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Human amniotic fluid stem cell therapy can help regain bladder function in type 2 diabetic rats

World Journal of Stem Cells 2022年第5期14卷 330-346页

作者： ching-Chung Liang Steven W Shaw yung-Hsin Huang Tsong-Hai lee Female Urology Section Department of Obstetrics and GynecologyLinkou Chang Gung Memorial HospitalCollege of MedicineChang Gung UniversityTaoyuan 333Taiwan Division of Obstetrics Department of Obstetrics and GynecologyTaipei Chang Gung Memorial HospitalTaipei 105Taiwan Prenatal Cell and Gene Therapy Group Institute for Women’s HealthUniversity College LondonLondon WC1E 6BTUnited Kingdom Stroke Center and Department of Neurology Linkou Chang Gung Memorial HospitalCollege of MedicineChang Gung UniversityTaoyuan 333Taiwan

BACKGROUND Diabetes mellitus(DM)is a serious and growing global health *** is estimated that 80%of diabetic patients have micturition problems such as poor emptying,urinary incontinence,urgency,and urgency *** with diabetic bladder dysfunction are often resistant to currently available *** is necessary to develop new and effective treatment *** To examine the therapeutic effect of human amniotic fluid stem cells(hAFSCs)therapy on bladder dysfunction in a type 2 diabetic rat *** Sixty female Sprague-Dawley rats were divided into five groups:Group 1,normal-diet control(control);group 2,high-fat diet(HFD);group 3,HFD plus streptozotocin-induced DM(DM);group 4,DM plus insulin treatment(DM+insulin);group 5,DM plus hAFSCs injection via tail vein(DM+hAFSCs).Conscious cystometric studies were done at 4 and 12 wk after insulin or hAFSCs treatment to measure peak voiding pressure,voided volume,intercontraction interval,bladder capacity,and residual *** and/or mRNA expression of muscarinic receptors,nerve growth factor(NGF),and sensory nerve markers in the bladder and insulin,MafA,and pancreatic-duodenal homeobox-1(PDX-1)in pancreatic beta cells were *** Compared with DM rats,insulin but not hAFSCs treatment could reduce the bladder weight and improve the voided volume,intercontraction interval,bladder capacity,and residual volume(P0.05).The immunoreactivities and mRNA expression of M2-and M3-muscarinic receptors(M2 and M3)were increased mainly at 4 wk(P<0.05),while the number of beta cells in islets and the immunoreactivities and/or mRNA of NGF,calcitonin gene-related peptide(CGRP),substance P,insulin,MafA,and PDX-1 were decreased in DM rats(P<0.05).However,insulin and hAFSCs treatment could help to regain the expression of M2,M3,NGF,CGRP,substance P,MafA

关键词： Amniotic fluid Bladder dysfunction Diabetes Insulin Stem cells

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Double balloon endoscopy increases the ERCP success rate in patients with a history of Billroth Ⅱ gastrectomy

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World Journal of Gastroenterology 2010年第36期16卷 4594-4598页

作者： Jui-Hsiang Tang yung-Kuan Tsou Hao-Tsai Cheng Mu-Hsien lee ching-Song lee Nai-Jen Liu Division of Digestive Therapeutic Endoscopy Department of Gastroenterology and HepatologyChang Gung Memorial Hospital College of Medicine Chang Gung University

AIM:To evaluate the effect of double balloon endoscope(DBE)on the endoscopic retrograde cholangio-pancreatography(ERCP)success rate in patients with a history of BillrothⅡ(BⅡ)***:From April 2006 to March 2007,32 patients with a BⅡgastrectomy underwent 34 ERCP *** all cases,the ERCP procedures were started using a *** intubation of the afferent loop or reaching the papilla failed,we changed to DBE for the ERCP procedure(DBE-ERCP).We assessed the success rate of afferent loop intubation,reaching the major papilla,selective cannulation,possibility of therapeutic approaches,procedure-related complications,and the overall success ***:Among the 32 patients with a history of BⅡgastrectomy,the duodenoscope was successfully passed up to the papilla in 22 patients(69%),and cannulation was successfully performed in 20 patients(63%).Six patients(2 with failure in afferent loop intubation and 4 with failure in reaching the papilla)underwent *** DBE reached the papilla in all the 6 patients(100%)and selective cannulation was successful in 5 patients(83%).Four patients(67%)who had common bile duct stones were successfully *** patient underwent diagnostic ERCP only and the other one,in whom selective cannulation failed,was diagnosed with papilla cancer proven by *** were no complications related to the *** overall ERCP success rate increased to 88%(28/32).CONCLUSION:The overall ERCP success rate increases with DBE in patients with a previous BⅡgastrectomy.

关键词： Double balloon endoscopy Endoscopic retrograde cholangiopancreatography BillrothⅡgastrectomy

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Cell membrane-derived vesicles for delivery of therapeutic agents

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2096-2113页

作者： Quoc-Viet Le Jaiwoo lee Hobin lee Gayong Shim yu-Kyoung Oh College of Pharmacy and Research Institute of Pharmaceutical Sciences Seoul National UniversitySeoul 08826Republic of Korea School of Systems Biomedical Science Soongsil UniversitySeoul 06978Republic of Korea

Cell membranes have recently emerged as a new source of materials for molecular delivery *** membranes have been extruded or sonicated to make nanoscale *** synthetic lipid or polymeric nanoparticles,cell membrane-derived vesicles have a unique multicomponent feature,comprising lipids,proteins,and *** cell membrane-derived vesicles contain the intrinsic functionalities and signaling networks of their parent cells,they can overcome various obstacles encountered in ***,the different natural combinations of membranes from various cell sources expand the range of cell membrane-derived vesicles,creating an entirely new category of drug-delivery *** membrane-derived vesicles can carry therapeutic agents within their interior or can coat the surfaces of drug-loaded core *** membranes typically come from single cell sources,including red blood cells,platelets,immune cells,stem cells,and cancer ***,recent studies have reported hybrid sources from two different types of *** review will summarize approaches for manufacturing cell membrane-derived vesicles and treatment applications of various types of cell membrane-derived drug-delivery systems,and discuss challenges and future directions.

关键词： Cell membrane-derived vesicles Membrane engineering Drug-delivery systems Blood cells Immune cells Stem cells Cancer cells Manufacturing

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Influence of Bi addition on dynamic recrystallization and precipitation behaviors during hot extrusion of pure Mg

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Journal of Materials Science & Technology 2020年第9期44卷 62-75页

作者： Jongbin Go Jong Un lee Hui yu Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu41566Republic of Korea School of Materials Science and Engineering Hebei University of TechnologyTianjin300130China

Low material cost and high extrudability for ensuring price competitiveness with Al alloys,as well as excellent mechanical properties,are essential for expanding the application range of Mg *** is a promising alloying element for developing extruded Mg alloys that satisfy such *** is inexpensive,exhibits a high solubility limit,and forms a thermally stable Mg3Bi2 phase,which improves the commercial viability and enables the high-speed extrusion of Mg–Bi *** this study,the effects of Bi addition on the dynamic recrystallization(DRX)and dynamic precipitation behaviors during hot extrusion of a pure Mg and the resultant microstructure and mechanical properties of the extruded materials were *** addition of 6 wt%and 9 wt%Bi to a pure Mg yielded numerous fine Mg3Bi2 precipitates during the early stage of hot ***,the area fraction of dynamic recrystallized(DRXed)grains decreased because of DRX-behavior suppression by the Zener pinning ***,the DRXed grain size was substantially reduced through the grain-boundary pinning *** size and number of undissolved Mg3Bi2 particles in the homogenized billets increased when the Bi content was increased,which resulted in increased DRX fractions owing to the enhanced levels of particle stimulated *** addition yielded considerable strength improvement of the extruded pure ***,the extruded Mg–Bi binary materials were less ductile than the extruded pure Mg *** lower ductility resulted from the cracking at twins formed in the coarse unDRXed grains of the Mg-6Bi material and the cracking at large undissolved Mg3Bi2 particles in the Mg-9Bi material.

关键词： Magnesium Bi addition Extrusion Recrystallization Precipitation

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液态甲烷管道预冷过程的仿真研究

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航空动力学报 2024年第4期39卷 244-250页

作者：陈玉孙得川曾卓雄上海电力大学能源与机械工程学院上海201306 大连理工大学力学与航空航天学院辽宁大连116024

低温推进剂液体火箭发动机在推进剂加注时需要进行管道预冷以避免推进剂气化。为揭示管路预冷过程中低温流体的两相流动特性,针对小型液氧/甲烷发动机液态甲烷管道的预冷过程进行了研究。采用lee蒸发模型,模拟并分析了不同入口流量下的... 详细信息

低温推进剂液体火箭发动机在推进剂加注时需要进行管道预冷以避免推进剂气化。为揭示管路预冷过程中低温流体的两相流动特性,针对小型液氧/甲烷发动机液态甲烷管道的预冷过程进行了研究。采用lee蒸发模型,模拟并分析了不同入口流量下的湍流传热过程,得到了管道预冷过程中甲烷的体积分数、温度、压力和速度的变化规律。结果表明:在管道预冷过程中,液态甲烷会发生闪蒸现象,甲烷的温度和压力的变化是影响闪蒸的主要因素;在低流量时,预冷时间与质量流量呈负相关,当质量流量增大到一定程度后,预冷时间趋于稳定值。研究结果可预示容许时间内的最优预冷流量,对提高预冷效率和改进低温推进剂加注过程具有指导作用。

关键词：液态甲烷预冷过程相变 lee模型闪蒸

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Temporary coronary sinus pacing to improve ventricular dyssynchrony with cardiogenic shock: A case report

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World Journal of Clinical Cases 2021年第20期9卷 5562-5567页

作者： Teressa Reanne Ju Hsin Tseng Hsin-Ti Lin Alexander lee Wang Chi Chan lee Yi-ching Lai Department of Internal Medicine NewYork-Presbyterian Queens HospitalQueensNY 11355United States School of Medicine China Medical UniversityTaichung City 40447Taiwan Department of Critical Care Medicine Guam Regional Medical CityDededo 96929Guam Department of Cardiology Division of Internal MedicineChina Medical University HospitalTaichung City 40447Taiwan

BACKGROUND Temporary transvenous pacing through the coronary sinus is a novel approach rarely used in treating unstable *** modality could provide cardiac pacing while achieving better ventricular *** present a case who received cardiac pacing through the coronary sinus and provide a summary of evidence in the current *** SUMMARY A 55-year-old woman with a history of advanced heart failure was admitted to the rehabilitation ward after a recent *** hospitalization,she had paroxysmal atrial fibrillation with rapid ventricular response resulting from fluid *** atrial fibrillation was spontaneously reversed to sinus rhythm after diuresis,she developed multiple episodes of polymorphic ventricular tachycardia along with sinus bradycardia and prolonged QTc *** became hypotensive despite appropriate medical *** through her implantable cardioverter-defibrillator was attempted but worsened her *** dyssynchrony was *** transvenous atrial pacing through the coronary sinus was performed,which stabilized her blood pressure and improved end-organ perfusion.A permanent biventricular pacemaker was later implanted,and she was safely discharged to a nursing *** Temporary transvenous pacing through the coronary sinus,a novel approach to treat unstable bradycardia,may reduce ventricular dyssynchrony.

关键词： Cardiac resynchronization Artificial pacemaker Coronary sinus Heart failure Cardiogenic shock Case report

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利用TALEN技术创建RPE65基因编辑犬

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农业生物技术学报 2024年第6期32卷 1452-1461页

作者：徐铮李振诚赖威仲许博钱雨玉陈晨王晶张勇冯冲魏彦明甘肃农业大学动物医学院甘肃省动物生殖生理及繁殖调控重点实验室苏州启辰生物科技有限公司

视网膜色素上皮65 (retinal pigment epithelium 65, RPE65)基因在视循环中起重要作用，当RPE65基因发生突变时，视锥、视杆细胞功能丧失，严重的患者会视力丧失。为构建RPE65基因突变动物疾病模型，本研究利用转录激活因子样效应物核酸... 详细信息

视网膜色素上皮65 (retinal pigment epithelium 65, RPE65)基因在视循环中起重要作用，当RPE65基因发生突变时，视锥、视杆细胞功能丧失，严重的患者会视力丧失。为构建RPE65基因突变动物疾病模型，本研究利用转录激活因子样效应物核酸酶(transcription activator-like effector nucleases,TALENs)基因编辑技术，以比格犬(Canis lupus familiaris)为实验动物，针对RPE65基因第3号和第7号外显子构建表达载体，结合显微操作创建RPE65基因编辑犬。通过临床观察、常规眼科检查、眼底照相(fundus photography, FP)、光学相干断层扫描(optical coherence tomography, OCT)和全视野视网膜电图(electroretinography, ERG)对幼犬视功能进行表型分析检测。T7E1酶切和基因测序结果显示，最终获得2只RPE65基因编辑雄性幼犬。眼科表型分析表明，RPE65基因编辑幼犬眼底血管稀疏纤细；ERG结果显示，光感受器细胞的电位活动a波、b波振幅降低，峰时延长，提示视网膜功能受损。本研究利用TALEN基因编辑技术构建的RPE65基因编辑幼犬存在视功能障碍，可为RPE65基因突变诱导的视网膜疾病及相关研究提供参考，还为治疗手段的开发、临床药物的筛选提供良好的动物疾病模型。

关键词：比格犬转录激活因子样效应物核酸酶(TALEN) 视网膜色素上皮65(RPE65) 基因编辑视网膜

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The best method of detecting prior Helicobacter pylorimfection

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World Journal of Gastroenterology 2005年第36期11卷 5672-5676页

作者： Chien-yu Lu Chao-Hung Kuo Yi-ching Lo Hung-Yi Chuang yuan-Chieh Yang I-Chen Wu Fang-long yu Yi-Chen lee Chang-Ming Jan Wen-Ming Wang Deng-Chyang Wu Division of Gastroenterology Department of Internal Medicine Kaohsiung Medical University Hospital Taiwan China Department of Pharmacology Kaohsiung Medical University Taiwan China Department of Occupational Medicine and School of Public Health Kaohsiung Medical University Taiwan China Department of Clinical Pathology Kaohsiung Medical University Hospital Taiwan China Department of Internal Medicine Kaohsiung Municipal United Hospital Kaohsiung Taiwan China

AIM： Prior Helicobacterpylori （Hpylori infection has often been underestimated. These underestimations have misled physicians attempting to determine the significance between Hpyloriand certain gastrointestinal lesions such as intestinal metaplasia, atrophic gastritis, and gastric cancer. Our study endeavored to debit past Hppylorinfections accurately, easily, and rapidly with the newly developed irnmunoblot kit, Helico Blot 2.1. METHODS： Thirty-three patients, including 25 H pylori infected and 8 uninfected cases, were enrolled in our study. All patients received consecutive gastroendoscopic examinations and ^3C-urea breath test （UBT） tests at 6- or 12-mo intervals for up to 4 years. Serum samples were obtained from each patient at the same time. Intragastric H pylori infection was confirmed in accordance with the gold standard. Twenty-five H pylori-infected patients received triple therapies after initial bacterial confirmation, and were successful in eradicating their infections. Serially obtained sera were tested by means of Helico Blot 2.1. RESULTS： Current infection marker detected by Helico Blot 2.1 was unreliable for representing ongoing Hpylori infection. Only 35 and 37 ku antibodies of H pylorihad significant seroconversion rates 1 year after having been cured. The seroposiUve rates of 116 ku （cytotoxin-associated antigen [CagA]） and Helico Blot 2.1 were nearly 100% during 4-year follow-up period. Both CagA antigen and Helico blot 2.1 could serve as indicators of long-term H pylori infection. CONCLUSION： Helico Blot 2.1 can detect past H pylori infections for up to 4 years, and is the best method to date for detecting previous long-term H pylori infection. 2005 The WJG Press and Elsevier Inc. All rights reserved.

关键词： Helicobacter pylori Long-term infection Diagnosis Serum

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Impact of Diabetes Mellitus on the Treatment Outcomes of Chemotherapy in Women with Breast Cancer——A Population-Based Prospective Cohort Study

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Journal of Electronic Science and Technology 2015年第1期13卷 87-93页

作者： yu-ching Chen Cheng-Wei Chang Jorng-Tzong Horng Yan-Jun Chen Jin-Tsung Yang Department of Bioinformatics Asia University Department of Information Management Hsing Wu University Department of Computer Science and Information Engineering National Central University Office of Physical Education National Central University

There are few population-based data in investigating the impact of diabetes on chemotherapy adverse effects and treatment outcomes of non-metastatic breast cancer. The purpose of this study is to evaluate whether diabetes affects the patterns of use in chemotherapy, toxic effects of chemotherapy, and treatment outcomes for non-metastatic breast cancer in Taiwan. The study results can provide physicians for making a decision whether or not to use chemotherapy based on the individual patients＇ condition.

关键词： Chemotherapy diabetes mellitus national insurance research database non-metastatic breast cancer population-based study

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Cluster-Based Saliency-Guided Content-Aware Image Retargeting

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Journal of Electronic Science and Technology 2017年第2期15卷 141-146页

作者： Li-Wei Kang ching-yu Tseng Chao-Long Jheng Ming-Fang Weng Chao-yung Hsu Graduate School of Engineering Science and Technology and the Department of Computer Science and Information Engineering MPI Corporation Hsinchu Changing Information Technology Inc.Hsinchu 308 Institute for Information Industry Taipei 106 automation and Instrumentation System Development Sec. China Steel CorporationKaohsiung 81233

Straightforward image resizing operators without considering image contents （e.g., uniform scaling） cannot usually produce satisfactory results, while content-aware image retargeting aims to arbitrarily change image size while preserving visually prominent features. In this paper, a cluster-based saliency-guided seam carving algorithm for content- aware image retargeting is proposed. To cope with the main drawback of the original seam carving algorithm relying on only gradient-based image importance map, we integrate a gradient-based map and a cluster-based saliency map to generate a more reliable importance map, resulting in better single image retargeting results. Experimental results have demonstrated the efficacy of the proposed algorithm.

关键词： Index Terms--Content-aware image retargeting image resizing multimedia adaptation saliency detection seam carving.

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