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Evidence of Synergistic Activity of Medicinal Plant Extracts against Neuraminidase Inhibitor Resistant Strains of Influenza Viruses

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Advances in Microbiology 2014年第16期4卷 1260-1277页

作者： Dhivya Rajasekaran Enzo A. Palombo Tiong Chia Yeo Diana Lim Siok Ley chu lee tu Francois Malherbe Lara Grollo Department of Chemistry and Biotechnology Faculty of Science Engineering and Technology Swinburne University of Technology Hawthorn Australia Sarawak Biodiversity Centre Kuching Malaysia

The frequent emergence of drug resistant influenza viral strains emphasizes the urgent and continual need to develop new antiviral drugs. Given the encouraging findings of previous studies on antiviral compounds from plant sources, this study focused on medicinal plants from Borneo that were traditionally used to treat symptoms of influenza infection. Following the promising results of earlier investigations, four plant extracts that demonstrated multiple modes of viral inhibition were studied against wild-type and neuraminidase (NA) inhibitor-resistant strains of Types A and B influenza viruses. The extracts exhibited more pronounced activities against the wild-type viruses than the NA inhibitor-resistant strains. Variations in the antiviral potential of the extracts collected from different parts of the same plant were also evidenced in the in vitro micro-inhibition assays. Even though all plant extracts affected NA activity of all viruses, only two extracts demonstrated hemagglutination inhibitory (HI) activities against Type A pandemic H1N1 and Type B viruses. Furthermore, Receptor Destroying Enzyme (RDE) treatments of extracts exhibiting HI activities indicated the presence of sialic acid (SA)-like component(s) that may be responsible for HI activity. Since the antiviral potential of extracts was not completely suppressed by RDE, the possibility of non SA-like antiviral components cannot be ruled out. Therefore, synergistic activity between SA-like and non SA-like components contained in the plant extracts may be responsible for the demonstrated antiviral potential. The results also indicated the presence of non SA-like components that may act against other viral proteins apart from hemagglutinin (HA) and NA. Hence, this study supports the presence of multiple antiviral components that act against different viral proteins or interfere with different stages of viral replication. Our results suggest that these plant extracts have the potential to be developed as

关键词： Influenza Antivirals Medicinal Plant Extracts Hemagglutination Inhibition Neuraminidase Inhibition Sialic Acid-Like RDE

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A nano-functionalized real-time electrochemiluminescent biosensor for alanine transaminase assay

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Science China Chemistry 2011年第5期54卷 816-821页

作者： chu HaiHong WU MeiSheng CAI Xia tu YiFeng Institute of Analytical Chemistry Department of ChemistrySoochow UniversitySuzhou 215123China

An electrochemiluminescent (ECL) biosensor was constructed for selective assay of alanine aminotransferase (ALT) based on the enzymatically catalyzed oxidation of pyruvate by pyruvate oxidase (PYOD). The composite of potassium ferricyanide and carbon nanotube was adopted to pre-functionalize the basal platinum electrode while the potassium ferricyanide acted as the activator of PYOD. The ALT catalyzed the reaction of L-alanine and-ketoglutarate to produce pyruvate which could be further enzymatically oxidized by PYOD to yield H2O2 to intensify the ECL of luminol. The biosensor showed rapid response for real-time measurement of ALT in the linear concentration range from 0.00475 to 350 U/L (r = 0.993) with a relatively standard deviation of 2.5% (CALT = 47.5 U/L,n = 6). The biosensor was applied to assay the ALT in rat serum with average recovery of 90.5%.

关键词： alanine aminotransferase electrochemiluminescent biosensor luminol pyruvate oxidase carbon nanotubes

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The Construct of A Neutral Medium Applicable Electrochemiluminescent Sensor Based on the Chemical Modification of Cysteine and Luminol

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稀有金属材料与工程 2006年第A03期35卷 409-412页

作者： tu Yifeng chu Haihong Guo Wenying Di Junwei Institute of Analytical Chemistry College of Chemistry and Chemical Engineering Suzhou University Suzhou 215123 China

In the phosphate buffer solution of pH＞7,the cysteine sensitized the electrochemiluminescence (ECL) of *** could be modified on the surface of platinum electrode and furthermore adsorbing the luminol on its exterior to construct an ECL *** ECL intensity of this sensor was strong enough and very *** wasn't obvious decrease of ECL intensity for thirty times of using in 48 hours with the relative standard deviation (RSD) of 0.98%.It could be used to determine some quenching effective molecules such as superoxide dismutase (SOD) with negative response upon the concentration range from 4.8 IU/ml to 57.6 IU/ml.

关键词： electrochemiluminescent sensor chemical modification luminol cysteine sensitization superoxide dismutase

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Analysis and Control of Modular Multi-terminal DC Power Flow Controller with Fault Current Limiting Function

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Journal of Modern Power Systems and Clean Energy 2021年第6期9卷 1375-1385页

作者： Qianming Xu Xinyu Huang Xu chu Mingshen Li Zhikang Shuai chunming tu Josep M.Guerrero College of Electrical and Information Engineering Hunan University Department of Energy Technology Aalborg University

In order to overcome the problems of power flow control and fault current limiting in multi-terminal high voltage direct current(MTDC)grids,this paper proposes a modular multi-terminal DC power flow controller(MM-DCPFC)with fault current limiting *** topology structure,operation principle,and equivalent circuit of MM-DCPFC are introduced,and such a structure has the advantages of modularity and *** power balance mechanism is studied and a hierarchical power balance control strategy is *** results show that MM-DCPFC can achieve internal power exchange,which avoids the use of external power *** fault characteristics of MM-DCPFC are analyzed,fault current limiting and self-protection methods are proposed,and the factors affecting the current limiting capability are *** simulation models are established in PLECS,and the simulation results verify the effectiveness of MM-DCPFC in power flow control,fault current limiting,and *** addition,a prototype is developed to validate the function and control method of MM-DCPFC.

关键词： Fault current limiting multi-terminal high volt-age direct current(MTDC)grid power balance DC power flow controller

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Real-Time Monitoring and Quantitative Evaluation of Cavitation Bubbles Induced by High Intensity Focused Ultrasound Using B-Mode Imaging

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Chinese Physics Letters 2014年第3期31卷 91-95页

作者： YU Jie CHEN chu-Yi CHEN Gong GUO Xia-Sheng MA Yong tu Juan ZHANG Dong Key Laboratory of Modern Acoustics School of Physics Nanjing University Nanjing 210093 Traditional Chinese Medicine Hospital of Jiangsu Province Nanjing 210023 State Key Laboratory of Acoustics Chinese Academy of Sciences Beijing 100190

A software-based method is proposed to eliminate the flooding interference strips in B-mode images, and to evaluate the cavitation bubbles generated during high intensity focused ultrasound （HIFU） exposures. In vitro tissue phantoms are exposed to 1.12 MHz HIFU pulses with a fixed 100 Hz pulse repetition frequency. HIFU-induced cavitation bubbles are detected as hyperechoic regions in B-mode images. The temporal evolution of cavitation bubbles, generated by HIFU pulses with varying driving amplitude and pulse length, is analyzed by measuring the time-varying area of the hyperechoic region. The results show that： first, it is feasible to monitor HIFU-induced cavitation bubble activity in real-time using B-mode imaging; second, more cavitation bubbles can be generated with higher acoustic energy delivered; third, the hyperechoic region is observed to shrink gradually after ceasing the HIFU pulses, which indicates the dissolution of cavitation bubbles. This work will be helpful for developing an effective tool to realize real-time monitoring and quantitative evaluation of HIFU-induced cavitation bubble activity using a current commercialized B-mode machine.

关键词： CAVITATION RESEARCH HIGH-intensity focused ultrasound IMAGING systems QUANTITATIVE research PHYSICS research

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Binding Equilibrium Studies Between Co^(2+) and HSA or BSA

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Chemical Research in Chinese Universities 2000年第3期16卷 276-279页

作者： BIAN He dong LIANG Hong tu chu qiao ZHANG Hong zhi SHEN Pan wen Research Institute of Bioinorganic Chemistry Department of Chemistry and Chemical EngineeringGuangxi Normal UniversityGuilin 541004P.R.China Department of Chemistry Nankai UniversityTianjinP.R.China

The interaction of HSA and BSA with Co2+ and a carboxyl atom of Asp is investigated. The number of binding sites and the cooperation among the binding sites are analyzed. According to the equilibrium dialysis results and the study of competition between Co2+ and Cu2+, Ca2+ or Zn2+ to be bound to HSA or BSA, it is suggested that there are three strong binding sites of in both HSA and BSA.

关键词： Co 2+ serum albumin Equilibrium dialysis Coordination analysis Positive cooperative effect

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Sustainable chemical upcycling of waste polyolefins by heterogeneous catalysis

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SusMat 2022年第2期2卷 161-185页

作者： Mingyu chu Weilin tu Shuangqiao Yang Congyang Zhang Qingye Li Qiao Zhang Jinxing Chen Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhouP.R.China State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityChengduP.R.China Department of Chemistry University of Western OntarioLondonOntarioCanada College of Food Science Sichuan Agricultural UniversityYa’anP.R.China

The mass production of disposable polyolefin products has led to serious plastic pollution and an imbalance between manufacturing and *** these challenges,the chemical upcycling of waste polyolefins has attracted extensive attention due to its high efficiency and economic ***,we review the development of polyolefin chemical upcycling in heterogeneous *** status quo of polyolefin recycling is first *** then introduce the advanced strategies for chemical upcycling in the view of different value-added products and discuss their challenges and *** in-depth analysis centers on the catalytic mechanism and the design principle of heterogeneous cata***,we outlook the promising directions to facilitate the degradation process via polymer and catalyst design and optimized catalytic *** strategies are expected to promote the chemical upcycling of polyolefins,bringing great promise for the sustainable development of society.

关键词： chemical upcycling heterogeneous catalysis plastic recovery polyolefin value-added products

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Pulling force of acoustic-vortex beams on centered elastic spheres based on the annular transducer model

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Chinese Physics B 2020年第5期29卷 318-325页

作者： Yuzhi Li Qingdong Wang Gepu Guo Hongyan chu Qingyu Ma Juan tu Dong Zhang School of Physics and Technology Nanjing Normal UniversityNanjing 210023China College of Ocean Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Institute of Acoustics Nanjing UniversityNanjing 210093China

To solve the difficulty of generating an ideal Bessel beam,an simplified annular transducer model is proposed to study the axial acoustic radiation force(ARF)and the corresponding negative ARF(pulling force)exerted on centered elastic spheres for acoustic-vortex(AV)beams of arbitrary *** on the theory of acoustic scattering,the axial distributions of the velocity potential and the ARF for AV beams of different orders generated by the annular transducers with different physical sizes are *** is proved that the pulling force can be generated by AV beams of arbitrary orders with multiple axial *** pulling force is more likely to exert on the sphere with a smaller k0a(product of the wave number and the radius)for the AV beam with a bigger topological charge due to the strengthened off-axis acoustic *** pulling force decreases with the increase of the axial distance for the sphere with a bigger *** pulling force areas with wider axial regions can be formed by AV beams using a bigger-sized annular *** theoretical results demonstrate the feasibility of generating the pulling force along the axes of AV beams using the experimentally applicable circular array of planar transducers,and suggest application potentials for multi-position stable object manipulations in biomedical engineering.

关键词： acoustic radiation force pulling force acoustic-vortex beams annular transducer model acoustic scattering

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A New PCR/LDR-Based Multiplex Functional Molecular Marker for Marker-Assisted Breeding in Rice

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Rice science 2021年第1期28卷 6-10页

作者： chu Huangwei tu Rongjian Niu Fuan Zhou Jihua Sun Bin Luo Zhongyong Cheng Can Cao Liming Institute of Crop Breeding and Cultivation Shanghai Academy of Agricultural SciencesShanghai 201403China

Marker-assisted selection or marker-aided selection(MAS)provides an effective complementary approach for conventional rice breeding with precise and speedy mobilization of target genes into elite genetic *** targeted genes,however,may not be selected in the course of MAS due to the occasional recombination between the marker and the target gene/QTL during the many cycles of meiosis involved in breeding *** leads to failure in the selection of target traits(Gopalakrishnan et al,2008).

关键词： breeding elite Marker

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3D Chromatin Architecture of Large Plant Genomes Determined by Local A/B Compartments

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Molecular Plant 2017年第12期10卷 1497-1509页

作者： Pengfei Dong Xiaoyu tu Po-Yu chu Peitao Lu Ning Zhu Donald Grierson Baijuan Du Pinghua Li Silin Zhong State Key Laboratory of Crop Biology College of Agronomy Shandong Agricultural University Tai'an Shandong China State Key Laboratory of Agrobiotechnology School of Life Sciences The Chinese University of Hong Kong Hong Kong China Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang University Hangzhou Zhejiang China These authors contributed equally to this article.

The spatial organization of the genome plays an important role in the regulation of gene expression. How- ever, the core structural features of animal genomes, such as topologically associated domains （TADs） and chromatin loops, are not prominent in the extremely compact Arabidopsis genome. In this study, we examine the chromatin architecture, as well as their DNA methylation, histone modifications, accessible chromatin, and gene expression, of maize, tomato, sorghum, foxtail millet, and rice with genome sizes ranging from 0.4 to 2.4 Gb. We found that these plant genomes can be divided into mammalian-like A/B compartments. At higher resolution, the chromosomes of these plants can be further partitioned to local AJB compartments that reflect their euchromatin, heterochromatin, and polycomb status. Chromatins in all these plants are organized into domains that are not conserved across species. They show similarity to the Drosophila compartment domains, and are clustered into active, polycomb, repressive, and interme- diate types based on their transcriptional activities and epigenetic signatures, with domain border overlaps with the local A/B compartment junctions. In the large maize and tomato genomes, we observed extensive chromatin loops. However, unlike the mammalian chromatin loops that are enriched at the TAD border, plant chromatin loops are often formed between gene islands outside the repressive domains and are closely associated with active compartments. Our study indicates that plants have complex and unique 3D chromatin architectures, which require further study to elucidate their biological functions.

关键词： Hi-C chromatin loop compartment domain local compartment

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