教师的高标准要求,强化职后教师教育的改革与创新。在分析我国高职院校学前教育专业的特殊性和教师专业发展实际基础上,跟踪国内外教师专业变革和发展的趋势,提出了构建高职院校学前教育教师专业学习共同体的必要性和迫切性。借鉴国内外共同体、学习共同体的理论,阐释了高职院校学前教育教师专业学习共同体的含义,并概括了其具有自组织、草根性、综合性、全面性、共享性等五个方面的特点。上述研究和探讨,旨在弥补高职院校学前教育专业教师职后发展的短板,为实现教师可持续、高质量和终身发展提供可借鉴的创新路径,为构建具有中国特色的高职院校学前教育教师专业学习共同体理论提供思路和启迪。

关键词：高职院校学前教育专业教师专业学习共同体教师发展

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Broadband 1T-polytype tantalum disulfide saturable absorber for solid-state bulk lasers

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Photonics Research 2022年第9期10卷 2122-2132页

作者： MENGXIA WANG HAILONG QIU TIANWEN YANG ZHENGPING WANG chuanrui ZHAO YUANAN ZHAO TING YU YUYAO JIANG MEILING chen YAFEI LIAN GE ZHANG HONGJUN LIU ZHANGGUI HU JIANDA SHAO Laboratory of Thin Film Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Tianjin Key Laboratory of Functional Crystal Materials Institute of Functional CrystalTianjin University of TechnologyTianjin 300384China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China Laboratory of High Power Fiber Laser Technology Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China College of Science Shanghai UniversityShanghai 200444China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China

1T-polytype tantalum disulfide(1T-TaS_(2)),an emerging strongly correlated material,features a narrow bandgap of 0.2 e V,bridging the gap between zero-bandgap graphene and large-bandgap 2D nonlinear optical(NLO)*** with its intense light absorption,high carrier concentration,and high mobility,1T-TaS_(2) shows considerable potential for applications in broadband optoelectronic ***,its NLO characteristics and related applications have rarely been ***,1T-TaS_(2) nanosheets are prepared by chemical vapor *** ultrafast carrier dynamics in the 400–1100 nm range and broadband NLO performance in the 515–2500 nm range are systematically studied using femtosecond *** obvious saturable absorption phenomenon is observed in the visible to IR *** nonlinear absorption coefficient is measured to be-22.60±0.52 cm MW-1under 1030 nm,which is larger than that of other typical 2D saturable absorber(SA)materials(graphene,black phosphorus,and MoS_(2))under similar experimental *** on these findings,using 1T-TaS_(2) as a new SA,passively Q-switched laser operations are successfully performed at 1.06,1.34,and 1.94μ*** results highlight the promise of 1T-TaS_(2) for broadband optical modulators and provide a potential candidate material system for mid-IR nonlinear optical applications.

关键词： saturable switched absorber

Improved multiferroic in EuTiO_(3) films by interphase strain engineering

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Chinese Chemical Letters 2023年第7期34卷 379-383页

作者： Yiyan Fan Shiqing Q.Deng Tianyu Li Qinghua Zhang Shuai Xu Hao Li chuanrui Huo jiaou Wang Lin Gu Kuijuan Jin Oswaldo Dieguez Er-jia Guo Jun chen Beijing Advanced Innovation Center for Materials Genome Engineering Department of Physical ChemistryUniversity of Science and Technology BeijingBeijing 100083China School of Mathematics and Physics University of Science and Technology BejingBejing 100083China Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China Institute of High Energy Physics Chinese Academy of SciencesBejing 100049China Department of Physics University of Chinese Academyof SciencesBeijing100049China Songshan Lake Materials Laboratory Dongguan 523808China National Center for Electron Microscopy in Beijing School of Materials science and EngineeringTsinghua UniversityBeijing 100084China Department of Materials Science and Engineering Faculty of EngineeringTel Aviv UniversityTel Aviv 6997801Israel

Interphase strain engineering provides a unique methodology to significantly modify the lattice structure across a single film,enabling the emergence and manipulation of novel functionalities that are inaccessible in the context of traditional strain engineering *** this work,by using the interphase strain,we achieve a ferromagnetic state with enhanced Curie temperature and a room-temperature polar state in EuO secondary phase-tunned EuTiO_(3) thin films.A combination of atomic-scale electron microscopy and synchrotron X-ray spectroscopy unravels the underlying mechanisms of the ferroelectric and ferromagnetic properties ***,the EuO secondary phase is found to be able to dramatically distort the TiO_6 octahedra,which favors the non-centrosymmetric polar state,weakens antiferromagnetic Eu-Ti-Eu interactions,and enhances ferromagnetic Eu-O-Eu *** work demonstrates the feasibility and effectiveness of interphase strain engineering in simultaneously promoting ferroelectric and ferromagnetic performance,which would provide new thinking on the property regulation of numerous strongly correlated functional materials.

关键词： EuTiO_(3) Magnetic phase transition Polar state Interphase strain engineering

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基于椭圆拓扑变换的叶片二维叶型参数化方法

机械工程学报 2023年第7期59卷 81-91页

作者：佀传瑞成金鑫陈志同张云朱正清陈明升北京航空航天大学机械工程及自动化学院北京100191 北京科技大学机械工程学院北京100083 北方工业大学机械与材料工程学院北京100144 北京航空航天大学能源与动力工程学院北京100191

叶型参数化方法服务于叶片设计、制造和再制造全生命周期。针对目前叶型参数化方法难以兼顾造型参数几何含义直观和叶型曲率及曲率导数的连续性问题,提出了一种基于椭圆拓扑变换的二维叶型参数化方法。该方法基于椭圆与叶型曲率分布特... 详细信息

叶型参数化方法服务于叶片设计、制造和再制造全生命周期。针对目前叶型参数化方法难以兼顾造型参数几何含义直观和叶型曲率及曲率导数的连续性问题,提出了一种基于椭圆拓扑变换的二维叶型参数化方法。该方法基于椭圆与叶型曲率分布特征与拓扑结构的一致性,通过构造多个拓扑变换使椭圆变形成二维叶型。在变形过程中,建立了叶型主要几何特征参数与造型参数的一一对应关系且自然地保持了椭圆的高阶连续性。为验证该方法的有效性,对不同几何特征的叶型进行了反演验证。结果表明,与现有方法相比,该方法可用更少的造型参数实现更高的拟合精度;反演叶型曲率及曲率的导数均连续变化;反演叶型和原始叶型气动性能保持很好的一致性;改变单个造型参数可直观地改变叶型几何特征。因此,该参数化方法更易设计出低损失高负荷的叶型,传递的设计意图也更易被制造和再制造环节理解使用,有利于保障叶片的最终服役性能。

关键词：参数化方法椭圆拓扑变换叶片二维叶型叶片全生命周期