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Brain development in newborns and infants after ECMO

World Journal of Pediatrics 2024年第6期20卷 556-568页

作者： Kai Yan Lu-Kun Tang fei-Fan Xiao Peng Zhang guo-Qiang Cheng Lai-Shuan Wang Chun-Mei Lu Meng-Meng Ge Li-Yuan Hu Yuan-Feng Zhou Tian-Tian Xiao Yan Xu Zhao-Qing Yin Gang-Feng Yan guo-Ping Lu Qi Li Wen-Hao Zhou Department of Neonatology Children Hospital of Fudan UniversityShanghai 201102China Kunming Medical University Affiliated Dehong Hospital DehongYunnanChina Graduate School Kunming Medical UniversityKunmingYunnanChina Department of Neurology Children's Hospital of Fudan UniversityShanghaiChina School of Medicine Chengdu Women's and Children's Central HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanChina Department of Intensive Care Medicine Children's Hospital of Fudan UniversityShanghaiChina Department of Intensive Care Medicine The Sixth Medical Center of PLA General HospitalBeijingChina Key Laboratory of Neonatology National Health Care CommissionShanghaiChina

Background Extracorporeal membrane oxygenation(ECMO)not only significantly improves survival rates in severely ill neonates but also is associated with long-term neurodevelopmental *** systematically review the available literature on the neurodevelopmental outcomes of neonates and infants who have undergone ECMO treatment,with a focus on motor deficits,cognitive impairments,sensory impairments,and developmental *** review aims to understand the incidence,prevalence,and risk factors for these problems and to explore current nursing care and management *** sources A comprehensive literature search was performed across PubMed,EMBASE,and Web of Science using a wide array of keywords and phrases pertaining to ECMO,neonates,infants,and various facets of *** initial screening involved reviewing titles and abstracts to exclude irrelevant articles,followed by a full-text assessment of potentially relevant *** quality of each study was evaluated based on its research methodology and statistical ***,citation searches were conducted to identify potentially overlooked *** the focus was primarily on neonatal ECMO,studies involving children and adults were also included due to the limited availability of neonate-specific *** About 50%of neonates post-ECMO treatment exhibit varying degrees of brain injury,particularly in the frontal and temporoparietal white matter regions,often accompanied by neurological *** occur in 18%–23%of neonates within the first 24 hours,and bleeding events occur in 27%–60%of ECMO procedures,with up to 33%potentially experiencing ischemic *** some studies suggest that ECMO may negatively impact hearing and visual development,other studies have found no significant differences;hence,the influence of ECMO remains *** terms of cognitive,language,and intellectual development,ECMO treatment may be associated with potential deve

关键词： Brain development Extracorporeal membrane oxygenation Infants Neonates Neurological outcomes

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Mapping of powdery mildew resistance genes transferred to common wheat from wild emmer wheat revealed three functional Pm60 haplotypes

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The Crop Journal 2024年第2期12卷 540-548页

作者： Wenxin Wei Nannan Liu Shengnan Zhang Jing Zhang Wei Pan Xiaoming Xie Zuhuan Yang Junna Sun Jun Ma Zhaorong Hu Weilong guo Qiaoling Luo Jingzhong Xie fei He Yinghui Li Chaojie Xie Qixin Sun Key Laboratory of Crop Heterosis and Utilization(MOE)/Key Laboratory of Crop Genetic Improvement China Agricultural UniversityBeijing 100193China Institute of Advanced Agricultural Science Peking UniversityWeifang 261200ShandongChina Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina Institute of Evolution University of HaifaMt.CarmelHaifa 3498838Israel

Powdery mildew(PM),caused by Blumeria graminis ***(Bgt),is one of the destructive wheat diseases *** emmer wheat(Triticum turgidum ***,WEW),a tetraploid progenitor of common wheat,is a valuable genetic resource for wheat disease resistance breeding *** developed three hexaploid pre-breeding lines with PM resistance genes derived from three WEW *** resistant pre-breeding lines were crossed with susceptible common wheat *** in the F2populations were 3 resistant:1 susceptible,suggesting a single dominant allele in each resistant *** of the resistance gene in each line indicated a single locus on the long arm of chromosome 7A,at the approximate location of previously cloned Pm60 from *** sequencing revealed three different Pm60 haplotypes(Hap 3,Hap 5,and Hap 6).Co-segregating diagnostic markers were developed for identification and selection of each *** resistance function of each haplotype was verified by the virus-induced gene silencing(VIGS).Common wheat lines carrying each of these Pm60 haplotypes were resistant to most Bgt isolates and differences in the response arrays suggested allelic variation in response.

关键词： Alleles Blumeria graminus Marker-assisted selection Molecular marker Triticum dicoccoides

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Identification of NR3C2 as a functional diagnostic and prognostic biomarker and potential therapeutic target in non‐small cell lung cancer

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Cancer Innovation 2024年第4期3卷 67-86页

作者： Yuan‐yuan Sun Hai‐cheng Gao Peng guo Na Sun Chan Peng Zhi‐hua Cheng Jing Gu Jin‐yi Liu fei Han Department of Clinical Pharmacy Jilin University School of Pharmaceutical SciencesChangchunChina Institute of Toxicology College of Preventive MedicineArmy Medical UniversityChongqingChina Department of Hepatobiliary Surgery Third Affiliated Hospital of Chongqing Medical UniversityChongqingChina Breast and Thyroid Surgery Southwest HospitalArmy Medical UniversityChongqingChina College of Pharmaceutical Sciences Southwest UniversityChongqingChina Vascular Surgery Department General Surgery CenterFirst Hospital of Jilin UniversityChangchunChina Department of Toxicology School of Public HealthChongqing Medical UniversityChongqingChina Laboratory of Reproductive Biology Chongqing Medical UniversityChongqingChina

Background:Non‐small cell lung cancer(NSCLC),including the lung squamous cell carcinoma(LUSC)and lung adenocarcinoma(LUAD)subtypes,is a malignant tumor type with a poor 5‐year survival *** identification of new powerful diagnostic biomarkers,prognostic biomarkers,and potential therapeutic targets in NSCLC is urgently ***:The UCSC Xena,UALCAN,and GEO databases were used to screen and analyze differentially expressed genes,regulatory modes,and genetic/epigenetic alterations in *** UCSC Xena database,GEO database,tissue microarray,and immunohistochemistry staining analyses were used to evaluate the diagnostic and prognostic ***‐of‐function assays were performed to examine the *** ESTIMATE,TIMER,Linked Omics,STRING,and DAVID algorithms were used to analyze potential molecular ***:NR3C2 was identified as a potentially important molecule in ***3C2 is expressed at low levels in NSCLC,LUAD,and LUSC tissues,which is significantly related to the clinical indexes of these *** operating characteristic curve analysis suggests that the altered NR3C2 expression patterns have diagnostic value in NSCLC,LUAD,and especially LUSC *** NR3C2 expression levels can help predict poor prognosis in NSCLC and LUAD patients but not in LUSC *** results have been confirmed both with database analysis and real‐world clinical samples on a tissue *** number variation contributes to low NR3C2 expression levels in NSCLC and LUAD,while promoter DNA methylation is involved in its downregulation in *** NR3C2 promoter methylation sites have high sensitivity and specificity for LUSC diagnosis with clinical application ***3C2 may be a key participant in NSCLC development and progression and is closely associated with the tumor microenvironment and immune cell ***3C2 co‐expressed genes are involved in many cancer‐related signaling pathways,further supporting a potentially si

关键词： diagnosis and prognosis expression regulation function immune cell infiltration non‐small cell lung cancer NR3C2 therapeutic target tumor microenvironment

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节点链路同时映射的多类型服务资源编排算法

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通信学报 2024年第4期45卷 54-64页

作者：冯川张旭马天纯郭磊重庆邮电大学大数据智能计算重点实验室重庆400065 重庆邮电大学通信与信息工程学院重庆400065 重庆邮电大学智能通信与网络安全研究院重庆400065

为了解决虚拟网络请求阻塞率较高和底层物理网络资源利用率较低的问题,提出一种基于节点链路同时映射的多类型服务资源编排的算法。在映射首节点时,考虑物理网络节点属性;在映射节点链路元组时,综合考虑物理网络节点属性和链路属性;在... 详细信息

为了解决虚拟网络请求阻塞率较高和底层物理网络资源利用率较低的问题,提出一种基于节点链路同时映射的多类型服务资源编排的算法。在映射首节点时,考虑物理网络节点属性;在映射节点链路元组时,综合考虑物理网络节点属性和链路属性;在映射链路时,考虑网络链路属性,从而在包含多类型服务资源的底层物理网络中找到虚拟网络请求的映射策略。仿真结果显示,所提算法可以降低虚拟网络请求的阻塞率,提高物理网络多种类型资源的利用效率。

关键词：软件定义网络网络功能虚拟化虚拟网络映射多类型资源编排

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A graph-based pan-genome of Brassica oleracea provides new insights into its domestication and morphotype diversification

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Plant Communications 2024年第2期5卷 261-278页

作者： Ning guo Shenyun Wang Tianyi Wang Mengmeng Duan Mei Zong Liming Miao Shuo Han Guixiang Wang Xin Liu Deshuang Zhang Chengzhi Jiao Hongwei Xu Liyang Chen Zhangjun fei Jianbin Li Fan Liu State Key Laboratory of Vegetable Biobreeding National Engineering Research Center for VegetablesBeijing Key Laboratory of Vegetable Germplasm ImprovementKey Laboratory of Biology and Genetics Improvement of Horticultural Crops(North China)Beijing Vegetable Research CenterBeijing Academy of Agriculture and Forestry ScienceBeijing 100097China Jiangsu Key Laboratory for Horticultural Crop Genetic Improvement Vegetable Research InstituteJiangsu Academy of Agricultural ScienceNanjingJiangsuChina Smartgenomics Technology Institute Tianjin 301700China Boyce Thompson Institute IthacaNYUSA

The domestication of Brassica oleracea has resulted in diverse morphological types with distinct patterns of organ *** we report a graph-based pan-genome of *** constructed from high-quality genome assemblies of different *** pan-genome harbors over 200 structural variant hotspot regions enriched in auxin-andflowering-related *** genomic analyses revealed that early domestication of *** focused on leaf or stem *** resulting from agricultural practices and variety improvement were detected among different ***-sweep and pan-genome analyses identified an auxin-responsive small auxin up-regulated RNA gene and a CLAV-ATA3/ESR-RELATED family gene as crucial players in leaf–stem differentiation during the early stage of *** domestication and the BoKAN1 gene as instrumental in shaping the leafy heads of cabbage and Brussels *** pan-genome and functional analyses further revealed that variations in the BoFLC2 gene play key roles in the divergence of vernalization andflowering characteristics among different morphotypes,and variations in thefirst intron of BoFLC3 are involved infine-tuning theflowering process in *** study provides a comprehensive understanding of the pan-genome of *** and sheds light on the domestication and differential organ development of this globally important crop species.

关键词： Brassica oleracea graph-based pan-genome structural variants SV domestication morphotype diversification

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Balancing the minimum error rate and minimum copy consumption in quantum state discrimination

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中国科学技术大学学报 2024年第7期54卷 40-42,39,I0002,I0003页

作者： Boxuan Tian Zhibo Hou guo-Yong Xiang chuan-Feng Li Guang-Can guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center For Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China

Extracting more information and saving quantum resources are two main aims for quantum ***,the optimization of strategies for these two objectives varies when discriminating between quantum states■and■through multiple *** this study,we introduce a novel state discrimination model that reveals the intricate relationship between the average error rate and average copy *** integrating these two crucial metrics and minimizing their weighted sum for any given weight value,our research underscores the infeasibility of simultaneously minimizing these metrics through local measurements with one-way *** findings present a compelling trade-off curve,highlighting the advantages of achieving a balance between error rate and copy consumption in quantum discrimination tasks,offering valuable insights into the optimization of quantum resources while ensuring the accuracy of quantum state discrimination.

关键词： quantum measurement quantum control quantum state discrimination

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基于序列贝叶斯更新的锂电池剩余寿命预测

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计算机集成制造系统 2024年第2期30卷 635-642页

作者：赵斐郭明刘学娟东北大学秦皇岛分校河北秦皇岛066004 东北大学工商管理学院辽宁沈阳110819 北京科技大学经济与管理学院北京100083

针对贝叶斯方法在更新模型参数时无法充分利用历史退化数据的问题,提出基于序列贝叶斯的在线更新方法实时估计锂电池退化模型参数。构建基于指数函数的非线性维纳退化模型描述变工况下锂电池容量的退化路径,并采用最大似然估计法估计初... 详细信息

针对贝叶斯方法在更新模型参数时无法充分利用历史退化数据的问题,提出基于序列贝叶斯的在线更新方法实时估计锂电池退化模型参数。构建基于指数函数的非线性维纳退化模型描述变工况下锂电池容量的退化路径,并采用最大似然估计法估计初始时刻的模型参数;利用实时容量监测数据,基于序列贝叶斯更新方法在线更新退化模型中的漂移系数;推导锂电池剩余寿命的概率密度函数并预测剩余寿命。通过对不同工况下的锂电池退化数据进行实例验证表明,与基于幂指数和线性函数的退化模型相比,由于序列贝叶斯方法能够实时更新锂电池非线性退化模型参数,采用所提模型预测的剩余寿命精度更高。

关键词：维纳过程最大似然估计序列贝叶斯更新剩余寿命非线性退化

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Exploration of the efficacy and mechanism of treating head wind disease with the combination change of ginger volatile oil and gingerol by using content-weighted network pharmacology technology

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TMR Modern Herbal Medicine 2024年第1期7卷 43-56页

作者： Wei-Xiang Wang fei Yan fei Luan Ya-Jun Shi Xiao-fei Zhang Dong-Yan guo Bing-Tao Zhai Jun-Bo Zou Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research College of PharmacyShaanxi University of Chinese MedicineXianyang 712046China

Background:Exploring the efficacy,potential components,and mechanism of the combination of ginger essential oil and gingerols in the treatment of head wind disease based on network pharmacology technology with content ***:The experimental groups were divided into:0:10,1:4,1:2,1:1,2:1,4:1,10:*** relative content(Ri)of the chemical constituents of ginger's volatile oil was determined using gas chromatography-mass spectrometry(GC-MS).Additionally,the physicochemical and biological property parameters(LogP,MDCK,PPB,MW)of the components were *** assess the quantitative effect of the components,a grading score was performed,and the quantitative effect index(Ki)was ***,the target effect index(Ti)was calculated by combining the component-target matching score(Fit score).Using these calculations,the target effect score A was determined under the influence of multiple components targeting different *** targets with A≥1000 were *** predict the targets related to head wind disease,the Comparative Toxicogenomics Database(https://***/),Gene Cards(https://***/),and Disgenet database(https://***/)were *** key targets,obtained from different proportions of ginger's volatile oil and gingerol,were intersected with the predicted *** facilitated network pharmacological analysis and verification of the ***:The content of volatile oil in ginger demonstrated an impact on key targets associated with the volatile oil *** specific combination of volatile oil consistently activated distinct pathways,with variations stemming from changes in *** testing revealed that different combinations of ginger's volatile oil and gingerol effectively alleviated migraine symptoms in ***:Through the application of content-weighted network pharmacology technology and pharmacodynamic verification,it was determined that altering the ratio between ginge

关键词： network pharmacology volatile oil of ginger weight of content head wind disease

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Probing quantum causality with geometric asymmetry in spatial-temporal correlations

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Science China(Information Sciences) 2024年第9期67卷 294-305页

作者： Yu MENG Zheng-Hao LIU Zhikuan ZHAO Peng YIN Yi-Tao WANG Wei LIU Zhi-Peng LI Yuan-Ze YANG Zhao-An WANG Jin-Shi XU Shang YU Jian-Shun TANG chuan-Feng LI Guang-Can guo CAS Key Laboratory of Quantum Information University of Science and Technology of China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China Department of Computer Science Eidgen?ssische Technische Hochschule Zürich Hefei National Laboratory Department of Physics Imperial College London Research Center for Quantum Sensing Zhejiang Lab

Causation promotes the understanding of correlation to an advanced stage by elucidating its underlying mechanism. Although statisticians have specified the possible causal relations among correlations,inferring causal structures is impossible from only the observed correlations in the classical world. Quantum correlations encapsulating the most defining aspects of quantum physics have taken a new turn for the causal inference problem — the two-point spatial and temporal quantum correlations with observationally discernible characteristics correspond exactly to the two most basic causal structures. However, a direct causal interpretation for quantum correlations has only been established in very limited cases. Here, we explore to what extent quantum correlations promote causal inference. Theoretically, we have found that the distinguishable causal regime of two-point Pauli correlations can be expanded from a single value to an asymmetric interval, and the causal structures determining the quantum correlations can be interpreted by a simple distance criterion. Experimentally, we have devised and implemented a versatile non-unital quantum channel in an optical architecture to directly observe such an asymmetric interval. The setup enabled quantum causal inference without any requirement of active intervention, which is impossible in the classical realm. Our work facilitates the identification of causal links among quantum variables and provides insight into characterizing causation and spatial-temporal correlation in quantum mechanics.

关键词： causality quantum information quantum channel channel-state duality non-unital channel

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脓毒症大鼠血小板受体CD62P的表达及替格瑞洛的心脏保护作用

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中华急诊医学杂志 2024年第2期33卷 172-178页

作者：郭沛雨郭飞黄海单亮青岛大学附属医院重症医学科青岛266061 青岛大学医学部青岛266061

目的探讨脓毒症大鼠血小板受体CD62P表达情况以及替格瑞洛的抗炎作用及其对脓毒症大鼠心肌损伤的保护作用。方法采用SD雄性大鼠32只,以随机数字表法将大鼠分为4组:假手术组(sham)、脓毒症组(cecal ligation and puncture,CLP)、低剂量... 详细信息

目的探讨脓毒症大鼠血小板受体CD62P表达情况以及替格瑞洛的抗炎作用及其对脓毒症大鼠心肌损伤的保护作用。方法采用SD雄性大鼠32只,以随机数字表法将大鼠分为4组:假手术组(sham)、脓毒症组(cecal ligation and puncture,CLP)、低剂量给药组(low dose,LD):给药剂量为10 mg/kg、高剂量给药组(high dose,HD):给药剂量为50 mg/kg,每组8只。假手术组大鼠仅进行开关腹并剥离盲肠处理,脓毒症组、低剂量给药组和高剂量给药组的大鼠采用CLP法构建脓毒症大鼠模型,给药组分别按照10 mg/kg及50 mg/kg用量进行替格瑞洛灌胃给药,假手术组及脓毒症组则按照1 mL/kg进行生理盐水灌胃处理。分别于手术前12 h及手术后12 h两次对大鼠进行灌胃给药。各组大鼠造模后24 h经腹主动脉取血并采集病理标本。应用流式细胞术检测各组大鼠血小板表面受体CD62P的表达情况;采用酶联免疫吸附试验(ELISA)法检测IL-6、TNF-α水平;检测心肌损伤标志物:CKMB、LDH水平;并检测转氨酶、肌酐、白细胞水平;对心肌组织进行HE染色观察病理形态;通过TUNEL法观察心肌细胞凋亡情况。结果①流式结果可见与sham组相比,CLP组的CD62P表达水平明显增加(P<0.01),两组给药组与CLP组相比CD62P的表达水平均明显降低,HD组更为显著(P<0.01)。②ELISA结果显示与sham组相比CLP组的IL-6、TNF-α水平显著升高(P<0.01),HD组较CLP组显著降低(P<0.05),LD组IL-6水平下降不明显。CLP组的TNF-α水平与sham组相比明显升高(P<0.01)。③CLP组和两组替格瑞洛干预组与sham组相比,CKMB和LDH的表达水平均有显著增加(P<0.01),给药组与CLP组相比CKMB、LDH均有明显下降(P<0.05),HD组下降更明显(P<0.01)。;④与sham组相比,CLP组大鼠血WBC,ALT,CR值升高明显,而使用替格瑞洛进行干预后,大鼠的WBC、ALT、CR值下降明显(P<0.05),且差异与剂量明显相关。⑤病理结果显示:sham组心肌细胞形态正常,CLP组心肌细胞损伤最重,LD组及HD组心肌细胞损伤较CLP组明显减轻。⑥Tunel染色显示与Sham组可见的少量阳性细胞比较,CLP组可见大量被染色的阳性细胞,LD组和HD组心肌细胞凋亡与CLP组相比明显减少。结论脓毒症激活血小板,刺激CD62P的过度表达,进而诱导炎症反应的过度激活,引起心肌细胞的凋亡和损伤,导致脓毒性心肌损伤;替格瑞洛的心脏保护作用可能与抑制血小板活化后CD62P表达的减少有关,且CD62P的表达与替格瑞洛之间存在剂量依赖关系。

关键词：脓毒症 CD62P P选择素替格瑞洛心肌损伤血小板血小板受体脓毒性心肌病

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