Cell membrane-derived vesicles for delivery of therapeutic agents

作     者：Quoc-Viet Le Jaiwoo Lee Hobin Lee Gayong Shim Yu-Kyoung Oh Quoc-Viet Le;Jaiwoo Lee;Hobin Lee;Gayong Shim;Yu-Kyoung Oh

作者机构：College of Pharmacy and Research Institute of Pharmaceutical SciencesSeoul National UniversitySeoul 08826Republic of Korea School of Systems Biomedical ScienceSoongsil UniversitySeoul 06978Republic of Korea 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2021年第11卷第8期

页      面：2096-2113页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by grants from the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(NRF-2021R1A2B5B03002123,NRF-2018R1A5A2024425,Republic of Korea) the Korea Medical Device Development Fund grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Trade,Industry and Energy,the Ministry of Health&Welfare,the Ministry of Food and Drug Safety NTIS Number:9991007273,Republic of Korea) the Korean Health Technology R&D Project(No.HI18C2177,HI19C0664,Republic of Korea),Ministry of Health&Welfare 

主　　题：Cell membrane-derived vesicles Membrane engineering Drug-delivery systems Blood cells Immune cells Stem cells Cancer cells Manufacturing 

摘      要：Cell membranes have recently emerged as a new source of materials for molecular delivery *** membranes have been extruded or sonicated to make nanoscale *** synthetic lipid or polymeric nanoparticles,cell membrane-derived vesicles have a unique multicomponent feature,comprising lipids,proteins,and *** cell membrane-derived vesicles contain the intrinsic functionalities and signaling networks of their parent cells,they can overcome various obstacles encountered in ***,the different natural combinations of membranes from various cell sources expand the range of cell membrane-derived vesicles,creating an entirely new category of drug-delivery *** membrane-derived vesicles can carry therapeutic agents within their interior or can coat the surfaces of drug-loaded core *** membranes typically come from single cell sources,including red blood cells,platelets,immune cells,stem cells,and cancer ***,recent studies have reported hybrid sources from two different types of *** review will summarize approaches for manufacturing cell membrane-derived vesicles and treatment applications of various types of cell membrane-derived drug-delivery systems,and discuss challenges and future directions.