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Evidence of Synergistic Activity of Medicinal Plant Extracts against Neuraminidase Inhibitor Resistant Strains of Influenza Viruses

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Advances in Microbiology 2014年第16期4卷 1260-1277页

作者： Dhivya Rajasekaran Enzo A. Palombo Tiong Chia Yeo Diana Lim Siok Ley chu lee tu Francois Malherbe Lara Grollo Department of Chemistry and Biotechnology Faculty of Science Engineering and Technology Swinburne University of Technology Hawthorn Australia Sarawak Biodiversity Centre Kuching Malaysia

The frequent emergence of drug resistant influenza viral strains emphasizes the urgent and continual need to develop new antiviral drugs. Given the encouraging findings of previous studies on antiviral compounds from plant sources, this study focused on medicinal plants from Borneo that were traditionally used to treat symptoms of influenza infection. Following the promising results of earlier investigations, four plant extracts that demonstrated multiple modes of viral inhibition were studied against wild-type and neuraminidase (NA) inhibitor-resistant strains of Types A and B influenza viruses. The extracts exhibited more pronounced activities against the wild-type viruses than the NA inhibitor-resistant strains. Variations in the antiviral potential of the extracts collected from different parts of the same plant were also evidenced in the in vitro micro-inhibition assays. Even though all plant extracts affected NA activity of all viruses, only two extracts demonstrated hemagglutination inhibitory (HI) activities against Type A pandemic H1N1 and Type B viruses. Furthermore, Receptor Destroying Enzyme (RDE) treatments of extracts exhibiting HI activities indicated the presence of sialic acid (SA)-like component(s) that may be responsible for HI activity. Since the antiviral potential of extracts was not completely suppressed by RDE, the possibility of non SA-like antiviral components cannot be ruled out. Therefore, synergistic activity between SA-like and non SA-like components contained in the plant extracts may be responsible for the demonstrated antiviral potential. The results also indicated the presence of non SA-like components that may act against other viral proteins apart from hemagglutinin (HA) and NA. Hence, this study supports the presence of multiple antiviral components that act against different viral proteins or interfere with different stages of viral replication. Our results suggest that these plant extracts have the potential to be developed as

关键词： Influenza Antivirals Medicinal Plant Extracts Hemagglutination Inhibition Neuraminidase Inhibition Sialic Acid-Like RDE

Hybrid Optimization Algorithm for Handwritten Document Enhancement

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Computers, Materials & Continua 2024年第3期78卷 3763-3786页

作者： Shu-chuan chu Xiaomeng Yang Li Zhang Václav Snášel Jeng-Shyang Pan College of Computer Science and Engineering Shandong University of Science and TechnologyQingdao266590China School of Information and Control Engineering Qingdao University of TechnologyQingdao266520China Faculty of Electrical Engineering and Computer Science VŠB-TU OstravaOstrava70080Czech Republic Department of Information Management Chaoyang University of TechnologyTaichung41349Taiwan

The Gannet Optimization Algorithm (GOA) and the Whale Optimization Algorithm (WOA) demonstrate strong performance;however, there remains room for improvement in convergence and practical applications. This study introduces a hybrid optimization algorithm, named the adaptive inertia weight whale optimization algorithm and gannet optimization algorithm (AIWGOA), which addresses challenges in enhancing handwritten documents. The hybrid strategy integrates the strengths of both algorithms, significantly enhancing their capabilities, whereas the adaptive parameter strategy mitigates the need for manual parameter setting. By amalgamating the hybrid strategy and parameter-adaptive approach, the Gannet Optimization Algorithm was refined to yield the AIWGOA. Through a performance analysis of the CEC2013 benchmark, the AIWGOA demonstrates notable advantages across various metrics. Subsequently, an evaluation index was employed to assess the enhanced handwritten documents and images, affirming the superior practical application of the AIWGOA compared with other algorithms.

关键词： Metaheuristic algorithm gannet optimization algorithm hybrid algorithm handwritten document enhancement

镀锌废酸液溶剂萃取分离与资源化回收锌铁的研究进展

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中国有色金属学报 2024年第7期34卷 2383-2398页

作者：冯鑫初国君汪涵石晓磊涂继国北京科技大学绿色低碳钢铁冶金全国重点实验室北京100083 吉林华信新型结构科技有限公司吉林132300 北京科技大学绿色低碳冶炼与资源综合利用联合实验室北京100083

镀锌废酸液含有高浓度亚铁盐、锌盐和残余酸,同时具有酸性强、腐蚀性强以及不易处理等特点。若对镀锌废酸液不能进行有效处理并直接排放,将对周围环境造成显著破坏,并导致严重的资源浪费。溶剂萃取法是一种极具应用潜力的镀锌废酸液处... 详细信息

镀锌废酸液含有高浓度亚铁盐、锌盐和残余酸,同时具有酸性强、腐蚀性强以及不易处理等特点。若对镀锌废酸液不能进行有效处理并直接排放,将对周围环境造成显著破坏,并导致严重的资源浪费。溶剂萃取法是一种极具应用潜力的镀锌废酸液处理方法,具有高选择性、多功能性和产品纯度高的特点,特别是在处理含锌离子废液方面具有显著优势。本文全面总结了不同酸碱萃取剂条件下处理镀锌废酸液的萃取机理及影响因素,并对镀锌废酸液中高附加值成分的回收进行了系统阐述。此外,总结了溶剂萃取法资源化回收镀锌废酸液的发展现状,并展望了锌、铁高效分离与回收的未来研究方向,为相关技术产业化提供重要的理论依据,并促进镀锌废酸液的可持续处理与资源化利用。

关键词：镀锌废酸溶剂萃取萃取机制锌铁分离高值产品回收

典型时代中典型作品的身份界定与关系探求——以王希孟《千里江山图》为中心

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清华大学学报（哲学社会科学版） 2024年第3期39卷 164-184,246页

作者：楚小庆南通大学艺术学院南通226019 南京博物院艺术研究所南京210016

《千里江山图》青绿山水长卷是一件创作于北宋时期、在中国艺术史上具备里程碑意义的典型作品,其历史身份特殊,精神内涵丰富,整体美学风格由多方因素影响合力形成,创作目标与任务性质紧密围绕宋徽宗的思想文化理念和国家治理实践,是绘... 详细信息

《千里江山图》青绿山水长卷是一件创作于北宋时期、在中国艺术史上具备里程碑意义的典型作品,其历史身份特殊,精神内涵丰富,整体美学风格由多方因素影响合力形成,创作目标与任务性质紧密围绕宋徽宗的思想文化理念和国家治理实践,是绘画发展历史转折期中引领时代风尚、表征美学观念的重要标志。《千里江山图》的款识是为典型,形象反映了当时专业画工群体社会地位低下、社会习俗追求画面完整与纯粹装饰效果、王希孟工作岗位的特殊及其生命的短暂等时代问题。在这一典型时期,立德、立言的含义逐渐延伸并开始涵盖绘画,以绘画创作为样板,以《千里江山图》等一批画作为导向标志、重要载体和内在推动力,艺术本体的创新目的、社会功用及美学立场均发生了重大改变,逐步由“文以载道”进入到“以艺立言”的国家话语体系和社会运行机制之中。贯穿该画作景物内容构成选择的价值理念及其美学风格,形象反映了当时社会审美风尚的重大转型,画面中一般城乡民用建筑与创作者在创作中后期二次添加皇家宫殿庙宇的建筑等级规制,深刻表达了王希孟的忠君思想,以及由热情赞颂劳动美学、真实反映基层人民生活到尊崇无上皇权价值理念的转变。

关键词：王希孟《千里江山图》款识身份以艺立言价值理念

Using Network Pharmacology to Explore Therapeutic Effect of Polygonum capitatum on Renal Calculus in Rats

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Medicinal Plant 2024年第3期15卷 45-49页

作者： Bo tu Xu ZHANG Yan LIN Huang YANG Minghui HE Engineering Research Center of Chronic Disease Prevention and Treatment of Authentic Medicinal Materials in Guizhou Higher Education Institutions School of Pharmaceutical SciencesGuizhou Medical UniversityGuiyang 550025China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550004China

[Objectives]To explore the therapeutic effect of Polygonum capitatum on renal calculus in rats based on network pharmacology.[Methods]Through the preliminary construction of ***-urolithiasis disease target network,explore the active components,action pathway and action target of ***-urolithiasis treatment,and use 1%ethylene glycol+2%ammonium chloride to induce SD rat kidney calcium oxalate stone model to verify the efficacy of ***-urolithiasis treatment.[Results]Through the network pharmacological prediction,it is found that the important active components in *** were quercetin,gallic acid,rutin,silybin,catechin,kaempferol and so on;potential active targets include INS,CAT,IL-6,MOCOS,*** results also suggest that forkhead transcription factor signaling pathway(FoxO signaling pathway),tumor necrosis factor signaling pathway(TNF signaling pathway)and hypoxia-inducible factor signaling pathway(HIF-1 signaling pathway)are the core *** results of biochemical indicators in animal experiment showed that the contents of serum urea nitrogen(BUN),creatinine(Cr)and malondialdehyde(MDA)in renal tissue in the treatment group(200,500 mg/kg)were significantly lower than those in the model group,while the content of superoxide dismutase(SOD)was significantly higher than that in the model *** addition,the kidney tissue H&E staining sections showed that *** alcohol extract administration group rats kidney calcium oxalate crystals were significantly reduced compared with the model group,the degree of renal tubular lumen expansion was lighter than the model group,suggesting that *** alcohol extract has the effect of improving renal calculus in rats.[Conclusions]This study provides a theoretical reference for the deep development of *** in the treatment of renal calculus.

关键词： Polygonum capitatum Urolithiasis Network pharmacology

基于图像学视阈下的马山楚墓出土“田猎纹绦”织物解读

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丝绸 2024年第4期61卷 18-26页

作者：涂雨潇李正苏州大学纺织与服装工程学院江苏苏州215123 苏州大学艺术学院江苏苏州215123

战国时期马山楚墓出土的“田猎纹绦”织物图像开创了将人物、动物和场景并置于同一画面中的先河,文章以全新的图像学视角完善战国时期服饰与质料系统。通过图像学和叙事学等研究方法将江陵马山一号楚墓出土的“田猎纹绦”实物资料及图... 详细信息

战国时期马山楚墓出土的“田猎纹绦”织物图像开创了将人物、动物和场景并置于同一画面中的先河,文章以全新的图像学视角完善战国时期服饰与质料系统。通过图像学和叙事学等研究方法将江陵马山一号楚墓出土的“田猎纹绦”实物资料及图像逐层递进剖析,立足于“前图像志描述”“图像志分析”和“图像学解释”的图像学视角去还原田猎角色的形象构建,提出田猎图像的叙事特征,并挖掘出田猎活动风靡的发展缘由。研究表明:通过图像学知识分解并深挖“田猎纹绦”存在着图像叙事的直观性、象征性和共时性等特征,感受角色赋予的运动精神,总结了军事、祭祀、农业和娱乐等因素是构成战国时期田猎活动盛行的主要动因。

关键词：田猎纹绦图像学田猎文化形象构建叙事特征织物图像

Hepatocyte growth factor enhances the ability of dental pulp stem cells to ameliorate atherosclerosis in apolipoprotein E-knockout mice

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World Journal of Stem Cells 2024年第5期16卷 575-590页

作者： Han Duan Ning Tao Lin Lv Kai-Xin Yan Yong-Gang You Zhuang Mao Chang-Yao Wang Xue Li Jia-Yan Jin chu-Tse Wu Hua Wang School of Life Sciences Hebei UniversityBaoding 071002Hebei ProvinceChina Beijing Institute of Radiation Medicine Beijing 100850China Department of Cardiology The Sixth Medical CentreChinese People’s Liberation Army General HospitalBeijing 100037China Department of Orthopaedics The Fourth Medical CentreChinese People’s Liberation Army General HospitalBeijing 100853China Third Cadet Regiment School of Basic Medical ScienceAir Force Medical UniversityXi’an 710032Shaanxi ProvinceChina

BACKGROUND Atherosclerosis(AS),a chronic inflammatory disease of blood vessels,is a major contributor to cardiovascular *** pulp stem cells(DPSCs)are capable of exerting immunomodulatory and anti-inflammatory effects by secreting cytokines and exosomes and are widely used to treat autoimmune and inflam-mation-related *** growth factor(HGF)is a pleiotropic cytokine that plays a key role in many inflammatory and autoimmune *** To modify DPSCs with HGF(DPSC-HGF)and evaluate the therapeutic effect of DPSC-HGF on AS using an apolipoprotein E-knockout(ApoE-/-)mouse model and an in vitro cellular *** ApoE-/-mice were fed with a high-fat diet(HFD)for 12 wk and injected with DPSC-HGF or Ad-Null modified DPSCs(DPSC-Null)through tail vein at weeks 4,7,and 11,respectively,and the therapeutic efficacy and mechanisms were analyzed by histopathology,flow cytometry,lipid and glucose measurements,real-time reverse transcription polymerase chain reaction(RT-PCR),and enzyme-linked immunosorbent assay at the different time points of the *** in vitro inflammatory cell model was established by using RAW264.7 cells and human aortic endothelial cells(HAOECs),and indirect co-cultured with supernatant of DPSC-Null(DPSC-Null-CM)or DPSC-HGF-CM,and the effect and mechanisms were analyzed by flow cytometry,RT-PCR and western *** factor-κB(NF-κB)activators and inhibitors were also used to validate the related signaling *** DPSC-Null and DPSC-HGF treatments decreased the area of atherosclerotic plaques and reduced the expression of inflammatory factors,and the percentage of macrophages in the aorta,and DPSC-HGF treatment had more pronounced *** treatment had no effect on serum lipoprotein *** FACS results showed that DPSCs treatment reduced the percentages of monocytes,neutrophils,and M1 macrophages in the peripheral blood and ***-Null-CM and DPSC-HGF-CM reduced adhesion molecule expression in tu

关键词： Atherosclerosis Apolipoprotein E-knockout mice Cell therapy Dental pulp stem cells Hepatocyte growth factor

RCMNAAPE在旋转机械故障诊断中的应用

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机电工程 2024年第6期41卷 1039-1049页

作者：储祥冬戴礼军涂金洲罗震寰于震秦磊江苏中烟工业有限责任公司淮阴卷烟厂江苏淮安223002 颐中(青岛)烟草机械有限公司山东青岛266000 武汉理工大学机电工程学院湖北武汉430070

针对精细复合多尺度排列熵(RCMPE)无法充分提取旋转机械振动信号中的故障信息,从而导致旋转机械故障识别准确率不稳定这一缺陷,提出了一种基于精细复合多尺度归一化幅值感知排列熵(RCMNAAPE)、拉普拉斯分数(LS)和灰狼算法优化支持向量机... 详细信息

针对精细复合多尺度排列熵(RCMPE)无法充分提取旋转机械振动信号中的故障信息,从而导致旋转机械故障识别准确率不稳定这一缺陷,提出了一种基于精细复合多尺度归一化幅值感知排列熵(RCMNAAPE)、拉普拉斯分数(LS)和灰狼算法优化支持向量机(GWO-SVM)的旋转机械故障诊断方法。首先,利用幅值感知排列熵替换了RCMPE中的排列熵,提出了RCMNAAPE,并将其用于提取旋转机械振动信号的故障特征生成特征样本;随后,采用了LS从原始的高维故障特征向量中筛选出较少的能够更准确描述故障状态的特征,构造敏感特征样本;最后,将低维的故障特征向量输入由灰狼算法优化的支持向量机中进行了训练和测试,完成了旋转机械样本的故障识别和分类,利用滚动轴承和齿轮箱故障数据集将RCMNAAPE-LS-GWO-SVM与其他故障诊断方法进行了对比分析,并开展了评估。研究结果表明:基于RCMNAAPE-LS-GWO-SVM的故障诊断方法能够有效识别旋转机械的各类故障,其识别准确率高于其他对比的故障诊断方法,其中滚动轴承故障的识别准确率达到99.33%,齿轮箱故障的识别准确率达到98.67%。虽然,该方法的特征提取效率不佳,平均特征提取时间分别为153.02 s和163.98 s,仅优于精细复合多尺度模糊熵(RCMFE),但其综合性能更加优异。

关键词：故障识别准确率滚动轴承齿轮箱精细复合多尺度归一化幅值感知排列熵拉普拉斯分数灰狼优化支持向量机

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从气质特征角度看乳腺癌的肝郁属性

新中医 2024年第7期56卷 195-200页

作者：金岚屠思远褚美玲陈红风上海中医药大学附属龙华医院上海200032

目的:从气质特征角度揭示以肝郁论治乳腺癌的可行性。方法:采用艾森克人格问卷简式量表中国版收集251例乳腺癌患者的气质特征,分析四维度量表标准分的含义,获得4种气质类型的人员分布,分析各维度量表之间的相关性及其内涵。结果:乳腺癌... 详细信息

目的:从气质特征角度揭示以肝郁论治乳腺癌的可行性。方法:采用艾森克人格问卷简式量表中国版收集251例乳腺癌患者的气质特征,分析四维度量表标准分的含义,获得4种气质类型的人员分布,分析各维度量表之间的相关性及其内涵。结果:乳腺癌患者的神经质、内外向、测谎、精神质的标准分分别集中在41.73~62.07分、45.98~60.62分、48.49~58.55分、42.53~53.08分,情绪不稳者占比35.86%,外向者占比39.44%,坦诚性较高者占比79.68%,精神质占比8.77%。中间型气质占60.16%,内向不稳定(抑郁质)多于其他3种气质类型,外向稳定(多血质)的典型型占比最高为54.17%。情绪的稳定性与个性的内外向呈较强的正相关性(rs=0.704,P<0.01)。内向不稳定(抑郁质)的乳腺癌患者的典型情绪占比显著高于内外向和外向型患者(P<0.01)。结论:乳腺癌患者的气质特征从中医的角度理解可以分为因肝气太强或肝气不足所致的两种不同类型的肝郁,中医药认识和防治乳腺癌可从这两点入手有的放矢。

关键词：乳腺癌艾森克人格问卷简式量表气质肝郁