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Cellular models of stress resistance may pave ways to fight neurodegenerative diseases

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Neural Regeneration Research 2025年第9期20卷 2579-2580页

作者： Thu Nguyen Minh Pham christian Behl Institute of Pathobiochemistry University Medical Center of the Johannes Gutenberg UniversityMainzGermany

Alzheimer's disease(AD),the most common form of neurodegeneration,is characterized by selective neuronal vulnerability and brain regionselective neuron *** entorhinal cortex and hippoc,ampal CA1 projection neurons are at greater risk in AD whereas other regions display resistance to ***,the cerebellum,a phylogenetically very old region,is affected only very late in the disease progression.

关键词： cortex resistance Alzheimer

Many faces of neuronal activity manipulation in Drosophila

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Neural Regeneration Research 2025年第9期20卷 2574-2576页

作者： Amber krebs Steffen kautzmann christian klämbt Institut für Neuro-und Verhaltensbiologie MünsterGermany

Animals exhibit complex responses to external and internal *** information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane *** can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.

关键词： manipulation potential. neuronal

App-based assessment of memory functions in patients after transfemoral aortic valve replacement

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Journal of Geriatric Cardiology 2023年第9期20卷 664-672页

作者： Jonathan Nübel Michael Hauptmann Julika Schön Georg Fritz christian Butter Anja Haase-Fielitz Department of Cardiology University Hospital Heart Centre BrandenburgBrandenburg Medical School(MHB)Theodor FontaneBernauGermany Institute of Biostatistics and Registry Research Brandenburg Medical School Theodor FontaneNeuruppinGermany Faculty of Health Sciences(FGW) Joint Faculty of the University of Potsdamthe Brandenburg Medical School Theodor Fontane and the Brandenburg Technical University Cottbus-SenftenbergCottbusGermany Anesthesia and Intensive Care University Hospital Ruppin Brandenburg(ukrb)Brandenburg Medical School(MHB)Theodor FontaneNeuruppinGermany Department of Anesthesiology Intensive Care and Pain TherapyUniversity Hospital Heart Centre BrandenburgBrandenburg Medical School(MHB)Theodor FontaneBernauGermany Institute of Social Medicine and Health System Research Otto von Guericke University MagdeburgGermany

BACkGROUND Transfemoral aortic valve replacement(TAVR)is the standard treatment for elderly patients with aortic valve *** safe and well-established,there is a risk of intraprocedural hemodynamic instability and silent cerebral embolism,which can lead to a decline in neurocognitive function and *** clinical practice,comprehensive cognitive testing is difficult to ***-assisted digital applications may help to optimize diagnosis and *** Neurocognitive function was assessed by validated psychometric tests using“Δelta-App”,which uses artificial intelligence and computational linguistic methods for extraction and *** function was assessed using the‘Consortium to Establish a Registry for Alzheimer’s Disease’(CERAD)word list and digit span task(DST)before TAVR and before hospital *** study is registered in the German Register of Clinical Trials(https://***/search/de/trial/DRkS00020813).RESULTS From October 2020 until March 2022,141 patients were enrolled at University Hospital Heart Centre *** age was 81±6 years,42.6%were *** between the pre-and post-interventional test was on average 6±3 *** function before TAVR was found to be below average in relation to age and educational *** pre-post TAVR comparison showed significant improvements in the wordlist repeat,Pk.

关键词： patients impaired valve

Evolution of phase stresses in Al/SiCp composite during thermal cycling and compression test studied using diffraction and self-consistent models

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Journal of Materials Science & Technology 2020年第1期36卷 176-189页

作者： Przemyslaw kot Andrzej Baczmański Elzbietaa Gadalińska Sebastian Wroński Marcin Wroński Miroslaw Wróbel Gizo Bokuchava christian Scheffzük krzysztof Wierzbanowski AGH University of Science and Technology Faculty of Physics and Applied Computer Scienceal.Mickiewicza 3030-059 Krakow.Poland Institute of Aviation Materials&Structures Research Centeral.Krakowska 110/11402-256 WarsawPoland AGH University of Science and Technology Faculty of Metals Engineering and Industrial Computer Scienceal.Mickiewicza 3030-059 KrakowPoland Joint Institute for Nuclear Research Frank Laboratory of Neutron PhysicsJoliot-Curie 6141980 DubnaRussia karlsruhe Institute of Technology Institute of Applied GeosciencesAdenauerring 20b76131 KarlsruheGermany

In this work,the evolutions of stresses in both phases of the Al/SiCp composite subjected to thermal cycling during in situ compression test were measured using Time of Flight neutron *** was confirmed that inter-phase stresses in the studied composite can be caused by differences in the coefficient of thermal expansion for the reinforcement and matrix,leading to a different variation of phase volumes during sample heating or *** results of the diffraction experiment during thermal cycling were well predicted by the Thermo-Mechanical Self-Consistent *** experimental study of elastic-plastic deformation was carried out in situ on a unique diffractometer EPSILON-MDS(JINR in Dubna,Russia)with nine detector banks measuring interplanar spacings simultaneously in 9 orientations of scattering *** the first time,the performed analysis of experimental data allowed to study the evolution of full stress tensor in both phases of the composite and to consider the decomposition of this tensor into deviatoric and hydrostatic *** was found that the novel Developed Thermo-Mechanical SelfConsistent model correctly predicted stress evolution during compressive loading,taking into account the relaxation of thermal origin hydrostatic *** comparison of this model with experimental data at the macroscopic level and the level of phases showed that strengthening of the Al/SiCp composite is caused by stress transfer from the plastically deformed A12124 matrix to the elastic SiCp reinforcement,while thermal stresses relaxation does not significantly affect the overall composite properties.

关键词： Stress relaxation Strengthening mechanism Plastic deformation Multiscale model Metal matrix composites Neutron diffraction

Aggresome-aggrephagy transition process:geting closer to the functional roles of HDAC6 and BAG3

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Neural Regeneration Research 2024年第6期19卷 1181-1182页

作者： Hagen körschgen christian Behl The Autophagy Lab Institute of PathobiochemistryUniversity Medical Center of the Johannes Gutenberg University MainzMainzGermany

Misfolding of proteins as well as their aggregation is a major driver of age-related neurodegenerative ***,cells have evolved sophisticated protein quality control *** the ubiquitin-proteasome-system(UPS)and the autop... 详细信息

关键词： closer system transition

Biologically Inspired Girder Structure for the Synchrotron Radiation Facility PETRA IV

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Journal of Bionic Engineering 2023年第5期20卷 1996-2017页

作者： Simone Andresen Norbert Meyners Daniel Thoden Markus körfer christian Hamm Bionic Lightweight Design&Functional Morphology Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research(AWI)Am Handelshafen 1227570BremerhavenGermany Deutsches Elektronen-Synchrotron(DESY) Notkestraße 8522607HamburgGermany

Lightweight structures are widely used across different industry ***,they get easily excited by external influences,such as *** high vibration amplitudes can be avoided by shifting the structural eigenfrequencies,which can be achieved adapting the structural design considering optimisation procedures and structures primarily inspired by *** procedures has been applied to the development process of a girder structure installed in a synchrotron radiation facility to support heavy magnets and other *** objective was to design a 2.9 m long girder structure with high eigenfrequencies,a high stiffness and a low *** on a topology optimisation result,a parametric beam–shell model including biologically inspired structures(e.g.,Voronoi combs,ribs,and soft and organic-looking transitions)was built *** subsequent cross-sectional optimisation using evolutionary strategic optimisation revealed an optimum girder structure,which was successfully manufactured using the casting *** measurements validated the numerical *** changes in the specifications can be implemented in the bio-inspired development process to obtain adapted girder structures.

关键词： Biomimetics Eigenfrequency maximisation Evolutionary structural optimisation Lightweight design Topology optimisation Voronoi combs

The role of hypogonadism in klinefelter Syndrome

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Asian Journal of Andrology 2014年第2期16卷 185-191,I0007页

作者： christian Host Anne Skakkeb k kristian A Groth Anders Bojesen Departments of Pediatrics Endocrinology and Internal Medicine (MEA) Molecular Medicine Cardiology Aarhus University Hospital Aarhus Department of Clinical Genetics Vejle Hospital Vejlep Institute of Regional Health Research University of Southern Denmark Odense Denmark.

klinefelter syndrome （kS）（47, XXY） is the most abundant sex-chromosome disorder, and is a common cause of infertility and hypogonadism in men. Most men with kS go through life without knowing the diagnosis, as only 25% are diagnosed and only a few of these before puberty. Apart from hypogonadism and azoospermia, most men with kS suffer from some degree of learning disability and may have various kinds of psychiatric problems. The effects of long-term hypogonadism may be difficult to discern from the gene dose effect of the extra X-chromosome. Whatever the cause, alterations in body composition, with more fat and less muscle mass and diminished bone mineral mass, as well as increased risk of metabolic consequences, such as type 2 diabetes and the metabolic syndrome are all common in kS. These findings should be a concern as they are not simply laboratory findings; epidemiological studies in kS populations show an increased risk of beth hospitalization and death from various diseases. Testosterone treatment should be offered to kS patients from early puberty, to secure a proper masculine development, nonetheless the evidence is weak or nonexisting, since no randomized controlled trials have ever been published. Here, we will review the current knowledge of hypogonadism in kS and the rationale for testosterone treatment and try to give our best recommendations for surveillance of this rather common, but often ignored, syndrome.

关键词： androgen receptor body composition bone density hypogonadism infertility klinefelter syndrome learning disorders male testosterone

Schrodinger and klein-Gordon theories of black holes from the quantization of the Oppenheimer and Snyder gravitational collapse

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Communications in Theoretical Physics 2023年第9期75卷 122-135页

作者： christian Corda SUNY Polytechnic Institute 13502 UticaNew YorkUSAIstituto Livi59100 PratoTuscanyItaly and International Institute for Applicable Mathematics and Information SciencesB M Birla Science CentreAdarshnagarHyderabad 500063India

The Schrodinger equation of the Schwarzschild black hole(BH) has been recently derived by the author and collaborators. The BH is composed of a particle, the 'electron', interacting with a central field, the 'nucleus'. Via de Broglie's hypothesis, one interprets the 'electron' in terms of BH horizon's modes. Quantum gravity effects modify the BH semi-classical structure at the Schwarzschild scale rather than at the Planck scale. The analogy between this BH Schrodinger equation and the Schrodinger equation of the s states of the hydrogen atom permits us to solve the same equation. The quantum gravitational quantities analogous of the fine structure constant and of the Rydberg constant are not constants, but the dynamical quantities have well-defined discrete spectra. The spectrum of the 'gravitational fine structure constant' is the set of non-zero natural numbers. Therefore, BHs are well-defined quantum gravitational systems obeying Schrodinger's theory: the 'gravitational hydrogen atoms'. By identifying the potential energy in the BH Schrodinger equation as being the gravitational energy of a spherically symmetric shell, a different nature of the quantum BH seems to surface. BHs are self-interacting, highly excited,spherically symmetric, massive quantum shells generated by matter condensing on the apparent horizon, concretely realizing the membrane paradigm. The quantum BH described as a'gravitational hydrogen atom' is a fictitious mathematical representation of the real, quantum BH, a quantum massive shell having a radius equal to the oscillating gravitational *** consequences emerge from this result:(i) BHs have neither horizons nor singularities;(ii) there is neither information loss in BH evaporation, nor BH complementarity, nor firewall paradox. These results are consistent with previous ones by Hawking, Vaz, Mitra and ***, the special relativistic corrections to the BH Schrodinger equation give the BH klein–Gordon equation and the cor

关键词： quantum black holes information paradox quantum shells quantum levels Schrodinger and klein-Gordon theories

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy